{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:30:34Z","timestamp":1777566634542,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007051","name":"Uppsala Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","award":["5U19AI104209"],"award-info":[{"award-number":["5U19AI104209"]}],"id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","award":["R01AR067145"],"award-info":[{"award-number":["R01AR067145"]}],"id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jaip.2017.01.016","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T15:30:20Z","timestamp":1490628620000},"page":"1325-1334.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"title":["Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children"],"prefix":"10.1016","volume":"5","author":[{"given":"Sandra","family":"Andorf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus P.","family":"Borres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4287-7324","authenticated-orcid":false,"given":"Whitney","family":"Block","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Tupa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer B.","family":"Bollyky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanitha","family":"Sampath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Elizur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Lidholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Galli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca S.","family":"Chinthrajah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari C.","family":"Nadeau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2017.01.016_bib1","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1542\/peds.2011-0204","article-title":"The prevalence, severity, and distribution of childhood food allergy in the United States","volume":"128","author":"Gupta","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2017.01.016_bib2","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.jaci.2013.07.018","article-title":"Prevalence of self-reported food allergy in the National Health and Nutrition Examination Survey (NHANES) 2007-2010","volume":"132","author":"McGowan","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib3","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2500\/aap.2016.37.3924","article-title":"Approach to evaluation and management of a patient with multiple food allergies","volume":"37","author":"Bird","year":"2016","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2017.01.016_bib4","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0091-6749(99)70198-3","article-title":"Allergenicity of goat\u2019s milk in children with cow\u2019s milk allergy","volume":"103","author":"Bellioni-Businco","year":"1999","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib5","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1046\/j.1398-9995.2003.00342.x","article-title":"Cashew allergy: observations of 42 children without associated peanut allergy","volume":"58","author":"Ranc\u00e9","year":"2003","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jaci.2008.04.014","article-title":"The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy","volume":"122","author":"Maloney","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1081-1206(10)61187-8","article-title":"Cross-reactivity among edible nuts: double immunodiffusion, crossed immunoelectrophoresis, and human specific IgE serologic surveys","volume":"95","author":"Goetz","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/all.12554","article-title":"Peanut allergy is common among hazelnut-sensitized subjects but is not primarily the result of IgE cross-reactivity","volume":"70","author":"Masthoff","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2017.01.016_bib9","first-page":"162","article-title":"Cross-reactivity syndromes in food allergy","volume":"21","author":"Garc\u00eda","year":"2011","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12887-016-0673-z","article-title":"The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: a retrospective cohort study","volume":"16","author":"Hill","year":"2016","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.jaip.2017.01.016_bib11","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s11882-012-0318-8","article-title":"Overview of component resolved diagnostics","volume":"13","author":"Treudler","year":"2013","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2017.01.016_bib12","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J\u00a0R Stat Soc B"},{"key":"10.1016\/j.jaip.2017.01.016_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1469-8137.1912.tb05611.x","article-title":"The distribution of the flora in the alpine zone","volume":"11","author":"Jaccard","year":"1912","journal-title":"New Phytol"},{"key":"10.1016\/j.jaip.2017.01.016_bib14","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1093\/bioinformatics\/btl117","article-title":"Pvclust: an R package for assessing the uncertainty in hierarchical clustering","volume":"22","author":"Suzuki","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaip.2017.01.016_bib15","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/all.12826","article-title":"Cross-sensitization profiles of edible nuts in a birch-endemic area","volume":"71","author":"Uotila","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2017.01.016_bib16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2332\/allergolint.10-OA-0222","article-title":"Pistachio allergy-prevalence and in\u00a0vitro cross-reactivity with other nuts","volume":"60","author":"Noorbakhsh","year":"2011","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2017.01.016_bib17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jaci.2015.03.037","article-title":"Sensitization to cashew nut 2S albumin, Ana o 3, is highly predictive of cashew and pistachio allergy in Greek children","volume":"136","author":"Savvatianos","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib18","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/0091-6749(88)90135-2","article-title":"Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual","volume":"82","author":"Bock","year":"1988","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jaci.2005.04.019","article-title":"Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens","volume":"116","author":"Jahn-Schmid","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib20","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s11882-014-0426-8","article-title":"Cross-reactivity