{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:56:27Z","timestamp":1787068587503,"version":"build-2736575974"},"reference-count":91,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T00:00:00Z","timestamp":1741910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"India Ministry of Science & Technology Department of Biotechnology","doi-asserted-by":"publisher","award":["BT\/PR40164\/BTIS\/137\/17\/2021"],"award-info":[{"award-number":["BT\/PR40164\/BTIS\/137\/17\/2021"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ayurveda and Integrative Medicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jaim.2025.101161","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T16:53:05Z","timestamp":1750697585000},"page":"101161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacoinformatics in identifying therapeutically important chemical species from Ayurvedic formulations employed in treating COVID-19 patients"],"prefix":"10.1016","volume":"16","author":[{"given":"Akash G.","family":"Kendre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramadas","family":"Maganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8650-7414","authenticated-orcid":false,"given":"Sumit","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay M.","family":"Jachak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7064-8561","authenticated-orcid":false,"given":"Prasad V.","family":"Bharatam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib1","first-page":"1","article-title":"Natural history of long-COVID in a nationwide, population cohort study","volume":"14","author":"Hastie","year":"2023","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.jaim.2025.101161_bib2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41591-020-0820-9","article-title":"The proximal origin of SARS-CoV-2","volume":"26","author":"Andersen","year":"2020","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib3","first-page":"1","article-title":"Epidemiological drivers of transmissibility and severity of SARS-CoV-2 in England","volume":"14","author":"Perez-Guzman","year":"2023","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.jaim.2025.101161_bib4","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jinf.2020.03.041","article-title":"Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis","volume":"80","author":"Fu","year":"2020","journal-title":"J Infect"},{"key":"10.1016\/j.jaim.2025.101161_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198114","article-title":"COVID-19 Vaccine: a comprehensive status report","volume":"288","author":"Kaur","year":"2020","journal-title":"Virus Res"},{"issue":"3","key":"10.1016\/j.jaim.2025.101161_bib6","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1080\/07391102.2020.1825232","article-title":"Repurposing drugs for treatment of SARS-CoV-2 infection: computational design insights into mechanisms of action","volume":"40","author":"Kandwal","year":"2022","journal-title":"J Biomol Struct Dyn"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaim.2020.11.010","article-title":"Pathophysiology of Covid-19 and host centric approaches in Ayurveda","volume":"13","author":"Pandkar","year":"2022","journal-title":"J Ayurveda Integr Med"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib8","first-page":"9","article-title":"Natural products as a foundation for drug discovery","volume":"46","author":"Beutler","year":"2009","journal-title":"Curr Protoc Pharmacol"},{"key":"10.1016\/j.jaim.2025.101161_bib9","first-page":"1","article-title":"The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety","volume":"4","author":"Ekor","year":"2014","journal-title":"Front Neurol"},{"key":"10.1016\/j.jaim.2025.101161_bib10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbi.2020.05.003","article-title":"Time to realise the true potential of Ayurveda against COVID-19","volume":"87","author":"Golechha","year":"2020","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaim.2020.08.001","article-title":"Understanding COVID - 19 pandemic \u2013 a comprehensive Ayurvedic perspective","volume":"13","author":"Adluri","year":"2022","journal-title":"J Ayurveda Integr Med"},{"issue":"5","key":"10.1016\/j.jaim.2025.101161_bib12","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1089\/acm.2020.0129","article-title":"Public health approach of Ayurveda and yoga for COVID-19 prophylaxis","volume":"26","author":"Tillu","year":"2020","journal-title":"J Altern Complement Med"},{"key":"10.1016\/j.jaim.2025.101161_bib13","article-title":"Prevalence and factors associated with utilization of ayurvedic drugs during COVID-19. A community-based cross-sectional study","volume":"19","author":"Satyanarayana","year":"2023","journal-title":"Clin Epidemiol Glob