{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:58:36Z","timestamp":1782230316433,"version":"3.54.5"},"reference-count":129,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.jaip.2014.09.010","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T07:01:23Z","timestamp":1415257283000},"page":"664-670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Childhood Asthma-Predictive Phenotype"],"prefix":"10.1016","volume":"2","author":[{"given":"Theresa W.","family":"Guilbert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Mauger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert F.","family":"Lemanske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2014.09.010_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life","volume":"332","author":"Martinez","year":"1995","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib2","series-title":"Wheezing Disorders in the Preschool Child: Pathogenesis and Management","author":"Martinez","year":"2003"},{"key":"10.1016\/j.jaip.2014.09.010_bib3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2014.09.010_bib4","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1136\/thx.52.11.946","article-title":"Peak flow variability, methacholine responsiveness and atopy as markers for detecting different wheezing phenotypes in childhood","volume":"52","author":"Stein","year":"1997","journal-title":"Thorax J"},{"key":"10.1016\/j.jaip.2014.09.010_bib5","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jaci.2004.09.020","article-title":"Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma","volume":"114","author":"Guilbert","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"Pt 1","key":"10.1016\/j.jaip.2014.09.010_bib6","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1164\/ajrccm.160.5.9811002","article-title":"Risk factors for early, persistent, and late-onset wheezing in young children. SIDRIA Collaborative Group","volume":"160","author":"Rusconi","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib7","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1136\/thx.2007.093187","article-title":"Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood","volume":"63","author":"Henderson","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2014.09.010_bib8","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJMoa022363","article-title":"A\u00a0longitudinal, population-based, cohort study of childhood asthma followed to adulthood","volume":"349","author":"Sears","year":"2003","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib9","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1164\/ajrccm.162.6.9812019","article-title":"Association between allergy and asthma from childhood to middle adulthood in an Australian cohort study","volume":"162","author":"Wolfe","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib10","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1183\/09031936.00002108","article-title":"Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach","volume":"32","author":"Brand","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2014.09.010_bib11","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jaci.2010.04.018","article-title":"Symptom-pattern phenotype and pulmonary function in preschool wheezers","volume":"126","author":"Sonnappa","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1651-2227.2009.01508.x","article-title":"The transient value of classifying preschool wheeze into episodic viral wheeze and multiple trigger wheeze","volume":"99","author":"Schultz","year":"2010","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jaip.2014.09.010_bib13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1164\/rccm.201307-1198OC","article-title":"Clinical and epidemiologic phenotypes of childhood asthma","volume":"189","author":"Depner","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib14","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1164\/rccm.201104-0660OC","article-title":"Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life","volume":"185","author":"Jackson","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-065X.2011.01029.x","article-title":"The genetics of asthma and allergic disease: a 21st century perspective","volume":"242","author":"Ober","year":"2011","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaip.2014.09.010_bib16","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0140-6736(08)61447-6","article-title":"Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study","volume":"372","author":"Stern","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2014.09.010_bib17","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1164\/rccm.200406-695OC","article-title":"Wheeze phenotypes and lung function in preschool children","volume":"171","author":"Lowe","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib18","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1365-2222.2003.01657.x","article-title":"Characterization of wheezing phenotypes in the first 10 years of life","volume":"33","author":"Kurukulaaratchy","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2014.09.010_bib19","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1183\/09031936.00023409","article-title":"Lung function and bronchodilator response in 4-year-old children with different wheezing phenotypes","volume":"35","author":"Oostveen","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2014.09.010_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.aller.2009.06.008","article-title":"The connection between early life wheezing and subsequent asthma: the viral march","volume":"37","author":"Martinez","year":"2009","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jaip.2014.09.010_bib21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/ACI.0b013e3282f14a17","article-title":"Prevention of allergic respiratory disease in infants: current aspects and future perspectives","volume":"7","author":"Holt","year":"2007","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib22","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.jaci.2010.01.024","article-title":"Do early-life viral infections cause asthma?","volume":"125","author":"Sly","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1136\/adc.2003.038539","article-title":"Reported versus confirmed wheeze and lung function in early life","volume":"89","author":"Lowe","year":"2004","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaip.2014.09.010_bib24","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jaci.2012.04.043","article-title":"\u201cTo wheeze or not to wheeze\u201d: That is not the question","volume":"130","author":"Skytt","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1513\/pats.200607-146JG","article-title":"African Americans with asthma: genetic insights","volume":"4","author":"Barnes","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaip.2014.09.010_bib26","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrg2415","article-title":"Sex-specific genetic architecture of human