{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:15:36Z","timestamp":1790709336107,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jaip.2019.02.007","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T12:01:27Z","timestamp":1550232087000},"page":"1912-1919","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Adverse Events in Oral Immunotherapy for the Desensitization of Cow's Milk Allergy in Children: A Randomized Controlled Trial"],"prefix":"10.1016","volume":"7","author":[{"given":"Sarah","family":"De Schryver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Mazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann E.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvan","family":"St. Pierre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Lejtenyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Langlois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar","family":"Torabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei W.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond S.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Baerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Ben-Shoshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2019.02.007_bib1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/all.12423","article-title":"Prevalence of common food allergies in Europe: a systematic review and meta-analysis","volume":"8","author":"Nwaru","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jaip.2014.11.006","article-title":"Adjusting for nonresponse bias corrects overestimates of food allergy prevalence","volume":"3","author":"Soller","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.02.007_bib3","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2017.11.003","article-title":"A\u00a0review and update on epidemiology, pathogenesis, diagnosis, prevention and management","volume":"141","author":"Sicherer","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib4","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jaci.2007.08.023","article-title":"The natural history of IgE mediated cow\u2019s milk allergy","volume":"120","author":"Skripak","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib5","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1399-3038.2010.01040.x","article-title":"Predictive factors for the persistence of cow\u2019s milk allergy","volume":"21","author":"Santos","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jaip.2014.10.001","article-title":"Baked milk- and egg-containing diet in the management of milk and egg allergy","volume":"3","author":"Leonard","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.02.007_bib7","first-page":"CD009542","article-title":"Oral immunotherapy for milk allergy","volume":"11","author":"Yeung","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jaip.2019.02.007_bib8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/all.13319","article-title":"EAACI Guidelines on allergen immunotherapy: IgE mediated food allergy","volume":"73","author":"Pajno","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib9","first-page":"298","article-title":"Safety and efficacy profile and immunological changes associated with oral immunotherapy for IgE-mediated cow\u2019s milk allergy in children: systematic review and meta-analysis","volume":"24","author":"Martorell Calatayud","year":"2014","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1157\/13110311","article-title":"Oral rush desensitization to cow milk. Following of desensitized patients during three years","volume":"35","author":"Martorell Aragones","year":"2007","journal-title":"Allergol Immunopathol"},{"key":"10.1016\/j.jaip.2019.02.007_bib11","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jaci.2005.12.1303","article-title":"Second symposium on the definition and management of anaphylaxis: summary report\u2014second National Institute of Allergy and Infectious Disease\/Food Allergy and Anaphylaxis Network symposium","volume":"117","author":"Sampson","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib12","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1398-9995.2007.01421.x","article-title":"Management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology","volume":"62","author":"Muraro","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib13","doi-asserted-by":"crossref","first-page":"e20163438","DOI":"10.1542\/peds.2016-3438","article-title":"Section on Allergy and Immunology; Section on Pediatric Pulmonology and Sleep Medicine. Clinical tools to assess asthma control in children","volume":"139","author":"Dinakar","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2019.02.007_bib14","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1542\/peds.2014-3678","article-title":"Translating atopic dermatitis management guidelines into practice for primary care providers","volume":"136","author":"Eichenfield","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2019.02.007_bib15","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1365-2222.1997.tb01190.x","article-title":"Clinical characteristics of peanut allergy","volume":"27","author":"Hourihane","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib16","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S1081-1206(10)60056-7","article-title":"Availability of the epinephrine autoinjector at school in children with peanut allergy","volume":"100","author":"Ben-Shoshan","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2222.2011.03948.x","article-title":"Oral immunotherapy for IgE-mediated cow\u2019s milk allergy: a systematic review and meta-analysis","volume":"42","author":"Brozek","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib18","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/all.13124","article-title":"Allergen immunotherapy for IgE mediated food allergy: a systematic review and meta-analysis","volume":"72","author":"Nurmatov","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1177\/0394632017697986","article-title":"Side effects and their impact on the success of milk oral immunotherapy (OIT) in children","volume":"30","author":"Mori","year":"2017","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.jaip.2019.02.007_bib20","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/cea.12012","article-title":"Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test","volume":"43","author":"Vazquez-Ortiz","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib21","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaci.2014.11.034","article-title":"Administration of a probiotic with peanut oral immunotherapy: a randomized trial","volume":"135","author":"Tang","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib22","first-page":"97","article-title":"Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomized, double-blind placebo-controlled trial","volume":"1","author":"Hsiao","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2019.02.007_bib23","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1111\/all.12262","article-title":"A\u00a0majority of parents of children with peanut allergy fear using the epinephrine auto-injector","volume":"68","author":"Chad","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.anai.2017.06.001","article-title":"Factors associated with epinephrine administration for anaphylaxis in children before arrival to the emergency department","volume":"119","author":"Robinson","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib25","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jpeds.2016.09.028","article-title":"The risk of recurrent anaphylaxis","volume":"180","author":"O\u2019Keefe","year":"2017","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jaip.2019.02.007_bib26","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.anai.2010.03.015","article-title":"Oral immunotherapy for cow\u2019s milk allergy with a weekly up-dosing regimen: a randomized single-blinded controlled study","volume":"105","author":"Pajno","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib27","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/j.1398-9995.2010.02348.x","article-title":"Life-threatening asthma reaction caused by desensitization to milk","volume":"65","author":"Nieto","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/pai.12854","article-title":"Cow\u2019s milk allergic children\u2014can component-resolved diagnostics predict duration and severity?","volume":"29","author":"Petersen","year":"2018","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/2045-7022-4-25","article-title":"The impact of structural integrity and route of administration on the antibody specificity against three cow\u2019s milk allergens\u2014a study in Brown Norway rats","volume":"4","author":"Madsen","year":"2014","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1081-1206(10)62123-0","article-title":"Natural course of cow\u2019s milk allergy in childhood atopic eczema","volume":"89","author":"Oranje","year":"2002","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib30","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jaci.2016.07.030","article-title":"Novel baseline predictors of allergic side effects during peanut oral immunotherapy","volume":"138","author":"Virkud","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib32","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/j.1398-9995.2012.02877.x.","article-title":"Co-factor-enhanced food allergy","volume":"67","author":"Cardona","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2019.02.007_bib33","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jaci.2015.10.005","article-title":"A\u00a0randomized, double-blind placebo-controlled study of omalizumab combined with oral immunotherapy for the treatment of cow\u2019s milk allergy","volume":"137","author":"Wood","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.02.007_bib34","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.jaci.2011.04.009","article-title":"Rapid oral desensitization in combination with omalizumab therapy in patients with cow\u2019s milk allergy","volume":"127","author":"Nadeau","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819301710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819301710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:18:13Z","timestamp":1761974293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219819301710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S2213219819301710"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2019.02.007","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adverse Events in Oral Immunotherapy for the Desensitization of Cow's Milk Allergy in Children: A Randomized Controlled Trial","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2019.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}