Heal"},{"issue":"11","key":"10.1016\/j.jaim.2025.101161_bib14","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1007\/s11655-021-3512-5","article-title":"Frequently used allopathic and traditional medicine for COVID-19 treatment and feasibility of their integration","volume":"28","author":"Upadhayay","year":"2022","journal-title":"Chin J Integr Med"},{"issue":"7","key":"10.1016\/j.jaim.2025.101161_bib15","first-page":"906","article-title":"The plausible role of indian traditional medicine in combating corona virus (SARS-CoV-2): a mini-review","volume":"22","author":"Adithya","year":"2021","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.jaim.2025.101161_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153361","article-title":"Herbal immune-boosters: substantial warriors of pandemic Covid-19 battle","volume":"85","author":"Khanna","year":"2021","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.jaim.2025.101161_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/ecam\/neh140","article-title":"Ayurveda and traditional Chinese medicine: a comparative overview","volume":"2","author":"Patwardhan","year":"2005","journal-title":"Evid base Compl Alternative Med"},{"key":"10.1016\/j.jaim.2025.101161_bib18","series-title":"Computer aided drug design in \u2015drug discovery and development\u2016","first-page":"137","author":"Bharatam","year":"2021"},{"issue":"9","key":"10.1016\/j.jaim.2025.101161_bib19","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1021\/acs.jmedchem.5b01684","article-title":"Role of molecular dynamics and related methods in drug discovery","volume":"59","author":"De Vivo","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.jaim.2025.101161_bib20","doi-asserted-by":"crossref","unstructured":"Priyadarsinee L, Jamir E, Nagamani S, Mahanta HJ, et al. Molecular Property Diagnostic Suite for COVID-19 (MPDS COVID-19): An open access disease specific drug discovery portal. GigaByte. https:\/\/doi.org\/10.46471\/gigabyte.114.","DOI":"10.46471\/gigabyte.114"},{"issue":"3","key":"10.1016\/j.jaim.2025.101161_bib21","article-title":"Ayurvedic formulations: potential COVID-19 therapeutics?","volume":"2","author":"Ali","year":"2022","journal-title":"Phytomed Plus"},{"key":"10.1016\/j.jaim.2025.101161_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmolb.2020.613401","article-title":"Molecular docking studies on the anti- viral effects of compounds from kabasura kudineer on SARS-CoV-2 3CLpro","volume":"7","author":"Vincent","year":"2020","journal-title":"Front Mol Biosci"},{"issue":"11","key":"10.1016\/j.jaim.2025.101161_bib23","article-title":"Ayurvedic medicinal plants against COVID-19: an in silico analysis","volume":"16","author":"Khuntia","year":"2021","journal-title":"Nat Prod Commun"},{"issue":"18","key":"10.1016\/j.jaim.2025.101161_bib24","doi-asserted-by":"crossref","first-page":"8405","DOI":"10.1080\/07391102.2021.1922095","article-title":"Repurposing of the herbal formulations: molecular docking and molecular dynamics simulation studies to validate the efficacy of phytocompounds against SARS-CoV-2 proteins","volume":"40","author":"Joshi","year":"2022","journal-title":"J Biomol Struct Dyn"},{"issue":"4","key":"10.1016\/j.jaim.2025.101161_bib25","first-page":"79","article-title":"Pharmacoinformatics in identifying potential inhibitors of key SARS-CoV-2 enzymes among the phytochemicals from Murraya koenigii and Vitex negundo","volume":"16","author":"Sharma","year":"2022","journal-title":"Curr Res Info Pharm Sci"},{"key":"10.1016\/j.jaim.2025.101161_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1878-5085-5-19","article-title":"Bridging Ayurveda with evidence-based scientific approaches in medicine","volume":"5","author":"Patwardhan","year":"2014","journal-title":"EPMA J"},{"key":"10.1016\/j.jaim.2025.101161_bib27","article-title":"In vitro anti-inflammatory and in silico anti-viral assessment of phytoconstituents in polyherbal ayurvedic formulation 'Arogyamrita Kwath'","author":"Dey","year":"2024","journal-title":"J Ayurveda Integr Med"},{"issue":"2","key":"10.1016\/j.jaim.2025.101161_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11418-021-01591-1","article-title":"Saponin constituents of Achyranthes root","volume":"76","author":"Kiuchi","year":"2022","journal-title":"J Nat Med"},{"issue":"3","key":"10.1016\/j.jaim.2025.101161_bib29","doi-asserted-by":"crossref","DOI":"10.2144\/fsoa-2022-0068","article-title":"Phytochemical and biological review of Aegle marmelos Linn","volume":"9","author":"Monika","year":"2023","journal-title":"Future Sci OA"},{"issue":"17","key":"10.1016\/j.jaim.2025.101161_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/0973-7847.156350","article-title":"Alpinia calcarata Roscoe: a potential phytopharmacological