{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T06:00:20Z","timestamp":1774418420777,"version":"3.50.1"},"reference-count":16,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.jaip.2018.06.022","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T10:55:55Z","timestamp":1534416955000},"page":"728-731.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sensitization to amoxicillin\/clavulanic acid may underlie severe rashes in children treated for infectious mononucleosis"],"prefix":"10.1016","volume":"7","author":[{"given":"Francesca","family":"Mori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Fili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Barni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Giovannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Capone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio M.","family":"Novembre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Parronchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2018.06.022_bib1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1001\/jama.2016.2111","article-title":"Does this patient have infectious mononucleosis? The rational clinical examination systematic review","volume":"315","author":"Ebell","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2018.06.022_bib2","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1542\/peds.40.5.910","article-title":"Skin rash with infectious mononucleosis and ampicillin","volume":"40","author":"Patel","year":"1967","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2018.06.022_bib3","doi-asserted-by":"crossref","first-page":"e1424","DOI":"10.1542\/peds.2012-1575","article-title":"Incidence of rash after amoxicillin treatment in children with infectious mononucleosis","volume":"131","author":"Chovel-Sella","year":"2013","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2018.06.022_bib4","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1093\/cid\/cit553","article-title":"Do penicillins really increase the frequency of a rash when given during Epstein-Barr virus primary infection?","volume":"57","author":"Hocqueloux","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2018.06.022_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/1060028016669525","article-title":"Antibiotic-induced rash in patients with infectious mononucleosis","volume":"51","author":"Thompson","year":"2017","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jaip.2018.06.022_bib6","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000481988","article-title":"Incidence of antibiotic-related rash in children with Epstein-Barr Virus infection and evaluation of the frequency of confirmed antibiotic hypersensitivity","volume":"176","author":"Dibek Misirlioglu","year":"2018","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2018.06.022_bib7","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1046\/j.1365-2133.2002.05021.x","article-title":"Amoxicillin-induced exanthema in young adults with infectious mononucleosis: demonstration of drug-specific lymphocyte reactivity","volume":"147","author":"Renn","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2018.06.022_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1710-1492-11-1","article-title":"Amoxicillin rash in patients with infectious mononucleosis: evidence of true drug sensitization","volume":"11","author":"\u00d3nodi-Nagy","year":"2015","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaip.2018.06.022_bib9","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1111\/j.1398-9995.2007.01518.x","article-title":"Amoxicillin-induced exanthema in patients with infectious mononucleosis: allergy or transient immunostimulation?","volume":"62","author":"Jappe","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.06.022_bib10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jmii.2014.06.012","article-title":"Drug reaction with eosinophilia and systemic symptoms during primary Epstein-Barr virus infection","volume":"48","author":"Nanishi","year":"2015","journal-title":"J\u00a0Microbiol Immunol Infect"},{"key":"10.1016\/j.jaip.2018.06.022_bib11","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/all.12774","article-title":"Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group","volume":"71","author":"Gomes","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.06.022_bib12","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3390\/ijms18061222","article-title":"The value of in\u00a0vitro tests to diminish drug challenges","volume":"18","author":"Mayorga","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaip.2018.06.022_bib13","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/all.12636","article-title":"Selective immediate responders to amoxicillin and clavulanic acid tolerate penicillin derivative administration after confirming the diagnosis","volume":"70","author":"Blanca-Lopez","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.06.022_bibE1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/bjd.12501","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study","volume":"169","author":"Kardaun","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2018.06.022_bibE2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/all.12774","article-title":"Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group","volume":"71","author":"Gomes","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.06.022_bibE3","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.4049\/jimmunol.163.2.1053","article-title":"Highly Th2-skewed cytokine profile of beta-lactam-specific T cells from nonatopic subjects with adverse drug reactions","volume":"163","author":"Brugnolo","year":"1999","journal-title":"J\u00a0Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219818304252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219818304252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:15:59Z","timestamp":1761974159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219818304252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S2213219818304252"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2018.06.022","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sensitization to amoxicillin\/clavulanic acid may underlie severe rashes in children treated for infectious mononucleosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2018.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}