{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:22:21Z","timestamp":1782858141378,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ayurveda and Integrative Medicine"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jaim.2025.101256","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T22:52:17Z","timestamp":1762555937000},"page":"101256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["In vivo and in silico toxicity studies of hydroalcoholic extract of Vetiveria zizanioides roots"],"prefix":"10.1016","volume":"16","author":[{"given":"Pranali B.","family":"Yeram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6229-1574","authenticated-orcid":false,"given":"Amisha","family":"Vora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-7907","authenticated-orcid":false,"given":"Yogesh A.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jaim.2025.101256_bib1","first-page":"1","article-title":"The growing use of herbal medicines : issues relating to adverse reactions and challenges in monitoring safety","volume":"4","author":"Ekor","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jaim.2025.101256_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2022.960556","article-title":"Editorial : clinical safety of natural products , an evidence-based approach","volume":"13","author":"Heydari","year":"2022","journal-title":"Front Pharmacol"},{"issue":"9","key":"10.1016\/j.jaim.2025.101256_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jfbc.13901","article-title":"Nephroprotective activity of Vetiveria zizanioides (L.) Nash supplement in doxorubicin-induced nephrotoxicity model of Wistar rats","volume":"45","author":"Amarasiri","year":"2021","journal-title":"J Food Biochem"},{"issue":"33","key":"10.1016\/j.jaim.2025.101256_bib4","doi-asserted-by":"crossref","first-page":"44667","DOI":"10.1007\/s11356-021-15145-1","article-title":"Chrysopogon zizanioides\u2014a review on its pharmacognosy, chemical composition and pharmacological activities","volume":"28","author":"Grover","year":"2021","journal-title":"Environ Sci Pollut Res"},{"key":"10.1016\/j.jaim.2025.101256_bib5","doi-asserted-by":"crossref","first-page":"15597","DOI":"10.1007\/s11356-021-12652-z","article-title":"Potential therapeutic effect of Chrysopogon zizanioides (Vetiver) as an anti-inflammatory agent","volume":"28","author":"Grover","year":"2021","journal-title":"Environ Sci Pollut Res"},{"key":"10.1016\/j.jaim.2025.101256_bib6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.fct.2015.04.018","article-title":"Vetiver oil (Java) attenuates cisplatin-induced oxidative stress, nephrotoxicity and myelosuppression in Swiss albino mice","volume":"81","author":"Sinha","year":"2015","journal-title":"Food Chem Toxicol"},{"issue":"12","key":"10.1016\/j.jaim.2025.101256_bib7","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.3109\/13880209.2013.799710","article-title":"Anticonvulsant activity of ethanol extracts of Vetiveria zizanioides roots in experimental mice","volume":"51","author":"Gupta","year":"2013","journal-title":"Pharm Biol"},{"issue":"4","key":"10.1016\/j.jaim.2025.101256_bib8","first-page":"1","article-title":"Biological activity of vetiver (Vetiveria zizanioides) essential oil in human dermal fibroblasts Biological activity of vetiver (Vetiveria zizanioides) essential oil in human dermal fibroblasts","volume":"38","author":"Han","year":"2017","journal-title":"Cogent Med"},{"issue":"1","key":"10.1016\/j.jaim.2025.101256_bib9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.foodchem.2012.02.131","article-title":"Study of the chemical composition, antioxidant activity and anti-inflammatory activity of essential oil from Vetiveria zizanioides","volume":"134","author":"Chou","year":"2012","journal-title":"Food Chem"},{"issue":"10","key":"10.1016\/j.jaim.2025.101256_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules24101897","article-title":"Chemical Composition, Antioxidant, and Antimicrobial Activities of Vetiveria zizanioides (L.) Nash Essential Oil Extracted by Carbon Dioxide Expanded Ethanol","volume":"24","author":"David","year":"2019","journal-title":"Molecules"},{"issue":"13","key":"10.1016\/j.jaim.2025.101256_bib11","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1055\/a-1699-3284","article-title":"Antimicrobial formulation of Chrysopogon zizanioides essential oil in an emulsified lotion for acne","volume":"88","author":"Kurrimboccus","year":"2022","journal-title":"Planta Med"},{"key":"10.1016\/j.jaim.2025.101256_bib12","first-page":"2671","article-title":"Indian medicinal plants","volume":"IV","author":"Kirtikar","year":"1999","journal-title":"International Book Distributors, Dehradun"},{"key":"10.1016\/j.jaim.2025.101256_bib13","series-title":"The Ayurvedic Pharmacopoeia of India, part1vol III","first-page":"219","year":"2001"},{"key":"10.1016\/j.jaim.2025.101256_bib14","series-title":"Test No. 423: acute oral toxicity - acute toxic class method","year":"2008"},{"key":"10.1016\/j.jaim.2025.101256_bib15","series-title":"Test No. 407: OECD guidelines for the testing of chemicals: repeated dose 28-day oral toxicity study in rodents","year":"2008"},{"issue":"2","key":"10.1016\/j.jaim.2025.101256_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/0971-6580.97203","article-title":"Toxicological evaluation of the methanol extract of Gmelina arborea roxb. bark in mice and rats","volume":"19","author":"Kulkarni","year":"2012","journal-title":"Toxicol Int"},{"issue":"12","key":"10.1016\/j.jaim.2025.101256_bib17","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3109\/13880209.2010.489228","article-title":"Toxicological studies on aqueous extract of Gmelina arborea in rodents","volume":"48","author":"Kulkarni","year":"2010","journal-title":"Pharm Biol"},{"issue":"3","key":"10.1016\/j.jaim.2025.101256_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.vascn.2007.03.001","article-title":"Measurement of glomerular filtration rate in the conscious rat","volume":"56","author":"Pestel","year":"2007","journal-title":"J Pharmacol Toxicol Methods"},{"issue":"3","key":"10.1016\/j.jaim.2025.101256_bib19","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1080\/01480545.2020.1833906","article-title":"In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy","volume":"45","author":"Laddha","year":"2022","journal-title":"Drug Chem Toxicol"},{"issue":"3","key":"10.1016\/j.jaim.2025.101256_bib20","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/0192623318761348","article-title":"Use of severity grades to characterize histopathologic changes","volume":"46","author":"Schafer","year":"2018","journal-title":"Toxicol Pathol"},{"issue":"1","key":"10.1016\/j.jaim.2025.101256_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-023-03863-7","article-title":"Sub-chronic toxicity of the aqueous leaf extract of Ocimum lamiifolium Hochst. ex Benth on biochemical parameters and histopathology of liver and kidney in rats: in vivo and in- silico toxicity studies","volume":"23","author":"Adane","year":"2023","journal-title":"BMC Complement Med Ther"},{"issue":"1","key":"10.1016\/j.jaim.2025.101256_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaim.2025.101256_bib23","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.toxrep.2020.04.006","article-title":"28-day repeated oral dose toxicity study of an aqueous extract of Gryllus bimaculatus in Sprague-Dawley rat","volume":"7","author":"Yu","year":"2020","journal-title":"Toxicol Rep"}],"container-title":["Journal of Ayurveda and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947625001329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947625001329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T16:21:20Z","timestamp":1765297280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0975947625001329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0975947625001329"],"URL":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101256","relation":{},"ISSN":["0975-9476"],"issn-type":[{"value":"0975-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vivo and in silico toxicity studies of hydroalcoholic extract of Vetiveria zizanioides roots","name":"articletitle","label":"Article Title"},{"value":"Journal of Ayurveda and Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaim.2025.101256","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Science and Technology and World Ayurveda Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101256"}}