disease","volume":"9","author":"Ober","year":"2008","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jaip.2014.09.010_bib27","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1164\/ajrccm.163.2.2006009","article-title":"Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children","volume":"163","author":"Gilliland","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib28","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1067\/mai.2001.113048","article-title":"Caesarean section and risk of asthma and allergy in adulthood","volume":"107","author":"Xu","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jpeds.2008.01.029","article-title":"Cesarean section and risk of severe childhood asthma: a population-based cohort study","volume":"153","author":"Tollanes","year":"2008","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jaip.2014.09.010_bib30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1172\/JCI8272","article-title":"Early life origins of asthma","volume":"104","author":"Gern","year":"1999","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2014.09.010_bib31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1164\/rccm.200406-730OC","article-title":"Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13","volume":"171","author":"Sigurs","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib33","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/S0140-6736(00)02239-X","article-title":"Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma","volume":"355","author":"Gereda","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2014.09.010_bib34","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1056\/NEJMoa052632","article-title":"Childhood asthma after bacterial colonization of the airway in neonates","volume":"357","author":"Bisgaard","year":"2007","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib35","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1378\/chest.06-3008","article-title":"Increased risk of childhood asthma from antibiotic use in early life","volume":"131","author":"Kozyrskyj","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2014.09.010_bib36","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1378\/chest.129.3.610","article-title":"Does antibiotic exposure during infancy lead to development of asthma?: a systematic review and meta-analysis","volume":"129","author":"Marra","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2014.09.010_bib37","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1365-2222.2010.03691.x","article-title":"Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis","volume":"41","author":"Eyers","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2014.09.010_bib38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1513\/pats.200903-013ST","article-title":"An official American Thoracic Society Workshop report: obesity and asthma","volume":"7","author":"Dixon","year":"2010","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaip.2014.09.010_bib39","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/MCP.0b013e3283338fa7","article-title":"Recent insight into obesity and asthma","volume":"16","author":"Beuther","year":"2010","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib40","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/ni1005-957","article-title":"Sensitization to airborne environmental allergens: unresolved issues","volume":"6","author":"Holt","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib41","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1164\/rccm.200607-916OC","article-title":"Early-life allergen exposure and atopy, asthma, and wheeze up to 6 years of age","volume":"176","author":"Torrent","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib42","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1542\/peds.101.2.e8","article-title":"The burden of environmental tobacco smoke exposure on the respiratory health of children 2 months through 5 years of age in the United States: Third National Health and Nutrition Examination Survey, 1988 to 1994","volume":"101","author":"Gergen","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2014.09.010_bib43","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/oxfordjournals.aje.a009748","article-title":"Influence of parental smoking on respiratory symptoms during the first decade of life: the Tucson Children\u2019s Respiratory Study","volume":"149","author":"Stein","year":"1999","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaip.2014.09.010_bib44","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1164\/rccm.200605-722OC","article-title":"Regular smoking and asthma incidence in adolescents","volume":"174","author":"Gilliland","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib45","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.jaci.2008.02.041","article-title":"Cigarette smoking is associated with a greater risk of incident asthma in allergic rhinitis","volume":"121","author":"Polosa","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib46","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00001648-200301000-00012","article-title":"Synthetic bedding and wheeze in childhood","volume":"14","author":"Ponsonby","year":"2003","journal-title":"Epidemiology"},{"key":"10.1016\/j.jaip.2014.09.010_bib47","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-3016.2004.00563.x","article-title":"A\u00a0prospective association between cocoon use in infancy and childhood asthma","volume":"18","author":"Trevillian","year":"2004","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1016\/j.jaip.2014.09.010_bib48","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1398-9995.1994.tb00831.x","article-title":"Risk factors in early childhood for the development of atopic diseases","volume":"49","author":"Bjorksten","year":"1994","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2014.09.010_bib49","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1183\/09031936.00083406","article-title":"Air pollution and development of asthma, allergy and infections in a birth cohort","volume":"29","author":"Brauer","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2014.09.010_bib50","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/thx.2007.078964","article-title":"Relationship between air pollution, lung function and asthma in adolescents","volume":"62","author":"Islam","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2014.09.010_bib51","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/jpepsy\/jsh051","article-title":"Family influences on pediatric asthma","volume":"29","author":"Kaugars","year":"2004","journal-title":"J\u00a0Pediatr Psychol"},{"key":"10.1016\/j.jaip.2014.09.010_bib52","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.anai.2009.10.002","article-title":"From atopic dermatitis to asthma: the atopic march","volume":"105","author":"Spergel","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib53","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1046\/j.0905-6157.2003.00108.x","article-title":"Birth order and sibship size as independent risk factors for asthma, allergy, and