{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:16:08Z","timestamp":1791306968600,"version":"4.3.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ayurveda and Integrative Medicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jaim.2025.101176","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T15:02:12Z","timestamp":1757084532000},"page":"101176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case report on Ayurvedic management of progressive bulbar palsy-A rare amyotrophic lateral sclerosis phenotype"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-5238","authenticated-orcid":false,"given":"Sinimol Thekkekkoottumughath","family":"Peethambaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3396-5522","authenticated-orcid":false,"given":"Abhayadev","family":"Ashokan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varanasi","family":"Subhose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.jaim.2025.101176_bib1","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.4103\/0366-6999.211538","article-title":"Clinical features of isolated bulbar Palsy of amyotrophic lateral sclerosis in Chinese population","volume":"130","author":"Zhang","year":"2017","journal-title":"Chin Med J (Engl)."},{"issue":"2","key":"10.1016\/j.jaim.2025.101176_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaim.2022.100548","article-title":"A case report: Ayurvedic intervention in motor neuron disease contemplating Kaphavrutavata","volume":"13","author":"Policepatil","year":"2022","journal-title":"J Ayurveda Integr Med"},{"issue":"4","key":"10.1016\/j.jaim.2025.101176_bib3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ncl.2015.07.006","article-title":"Patterns of weakness, classification of motor neuron disease, and clinical diagnosis of sporadic amyotrophic lateral sclerosis","volume":"33","author":"Statland","year":"2015","journal-title":"Neurol Clin"},{"key":"10.1016\/j.jaim.2025.101176_bib4","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1007\/s00415-024-12435-9","article-title":"Update on recent advances in amyotrophic lateral sclerosis","volume":"271","author":"Riva","year":"2024","journal-title":"J Neurol"},{"key":"10.1016\/j.jaim.2025.101176_bib5","unstructured":"Acharya Yadavji T., editor Commentary Ayurveda Deepika of Chakrapanidatta on Charaka Samhita of Agnivesha, Chikitsasthana, Vatavyaadhichikitsaadhyaya. first ed. Varanasi: Chaukhambasurabharatiprakashan; 2016. p. 626. [Chapter 28] verse 224."},{"key":"10.1016\/j.jaim.2025.101176_bib6","unstructured":"Acharya Jadavji T., editor Commentary Nibandha Sangraha of Dalhanacharya on Sushruta Samhita of Sushruta, Nidanasthana, VatavyaadhiNidanaadhyaya. Varanasi: Chaukhamba Sanskrit Sansthan; 2015. p. 263. [Chapter 1] verse 39."},{"key":"10.1016\/j.jaim.2025.101176_bib7","unstructured":"Acharya Yadavji T., editor Commentary Ayurveda deepika of chakrapanidatta on CharakaSanhita of Agnivesha, Chikitsasthana, Vatavyaadhichikitsaadhyaya. first ed. Varanasi: Chaukhamba Surabharati prakashan; 2016. p. 624. [Chapter 28] verse 186-187."},{"key":"10.1016\/j.jaim.2025.101176_bib8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-021-00253-2","article-title":"The Gold Coast criteria increases the diagnostic sensitivity for amyotrophic lateral sclerosis in a Chinese population","volume":"10","author":"Shen","year":"2021","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.jaim.2025.101176_bib9","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s00415-017-8538-4","article-title":"Assessment of the factorial validity and reliability of the ALSFRS-R: a revision of its measurement model","volume":"264","author":"Bakker","year":"2017","journal-title":"J Neurol"},{"key":"10.1016\/j.jaim.2025.101176_bib10","unstructured":"Rao P., editor Bhaishajyaratnavali of Govinda Dasa. Swarabhedadhikaar. second ed. Varanasi: Chaukhambha Orientalia; 2009. [Chapter 17], verse 34-36."},{"key":"10.1016\/j.jaim.2025.101176_bib11","series-title":"Charaka Samhitha of Agnivesa with Chakrapani tika","author":"Acharya","year":"2001"},{"issue":"2","key":"10.1016\/j.jaim.2025.101176_bib12","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4103\/ijoy.ijoy_49_22","article-title":"Integrative approach improves fall risk and postural stability in spinocerebellar ataxia-2 - a case report","volume":"15","author":"Kulamarva","year":"2022","journal-title":"Int J Yoga"},{"key":"10.1016\/j.jaim.2025.101176_bib13","unstructured":"Sushruta Sushruta Samhita, Sthana Chikitsa In: Shastri Ambikadatta, editor. Mudhagarbha Chikitsa Adhyaya 15\/40-43. fourteenth ed. Varanasi: Chaukambha Sanksrit Prathishtan; 2003. p. 76. [Google Scholar]."},{"issue":"2","key":"10.1016\/j.jaim.2025.101176_bib14","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4103\/0974-8520.146225","article-title":"Effect of anuvasana basti with ksheerabala taila in sandhigata vata (osteoarthritis)","volume":"35","author":"Grampurohit","year":"2014","journal-title":"Ayu"},{"key":"10.1016\/j.jaim.2025.101176_bib15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.4103\/0257-7941.188188","article-title":"Efficacy of Nasya (nasal medication) in coma: a case study","volume":"35","author":"Ramteke","year":"2016","journal-title":"Anc Sci Life"},{"key":"10.1016\/j.jaim.2025.101176_bib16","unstructured":"Krishna L., editor Arogyarakshakalpadruma of Kaikkulangara Rama Warrier, Vatavyadhi chikitsa. first ed. Varanasi: Chaukhambha Sanskrit Series; 2004. [chapter 12], verse 67."