{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:34:21Z","timestamp":1790721261023,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jaip.2016.08.013","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T06:00:19Z","timestamp":1478152819000},"page":"171-175.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"title":["Increasing Emergency Department Visits for Anaphylaxis, 2005-2014"],"prefix":"10.1016","volume":"5","author":[{"given":"Megan S.","family":"Motosue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Fernanda","family":"Bellolio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly K.","family":"Van Houten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilay D.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronna L.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2016.08.013_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jaci.2005.12.1303","article-title":"Second symposium on the definition and management of anaphylaxis: summary report: second National Institute of Allergy and Infectious Disease\/Food Allergy and Anaphylaxis Network symposium","volume":"117","author":"Sampson","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S1081-1206(10)60883-6","article-title":"National study of US emergency department visits for acute allergic reactions, 1993 to 2004","volume":"98","author":"Gaeta","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1081-1206(10)60315-8","article-title":"Increasing anaphylaxis hospitalizations in the first 2 decades of life: New York State, 1990-2006","volume":"101","author":"Lin","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib4","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.jaci.2013.10.029","article-title":"Case fatality and population mortality associated with anaphylaxis in the United States","volume":"133","author":"Ma","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib5","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.jaci.2014.10.021","article-title":"Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data, 1992-2012","volume":"135","author":"Turner","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib6","first-page":"163","article-title":"Epidemiology of anaphylaxis: contributions from the last 10 years","volume":"25","author":"Tejedor-Alonso","year":"2015","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib7","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jaci.2003.11.033","article-title":"Vaccine Safety Datalink Team. Epidemiology of anaphylaxis among children and adolescents enrolled in a health maintenance organization","volume":"113","author":"Bohlke","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib8","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jaip.2013.08.012","article-title":"Retrospective study of drug-induced anaphylaxis treated in the emergency department or hospital: patient characteristics, management, and 1-year follow-up","volume":"2","author":"Banerji","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2016.08.013_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.aller.2010.12.012","article-title":"Anaphylaxis in children: a nine years retrospective study (2001-2009)","volume":"40","author":"Silva","year":"2012","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jaip.2016.08.013_bib10","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1377\/hlthaff.2014.0038","article-title":"Optum Labs: building a novel node in the learning health care system","volume":"33","author":"Wallace","year":"2014","journal-title":"Health Aff (Millwood)"},{"key":"10.1016\/j.jaip.2016.08.013_bib11","unstructured":"Optum. Optum Research Data Assets. 2015. Available from: https:\/\/www.optum.com\/content\/dam\/optum\/resources\/productSheets\/5302_Data_Assets_Chart_Sheet_ISPOR.pdf. Accessed March 18, 2016."},{"key":"10.1016\/j.jaip.2016.08.013_bib12","doi-asserted-by":"crossref","first-page":"e1001885","DOI":"10.1371\/journal.pmed.1001885","article-title":"The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statement","volume":"12","author":"Benchimol","year":"2015","journal-title":"PLoS Med"},{"key":"10.1016\/j.jaip.2016.08.013_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2010.04.017","article-title":"Algorithm for the diagnosis of anaphylaxis and its validation using population-based data on emergency department visits for anaphylaxis in Florida","volume":"126","author":"Harduar-Morano","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib14","first-page":"1","article-title":"Food allergy among U.S. children: trends in prevalence and hospitalizations","volume":"10","author":"Branum","year":"2008","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.jaip.2016.08.013_bib15","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1542\/peds.2011-0204","article-title":"The prevalence, severity, and distribution of childhood food allergy in the United States","volume":"128","author":"Gupta","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2016.08.013_bib16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.anai.2015.05.006","article-title":"Pediatric emergency department visits and hospitalizations due to food-induced anaphylaxis in Illinois","volume":"115","author":"Dyer","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib17","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.jaip.2014.03.014","article-title":"Nonsteroidal anti-inflammatory drugs are major causes of drug-induced anaphylaxis","volume":"2","author":"Aun","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2016.08.013_bib18","first-page":"40","article-title":"Portuguese Society of Allergology and Clinical Immunology; Drug Allergy Interest Group. Drug-induced anaphylaxis survey in Portuguese allergy departments","volume":"24","author":"Faria","year":"2014","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib19","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/j.1365-2125.2010.03774.x","article-title":"Epidemiology and risk factors for drug allergy","volume":"71","author":"Thong","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jaip.2016.08.013_bib20","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.jaci.2014.08.018","article-title":"Fatal anaphylaxis in the United States, 1999-2010: temporal patterns and demographic associations","volume":"134","author":"Jerschow","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib21","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jaci.2014.09.014","article-title":"Anaphylaxis: unique aspects of clinical diagnosis and management in infants (birth to age 2 years)","volume":"135","author":"Simons","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib22","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/all.12613","article-title":"Increased incidence of admissions for anaphylaxis in Spain 1998-2011","volume":"70","author":"Tejedor-Alonso","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2016.08.013_bib23","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1067\/mai.2002.127860","article-title":"Epinephrine dispensing patterns for an out-of-hospital population: a novel approach to studying the epidemiology of anaphylaxis","volume":"110","author":"Simons","year":"2002","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib24","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1399-3038.2011.01166.x","article-title":"Total serum tryptase levels are higher in young infants","volume":"22","author":"Belhocine","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib25","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1542\/peds.2011-1762","article-title":"Allergic reactions to foods in preschool-aged children in a prospective observational food allergy study","volume":"130","author":"Fleischer","year":"2012","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2016.08.013_bib26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jaci.2007.03.049","article-title":"Regional differences in EpiPen prescriptions in the United States: the potential role of vitamin D","volume":"120","author":"Camargo","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.08.013_bib27","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S1081-1206(10)60265-7","article-title":"Regional variation in epinephrine autoinjector prescriptions in Australia: more evidence for the vitamin D-anaphylaxis hypothesis","volume":"103","author":"Mullins","year":"2009","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219816303932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219816303932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:11:07Z","timestamp":1761973867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219816303932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S2213219816303932"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2016.08.013","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increasing Emergency Department Visits for Anaphylaxis, 2005-2014","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2016.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}