source of natural medicine","volume":"9","author":"Rahman","year":"2015","journal-title":"Pharmacogn Rev"},{"key":"10.1016\/j.jaim.2025.101161_bib31","first-page":"1","article-title":"Andrographis paniculata (burm. F.) wall. Ex nees: a review of ethnobotany, phytochemistry, and pharmacology","author":"Hossain","year":"2014","journal-title":"Sci World J"},{"issue":"23","key":"10.1016\/j.jaim.2025.101161_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules25235555","article-title":"Bergenia genus: traditional uses, phytochemistry and pharmacology","volume":"25","author":"Koul","year":"2020","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.jaim.2025.101161_bib33","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/BF02975187","article-title":"Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties","volume":"24","author":"Choi","year":"2001","journal-title":"Arch Pharm Res (Seoul)"},{"issue":"2","key":"10.1016\/j.jaim.2025.101161_bib34","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jep.2014.03.071","article-title":"Clerodendrum serratum (L.) Moon. - a review on traditional uses, phytochemistry and pharmacological activities","volume":"154","author":"Patel","year":"2014","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"10.1016\/j.jaim.2025.101161_bib35","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.jmedchem.6b00975","article-title":"The essential medicinal chemistry of curcumin","volume":"60","author":"Nelson","year":"2017","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1211\/jpp.61.01.0003","article-title":"Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties","volume":"61","author":"Lobo","year":"2008","journal-title":"J Pharm Pharmacol"},{"issue":"3","key":"10.1016\/j.jaim.2025.101161_bib37","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1002\/jsfa.9271","article-title":"Preliminary evaluation of quince (Cydonia oblonga Mill.) fruit as extraction source of antioxidant phytoconstituents for nutraceutical and functional food applications","volume":"99","author":"Sut","year":"2019","journal-title":"J Sci Food Agric"},{"issue":"2","key":"10.1016\/j.jaim.2025.101161_bib38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jep.2011.04.031","article-title":"An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC","volume":"136","author":"Rastogi","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.jaim.2025.101161_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113593","article-title":"Gmelina arborea\u2013an indigenous timber species of India with high medicinal value: a review on its pharmacology, pharmacognosy and phytochemistry","volume":"267","author":"Warrier","year":"2021","journal-title":"J Ethnopharmacol"},{"issue":"9","key":"10.1016\/j.jaim.2025.101161_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom10091341","article-title":"Metabolic diversity and therapeutic potential of Holarrhena pubescens: an important ethnomedicinal plant","volume":"10","author":"Zahara","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.jaim.2025.101161_bib41","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.matpr.2022.06.261","article-title":"A review on current status of traditional uses, phytochemistry, pharmacology and conservation of Inula racemosa Hook. f","volume":"68","author":"Jaiswal","year":"2022","journal-title":"Mater Today Proc"},{"issue":"5","key":"10.1016\/j.jaim.2025.101161_bib42","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4103\/0250-474X.98981","article-title":"A Review on the taxonomy, ethnobotany, chemistry and pharmacology of Oroxylum indicum vent","volume":"73","author":"Harminder","year":"2011","journal-title":"Indian J Pharm Sci"},{"issue":"2","key":"10.1016\/j.jaim.2025.101161_bib43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S2005-2901(11)60020-4","article-title":"Overview for various aspects of the health benefits of Piper longum linn. Fruit","volume":"4","author":"Kumar","year":"2011","journal-title":"J Acupunct Meridian Stud"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib44","first-page":"12","article-title":"Black pepper, the \u201cking of spices\u201d: chemical composition to applications","volume":"6","author":"Hammouti","year":"2019","journal-title":"Arab J Chem Environ Res"},{"issue":"3","key":"10.1016\/j.jaim.2025.101161_bib45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4172\/2167-0412.1000161","article-title":"A review on therapeutic potential of Piper nigrum L. (Black pepper): the king of spices","volume":"3","author":"Damanhouri","year":"2014","journal-title":"Med Aromat Plants"},{"issue":"4","key":"10.1016\/j.jaim.2025.101161_bib46","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jscs.2010.05.003","article-title":"Phytoconstituents