},{"key":"10.1016\/j.jaim.2025.101176_bib17","series-title":"Sahasrayogam","author":"Sharma","year":"1989"},{"key":"10.1016\/j.jaim.2025.101176_bib18","series-title":"Sahasrayogam","author":"Sharma","year":"1989"},{"key":"10.1016\/j.jaim.2025.101176_bib19","unstructured":"Prabhakara R.G., editor Translator and commentator, Sahasrayogam. New Delhi: Chaukhamba Publications; 2019. [Google Scholar]."},{"key":"10.1016\/j.jaim.2025.101176_bib20","unstructured":"Ayurvedic Formulary of India, Part I & II. New Delhi: Department of AYUSH, Ministry of Health & Family Welfare, Government of India; 2005. [Google Scholar]."},{"key":"10.1016\/j.jaim.2025.101176_bib21","series-title":"verse","first-page":"153","article-title":"Govind dasa virachita. In: Siddhi Nandan Mishra, editor. Bhaishajya Rathnavali. Chapter 18, Amavata chikitsitham","volume":"131-139","author":"Raviraj","year":"2019"},{"key":"10.1016\/j.jaim.2025.101176_bib22","doi-asserted-by":"crossref","unstructured":"Devi B.I., Kalaivannan J., Jones S., Janaki C.S., Sheriff D., Prabhu K., Balakrishnan D., Selvam A.D. Antioxidant Studies of Ayurvedic Medicine, Dhanwanthararishtam. J Pharm Bioallied Sci. 2024 ;16(Suppl 5):S4708-S4711. doi: 10.4103\/jpbs.jpbs_875_24. Epub 2025. PMID: 40061653; PMCID: PMC11888744.","DOI":"10.4103\/jpbs.jpbs_875_24"},{"key":"10.1016\/j.jaim.2025.101176_bib23","series-title":"Bhaishajya Rathnavali. Vatavyadhi Rogadhikara verse 141-144","first-page":"530","article-title":"Govind dasa virachita","author":"Raviraj","year":"2019"},{"issue":"6","key":"10.1016\/j.jaim.2025.101176_bib24","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1166\/jbn.2013.1597","article-title":"An intrinsic therapy of gold nanoparticles in focal cerebral ischemia-reperfusion injury in rats","volume":"9","author":"Liu","year":"2013","journal-title":"J Biomed Nanotechnol"},{"key":"10.1016\/j.jaim.2025.101176_bib25","unstructured":"Vagbhata. Ashtangahridaya with commentaries-Sarvangasundara of Arunadatta and Ayurvedarasayana of Hemadri; Annotated by: Kunte A.M. and Navre K.R. Pt. Hari Sadasiva Sastri Paradakara Bhishagacharya, editor. Uttara Sthana, Unmadachikitsaadhyaya. Chapter 16, verse 32. Varanasi: Chaukamba Subharati Prakashan; 2010. p. 231."},{"key":"10.1016\/j.jaim.2025.101176_bib26","unstructured":"Vagbhata. Ashtangahridaya with commentaries-Sarvangasundara of Arunadatta and Ayurvedarasayana of Hemadri; Annotated by: Kunte A.M. and Navre K.R. In: Pt. Hari Sadasiva Sastri Paradakara Bhishagacharya, editor. Sutrasthana, Shodhanaadiganasamgrahaneeyaaadhyaya. Chapter 15 verse 9-10. Varanasi: Chaukamba Subharati Prakashan; 2010. p. 141. Edition: Reprint."},{"key":"10.1016\/j.jaim.2025.101176_bib27","doi-asserted-by":"crossref","unstructured":"Tanna I.R., Aghera H.B., Ashok B.K., Chandola H.M. Protective role of Ashwagandharishta and flax seed oil against maximal electroshock induced seizures in albino rats. Ayu. 2012;33(1):114-118. doi: 10.4103\/0974-8520.100327. PMID: 23049195; PMCID: PMC3456848.","DOI":"10.4103\/0974-8520.100327"},{"key":"10.1016\/j.jaim.2025.101176_bib28","series-title":"Ashtangahridaya with commentaries-sarvangasundara of arunadatta and ayurvedarasayana of hemadri; annotated by: dr. Anna moreshwar kunte and krishna ramachandra shastri navre","first-page":"6","author":"Vagbhata","year":"2010"},{"key":"10.1016\/j.jaim.2025.101176_bib29","unstructured":"Kapoor R.C. Some observations on the metal-based preparations in the Indian Systems of Medicine. Ind. J. Trad. Knowl. 2010;9:562\u2013575. [Google Scholar]."},{"key":"10.1016\/j.jaim.2025.101176_bib30","doi-asserted-by":"crossref","unstructured":"Tubaki B.R., Tarapure S. Ayurveda management of Guillain-Barre syndrome: A case report. J. Ayurveda Integr. Med. 2020;11(1):73-77. doi: 10.1016\/j.jaim.2018.08.004. Epub 2019. PMID: 30661945; PMCID: PMC7125361.","DOI":"10.1016\/j.jaim.2018.08.004"}],"container-title":["Journal of Ayurveda and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S097594762500052X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S097594762500052X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T21:10:03Z","timestamp":1758834603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S097594762500052X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S097594762500052X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101176","relation":{},"ISSN":["0975-9476"],"issn-type":[{"value":"0975-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A case report on Ayurvedic management of progressive bulbar palsy-A rare amyotrophic lateral sclerosis phenotype","name":"articletitle","label":"Article Title"},{"value":"Journal of Ayurveda and Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101176","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Science and Technology and World Ayurveda Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101176"}}