eczema","volume":"14","author":"Bernsen","year":"2003","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib54","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1378\/chest.06-2818","article-title":"Asthma prevalence, family size, and birth order","volume":"131","author":"Goldberg","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2014.09.010_bib55","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJM200008243430803","article-title":"Siblings, day-care attendance, and the risk of asthma and wheezing during childhood","volume":"343","author":"Ball","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib56","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3109\/07853890008995945","article-title":"Daycare attendance, asthma and atopy","volume":"32","author":"Nystad","year":"2000","journal-title":"Ann Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib57","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00130832-200312000-00015","article-title":"Does exposure to dogs and cats in the first year of life influence the development of allergic sensitization?","volume":"3","author":"Ownby","year":"2003","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib58","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s11882-005-0040-x","article-title":"Pets and the development of allergic sensitization","volume":"5","author":"Simpson","year":"2005","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2014.09.010_bib59","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/aje\/kwn253","article-title":"Measles-mumps-rubella vaccination and asthma-like disease in early childhood","volume":"168","author":"Hviid","year":"2008","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaip.2014.09.010_bib60","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/ije\/dyp307","article-title":"Does BCG vaccination protect against the development of childhood asthma? A systematic review and meta-analysis of epidemiological studies","volume":"39","author":"El-Zein","year":"2010","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaip.2014.09.010_bib61","doi-asserted-by":"crossref","first-page":"e1269","DOI":"10.1542\/peds.2006-3569","article-title":"Is childhood vaccination associated with asthma? A meta-analysis of observational studies","volume":"120","author":"Balicer","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2014.09.010_bib62","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.jaci.2004.12.1139","article-title":"Diet as a risk factor for atopy and asthma","volume":"115","author":"Devereux","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib63","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1365-2222.2007.02685.x","article-title":"Maternal fish intake during pregnancy and atopy and asthma in infancy","volume":"37","author":"Romieu","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2014.09.010_bib64","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1164\/rccm.200512-1946OC","article-title":"Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children","volume":"174","author":"Devereux","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib65","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/ajcn\/85.3.853","article-title":"Maternal vitamin D intake during pregnancy and early childhood wheezing","volume":"85","author":"Devereux","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.jaip.2014.09.010_bib66","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jaci.2010.11.001","article-title":"Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis","volume":"127","author":"Nurmatov","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib67","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jaci.2004.07.036","article-title":"Breast-feeding reduces the risk of asthma during the first 4 years of life","volume":"114","author":"Kull","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib68","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1067\/mpd.2001.117006","article-title":"Breast-feeding and the risk of bronchial asthma in childhood: a systematic review with meta-analysis of prospective studies","volume":"139","author":"Gdalevich","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jaip.2014.09.010_bib69","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/thorax.56.3.192","article-title":"Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood","volume":"56","author":"Wright","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2014.09.010_bib70","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/ACI.0b013e32830d82ed","article-title":"Breastfeeding and allergies: time for a change in paradigm?","volume":"8","author":"Duncan","year":"2008","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib71","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1183\/09031936.00033707","article-title":"Farm exposure in utero may protect against asthma, hay fever and eczema","volume":"32","author":"Douwes","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2014.09.010_bib72","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nri2871","article-title":"Farm living: effects on childhood asthma and allergy","volume":"10","author":"von Mutius","year":"2010","journal-title":"Nat Rev Immunol"},{"issue":"Pt 1","key":"10.1016\/j.jaip.2014.09.010_bib73","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1164\/ajrccm.162.4.9912111","article-title":"A\u00a0clinical index to define risk of asthma in young children with recurrent wheezing","volume":"162","author":"Castro-Rodriguez","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib74","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/thx.2006.060616","article-title":"Severity of obstructive airways disease by age 2 years predicts asthma at 10 years of age","volume":"63","author":"Devulapalli","year":"2008","journal-title":"Thorax"},{"issue":"Pt 1","key":"10.1016\/j.jaip.2014.09.010_bib75","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1164\/ajrccm.160.5.9807019","article-title":"Can we predict which wheezy infants will continue to wheeze?","volume":"160","author":"Clough","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib76","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1183\/09031936.03.00005903","article-title":"Predicting persistent disease among children who wheeze during early life","volume":"22","author":"Kurukulaaratchy","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2014.09.010_bib77","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3109\/02770903.2011.626481","article-title":"A\u00a0simple tool to identify infants at high risk of mild to severe childhood asthma: the persistent asthma predictive score","volume":"48","author":"Vial Dupuy","year":"2011","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.jaip.2014.09.010_bib78","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.jaci.2013.07.007","article-title":"Predicting asthma in preschool children with asthma-like symptoms: validating and updating the PIAMA risk score","volume":"132","author":"Hafkamp-de