{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:31:56Z","timestamp":1790951516644,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jaip.2017.06.021","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T05:46:28Z","timestamp":1504676788000},"page":"1280-1287.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Anaphylaxis and Clinical Utility of Real-World Measurement of Acute Serum Tryptase in UK Emergency Departments"],"prefix":"10.1016","volume":"5","author":[{"given":"Richard J.","family":"Buka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Knibb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Crossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathryn L.","family":"Melchior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarnoud P.","family":"Huissoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Hackett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Dorrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamidipudi T.","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2017.06.021_bib1","unstructured":"National Institute for Health and Clinical Excellence guideline. Anaphylaxis: assessment and referral after emergency treatment. NICE guideline (CG134). 2011. Available from: http:\/\/www.nice.org.uk\/guidance\/cg134. Accessed July 11, 2017."},{"key":"10.1016\/j.jaip.2017.06.021_bib2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.anai.2014.10.007","article-title":"Emergency department diagnosis and treatment of anaphylaxis: a practice parameter","volume":"113","author":"Campbell","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib3","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jaci.2009.07.055","article-title":"Elevated serum cytokines during human anaphylaxis: identification of potential mediators of acute allergic reactions","volume":"124","author":"Stone","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s11882-008-0034-6","article-title":"Pathophysiology of food-induced anaphylaxis","volume":"8","author":"Lemon-Mul\u00e9","year":"2008","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2017.06.021_bib5","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1067\/mai.2000.107600","article-title":"Histamine and tryptase levels in patients with acute allergic reactions: an emergency department-based study","volume":"106","author":"Lin","year":"2000","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaci.2012.08.016","article-title":"Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis","volume":"131","author":"Vadas","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000339749","article-title":"Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis in 102 patients","volume":"160","author":"Sala-Cunill","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib8","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1111\/all.12702","article-title":"Anaphylaxis and ethnicity: higher incidence in British South Asians","volume":"70","author":"Buka","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2017.06.021_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/WOX.0b013e318211496c","article-title":"World Allergy Organization guidelines for the assessment and management of anaphylaxis","volume":"4","author":"Simons","year":"2011","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaip.2017.06.021_bib10","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1067\/mai.2001.119028","article-title":"Emergency department anaphylaxis: a review of 142 patients in a single year","volume":"108","author":"Brown","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.resuscitation.2008.02.001","article-title":"Emergency treatment of anaphylactic reactions\u2014guidelines for healthcare providers","volume":"77","author":"Soar","year":"2008","journal-title":"Resuscitation"},{"key":"10.1016\/j.jaip.2017.06.021_bib12","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1172\/JCI114051","article-title":"Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis","volume":"83","author":"Schwartz","year":"1989","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2017.06.021_bib13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.iac.2006.05.010","article-title":"Diagnostic value of tryptase in anaphylaxis and mastocytosis","volume":"26","author":"Schwartz","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2017.06.021_bib14","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4168\/aair.2014.6.4.304","article-title":"The utility of serum tryptase in the diagnosis of food-induced anaphylaxis","volume":"6","author":"Wongkaewpothong","year":"2014","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaip.2017.06.021_bib15","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/adc.2004.069914","article-title":"Paediatric emergency department anaphylaxis: different patterns from adults","volume":"91","author":"Braganza","year":"2006","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.jaip.2017.06.021_bib16","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.jaci.2015.09.001","article-title":"Tryptase levels in children presenting with anaphylaxis: temporal trends and associated factors","volume":"137","author":"De Schryver","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib17","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1111\/j.1365-2222.2011.03848.x","article-title":"An increase in serum tryptase even below 11.4 ng\/mL may indicate a mast cell-mediated hypersensitivity reaction: a prospective study in Hymenoptera venom allergic patients","volume":"41","author":"Borer-Reinhold","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2017.06.021_bib18","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/cei.12424","article-title":"Multi-centre retrospective analysis of anaphylaxis during general anaesthesia in the United Kingdom: aetiology and diagnostic performance of acute serum tryptase","volume":"178","author":"Krishna","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib19","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/00000542-200309000-00007","article-title":"Anaphylactic and anaphylactoid reactions occurring during anesthesia in France in 1999-2000","volume":"99","author":"Mertes","year":"2003","journal-title":"Anesthesiology"},{"key":"10.1016\/j.jaip.2017.06.021_bib20","first-page":"282","article-title":"Serum tryptase levels and markers of renal dysfunction in a population with chronic kidney disease","volume":"23","author":"Sirvent","year":"2010","journal-title":"J\u00a0Nephrol"},{"key":"10.1016\/j.jaip.2017.06.021_bib21","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jaci.2009.06.040","article-title":"Serum tryptase levels in atopic and nonatopic children","volume":"124","author":"Komarow","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib22","first-page":"30","article-title":"Serum tryptase concentrations in beekeepers with and without Hymenoptera venom allergy","volume":"23","author":"Carballada","year":"2013","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib23","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1056\/NEJM199208063270603","article-title":"Fatal and near-fatal anaphylactic reactions to food in children and adolescents","volume":"327","author":"Sampson","year":"1992","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2017.06.021_bib24","first-page":"120","article-title":"Can serum mast cell tryptase help diagnose anaphylaxis?","volume":"16","author":"Brown","year":"2004","journal-title":"Emerg Med Australas"},{"key":"10.1016\/j.jaip.2017.06.021_bib25","doi-asserted-by":"crossref","first-page":"AB71","DOI":"10.1016\/j.jaci.2010.12.292","article-title":"Dipeptidyl peptidase I as a serum marker of allergic reactions to food","volume":"127","author":"Whitworth","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2017.06.021_bib26","doi-asserted-by":"crossref","first-page":"AB143","DOI":"10.1016\/j.jaci.2010.12.567","article-title":"Mast cell carboxypeptidase as a confirmatory and predictive marker in allergic reactions to drugs","volume":"127","author":"Brown","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219817305056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219817305056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:15:00Z","timestamp":1761974100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219817305056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S2213219817305056"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2017.06.021","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anaphylaxis and Clinical Utility of Real-World Measurement of Acute Serum Tryptase in UK Emergency Departments","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2017.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}