of peanut allergens","volume":"14","author":"Bublin","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2017.01.016_bib21","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jaci.2010.07.026","article-title":"National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006","volume":"126","author":"Liu","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib22","first-page":"159845","article-title":"Sex disparity in food allergy: evidence from the PubMed Database","volume":"2009","author":"Kelly","year":"2009","journal-title":"J\u00a0Allergy"},{"key":"10.1016\/j.jaip.2017.01.016_bib23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jaci.2005.05.017","article-title":"Prevalences of positive skin test responses to 10 common allergens in the US population: results from the Third National Health and Nutrition Examination Survey","volume":"116","author":"Arbes","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib24","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0091-6749(03)02026-8","article-title":"Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study","volume":"112","author":"Sicherer","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jaci.2013.11.020","article-title":"Food allergy: epidemiology, pathogenesis, diagnosis, and treatment","volume":"133","author":"Sicherer","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib26","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/j.1398-9995.2006.01181.x","article-title":"Incorporating a gender dimension in food allergy research: a review","volume":"61","author":"DunnGalvin","year":"2006","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ajg.2011.342","article-title":"Influence of race and gender on the presentation of eosinophilic esophagitis","volume":"107","author":"Sperry","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jaip.2017.01.016_bib28","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jaci.2010.12.012","article-title":"Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy","volume":"127","author":"Nicolaou","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib29","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.jaip.2013.07.014","article-title":"Ara h 2 is the best predictor for peanut allergy in adults","volume":"1","author":"Klemans","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2017.01.016_bib30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000371675","article-title":"IgE-related examination in food allergy with focus on allergen components","volume":"101","author":"Borres","year":"2015","journal-title":"Chem Immunol Allergy"},{"key":"10.1016\/j.jaip.2017.01.016_bib31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/all.12530","article-title":"Predictive values of component-specific IgE for the outcome of peanut and hazelnut food challenges in children","volume":"70","author":"Beyer","year":"2015","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jaci.2009.10.008","article-title":"Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics","volume":"125","author":"Nicolaou","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib33","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jaci.2013.02.024","article-title":"Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults","volume":"132","author":"Masthoff","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2174\/1874091X00802010016","article-title":"2S albumin storage proteins: what makes them food allergens?","volume":"2","author":"Moreno","year":"2008","journal-title":"Open Biochem J"},{"key":"10.1016\/j.jaip.2017.01.016_bib35","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1002\/mnfr.201500071","article-title":"Cor\u00a0a\u00a014, the allergenic 2S albumin from hazelnut, is highly thermostable and resistant to gastrointestinal digestion","volume":"59","author":"Pfeifer","year":"2015","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jaip.2017.01.016_bib36","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/BJ20051728","article-title":"Structure and stability of 2S albumin-type peanut allergens: implications for the severity of peanut allergic reactions","volume":"395","author":"Lehmann","year":"2006","journal-title":"Biochem J"},{"key":"10.1016\/j.jaip.2017.01.016_bib37","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/mnfr.201000011","article-title":"Digestion of peanut allergens Ara h 1, Ara h 2, Ara h 3, and Ara h 6: a comparative in\u00a0vitro study and partial characterization of digestion-resistant peptide","volume":"54","author":"Koppelman","year":"2010","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.jaip.2017.01.016_bib38","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/0091-6749(88)90135-2","article-title":"Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual","volume":"82","author":"Bock","year":"1988","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib39","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1111\/all.12441","article-title":"EAACI Food Allergy and Anaphylaxis Guidelines: Managing patients with food allergy in the community","volume":"69","author":"Muraro","year":"2014","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib40","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jaci.2013.12.1037","article-title":"Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)","volume":"133","author":"Syed","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.01.016_bib41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1710-1492-10-7","article-title":"Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab","volume":"10","author":"B\u00e9gin","year":"2014","journal-title":"Allergy Asthma Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219817300302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219817300302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:12:22Z","timestamp":1761973942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219817300302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S2213219817300302"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2017.01.016","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Clinical Reactivity with Sensitization to Allergen Components in Multifood-Allergic Children","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2017.01.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}