Groen","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib79","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4104\/pcrj.2014.00003","article-title":"Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score","volume":"23","author":"van der Mark","year":"2014","journal-title":"Prim Care Respir J"},{"key":"10.1016\/j.jaip.2014.09.010_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2009.06.045","article-title":"Predicting the long-term prognosis of children with symptoms suggestive of asthma at preschool age","author":"Caudri","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib81","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/thx.2009.126912","article-title":"Prediction of asthma in symptomatic preschool children using exhaled nitric oxide, Rint and specific IgE","volume":"65","author":"Caudri","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2014.09.010_bib82","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jaci.2011.03.001","article-title":"Validation of the Asthma Predictive Index and comparison with simpler clinical prediction rules","volume":"127","author":"Leonardi","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib83","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.prrv.2012.08.004","article-title":"Predicting persistence of asthma in preschool wheezers: crystal balls or muddy waters?","volume":"14","author":"Fouzas","year":"2013","journal-title":"Paediatr Respir Rev"},{"key":"10.1016\/j.jaip.2014.09.010_bib84","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jaci.2012.05.007","article-title":"Predicting who will have asthma at school age among preschool children","volume":"130","author":"Savenije","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib85","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jaci.2010.06.032","article-title":"The Asthma Predictive Index: a very useful tool for predicting asthma in young children","volume":"126","author":"Castro-Rodriguez","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib86","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/ACI.0b013e3283464c4a","article-title":"The Asthma Predictive Index: early diagnosis of asthma","volume":"11","author":"Castro-Rodriguez","year":"2011","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"Suppl","key":"10.1016\/j.jaip.2014.09.010_bib87","first-page":"S94","article-title":"Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007","volume":"120","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib88","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMoa051378","article-title":"Long-term inhaled corticosteroids in preschool children at high risk for asthma","volume":"354","author":"Guilbert","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib89","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jaip.2012.10.008","article-title":"Evaluation of the modified asthma predictive index in high-risk preschool children","volume":"1","author":"Chang","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"Suppl","key":"10.1016\/j.jaip.2014.09.010_bib90","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1097\/INF.0b013e318168b718","article-title":"Viral respiratory infection and the link to asthma","volume":"27","author":"Gern","year":"2008","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaip.2014.09.010_bib91","series-title":"Pediatric Allergy","first-page":"366","article-title":"Infections and asthma","author":"Gern","year":"2003"},{"key":"10.1016\/j.jaip.2014.09.010_bib92","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.jaci.2006.12.669","article-title":"Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma","volume":"119","author":"Kusel","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib93","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bmj.324.7340.763","article-title":"Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study","volume":"324","author":"Green","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.jaip.2014.09.010_bib94","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1164\/ajrccm.159.3.9801052","article-title":"Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses","volume":"159","author":"Rakes","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib95","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.200312-1647OC","article-title":"Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life","volume":"170","author":"Copenhaver","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib96","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1542\/peds.2006-0524","article-title":"Cord blood cytokines and acute lower respiratory illnesses in the first year of life","volume":"119","author":"Ly","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2014.09.010_bib97","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2005.10.002","article-title":"Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life","volume":"117","author":"Gern","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib98","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1164\/rccm.201202-0330OC","article-title":"Human rhinovirus species and season of infection determine illness severity","volume":"186","author":"Lee","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib99","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jaci.2012.05.023","article-title":"Innate immune responses to rhinovirus are impaired by the high-affinity IgE receptor in allergic asthmatic children","volume":"130","author":"Durrani","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib100","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/01.inf.0000143642.72480.53","article-title":"Rhinovirus-associated wheezing in infancy: comparison with respiratory syncytial virus bronchiolitis","volume":"23","author":"Korppi","year":"2004","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jaip.2014.09.010_bib101","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1183\/09031936.00155808","article-title":"The clinical importance of rhinovirus-associated early wheezing","volume":"33","author":"Jartti","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2014.09.010_bib102","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jaci.2008.09.008","article-title":"Are persons with asthma at increased risk of pneumococcal infections, and can we prevent them?","volume":"122","author":"Hartert","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib103","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jaci.2008.07.029","article-title":"Increased risk of serious pneumococcal disease in patients with asthma","volume":"122","author":"Juhn","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib104","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1164\/ajrccm.163.6.2005116","article-title":"Persistent wheezing in very young children is associated with lower respiratory inflammation","volume":"163","author":"Krawiec","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib105","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1164\/rccm.200410-1404OC","article-title":"Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction","volume":"171","author":"Saglani","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib106","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1164\/rccm.200702-212OC","article-title":"Early