{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:17:03Z","timestamp":1778793423124,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020374","name":"Ministry of AYUSH, Government of India","doi-asserted-by":"publisher","award":["798\/2019"],"award-info":[{"award-number":["798\/2019"]}],"id":[{"id":"10.13039\/100020374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ayurveda and Integrative Medicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jaim.2025.101191","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T20:52:28Z","timestamp":1757191948000},"page":"101191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A randomized controlled study protocol to determine the safety and efficacy of Sivanarvembu Kuzhithailam in the management of Psoriasis (Kalanjagapadai)"],"prefix":"10.1016","volume":"16","author":[{"given":"Rathinamala","family":"Rathinam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-0015","authenticated-orcid":false,"given":"Gayathri","family":"Gunalan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-0828","authenticated-orcid":false,"given":"Lavanya","family":"Alagusolaiyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2203-6760","authenticated-orcid":false,"given":"Vinu Bharathi","family":"Balasubramaniam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-9415","authenticated-orcid":false,"given":"Rajendra Kumar","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathiyarajeswaran","family":"Parameswaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaim.2025.101191_bib1","series-title":"Psoriasis and its impact on quality of life","year":"2016"},{"key":"10.1016\/j.jaim.2025.101191_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/719641","article-title":"Exploratory clinical trial to evaluate the efficacy of a topical traditional Chinese herbal medicine in psoriasis vulgaris","volume":"2015","author":"Yan","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"issue":"Suppl 2","key":"10.1016\/j.jaim.2025.101191_bib3","doi-asserted-by":"crossref","first-page":"ii18","DOI":"10.1136\/ard.2004.033217","article-title":"Psoriasis: epidemiology, clinical features, and quality of life","volume":"64","author":"Langley","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaim.2025.101191_bib4","series-title":"Psoriasis: epidemiology, clinical features, co-morbidities, and clinical scoring","author":"Raychaudhuri","year":"2016"},{"key":"10.1016\/j.jaim.2025.101191_bib5","series-title":"Psoriasis: assessment and management","year":"2017"},{"issue":"4","key":"10.1016\/j.jaim.2025.101191_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.4103\/2229-5178.209622","article-title":"Topical therapies in psoriasis","volume":"8","author":"Torsekar","year":"2017","journal-title":"Indian Dermatol Online J"},{"issue":"4","key":"10.1016\/j.jaim.2025.101191_bib7","first-page":"278","article-title":"Diagnosis and management of psoriasis","volume":"63","author":"Kim","year":"2017","journal-title":"Can Fam Physician"},{"key":"10.1016\/j.jaim.2025.101191_bib8","series-title":"Yugi vaithya chinthamani","author":"Yugimunivar","year":"1998"},{"key":"10.1016\/j.jaim.2025.101191_bib9","series-title":"WHO international standard terminologies on siddha medicine","year":"2023"},{"issue":"8","key":"10.1016\/j.jaim.2025.101191_bib10","first-page":"3707","article-title":"Phytoconstituents of a traditional oil formulation inhibits IL-17A and TNF-\u03b1 involved in psoriasis: a molecular docking study","volume":"17","author":"Nayak","year":"2024","journal-title":"Res J Pharm Technol"},{"issue":"4","key":"10.1016\/j.jaim.2025.101191_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2021.100142","article-title":"Cytotoxic activity of Indigofera aspalathoides (vahl.) extracts in cervical cancer (HeLa) cells: ascorbic acid adjuvant treatment enhances the activity","volume":"1","author":"Ramya","year":"2021","journal-title":"Phytomed Plus"},{"key":"10.1016\/j.jaim.2025.101191_bib12","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s13205-021-02731-w","article-title":"Computational insights into the identification of a potent matrix metalloproteinase inhibitor from Indigofera aspalathoides to control cancer metastasis","volume":"11","author":"Paramashivam","year":"2021","journal-title":"3 Biotech"},{"issue":"1","key":"10.1016\/j.jaim.2025.101191_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-63136-2","article-title":"Anti-metastasis activity of 5,4\u2019-dihydroxy 6,8-dimethoxy 7-O- rhamnosyl flavone from *indigofera aspalathoides* vahl on breast cancer cells","volume":"14","author":"Al-Saeedi","year":"2024","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.jaim.2025.101191_bib14","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1248\/bpb.28.364","article-title":"Chemoprevention