{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:46:44Z","timestamp":1792788404889,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ayurveda and Integrative Medicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jaim.2026.101402","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:00:44Z","timestamp":1791820844000},"page":"101402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improvised cardiac function of siddha formulation Sikkanjar elixir\u00ae through CAMK2 and VEGF mechanism-in experimentally induced cardiac hypertrophy model in rats"],"prefix":"10.1016","volume":"17","author":[{"given":"S.","family":"Joseph Maria Adaikalam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tejasri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Arunagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Naveen Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2186-6554","authenticated-orcid":false,"given":"M.","family":"Ramanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaim.2026.101402_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.clnu.2011.10.008","article-title":"Reduction of serum lipids by the intake of the extract of garlic fermented with monascuspilosus: a randomized, double-blind, placebo-controlled clinical trial","volume":"31","author":"Higashikawa","year":"2012","journal-title":"Clin Nutr (Phila)"},{"key":"10.1016\/j.jaim.2026.101402_bib2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.clnesp.2017.11.010","article-title":"Percival SS aged garlic extract supplementation modifies inflammation and immunity of adults with obesity: a randomized, double-blind, placebo-controlled clinical trial","volume":"24","author":"Xu","year":"2018","journal-title":"Clin Nutr ESPEN"},{"key":"10.1016\/j.jaim.2026.101402_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.vph.2013.08.002","article-title":"Antiplatelet properties of natural products","volume":"59","author":"Vilahur","year":"2013","journal-title":"Vasc Pharmacol"},{"key":"10.1016\/j.jaim.2026.101402_bib4","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/ptr.2412","article-title":"Protective effects of dietary ginger (S rosc.) on lindane-induced oxidative stress in rats","volume":"22","author":"Ahmed","year":"2008","journal-title":"Phytother Res"},{"key":"10.1016\/j.jaim.2026.101402_bib5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1590\/S1807-59322008000600017","article-title":"Yusof YA Ginger extract (Zingiberofficinale) has anti-cancer and anti-inflammatory effects on ethionine-induced hepatoma rats","volume":"63","author":"Habib","year":"2008","journal-title":"Clinics"},{"key":"10.1016\/j.jaim.2026.101402_bib6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/10408398.2014.906382","article-title":"Schluesener H Health-promoting effects of the citrus flavanone hesperidin","volume":"57","author":"Li","year":"2017","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.jaim.2026.101402_bib7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4103\/2225-4110.139103","article-title":"Revisiting Terminalia arjuna - an Ancient cardiovascular drug","volume":"4","author":"Dwivedi","year":"2014","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.jaim.2026.101402_bib8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.etp.2010.04.004","article-title":"Raghu KG Cardioprotective effects of aqueous extract of Oxalis corniculata in experimental myocardial infarction","volume":"63","author":"Abhilash","year":"2011","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.jaim.2026.101402_bib9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4103\/0253-7613.51353","article-title":"Effects of methanolic extract of Cuminumcyminum on total serum cholesterol in ovariectomized rats","volume":"41","author":"Shirke","year":"2009","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.jaim.2026.101402_bib10","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1179\/135100002125000370","article-title":"Antioxidant properties of a Tinosporacordifolia polysaccharide against iron-mediated lipid damage and gamma-ray induced protein damage","volume":"7","author":"Subramanian","year":"2002","journal-title":"Redox Rep"},{"key":"10.1016\/j.jaim.2026.101402_bib11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4103\/0253-7613.93857","article-title":"A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3-hydroxy-3-methylglutaryl-coenzyme-A reductase inhibitor simvastatin","volume":"44","author":"Gopa","year":"2012","journal-title":"Indian J Pharmacol"},{"key":"10.1016\/j.jaim.2026.101402_bib12","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.3109\/13880209.2014.962058","article-title":"Starling emerald B anti-hyperlipidemic effect of methanol bark extract of Terminalia chebula in Male albino Wistar rats","volume":"53","author":"Reddy","year":"2015","journal-title":"Pharm Biol"},{"key":"10.1016\/j.jaim.2026.101402_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.lfs.2009.05.020","article-title":"Inhibitory effect of novel diallyldisulfideanalogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target","volume":"85","author":"Rai","year":"2009","journal-title":"Life Sci"},{"key":"10.1016\/j.jaim.2026.101402_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/1476-511X-10-202","article-title":"Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db\/db mice","volume":"10","author":"Tsuruta","year":"2011","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.jaim.2026.101402_bib15","doi-asserted-by":"crossref","first-page":"17985","DOI":"10.1073\/pnas.0605545103","article-title":"Angiotensin