{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:31:58Z","timestamp":1791941518137,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.jaip.2018.10.016","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T23:24:31Z","timestamp":1540423471000},"page":"1462-1468","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":153,"title":["The Severe Asthma Network in Italy: Findings and Perspectives"],"prefix":"10.1016","volume":"7","author":[{"given":"Enrico","family":"Heffler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Blasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Latorre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Menzella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Paggiaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girolamo","family":"Pelaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianenrico","family":"Senna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio Walter","family":"Canonica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Barbuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bradicich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianna","family":"Camiciottoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Caminati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselda","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Costantino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"Crimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangiola","family":"Crivellaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"D\u2019Adda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"D\u2019Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Favero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Foschino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Galeone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Guarnieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Parente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Passalacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Patella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Puggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erminia","family":"Ridolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Rolla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Savi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Scichilone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Solidoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Spadaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2018.10.016_bib1","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur Resp J"},{"key":"10.1016\/j.jaip.2018.10.016_bib2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1398-9995.2007.01523.x","article-title":"Therapy and Health Economics Working Group of the European Community Respiratory Health Survey II. The socio-economic burden of asthma is substantial in Europe","volume":"63","author":"Accordini","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.10.016_bib3","series-title":"WAO White Book on Allergy: Update 2013","first-page":"39","article-title":"Severe asthma","author":"Heaney","year":"2013"},{"key":"10.1016\/j.jaip.2018.10.016_bib4","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.rmed.2014.10.007","article-title":"Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR)","volume":"108","author":"Schleich","year":"2014","journal-title":"Resp Med"},{"key":"10.1016\/j.jaip.2018.10.016_bib5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3109\/02770903.2012.668255","article-title":"Omalizumab therapy in severe asthma: experience from the Spanish Registry\u2014some new approaches","volume":"49","author":"Vennera Mdel","year":"2012","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.jaip.2018.10.016_bib6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3109\/02770903.2012.757780","article-title":"Effects of omalizumab in non atopic asthma: results from a Spanish Multicentre Registry","volume":"50","author":"de Llano","year":"2013","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.jaip.2018.10.016_bib7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.pupt.2014.01.007","article-title":"Omalizumab management beyond clinical trials: the added value of a network model","volume":"29","author":"Caminati","year":"2014","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.jaip.2018.10.016_bib8","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1136\/thoraxjnl-2012-202093","article-title":"The at risk registers in severe asthma (ARRISA) study: a cluster-randomized controlled trial examining effectiveness and costs in primary care","volume":"67","author":"Smith","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2018.10.016_bib9","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1136\/thoraxjnl-2012-201869","article-title":"Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry","volume":"67","author":"Sweeney","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2018.10.016_bib10","doi-asserted-by":"crossref","first-page":"e102987","DOI":"10.1371\/journal.pone.0102987","article-title":"Statistical cluster analysis of the British Thoracic Society Severe Refractory Asthma Registry: clinical outcome and phenotype stability","volume":"9","author":"Newby","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jaip.2018.10.016_bib11","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/thoraxjnl-2013-204114","article-title":"The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry","volume":"70","author":"O'Neill","year":"2015","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2018.10.016_bib12","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/thoraxjnl-2015-207630","article-title":"Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry","volume":"71","author":"Sweeney","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2018.10.016_bib13","doi-asserted-by":"crossref","first-page":"1700019","DOI":"10.1183\/13993003.00019-2017","article-title":"on behalf of the COBRA study group. Clinical and biological characteristics of the French COBRA cohort of adult subjects with asthma","volume":"50","author":"Pretolani","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2018.10.016_bib14","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/all.13342","article-title":"RItA: the Italian severe\/uncontrolled asthma registry","volume":"73","author":"Maio","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2018.10.016_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12948-017-0065-4","article-title":"SANI\u2014Severe Asthma Network in Italy: a way forward to monitor severe asthma","volume":"15","author":"Senna","year":"2017","journal-title":"Clin Mol Allergy"},{"key":"10.1016\/j.jaip.2018.10.016_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/ACI.0b013e32835ad059","article-title":"Efficacy vs effectiveness trials: informing guidelines for asthma management","volume":"13","author":"Price","year":"2013","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.10.016_bib18","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/j.jaci.2017.07.014","article-title":"More than a decade follow-up in patients with severe or difficult-to-treat asthma: The Epidemiology and Natural History of Asthma: Outcomes and Treatment Regimens (TENOR) II","volume":"141","author":"Chipps","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"Suppl","key":"10.1016\/j.jaip.2018.10.016_bib19","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jaci.2011.06.048","article-title":"Asthma in the elderly: current understanding and future research needs\u2014a report of a National Institute on Aging (NIA) workshop","volume":"128","author":"Hanania","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2018.10.016_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/JAA.S125948","article-title":"Late-onset asthma: current perspectives","volume":"11","author":"Hirano","year":"2018","journal-title":"J\u00a0Asthma Allergy"},{"key":"10.1016\/j.jaip.2018.10.016_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fmed.2017.00135","article-title":"Anti-interleukin 5 (IL-5) and IL-5Ra biological drugs: efficacy, safety, and future perspectives in severe eosinophilic asthma","volume":"4","author":"Bagnasco","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jaip.2018.10.016_bib22","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.jaip.2017.04.024","article-title":"Biotherapeutics in chronic rhinosinusitis with and without nasal polyps","volume":"5","author":"Bachert","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2018.10.016_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.rmed.2017.01.008","article-title":"Longterm clinical outcomes of omalizumab therapy in severe allergic asthma: study of efficacy and safety","volume":"124","author":"Mansur","year":"2017","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2018.10.016_bib24","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1016\/S2213-2600(13)70199-1","article-title":"Integrating real-life studies in the global therapeutic research framework","volume":"1","author":"Roche","year":"2013","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2018.10.016_bib25","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jval.2017.08.3019","article-title":"Good practices for real-world data studies of treatment and\/or comparative effectiveness: recommendations from the Joint ISPOR-ISPE Special Task Force on real-world evidence in health care decision making","volume":"20","author":"Berger","year":"2017","journal-title":"Value Health"},{"key":"10.1016\/j.jaip.2018.10.016_bib26","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jclinepi.2017.05.004","article-title":"Series: pragmatic trials and real world evidence: paper 7. Safety, quality and monitoring","volume":"91","author":"Irving","year":"2017","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jaip.2018.10.016_bib27","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.jval.2017.03.008","article-title":"on behalf of GetReal Work Package 1. What is real-world data? A review of definitions based on literature and stakeholder interviews","volume":"20","author":"Makady","year":"2017","journal-title":"Value Health"},{"key":"10.1016\/j.jaip.2018.10.016_bib28","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1159\/000375314","article-title":"Are asthmatics enrolled in randomized trials representative of real-life outpatients?","volume":"89","author":"Battaglia","year":"2015","journal-title":"Respiration"},{"key":"10.1016\/j.jaip.2018.10.016_bib29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/thoraxjnl-2017-211148","article-title":"Big asthma data: getting bigger and more beautiful?","volume":"73","author":"Diver","year":"2018","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2018.10.016_bib30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1136\/thoraxjnl-2017-210650","article-title":"Exacerbation risk and characterisation of the UK\u2019s asthma population from infants to old age","volume":"73","author":"Bloom","year":"2018","journal-title":"Thorax"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219818306731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219818306731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:19:11Z","timestamp":1761974351000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219818306731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S2213219818306731"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2018.10.016","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Severe Asthma Network in Italy: Findings and Perspectives","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2018.10.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}