from the galls of Pistacia integerrima stewart","volume":"14","author":"Ahmad","year":"2010","journal-title":"J Saudi Chem Soc"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib47","first-page":"2102","article-title":"Phytochemistry, micropropagation and pharmacology of near threatened plant Pseudarthria viscida (L.) wight & arn","volume":"8","author":"Shaaganti","year":"2019","journal-title":"J Pharmacogn Phytochem"},{"issue":"6","key":"10.1016\/j.jaim.2025.101161_bib48","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/S0031-9422(96)00395-0","article-title":"Steroidal glycosides, indiosides A-E, from Solanum indicum","volume":"43","author":"Yahara","year":"1996","journal-title":"Phytochemistry"},{"issue":"2","key":"10.1016\/j.jaim.2025.101161_bib49","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0031-9422(73)80027-5","article-title":"Steroidal constituents of Solanum xanthocarpum","volume":"12","author":"Kusano","year":"1973","journal-title":"Phytochemistry"},{"issue":"10","key":"10.1016\/j.jaim.2025.101161_bib50","first-page":"732","article-title":"Phytochemistry of Solanum xanthocarpum: an amazing traditional healer","volume":"69","author":"Singh","year":"2010","journal-title":"J Sci Ind Res"},{"issue":"10","key":"10.1016\/j.jaim.2025.101161_bib51","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.3109\/13880209.2012.666981","article-title":"In vitro studies to assess the antidiabetic, antiperoxidative, and radical scavenging potential of Stereospermum colais","volume":"50","author":"Rani","year":"2012","journal-title":"Pharm Biol"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib52","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3329\/dujps.v13i1.21857","article-title":"Secondary metabolites from different extractives of Stereospermum suaveolens","volume":"13","author":"Begum","year":"2014","journal-title":"Dhaka Univ J Pharm Sci"},{"issue":"3","key":"10.1016\/j.jaim.2025.101161_bib53","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S2221-1691(12)60050-1","article-title":"Syzygium cumini (L.) Skeels: a review of its phytochemical constituents and traditional uses","volume":"2","author":"Ayyanar","year":"2012","journal-title":"Asian Pac J Trop Biomed"},{"issue":"9","key":"10.1016\/j.jaim.2025.101161_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02437","article-title":"The chemical constituents and diverse pharmacological importance of Tinospora cordifolia","volume":"5","author":"Sharma","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.jaim.2025.101161_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2021.111577","article-title":"A comprehensive chemical profiling of phytochemicals from Trachyspermum ammi and encapsulation for sustained release","volume":"147","author":"Dutta","year":"2021","journal-title":"LWT"},{"issue":"8","key":"10.1016\/j.jaim.2025.101161_bib56","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/S0031-9422(97)01086-8","article-title":"Alkaloids and other constituents from Tribulus terrestris","volume":"50","author":"Wu","year":"1999","journal-title":"Phytochemistry"},{"issue":"15","key":"10.1016\/j.jaim.2025.101161_bib57","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4103\/0973-7847.125530","article-title":"Phytopharmacological overview of Tribulus terrestris","volume":"8","author":"Chhatre","year":"2014","journal-title":"Pharmacogn Rev"},{"issue":"3","key":"10.1016\/j.jaim.2025.101161_bib58","doi-asserted-by":"crossref","first-page":"40","DOI":"10.22159\/ajpcr.2021.v14i3.40833","article-title":"Uraria Picta (Jacq.): a review on ethnomedical uses, phytochemistry, and biological activities","volume":"14","author":"Mane","year":"2021","journal-title":"Asian J Pharm Clin Res"},{"key":"10.1016\/j.jaim.2025.101161_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115604","article-title":"Phytochemical screening and effect of Viscum album L. on monoamine oxidase A and B activity and serotonin, dopamine and serotonin receptor 5-HTR1A levels in Galleria mellonealla (Lepidoptera)","volume":"298","author":"Szurpnicka","year":"2022","journal-title":"J Ethnopharmacol"},{"issue":"41","key":"10.1016\/j.jaim.2025.101161_bib60","doi-asserted-by":"crossref","first-page":"5388","DOI":"10.5897\/JMPR12.704","article-title":"Phytochemistry, pharmacology, and biotechnology of Withania somnifera and Withania coagulans: a review","volume":"6","author":"Jain","year":"2012","journal-title":"J Med Plants Res"},{"issue":"2","key":"10.1016\/j.jaim.2025.101161_bib61","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jep.2006.12.029","article-title":"Woodfordia fruticosa: traditional uses and recent findings","volume":"110","author":"Das","year":"2007","journal-title":"J