of N- nitrosodiethylamine-induced phenobarbital promoted liver tumors in rat by extract of *indigofera aspalathoides","volume":"28","author":"Rajkapoor","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jaim.2025.101191_bib15","first-page":"476","article-title":"Effect of *indigofera aspalathoides* leaf extract on hepatic xenobiotic enzymes activity in hamster with DMBA-Induced oral cancer","volume":"2","author":"Abraham","year":"2010","journal-title":"Int J Drug Dev Res"},{"issue":"5","key":"10.1016\/j.jaim.2025.101191_bib16","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1007\/s10787-024-01530-y","article-title":"Protective effect of 5,4'-dihydroxy-6,8-dimethoxy7-O-rhamnosylflavone from *indigofera aspalathoides* vahl on lipopolysaccharide-induced intestinal injury in mice","volume":"32","author":"AlZahrani","year":"2024","journal-title":"Inflammopharmacology"},{"issue":"6","key":"10.1016\/j.jaim.2025.101191_bib17","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/13880200902902489","article-title":"Effect of *indigofera aspalathoides* on complete Freund's adjuvant-induced arthritis in rats","volume":"47","author":"Rajkapoor","year":"2009","journal-title":"Pharm Biol"},{"issue":"1","key":"10.1016\/j.jaim.2025.101191_bib18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/J157v06n01_05","article-title":"Protective effect of *indigofera aspalathoides* against CCl4-induced hepatic damage in rats","volume":"6","author":"Rajkapoor","year":"2006","journal-title":"J Herb Pharmacother"},{"issue":"3\u20134","key":"10.1016\/j.jaim.2025.101191_bib19","article-title":"Pandiyaraja. Herbal treatment (Siddha) for psoriasis (A report on clinical research with special focus on histopathological aspect)","volume":"9","author":"Veluchamy","year":"1986","journal-title":"JRAS"},{"issue":"1","key":"10.1016\/j.jaim.2025.101191_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the pathogenesis of psoriasis: from Keratinocyte perspective","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.jaim.2025.101191_bib21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-2133.1999.02963.x","article-title":"Clinical measures of disease severity and outcome in psoriasis: a critical appraisal of their quality","volume":"141","author":"Ashcroft","year":"1999","journal-title":"Br J Dermatol"},{"issue":"3","key":"10.1016\/j.jaim.2025.101191_bib22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2230.1994.tb01167.x","article-title":"Dermatology life quality index (DLQI)--a simple practical measure for routine clinical use","volume":"19","author":"Finlay","year":"1994","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaim.2025.101191_bib23","series-title":"The siddha formulary of India","first-page":"104","year":"1992"},{"key":"10.1016\/j.jaim.2025.101191_bib24","series-title":"Siddha vaithiya thirattu","first-page":"223","author":"Kuppusamy Mudhaliar","year":"1998"},{"key":"10.1016\/j.jaim.2025.101191_bib25","series-title":"Clinical and experimental studies on the efficacy of 777 Oil\u2014A siddha preparation in the treatment of kalanjagapadai (psoriasis)","year":"1987"},{"key":"10.1016\/j.jaim.2025.101191_bib26","unstructured":"Uthamarayan CS Siddha Maruthuvanga Churukkam, third ed..Department of Indian medicine and homeopathy, Chennai, Govt.of Tamil Nadu."},{"issue":"6","key":"10.1016\/j.jaim.2025.101191_bib27","first-page":"859","article-title":"A 50% reduction in the psoriasis area and severity index (PASI 50) is a clinically significant endpoint in the assessment of psoriasis","volume":"50","author":"Carlin","year":"2004","journal-title":"J Am Acad Dermatol"}],"container-title":["Journal of Ayurveda and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947625000671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947625000671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:03:18Z","timestamp":1778792598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0975947625000671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0975947625000671"],"URL":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101191","relation":{},"ISSN":["0975-9476"],"issn-type":[{"value":"0975-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A randomized controlled study protocol to determine the safety and efficacy of Sivanarvembu Kuzhithailam in the management of Psoriasis (Kalanjagapadai)","name":"articletitle","label":"Article Title"},{"value":"Journal of Ayurveda and Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Science and Technology and World Ayurveda Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101191"}}