{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:54:14Z","timestamp":1790834054191,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jaip.2018.04.005","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T20:51:53Z","timestamp":1523566313000},"page":"2051-2058.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Twenty Years' Experience with Anaphylaxis-Like Reactions to Local Anesthetics: Genuine Allergy\u00a0is\u00a0Rare"],"prefix":"10.1016","volume":"6","author":[{"given":"Axel","family":"Trautmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Goebeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Stoevesandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2018.04.005_bib1","unstructured":"Schatz M. Allergic reactions to local anesthetics. In: Post TW, editor. UpToDate. Waltham, MA: Up To Date Inc; 2017. Accessed September 8, 2017."},{"key":"10.1016\/j.jaip.2018.04.005_bib2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-0536.2008.01366.x","article-title":"Hypersensitivity to local anaesthetics\u2014update and proposal of evaluation algorithm","volume":"59","author":"Thyssen","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.jaip.2018.04.005_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF02686088","article-title":"A\u00a0critical review of local anesthetic sensitivity","volume":"32","author":"Boren","year":"2007","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S0301-0546(02)79081-2","article-title":"Allergy to local anaesthetics in dentistry. Myth or reality?","volume":"30","author":"Baluga","year":"2002","journal-title":"Allergol Immunopathol"},{"key":"10.1016\/j.jaip.2018.04.005_bib5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02991110","article-title":"Anaphylactic and anaphylactoid reactions due to anesthetic agents","volume":"4","author":"Schatz","year":"1986","journal-title":"Clin Rev Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0091-6749(79)90211-2","article-title":"An approach to the patient with a history of local anesthetic hypersensitivity: experience with 90 patients","volume":"63","author":"deShazo","year":"1979","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib7","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0091-6749(96)80067-4","article-title":"Adverse reactions to local anesthetics: analysis of 197 cases","volume":"97","author":"Gall","year":"1996","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib8","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0091-6749(97)70064-2","article-title":"Allergic reaction caused by local anesthetic agents belonging to the amide group","volume":"99","author":"Cuesta-Herranz","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib9","first-page":"1222","article-title":"Case reports: type I hypersensitivity to lidocaine","volume":"6","author":"Haugen","year":"2007","journal-title":"J\u00a0Drugs Dermatol"},{"key":"10.1016\/j.jaip.2018.04.005_bib10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2044.2012.07314.x","article-title":"Immediate allergic cross-reactivity to levobupivacaine and ropivacaine","volume":"68","author":"Calderon","year":"2013","journal-title":"Anaesthesia"},{"key":"10.1016\/j.jaip.2018.04.005_bib11","first-page":"38","article-title":"The needle in the haystack: allergic anaphylaxis caused by the local anesthetic articaine","volume":"46","author":"Wieshuber","year":"2014","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib12","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.jaci.2007.12.1154","article-title":"IgE-mediated reaction to mepivacaine","volume":"121","author":"Venemalm","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/aas.12833","article-title":"No cases of perioperative allergy to local anaesthetics in the Danish Anaesthesia Allergy Centre","volume":"61","author":"Kvisselgaard","year":"2017","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.jaip.2018.04.005_bib14","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/all.12142","article-title":"Skin test concentrations for systemically administered drugs\u2014an ENDA\/EAACI Drug Allergy Interest Group position paper","volume":"68","author":"Brockow","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib15","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/cea.12437","article-title":"Aminopenicillin-associated exanthem: lymphocyte transformation testing revisited","volume":"44","author":"Trautmann","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib16","doi-asserted-by":"crossref","first-page":"666","DOI":"10.2214\/AJR.07.2872","article-title":"Anaphylaxis to iodinated contrast material: nonallergic hypersensitivity or IgE-mediated allergy?","volume":"190","author":"Trcka","year":"2008","journal-title":"Am J Roentgenol"},{"key":"10.1016\/j.jaip.2018.04.005_bib17","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/all.12313","article-title":"The EAACI\/GA(2) LEN\/EDF\/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update","volume":"69","author":"Zuberbier","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40733-015-0009-z","article-title":"Vocal cord dysfunction: a review","volume":"1","author":"Dunn","year":"2015","journal-title":"Asthma Res Pract"},{"key":"10.1016\/j.jaip.2018.04.005_bib19","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/all.12260","article-title":"Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs","volume":"68","author":"Kowalski","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib20","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/all.12350","article-title":"International consensus on drug allergy","volume":"69","author":"Demoly","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1067\/mai.2002.120953","article-title":"Natural rubber latex allergy after 12 years: recommendations and perspectives","volume":"109","author":"Charous","year":"2002","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib22","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/all.12436","article-title":"Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis","volume":"69","author":"Valent","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib23","doi-asserted-by":"crossref","first-page":"578","DOI":"10.14219\/jada.archive.1985.0160","article-title":"Psychophysiological