{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:52:08Z","timestamp":1790787128480,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.jaip.2016.11.006","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T00:00:40Z","timestamp":1482796840000},"page":"728-736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Basophil Activation Test is a Relevant Biomarker of the Outcome of Rapid Desensitization in Platinum Compounds-Allergy"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-7580","authenticated-orcid":false,"given":"Pedro","family":"Giavina-Bianchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta R\u00e9gnier","family":"Galv\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Picard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Caiado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana C.","family":"Castells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2016.11.006_bib1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1398-9995.2010.02441.x","article-title":"General considerations on rapid desensitization for drug hypersensitivity\u2014a consensus statement","volume":"65","author":"Cernadas","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2016.11.006_bib2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jaci.2008.02.044","article-title":"Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases","volume":"122","author":"Castells","year":"2008","journal-title":"J\u00a0Allergy and Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib3","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.jaci.2009.09.009","article-title":"Hypersensitivity reactions to mAbs: 105 desensitizations in 23 patients, from evaluation to treatment","volume":"124","author":"Brennan","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.anai.2010.08.002","article-title":"Drug allergy: an updated practice parameter","volume":"105","author":"Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1007\/s40521-015-0060-2","article-title":"Rapid desensitization in immediate hypersensitivity reaction to drugs","volume":"2","author":"Giavina-Bianchi","year":"2015","journal-title":"Curr Treat Options Allergy"},{"key":"10.1016\/j.jaip.2016.11.006_bib6","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1002\/eji.201040810","article-title":"Rapid IgE desensitization is antigen specific and impairs early and late mast cell responses targeting Fc\u03b5RI internalization","volume":"41","author":"Sancho-Serra","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib7","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jaci.2013.05.004","article-title":"Rapid desensitization induces internalization of antigen-specific IgE on mouse mast cells","volume":"132","author":"Oka","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib8","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.immuni.2009.06.026","article-title":"Small, mobile Fc\u025bRI receptor aggregates are signaling competent","volume":"31","author":"Andrews","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jaip.2016.11.006_bib9","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.jaci.2012.04.039","article-title":"Early suppression of basophil activation during allergen-specific immunotherapy by histamine receptor 2","volume":"130","author":"Novak","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib10","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/all.12105","article-title":"Hypersensitivity and desensitization to antineoplastic agents: outcomes of 189 procedures with a new short protocol and novel diagnostic tools assessment","volume":"68","author":"Madrigal-Burgaleta","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2016.11.006_bib11","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1111\/all.12228","article-title":"Rapid desensitization to chemotherapy and monoclonal antibodies is effective and safe","volume":"68","author":"Giavina-Bianchi","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2016.11.006_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s40259-013-0066-x","article-title":"Drug desensitization in the management of hypersensitivity reactions to monoclonal antibodies and chemotherapy","volume":"28","author":"Mezzano","year":"2014","journal-title":"BioDrugs"},{"key":"10.1016\/j.jaip.2016.11.006_bib13","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1200\/JCO.1999.17.4.1141","article-title":"Clinical features of hypersensitivity reactions to carboplatin","volume":"17","author":"Markman","year":"1999","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jaip.2016.11.006_bib14","doi-asserted-by":"crossref","first-page":"207084","DOI":"10.1155\/2010\/207084","article-title":"Hypersensitivity reactions associated with platinum antineoplastic agents: a systematic review","volume":"2010","author":"Makrilia","year":"2010","journal-title":"Met Based Drugs"},{"key":"10.1016\/j.jaip.2016.11.006_bib15","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1136\/ijgc-00009577-200807000-00003","article-title":"Analysis of the pattern of hypersensitivity reactions in patients receiving carboplatin retreatment for recurrent ovarian cancer","volume":"18","author":"Gadducci","year":"2008","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.jaip.2016.11.006_bib16","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jaci.2008.12.1128","article-title":"Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy","volume":"123","author":"Wanich","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jaci.2012.06.003","article-title":"Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance","volume":"131","author":"Ford","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jim.2006.12.002","article-title":"Flow cytometry for basophil activation markers: the measurement of CD203c up-regulation is as reliable as CD63 expression in the diagnosis of cat allergy","volume":"320","author":"Ocmant","year":"2007","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jaip.2016.11.006_bib19","doi-asserted-by":"crossref","first-page":"e108619","DOI":"10.1371\/journal.pone.0108619","article-title":"Basophil activation test using recombinant allergens: highly specific diagnostic method complementing routine tests in wasp venom allergy","volume":"9","author":"Balzer","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2016.11.006_bib20","doi-asserted-by":"crossref","first-page":"266","DOI":"10.5415\/apallergy.2013.3.4.266","article-title":"Recent applications of basophil activation tests in the diagnosis of drug hypersensitivity","volume":"3","author":"Song","year":"2013","journal-title":"Asia Pac Allergy"},{"key":"10.1016\/j.jaip.2016.11.006_bib21","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/cytob.21148","article-title":"Basophil activation test in the diagnosis and monitoring of mastocytosis patients with wasp venom allergy on immunotherapy","volume":"86","author":"Bidad","year":"2014","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.jaip.2016.11.006_bib22","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jaci.2015.01.012","article-title":"IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens","volume":"135","author":"Santos","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/j.1398-9995.2010.02432.x","article-title":"Benefit of the basophil activation test in deciding when to reintroduce cow's milk in allergic children","volume":"66","author":"Rubio","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2016.11.006_bib24","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.jaci.2013.06.038","article-title":"Basophil activation testing","volume":"132","author":"MacGlashan","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/cyto.b.20526","article-title":"CD203c-based