detection of airway wall remodeling and eosinophilic inflammation in preschool wheezers","volume":"176","author":"Saglani","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib107","first-page":"191","article-title":"Association between the Asthma Predictive Index and levels of exhaled nitric oxide in infants and toddlers with recurrent wheezing","volume":"111","author":"Balinotti","year":"2013","journal-title":"Arch Argent Pediatr"},{"key":"10.1016\/j.jaip.2014.09.010_bib108","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/02770903.2012.754030","article-title":"Young infants with recurrent wheezing and positive asthma predictive index have higher levels of exhaled nitric oxide","volume":"50","author":"Castro-Rodriguez","year":"2013","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.jaip.2014.09.010_bib109","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/ppul.21260","article-title":"Do risk factors for persistent asthma modify lung function in infants and young children with recurrent wheeze?","volume":"45","author":"Keklikian","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaip.2014.09.010_bib110","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0140-6736(99)03425-X","article-title":"Association of CCR5 delta32 with reduced risk of asthma","volume":"354","author":"Hall","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2014.09.010_bib111","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1164\/rccm.200302-278OC","article-title":"Age-specific relationship between CD14 and atopy in a cohort assessed from age 8 to 25 years","volume":"169","author":"O\u2019Donnell","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib112","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jaci.2003.10.043","article-title":"Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age","volume":"113","author":"Khoo","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib113","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jaci.2005.10.024","article-title":"IL-4\/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma","volume":"117","author":"Kabesch","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib114","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.jaci.2007.08.067","article-title":"Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data","volume":"120","author":"Baurecht","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jaci.2007.04.001","article-title":"Filaggrin null mutations are associated with increased asthma severity in children and young adults","volume":"120","author":"Palmer","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib116","doi-asserted-by":"crossref","DOI":"10.1111\/j.1398-9995.2008.01660.x","article-title":"Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults","author":"Basu","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2014.09.010_bib117","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nature06014","article-title":"Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma","volume":"448","author":"Moffatt","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaip.2014.09.010_bib118","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/ejhg.2010.38","article-title":"A\u00a0sequence variant on 17q21 is associated with age at onset and severity of asthma","volume":"18","author":"Halapi","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.jaip.2014.09.010_bib119","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.jaci.2008.06.041","article-title":"ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry","volume":"122","author":"Sleiman","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/rccm.200809-1436OC","article-title":"Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood","volume":"179","author":"Bisgaard","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib121","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMoa0806604","article-title":"Effect of 17q21 variants and smoking exposure in early-onset asthma","volume":"359","author":"Bouzigon","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib122","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1056\/NEJMoa1211592","article-title":"Rhinovirus wheezing illness and genetic risk of childhood-onset asthma","volume":"368","author":"Caliskan","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib123","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1183\/09031936.00153507","article-title":"Distinguishing phenotypes of childhood wheeze and cough using latent class analysis","volume":"31","author":"Spycher","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2014.09.010_bib124","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1164\/rccm.200907-1101OC","article-title":"Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study","volume":"181","author":"Simpson","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2014.09.010_bib125","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jaci.2010.11.015","article-title":"Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health\/National Heart, Lung, and Blood Institute Severe Asthma Research Program","volume":"127","author":"Fitzpatrick","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib126","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.jpeds.2013.11.037","article-title":"Childhood allergic asthma is not a single phenotype","volume":"164","author":"Just","year":"2014","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jaip.2014.09.010_bib127","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1183\/09031936.00123411","article-title":"Two novel, severe asthma phenotypes identified during childhood using a clustering approach","volume":"40","author":"Just","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2014.09.010_bib128","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.jaci.2013.10.006","article-title":"Phenotypes determined by cluster analysis in severe or difficult-to-treat asthma","volume":"133","author":"Schatz","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2014.09.010_bib129","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1164\/rccm.200504-525OC","article-title":"Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence","volume":"172","author":"Morgan","year":"2005","journal-title":"Am J Respir Crit Care Med"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219814004085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219814004085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:08:26Z","timestamp":1761973706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219814004085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":129,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S2213219814004085"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2014.09.010","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Childhood Asthma-Predictive Phenotype","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2014.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}