{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:33:39Z","timestamp":1784896419620,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jaip.2016.11.004","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T09:41:37Z","timestamp":1486978897000},"page":"990-997.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Urinary Leukotriene E4 to Determine Aspirin Intolerance in Asthma: A Systematic Review and Meta-Analysis"],"prefix":"10.1016","volume":"5","author":[{"given":"John B.","family":"Hagan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya M.","family":"Laidlaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Divekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin K.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Kita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald W.","family":"Volcheck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina R.","family":"Hagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devyani","family":"Lal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Harry G.","family":"Teaford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia J.","family":"Erwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Rank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2016.11.004_bib1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","article-title":"Global Initiative for Asthma (GINA) Program. The global burden of asthma: executive summary of the GINA Dissemination Committee report","volume":"59","author":"Masoli","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2016.11.004_bib2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2014.08.020","article-title":"Prevalence of aspirin-exacerbated respiratory disease among asthmatic patients: a meta-analysis of the literature","volume":"135","author":"Rajan","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jaci.2006.11.639","article-title":"Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program","volume":"119","author":"Moore","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1183\/09031936.03.00261903","article-title":"The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. European Network for Understanding Mechanisms of Severe Asthma","volume":"22","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2016.11.004_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1164\/ajrccm\/146.1.104","article-title":"Recovery of leukotriene E4 from the urine of patients with airway obstruction","volume":"146","author":"Drazen","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaip.2016.11.004_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0091-6749(05)80068-5","article-title":"Urinary leukotriene E4 levels during early and late asthmatic responses","volume":"86","author":"Manning","year":"1990","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib7","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1164\/ajrccm\/143.5_Pt_1.1025","article-title":"Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects","volume":"143","author":"Christie","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaip.2016.11.004_bib8","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.jaci.2011.12.979","article-title":"Asthma outcomes: biomarkers","volume":"129","author":"Szefler","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib9","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ (Clin Res ed)"},{"key":"10.1016\/j.jaip.2016.11.004_bib10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/2046-4053-3-74","article-title":"Systematic review automation technologies","volume":"3","author":"Tsafnat","year":"2014","journal-title":"Syst Rev"},{"key":"10.1016\/j.jaip.2016.11.004_bib11","series-title":"Cochrane handbook for systematic reviews of diagnostic test accuracy. Version 1.0.0","article-title":"Assessing methodological quality","author":"Reitsma","year":"2009"},{"key":"10.1016\/j.jaip.2016.11.004_bib12","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1148\/radiol.12120509","article-title":"Methods for calculating sensitivity and specificity of clustered data: a tutorial","volume":"265","author":"Genders","year":"2012","journal-title":"Radiology"},{"key":"10.1016\/j.jaip.2016.11.004_bib13","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0895-4356(03)00177-X","article-title":"The diagnostic odds ratio: a single indicator of test performance","volume":"56","author":"Glas","year":"2003","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jaip.2016.11.004_bib14","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S1081-1206(10)62084-4","article-title":"The natural history and clinical characteristics of aspirin-exacerbated respiratory disease","volume":"89","author":"Berges-Gimeno","year":"2002","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jaci.2014.07.031","article-title":"Prostaglandin D-2: a dominant mediator of aspirin-exacerbated respiratory disease","volume":"135","author":"Cahill","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib16","doi-asserted-by":"crossref","first-page":"422","DOI":"10.20452\/pamw.1379","article-title":"Incidence of aspirin hypersensitivity in patients with chronic rhinosinusitis and diagnostic value of urinary leukotriene E4","volume":"122","author":"Celejewska-Wojcik","year":"2012","journal-title":"Pol Arch Med Wewn"},{"key":"10.1016\/j.jaip.2016.11.004_bib17","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1046\/j.1365-2745.2002.01507.x","article-title":"A\u00a0comparative study of eicosanoid concentrations in sputum and urine in patients with aspirin-intolerant asthma","volume":"32","author":"Higashi","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2016.11.004_bib18","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1067\/mai.2002.124466","article-title":"Leukotriene C4 synthase promoter polymorphism in Japanese patients with aspirin-induced asthma","volume":"109","author":"Kawagishi","year":"2002","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib19","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1182\/blood-2011-10-384826","article-title":"Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes","volume":"119","author":"Laidlaw","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2016.11.004_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2332\/allergolint.09-OA-0166","article-title":"Increase