{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:46:02Z","timestamp":1791431162344,"version":"4.3.3"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jaip.2018.02.018","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T22:57:21Z","timestamp":1520290641000},"page":"2043-2050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["The Frequency and Clinical Features of Hypersensitivity Reactions to Antiepileptic Drugs in Children: A Prospective Study"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-5221","authenticated-orcid":false,"given":"Hakan","family":"Guvenir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Dibek Misirlioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersoy","family":"Civelek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muge","family":"Toyran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Buyuktiryaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayfur","family":"Ginis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5864-9054","authenticated-orcid":false,"given":"Murat","family":"Capanoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Gurkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alev","family":"Guven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8859-7187","authenticated-orcid":false,"given":"Can Naci","family":"Kocabas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2018.02.018_bib1","first-page":"363","article-title":"Drug hypersensitivity reactions: patterns of responses, drug involved and temporal variation in a large series of patients","volume":"22","author":"Dona","year":"2012","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2018.02.018_bib2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.iac.2014.04.005","article-title":"Hypersensitivity to antiepileptic drugs","volume":"34","author":"Ye","year":"2014","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2018.02.018_bib3","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.pharep.2014.11.009","article-title":"Antiepileptic drugs and adverse skin reactions: an update","volume":"67","author":"B\u0142aszczyk","year":"2015","journal-title":"Pharmacol Rep"},{"key":"10.1016\/j.jaip.2018.02.018_bib4","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1212\/01.wnl.0000261917.83337.db","article-title":"Comparison and predictors of rash associated with 15 antiepileptic drugs","volume":"68","author":"Arif","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jaip.2018.02.018_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/archderm.1990.01670250049006","article-title":"The incidence of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis: a population-based study with particular reference to reactions caused by drugs among outpatients","volume":"126","author":"Chan","year":"1990","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaip.2018.02.018_bib6","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1528-1167.2007.01041.x","article-title":"Idiosyncratic adverse reactions to antiepileptic drugs","volume":"48","author":"Zaccara","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.jaip.2018.02.018_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1001\/archderm.1993.01680220104023","article-title":"Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme","volume":"129","author":"Bastuji-Garin","year":"1993","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaip.2018.02.018_bib8","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2133.2006.07704.x","article-title":"Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: Does a DRESS syndrome really exist?","volume":"156","author":"Kardaun","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2018.02.018_bib9","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/j.1398-9995.2006.01136.x","article-title":"EAACI\/GA2LEN position paper: present status of the atopy patch test","volume":"61","author":"Turjanmaa","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.02.018_bib10","series-title":"Middleton's allergy: principles and practice","first-page":"1274","article-title":"Drug allergy","author":"Celik","year":"2014"},{"key":"10.1016\/j.jaip.2018.02.018_bib11","doi-asserted-by":"crossref","first-page":"e008298","DOI":"10.1136\/bmjopen-2015-008298","article-title":"A\u00a0prospective study of adverse drug reactions to antiepileptic drugs in children","volume":"5","author":"Anderson","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.jaip.2018.02.018_bib12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.seizure.2013.12.001","article-title":"Efficacy and tolerability of the first antiepileptic drug in children with newly diagnosed idiopathic epilepsy","volume":"23","author":"Y\u0131lmaz","year":"2014","journal-title":"Seizure"},{"key":"10.1016\/j.jaip.2018.02.018_bib13","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2174\/092986710790416326","article-title":"Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions","volume":"17","author":"Corsonello","year":"2010","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.jaip.2018.02.018_bib14","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/j.1528-1167.2007.01109.x","article-title":"Rash from antiepileptic drugs: influence by gender, age, and learning disability","volume":"48","author":"Alvestad","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.jaip.2018.02.018_bib15","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1212\/01.WNL.0000156354.20227.F0","article-title":"Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics","volume":"64","author":"Mockenhaupt","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jaip.2018.02.018_bib16","first-page":"695","article-title":"Influence of chemical structure on hypersensitivity reactions induced by antiepileptic drugs: the role of the aromatic ring","volume":"31","author":"Handoko","year":"2008","journal-title":"Drug"},{"key":"10.1016\/j.jaip.2018.02.018_bib17","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/01.fpc.0000199500.46842.4a","article-title":"Genetic susceptibility to carbamazepine induced cutaneous adverse drug reactions","volume":"16","author":"Hung","year":"2006","journal-title":"Pharmacogenet Genomics"},{"key":"10.1016\/j.jaip.2018.02.018_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5698\/1535-7511-11.6.189","article-title":"Carbamazepine hypersensitivity: progress toward predicting the unpredictable","volume":"11","author":"Gidal","year":"2011","journal-title":"Epilepsy Curr"},{"key":"10.1016\/j.jaip.2018.02.018_bib19","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.eplepsyres.2011.08.010","article-title":"Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans","volume":"97","author":"Kim","year":"2011","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jaip.2018.02.018_bib20","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.jaci.2011.08.013","article-title":"Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome","volume":"128","author":"Ko","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.02.018_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clineuro.2015.07.008","article-title":"Lamotrigine induced DIHS\/DRESS: manifestations, treatment, and outcome in 57 patients","volume":"138","author":"Wang","year":"2015","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.jaip.2018.02.018_bib22","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.jocn.2015.01.016","article-title":"Lamotrigine-induced severe cutaneous adverse reaction: update data from 1999-2014","volume":"22","author":"Wang","year":"2015","journal-title":"J\u00a0Clin Neurosci"},{"key":"10.1016\/j.jaip.2018.02.018_bib23","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1474-4422(03)00409-5","article-title":"Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs","volume":"2","author":"Patsalos","year":"2003","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jaip.2018.02.018_bib24","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/0091270004273678","article-title":"The safety and effectiveness of newer antiepileptics: a comparative postmarketing cohort study","volume":"45","author":"Acharya","year":"2005","journal-title":"J\u00a0Clin Pharmacol"},{"key":"10.1016\/j.jaip.2018.02.018_bib25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.nurx.2006.01.013","article-title":"New generation anticonvulsants for the treatment of epilepsy in children","volume":"3","author":"Donner","year":"2006","journal-title":"NeuroRx"},{"key":"10.1016\/j.jaip.2018.02.018_bib26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/428486a","article-title":"Medical genetics: a marker for Stevens-Johnson syndrome","volume":"428","author":"Chung","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jaip.2018.02.018_bib27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1001\/jama.2014.7859","article-title":"Genetic variants associated with phenytoin-related severe cutaneous adverse reactions","volume":"312","author":"Chung","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2018.02.018_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/tpj.2013.40","article-title":"HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis","volume":"14","author":"Genin","year":"2014","journal-title":"Pharmacogenomics J"},{"key":"10.1016\/j.jaip.2018.02.018_bib29","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/clpt.2013.55","article-title":"HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children","volume":"94","author":"Amstutz","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jaip.2018.02.018_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1517\/14740330903427969","article-title":"Genetic predisposition of life-threatening antiepileptic-induced skin reactions","volume":"9","author":"Chung","year":"2010","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.jaip.2018.02.018_bib31","first-page":"299","article-title":"Anticonvulsant drug hypersensitivity","volume":"12","author":"Galindo","year":"2002","journal-title":"J\u00a0Investig Allergol Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321981830117X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321981830117X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:16:57Z","timestamp":1761974217000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221321981830117X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S221321981830117X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2018.02.018","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Frequency and Clinical Features of Hypersensitivity Reactions to Antiepileptic Drugs in Children: A Prospective Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2018.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}