basophil activation test in allergy diagnosis: characteristics and differences to CD63 upregulation","volume":"78","author":"Sturm","year":"2010","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.jaip.2016.11.006_bib26","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1365-2222.2002.01305.x","article-title":"Flow cytometric basophil activation test by detection of CD63 expression in patients with immediate-type reactions to betalactam antibiotics","volume":"32","author":"Sanz","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2016.11.006_bib27","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1248\/bpb.b12-00150","article-title":"Evaluation of basophil CD203c as a predictor of carboplatin-related hypersensitivity reaction in patients with gynecologic cancer","volume":"35","author":"Iwamoto","year":"2012","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jaip.2016.11.006_bib28","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1111\/cas.12538","article-title":"Carboplatin-induced severe hypersensitivity reaction: role of IgE-dependent basophil activation and Fc\u03b5RI","volume":"105","author":"Iwamoto","year":"2014","journal-title":"Cancer Sci"},{"key":"10.1016\/j.jaip.2016.11.006_bib29","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00105-008-1653-5","article-title":"Basophil activation test as in\u00a0vitro assay for cisplatin allergy","volume":"59","author":"Viardot-Helmer","year":"2008","journal-title":"Hautarzt"},{"key":"10.1016\/j.jaip.2016.11.006_bib30","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.jaci.2003.12.591","article-title":"Revised nomenclature for allergy for global use: report of the Nomenclature Review Committee of the World Allergy Organization","volume":"113","author":"Johansson","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.jaci.2009.10.060","article-title":"Speaking the same language: the World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System","volume":"125","author":"Cox","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jaci.2004.04.029","article-title":"Clinical features and severity grading of anaphylaxis","volume":"114","author":"Brown","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib33","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1200\/JCO.1997.15.1.193","article-title":"Dose-effect study of carboplatin in ovarian cancer: a Danish Ovarian Cancer Group study","volume":"15","author":"Jakobsen","year":"1997","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.jaip.2016.11.006_bib34","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/BF00685679","article-title":"A\u00a0limited sampling method for estimation of the carboplatin area under the curve","volume":"31","author":"S\u00f8rensen","year":"1993","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.jaip.2016.11.006_bib35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000115885","article-title":"Diagnostic tests based on human basophils: more potentials and perspectives than pitfalls","volume":"146","author":"de Weck","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib36","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jaci.2013.09.021","article-title":"Health care use and serious infection prevalence associated with penicillin \u201callergy\u201d in hospitalized patients: a cohort study","volume":"133","author":"Macy","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2016.11.006_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2050-6511-15-1","article-title":"Hypersensitivity to oxaliplatin: clinical features and risk factors","volume":"15","author":"Parel","year":"2014","journal-title":"BMC Pharmacol Toxicol"},{"key":"10.1016\/j.jaip.2016.11.006_bib38","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000205263","article-title":"Hypersensitivity to oxaliplatin: an investigation of incidence and risk factors, and literature review","volume":"76","author":"Kim","year":"2009","journal-title":"Oncology"},{"key":"10.1016\/j.jaip.2016.11.006_bib39","doi-asserted-by":"crossref","first-page":"210","DOI":"10.7150\/ijms.8.210","article-title":"Risk factors for oxaliplatin-induced hypersensitivity reactions in Japanese patients with advanced colorectal cancer","volume":"8","author":"Seki","year":"2011","journal-title":"Int J Med Sci."},{"key":"10.1016\/j.jaip.2016.11.006_bib40","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000320613","article-title":"Oxaliplatin-free interval as a risk factor for hypersensitivity reaction among colorectal cancer patients treated with FOLFOX","volume":"79","author":"Mori","year":"2010","journal-title":"Oncology"},{"key":"10.1016\/j.jaip.2016.11.006_bib41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/annonc\/mdj042","article-title":"Hypersensitivity reactions to oxaliplatin: experience in a single institute","volume":"17","author":"Siu","year":"2006","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jaip.2016.11.006_bib42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaip.2013.08.011","article-title":"Oxaliplatin hypersensitivity: evaluation, implications of skin testing, and desensitization","volume":"2","author":"Wong","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2016.11.006_bib43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ygyno.2014.07.104","article-title":"Outpatient rapid 4-step desensitization for gynecologic oncology patients with mild to low-risk, moderate hypersensitivity reactions to carboplatin\/cisplatin","volume":"135","author":"Li","year":"2014","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.jaip.2016.11.006_bib44","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/bjc.2013.389","article-title":"Deleterious BRCA1\/2 mutation is an independent risk factor for carboplatinhypersensitivity reactions","volume":"109","author":"Moon","year":"2013","journal-title":"Br J Cancer"},{"key":"10.1016\/j.jaip.2016.11.006_bib45","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.iac.2006.05.010","article-title":"Diagnostic value of tryptase in anaphylaxis and mastocytosis","volume":"26","author":"Schwartz","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2016.11.006_bib46","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jaip.2013.06.002","article-title":"Carboplatin-, oxaliplatin-, and cisplatin\u2013specific IgE: cross-reactivity and value in the diagnosis of carboplatin and oxaliplatin allergy","volume":"1","author":"Caiado","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2016.11.006_bib47","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nm.2754","article-title":"Therapies for allergic inflammation: refining strategies to induce tolerance","volume":"18","author":"Akdis","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.jaip.2016.11.006_bib48","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jaci.2013.01.014","article-title":"IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses","volume":"131","author":"van de Veen","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219816305633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219816305633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:10:52Z","timestamp":1761973852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219816305633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S2213219816305633"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2016.11.006","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basophil Activation Test is a Relevant Biomarker of the Outcome of Rapid Desensitization in Platinum Compounds-Allergy","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2016.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}