II causes hypertension and cardiac hypertrophy through it receptors in the kidney","volume":"103","author":"Crowley","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jaim.2026.101402_bib16","first-page":"2758","article-title":"SIRT3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice","volume":"119","author":"Sundaresan","year":"2009","journal-title":"J Clin Investig"},{"key":"10.1016\/j.jaim.2026.101402_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7293861","article-title":"SIRT3: a new regulator of cardiovascular diseases","author":"Sun","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jaim.2026.101402_bib18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cardiores.2004.04.026","article-title":"Role of Ca2+\/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure","volume":"63","author":"Zhang","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jaim.2026.101402_bib19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1749-8090-6-54","article-title":"VEGF attenuates development from cardiac hypertrophy to heart failure after aortic stenosis through mitochondrial mediated apoptosis and cardiomyocyte proliferation","volume":"6","author":"Xu","year":"2011","journal-title":"J Cardiothorac Surg"},{"key":"10.1016\/j.jaim.2026.101402_bib20","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1096\/fj.09-143180","article-title":"Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory hypertrophy and preserves cardiac function after myocardial infarction","volume":"24","author":"Zentilin","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.jaim.2026.101402_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","volume":"15","author":"Pang","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jaim.2026.101402_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101034","article-title":"Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury","volume":"14","author":"Yang","year":"2024","journal-title":"J Pharm Anal"},{"key":"10.1016\/j.jaim.2026.101402_bib23","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0308-8146(02)00423-5","article-title":"Antioxidant capacity of phenolic phytochemicals from various cultivars of plums","volume":"81","author":"Kim","year":"2003","journal-title":"Food Chem"},{"key":"10.1016\/j.jaim.2026.101402_bib24","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.foodchem.2007.08.070","article-title":"Antioxidants and proteins in ethylene-treated kiwifruits","volume":"107","author":"Park","year":"2008","journal-title":"Food Chem"},{"key":"10.1016\/j.jaim.2026.101402_bib25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jss.2008.03.043","article-title":"Novel experimental model of pressure overload hypertrophy in rats","volume":"153","author":"Molina","year":"2009","journal-title":"J Surg Res"},{"key":"10.1016\/j.jaim.2026.101402_bib26","article-title":"Modified protocol for A mouse heart failure model using minimally invasive transverse aortic constriction","volume":"20","author":"Liu","year":"2020","journal-title":"STAR Protoc"},{"key":"10.1016\/j.jaim.2026.101402_bib27","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1002\/cpph.43","article-title":"Moser VC the irwin test and functional observational battery (FOB) for assessing the effects of compounds on behavior, physiology, and safety pharmacology in rodents","volume":"83","author":"Mathiasen","year":"2018","journal-title":"Curr Protoc Pharmacol"},{"key":"10.1016\/j.jaim.2026.101402_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaim.2026.101402_bib29","first-page":"93","article-title":"Superoxide dismutase assays","volume":"vol 105","author":"Floh\u00e9","year":"1984"},{"key":"10.1016\/j.jaim.2026.101402_bib30","first-page":"121","article-title":"Catalase in vitro","volume":"vol 105","author":"Aebi","year":"1984"},{"key":"10.1016\/j.jaim.2026.101402_bib31","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1042\/bj0940705","article-title":"Colorimetric micro-method for the determination of glutathione","volume":"94","author":"Owens","year":"1965","journal-title":"Biochem J"},{"key":"10.1016\/j.jaim.2026.101402_bib32","author":"Fischer","year":"2008"},{"key":"10.1016\/j.jaim.2026.101402_bib33","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev.pa.32.040192.001031","article-title":"Pharmacology of nonpeptide angiotensin II receptor antagonists","volume":"32","author":"Smith","year":"1992","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jaim.2026.101402_bib34","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.recesp.2019.02.023","article-title":"D'Ocon P beta-blockers: historical perspective and mechanisms of action","volume":"72","author":"Oliver","year":"2019","journal-title":"Rev Esp Cardiol"},{"key":"10.1016\/j.jaim.2026.101402_bib35","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1080\/07391102.2020.1739558","article-title":"Discovery of potential inhibitors for phosphodiesterase 5A, sodium-potassium pump and beta-adrenergic receptor from terminalia Arjuna: in silico approach","volume":"39","author":"Gaikwad","year":"2021","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.jaim.2026.101402_bib36","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1080\/14786419.2023.2252565","article-title":"Systematic elucidation of the multi-target pharmacological mechanism of Terminalia arjuna against congestive cardiac failure via network pharmacology and molecular modelling approaches","volume":"37","author":"Asghar","year":"2023","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.jaim.2026.101402_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911209","article-title":"Tryptamine, a