Ethnopharmacol"},{"issue":"12","key":"10.1016\/j.jaim.2025.101161_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules22122145","article-title":"Plants of the genus Zingiber as a source of bioactive phytochemicals: from tradition to pharmacy","volume":"22","author":"Sharifi-Rad","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jaim.2025.101161_bib63","series-title":"Zingiber officinale medicinal spices and vegetables from africa: therapeutic potential against metabolic, inflammatory, infectious and systemic diseases","first-page":"627","author":"Mbaveng","year":"2017"},{"issue":"2","key":"10.1016\/j.jaim.2025.101161_bib64","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.fct.2007.09.085","article-title":"Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research","volume":"46","author":"Ali","year":"2008","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib65","article-title":"A comprehensive insight into the phytochemical, pharmacological potential, and traditional medicinal uses of Albizia lebbeck (L.) benth","volume":"2022","author":"Balkrishna","year":"2022","journal-title":"Evid base Compl Alternative Med"},{"key":"10.1016\/j.jaim.2025.101161_bib66","first-page":"1","article-title":"Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox","volume":"7","author":"Nalimu","year":"2021","journal-title":"Future J Pharma Sci."},{"key":"10.1016\/j.jaim.2025.101161_bib67","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1007\/s12298-020-00859-2","article-title":"Phytochemical analysis, antioxidant activities and optimized extraction of embelin from different genotypes of Embelia ribes Burm f.: a woody medicinal climber from Western Ghats of India","volume":"26","author":"Kamble","year":"2020","journal-title":"Physiol Mol Biol Plants"},{"issue":"6","key":"10.1016\/j.jaim.2025.101161_bib68","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1080\/14786419.2015.1036268","article-title":"Chemical composition and medicinal significance of Fagonia cretica: a review","volume":"30","author":"Qureshi","year":"2016","journal-title":"Nat Prod Res"},{"issue":"12","key":"10.1016\/j.jaim.2025.101161_bib69","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/ptr.6178","article-title":"Liquorice (Glycyrrhiza glabra): a phytochemical and pharmacological review","volume":"32","author":"Pastorino","year":"2018","journal-title":"Phytother Res"},{"issue":"6","key":"10.1016\/j.jaim.2025.101161_bib70","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3390\/biom10060916","article-title":"Chemical composition and immunomodulatory activity of Hypericum perforatum essential oils","volume":"10","author":"Schepetkin","year":"2020","journal-title":"Biomolecules"},{"issue":"7\u20138","key":"10.1016\/j.jaim.2025.101161_bib71","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1515\/znc-2009-7-805","article-title":"Phytoconstituents of Jatropha curcas L. leaves and their immunomodulatory activity on humoral and cell-mediated immune response in chicks","volume":"64","author":"Abd-Alla","year":"2009","journal-title":"Z Naturforsch C"},{"key":"10.1016\/j.jaim.2025.101161_bib72","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1590\/S0102-695X2011005000196","article-title":"Chemical constituents and biological activities of species of Justicia: a review","volume":"22","author":"Corr\u00eaa","year":"2012","journal-title":"Rev Bras Farmacogn"},{"issue":"4","key":"10.1016\/j.jaim.2025.101161_bib73","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5530\/ax.2012.4.5","article-title":"Studies on phytochemical and In-Vitro antioxidant potential of Justicia beddomei (Clarke) Bennett","volume":"2","author":"Marathakam","year":"2012","journal-title":"Free Rad Antiox"},{"issue":"5","key":"10.1016\/j.jaim.2025.101161_bib74","first-page":"448","article-title":"Evaluation of phytochemical and pharmacological properties of seeds of Momordica charantia","volume":"10","author":"Zahan","year":"2020","journal-title":"Avicenna J Phytomed"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib75","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1080\/10942912.2018.1508161","article-title":"Phytochemical and bioactive compounds identification of Ocimum tenuiflorum leaves of methanol extract and its fraction with an anti-diabetic potential","volume":"21","author":"Mousavi","year":"2018","journal-title":"Int J Food Prop"},{"issue":"6","key":"10.1016\/j.jaim.2025.101161_bib76","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2174\/138920109789069314","article-title":"Pharmacology and chemistry of a potent hepatoprotective compound picroliv isolated from the roots and rhizomes of Picrorhiza kurroa royle ex benth. (Kutki)","volume":"10","author":"Verma","year":"2009","journal-title":"Curr Pharm