responses to dental injections","volume":"111","author":"Fiset","year":"1985","journal-title":"J\u00a0Am Dent Assoc"},{"key":"10.1016\/j.jaip.2018.04.005_bib24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jpsychires.2005.09.006","article-title":"Panic attack symptom dimensions and their relationship to illness characteristics in panic disorder","volume":"40","author":"Meuret","year":"2006","journal-title":"J\u00a0Psychiatr Res"},{"key":"10.1016\/j.jaip.2018.04.005_bib25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1001\/archpsyc.1994.03950050015002","article-title":"DSM-III-R generalized anxiety disorder in the National Comorbidity Survey","volume":"51","author":"Wittchen","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jaip.2018.04.005_bib26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1001\/archpsyc.1994.03950010008002","article-title":"Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey","volume":"51","author":"Kessler","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jaip.2018.04.005_bib27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/eurheartj\/ehi584","article-title":"Diagnostic criteria for vasovagal syncope based on a quantitative history","volume":"27","author":"Sheldon","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaip.2018.04.005_bib28","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/qjmed\/hcw089","article-title":"The management of vasovagal syncope","volume":"109","author":"Kenny","year":"2016","journal-title":"QJM"},{"key":"10.1016\/j.jaip.2018.04.005_bib29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/EJA.0000000000000137","article-title":"Local anaesthetics: 10 essentials","volume":"31","author":"Lirk","year":"2014","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.jaip.2018.04.005_bib30","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1001\/archinte.1983.00350110127026","article-title":"Local dental anesthesia with epinephrine. Minimal effects on the sympathetic nervous system or on hemodynamic variables","volume":"143","author":"Chernow","year":"1983","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jaip.2018.04.005_bib31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1834-7819.1998.tb00159.x","article-title":"Anaphylactic reaction following administration of lignocaine hydrochloride infiltration. Case report","volume":"43","author":"Ogunsalu","year":"1998","journal-title":"Aust Dent J"},{"key":"10.1016\/j.jaip.2018.04.005_bib32","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1034\/j.1398-9995.2003.00212.x","article-title":"Allergy to local anesthetics of the amide group with tolerance to procaine","volume":"58","author":"Morais-Almeida","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/0091-6749(84)90114-3","article-title":"Skin testing and incremental challenge in the evaluation of adverse reactions to local anesthetics","volume":"74","author":"Schatz","year":"1984","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib34","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1111\/all.12886","article-title":"In\u00a0vitro tests for drug hypersensitivity reactions: an ENDA\/EAACI Drug Allergy Interest Group position paper","volume":"71","author":"Mayorga","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1097\/ACI.0b013e328355b7cb","article-title":"Drug allergy in mast cell disease","volume":"12","author":"Brockow","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib36","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1046\/j.1365-2222.2003.01755.x","article-title":"Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy","volume":"33","author":"Haeberli","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2018.04.005_bib37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1710-1492-10-19","article-title":"Non-steroidal anti-inflammatory drug hypersensitivity: association with elevated basal serum tryptase?","volume":"10","author":"Seitz","year":"2014","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib38","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1515\/CCLM.2010.124","article-title":"Factors influencing serum total tryptase concentrations in a general adult population","volume":"48","author":"Gonzalez-Quintela","year":"2010","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jaip.2018.04.005_bib39","first-page":"172","article-title":"Management of patients at risk for adverse reactions to local anesthetics: analysis of 386 cases","volume":"8","author":"Troise","year":"1998","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib40","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0091-6749(87)90236-3","article-title":"Provocative challenge with local anesthetics in patients with a prior history of reaction","volume":"79","author":"Chandler","year":"1987","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.04.005_bib41","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s40629-015-0052-6","article-title":"Guideline for the diagnosis of drug hypersensitivity reactions: S2k-Guideline","volume":"24","author":"Brockow","year":"2015","journal-title":"Allergo J Int"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219818302757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219818302757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:15:29Z","timestamp":1761974129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219818302757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S2213219818302757"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2018.04.005","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Twenty Years' Experience with Anaphylaxis-Like Reactions to Local Anesthetics: Genuine Allergy\u00a0is\u00a0Rare","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2018.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}