in salivary cysteinyl-leukotriene concentration in patients with aspirin-intolerant asthma","volume":"60","author":"Ono","year":"2011","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2016.11.004_bib21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1398-9995.2009.02206.x","article-title":"Elevated urinary leukotriene E excretion in asthma: a comparison of HPLC-mass spectrometry and ELISA","volume":"65","author":"Sanak","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2016.11.004_bib22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1183\/09031936.93.05060693","article-title":"Urinary leukotriene E4 in bronchial asthma","volume":"5","author":"Smith","year":"1992","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2016.11.004_bib23","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jaci.2014.02.041","article-title":"Aspirin desensitization in patients with aspirin-induced and aspirin-tolerant asthma: a double-blind study","volume":"134","author":"Swierczynska-Krepa","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib24","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/0091-6749(88)90979-7","article-title":"The effects of inhaled leukotriene E4 on the airway responsiveness to histamine in subjects with asthma and normal subjects","volume":"82","author":"Arm","year":"1988","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1164\/ajrccm\/137.4.847","article-title":"Release of leukotrienes, prostaglandins, and histamine into nasal secretions of aspirin-sensitive asthmatics during reaction to aspirin","volume":"137","author":"Ferreri","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaip.2016.11.004_bib26","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jaci.2007.09.039","article-title":"Systemic responses after bronchial aspirin challenge in sensitive patients with asthma","volume":"121","author":"Makowska","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib27","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/0006-291X(87)90955-7","article-title":"The excretion of leukotriene E4 into urine following inhalation of leukotriene D4 by human individuals","volume":"148","author":"Verhagen","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaip.2016.11.004_bib28","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2500\/aap.2012.33.3541","article-title":"Aspirin-exacerbated respiratory disease: burden of disease","volume":"33","author":"Chang","year":"2012","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2016.11.004_bib29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.iac.2004.09.009","article-title":"Medications as asthma triggers","volume":"25","author":"Covar","year":"2005","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2016.11.004_bib30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2500\/ajr.2008.22.3148","article-title":"Asthma outcomes after endoscopic sinus surgery in aspirin-tolerant versus aspirin-induced asthmatic patients","volume":"22","author":"Awad","year":"2008","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.jaip.2016.11.004_bib31","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/02770909709055383","article-title":"Aspirin-induced asthma as a risk factor for asthma mortality","volume":"34","author":"Matsuse","year":"1997","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.jaip.2016.11.004_bib32","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.rmr.2014.04.100","article-title":"Aspirin hypersensitivity: characteristics and diagnostic approach [in French]","volume":"32","author":"Baudrand","year":"2015","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.jaip.2016.11.004_bib33","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.jaip.2016.03.004","article-title":"Diagnostic utility of urinary LTE4 in asthma, allergic rhinitis, chronic rhinosinusitis, nasal polyps, and aspirin sensitivity","volume":"4","author":"Divekar","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2016.11.004_bib34","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1081-1206(10)60692-8","article-title":"Aspirin challenge and desensitization for aspirin-exacerbated respiratory disease: a practice paper","volume":"98","author":"Macy","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2016.11.004_bib35","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1055\/s-0032-1325618","article-title":"Aspirin-exacerbated respiratory disease: update on pathogenesis and desensitization","volume":"33","author":"White","year":"2012","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2016.11.004_bib36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.aller.2011.05.015","article-title":"Prevalence of aspirin-exacerbated respiratory disease in patients with asthma in Turkey: a cross-sectional survey","volume":"40","author":"Bavbek","year":"2012","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jaip.2016.11.004_bib37","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2500\/aap.2013.34.3670","article-title":"The clinical dilemma of \u201csilent desensitization\u201d in aspirin-exacerbated respiratory disease","volume":"34","author":"White","year":"2013","journal-title":"Allergy Asthma Proc"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219816305608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219816305608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:12:13Z","timestamp":1761973933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219816305608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S2213219816305608"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2016.11.004","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary Leukotriene E4 to Determine Aspirin Intolerance in Asthma: A Systematic Review and Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2016.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma &#38; Immunology","name":"copyright","label":"Copyright"}]}}