Biotechnol"},{"issue":"4","key":"10.1016\/j.jaim.2025.101161_bib77","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ptr.6006","article-title":"Psoralea corylifolia L: ethnobotanical, biological, and chemical aspects: a review","volume":"32","author":"Alam","year":"2018","journal-title":"Phytother Res"},{"issue":"2","key":"10.1016\/j.jaim.2025.101161_bib78","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s13596-018-0305-2","article-title":"A literature-based phytochemical evidence and biological activities of Trichosanthes dioica Roxb","volume":"18","author":"Islam","year":"2018","journal-title":"Orient Pharm Exp Med"},{"key":"10.1016\/j.jaim.2025.101161_bib79","series-title":"LigPrep, schr\u00f6dinger","year":"2021"},{"key":"10.1016\/j.jaim.2025.101161_bib80","series-title":"Protein preparation wizard","year":"2021"},{"key":"10.1016\/j.jaim.2025.101161_bib81","series-title":"Glide","year":"2021"},{"key":"10.1016\/j.jaim.2025.101161_bib82","doi-asserted-by":"crossref","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib83","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J Mol Graph"},{"issue":"12","key":"10.1016\/j.jaim.2025.101161_bib84","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/s41564-017-0046-x","article-title":"Structural basis for maintenance of bacterial outer membrane lipid asymmetry","volume":"2","author":"Abell\u00f3n-Ruiz","year":"2017","journal-title":"Nat Microbiol"},{"issue":"3","key":"10.1016\/j.jaim.2025.101161_bib85","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.chembiol.2005.01.006","article-title":"The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus","volume":"12","author":"Tanner","year":"2005","journal-title":"Chem Biol"},{"issue":"1","key":"10.1016\/j.jaim.2025.101161_bib86","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1080\/07391102.2020.1811773","article-title":"Structure-based drug repurposing for targeting Nsp9 replicase and spike proteins of severe acute respiratory syndrome coronavirus 2","volume":"40","author":"Chandel","year":"2022","journal-title":"J Biomol Struct Dyn"},{"issue":"3","key":"10.1016\/j.jaim.2025.101161_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-021-02685-z","article-title":"Cordifolioside: potent inhibitor against Mpro of SARS-CoV-2 and immunomodulatory through human TGF-\u03b2 and TNF-\u03b1","volume":"11","author":"Manne","year":"2021","journal-title":"3 Biotech."},{"issue":"18","key":"10.1016\/j.jaim.2025.101161_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/embj.2020106275","article-title":"Mechanism and inhibition of the papain\u2010like protease, PLpro, of SARS\u2010CoV\u20102","volume":"39","author":"Klemm","year":"2020","journal-title":"EMBO J"},{"issue":"4","key":"10.1016\/j.jaim.2025.101161_bib89","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2217\/fvl-2020-0342","article-title":"Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an approach","volume":"16","author":"Choudhury","year":"2021","journal-title":"Future Virol"},{"issue":"12","key":"10.1016\/j.jaim.2025.101161_bib90","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1080\/07391102.2020.1775127","article-title":"Identification of potential inhibitors of SARS-CoV-2 endoribonuclease (EndoU) from FDA approved drugs: a drug repurposing approach to find therapeutics for COVID-19","volume":"39","author":"Chandra","year":"2021","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.jaim.2025.101161_bib91","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijbiomac.2020.12.038","article-title":"Ritonavir may inhibit exoribonuclease activity of nsp14 from the SARS-CoV-2 virus and potentiate the activity of chain terminating drugs","volume":"168","author":"Narayanan","year":"2021","journal-title":"Int J Biol Macromol"}],"container-title":["Journal of Ayurveda and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947625000373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947625000373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:15:37Z","timestamp":1762348537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0975947625000373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":91,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0975947625000373"],"URL":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101161","relation":{},"ISSN":["0975-9476"],"issn-type":[{"value":"0975-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacoinformatics in identifying therapeutically important chemical species from Ayurvedic formulations employed in treating COVID-19 patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Ayurveda and Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Science and Technology and World Ayurveda Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101161"}}