{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:50:43Z","timestamp":1790567443849,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.jaip.2017.06.010","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T13:00:32Z","timestamp":1501160432000},"page":"244-249.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Distinct Asthma Phenotypes Among Older Adults with Asthma"],"prefix":"10.1016","volume":"6","author":[{"given":"Alan P.","family":"Baptist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthi R.","family":"Karamched","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bani","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-5353","authenticated-orcid":false,"given":"Laurie","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter X.K.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.jaip.2017.06.010_bib2","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.2105\/AJPH.2009.162982","article-title":"Disparate inclusion of older adults in clinical trials: priorities and opportunities for policy and practice change","volume":"100","author":"Herrera","year":"2010","journal-title":"Am J Public Health"},{"key":"10.1016\/j.jaip.2017.06.010_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5415\/apallergy.2012.2.2.101","article-title":"Asthma in the elderly","volume":"2","author":"Gillman","year":"2012","journal-title":"Asia Pac Allergy"},{"key":"10.1016\/j.jaip.2017.06.010_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000441687","article-title":"Asthma: hospitalization trends and predictors of in-hospital mortality and hospitalization costs in the USA (2001-2010)","volume":"168","author":"Kaur","year":"2015","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2017.06.010_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.anai.2010.10.017","article-title":"Effect of age on asthma control: results from the National Asthma Survey","volume":"106","author":"Talreja","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2017.06.010_bib7","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.jaci.2012.01.061","article-title":"Age-related differences in clinical outcomes for acute asthma in the United States, 2006-2008","volume":"129","author":"Tsai","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.010_bib8","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/1049732309355288","article-title":"Age-specific factors influencing asthma management by older adults","volume":"20","author":"Baptist","year":"2010","journal-title":"Qual Health Res"},{"key":"10.1016\/j.jaip.2017.06.010_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1183\/09031936.00138707","article-title":"Global strategy for asthma management and prevention: GINA executive summary","volume":"31","author":"Bateman","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2017.06.010_bib10","series-title":"Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma","year":"2007"},{"key":"10.1016\/j.jaip.2017.06.010_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MCP.0000000000000125","article-title":"The revised 2014 GINA strategy report: opportunities for change","volume":"21","author":"Boulet","year":"2015","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.jaip.2017.06.010_bib12","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0140-6736(06)69290-8","article-title":"Asthma: defining of the persistent adult phenotypes","volume":"368","author":"Wenzel","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2017.06.010_bib13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1164\/rccm.200409-1181PP","article-title":"Severe asthma in adults","volume":"172","author":"Wenzel","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2017.06.010_bib14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/rccm.200906-0896OC","article-title":"Identification of asthma phenotypes using cluster analysis in the Severe\u00a0Asthma Research Program","volume":"181","author":"Moore","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2017.06.010_bib15","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1164\/rccm.200711-1754OC","article-title":"Cluster analysis and clinical asthma phenotypes","volume":"178","author":"Haldar","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2017.06.010_bib16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.anai.2014.09.020","article-title":"Classification and implementation of asthma phenotypes in elderly patients","volume":"114","author":"Park","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2017.06.010_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3109\/02770909609077762","article-title":"Asthma and its association with cardiovascular disease in the elderly. The Cardiovascular Health Study Research Group","volume":"33","author":"Enright","year":"1996","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.jaip.2017.06.010_bib19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1742-4933-7-8","article-title":"Characterization of leukotrienes in a pilot study of older asthma subjects","volume":"7","author":"Nyenhuis","year":"2010","journal-title":"Immun Ageing"},{"key":"10.1016\/j.jaip.2017.06.010_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1752-699X.2007.00033.x","article-title":"\u2018You have to learn to live with it\u2019: a qualitative and quantitative study of older people with asthma","volume":"1","author":"Goeman","year":"2007","journal-title":"Clin Respir J"},{"key":"10.1016\/j.jaip.2017.06.010_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000352053","article-title":"Longitudinal changes in clinical outcomes in older patients with asthma, COPD and asthma-COPD overlap syndrome","volume":"87","author":"Fu","year":"2014","journal-title":"Respiration"},{"key":"10.1016\/j.jaip.2017.06.010_bib22","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1001\/jama.283.14.1853","article-title":"The accuracy of patient history, wheezing, and laryngeal measurements in diagnosing obstructive airway disease. CARE-COAD1 Group. Clinical Assessment of the Reliability of the Examination-Chronic Obstructive Airways Disease","volume":"283","author":"Straus","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2017.06.010_bib23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jaip.2012.12.003","article-title":"Quality of life, health care utilization, and control in older adults with asthma","volume":"1","author":"Ross","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2017.06.010_bib25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1164\/rccm.200203-183OC","article-title":"Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease","volume":"167","author":"Fabbri","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2017.06.010_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1465-9921-12-1","article-title":"Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study","volume":"12","author":"Lee","year":"2011","journal-title":"Respir Res"},{"key":"10.1016\/j.jaip.2017.06.010_bib27","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2011.12.985","article-title":"Asthma outcomes workshop: overview","volume":"129","author":"Busse","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.010_bib28","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/01621459.1963.10500845","article-title":"Hierarchical grouping to optimize an objective function","volume":"58","author":"Ward","year":"1963","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.jaip.2017.06.010_bib29","series-title":"Classification and Regression Trees","author":"Breiman","year":"1984"},{"key":"10.1016\/j.jaip.2017.06.010_bib31","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/MCG.0b013e31825692ce","article-title":"Obesity and the elderly","volume":"46","author":"Mathus-Vliegen","year":"2012","journal-title":"J\u00a0Clin Gastroenterol"},{"key":"10.1016\/j.jaip.2017.06.010_bib32","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jaci.2016.06.061","article-title":"Asthma phenotypes in inner-city children","volume":"138","author":"Zoratti","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.010_bib33","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1164\/rccm.200309-1234OE","article-title":"Is forced expiratory volume in one second the best measure of severity in childhood asthma?","volume":"169","author":"Spahn","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2017.06.010_bib34","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1002\/ppul.23096","article-title":"Spirometry and regular follow-up do not improve quality of life in children or adolescents with asthma: cluster randomized controlled trials","volume":"50","author":"Abramson","year":"2015","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaip.2017.06.010_bib35","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1378\/chest.114.5.1336","article-title":"Effect of age upon airway obstruction and reversibility in adult patients with asthma","volume":"114","author":"Bellia","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2017.06.010_bib36","first-page":"861926","article-title":"The asthma-COPD overlap syndrome: a common clinical problem in the elderly","volume":"2011","author":"Zeki","year":"2011","journal-title":"J\u00a0Allergy (Cairo)"},{"key":"10.1016\/j.jaip.2017.06.010_bib37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s40266-017-0437-y","article-title":"Late-onset asthma: a diagnostic and management challenge","volume":"34","author":"Ulrik","year":"2017","journal-title":"Drugs Aging"},{"key":"10.1016\/j.jaip.2017.06.010_bib38","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1159\/000439310","article-title":"Different severity and severity predictors in early-onset and late-onset asthma: a Taiwanese population-based study","volume":"90","author":"Wu","year":"2015","journal-title":"Respiration"},{"key":"10.1016\/j.jaip.2017.06.010_bib40","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jaci.2013.08.003","article-title":"Predictors of response to tiotropium versus salmeterol in asthmatic adults","volume":"132","author":"Peters","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219817304750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219817304750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:13:57Z","timestamp":1761974037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219817304750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S2213219817304750"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2017.06.010","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct Asthma Phenotypes Among Older Adults with Asthma","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2017.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}