microbial metabolite in fermented rice bran suppressed lipopolysaccharide-induced inflammation in a murine macrophage model","volume":"23","author":"Agista","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaim.2026.101402_bib38","doi-asserted-by":"crossref","first-page":"12083","DOI":"10.1039\/D4FO03210A","article-title":"Anti-obesity and other health benefits of bioprocessed black rice bran in combination with green tea extract in 3T3-L1 preadipocyte cells and in mice on a high-fat diet","volume":"15","author":"Kwon","year":"2024","journal-title":"Food Funct"},{"key":"10.1016\/j.jaim.2026.101402_bib39","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2174\/1871525721666230223145218","article-title":"Organosulfur compounds in aged garlic extract ameliorate glucose induced diabetic cardiomyopathy by attenuating oxidative stress, cardiac fibrosis, and cardiac apoptosis","volume":"22","author":"Sharma","year":"2023","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"10.1016\/j.jaim.2026.101402_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109567","article-title":"Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210","volume":"125","author":"Lin","year":"2024","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.jaim.2026.101402_bib41","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1038\/s41401-020-00587-z","article-title":"6-Gingerol protects against cardiac remodelling by inhibiting the p38 mitogen-activated protein kinase pathway","volume":"42","author":"Ma","year":"2021","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.jaim.2026.101402_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157288","article-title":"Astragaloside VI attenuates mechanical stress-induced cardiac remodeling through piezo1-VDAC1 dependent endoplasmic reticulum unfolded protein response","volume":"148","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jaim.2026.101402_bib43","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Abel ED Cardiac metabolism in heart failure: implications beyond ATP production","volume":"113","author":"Doenst","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.jaim.2026.101402_bib44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11010-008-9711-y","article-title":"Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation","volume":"311","author":"Akki","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jaim.2026.101402_bib45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00395-005-0549-0","article-title":"Cardiac fatty acid metabolism is preserved in the compensated hypertrophic rat heart","volume":"101","author":"Degens","year":"2006","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jaim.2026.101402_bib46","first-page":"H742","article-title":"Lopaschuk GD Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts","volume":"267","author":"Allard","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jaim.2026.101402_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156982","article-title":"Chang X Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury","volume":"145","author":"Pu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jaim.2026.101402_bib48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jgr.2025.04.006","article-title":"Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model","volume":"49","author":"Pu","year":"2025","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jaim.2026.101402_bib49","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1186\/s12951-025-03667-6","article-title":"Chang X A novel ligustrazine-based nano delivery system protects against doxorubicin-induced cardiotoxicity by targeting the SIRT5-DUSP1 axis for mitochondrial repair","volume":"23","author":"Shi","year":"2025","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.jaim.2026.101402_bib50","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.7150\/ijbs.102424","article-title":"Targeting mitochondria by lipid-selenium conjugate drug results in malate\/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression","volume":"20","author":"Chang","year":"2024","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jaim.2026.101402_bib51","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12951-025-03420-z","article-title":"Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance","volume":"23","author":"Wang","year":"2025","journal-title":"J Nanobiotechnol"}],"container-title":["Journal of Ayurveda and Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947626000860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0975947626000860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:54Z","timestamp":1792787814000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0975947626000860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0975947626000860"],"URL":"https:\/\/doi.org\/10.1016\/j.jaim.2026.101402","relation":{},"ISSN":["0975-9476"],"issn-type":[{"value":"0975-9476","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improvised cardiac function of siddha formulation Sikkanjar elixir\u00ae through CAMK2 and VEGF mechanism-in experimentally induced cardiac hypertrophy model in rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Ayurveda and Integrative Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaim.2026.101402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Science and Technology and World Ayurveda Foundation.","name":"copyright","label":"Copyright"}],"article-number":"101402"}}