{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:40:13Z","timestamp":1778661613627,"version":"3.51.4"},"reference-count":15,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.jaip.2019.02.015","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T05:14:13Z","timestamp":1562130853000},"page":"2091-2092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Mastocytosis, Quinolones, MRGPRX2, and Anaphylaxis"],"prefix":"10.1016","volume":"7","author":[{"given":"Catherine R.","family":"Weiler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2019.02.015_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.iac.2016.08.017","article-title":"Mastocytosis and anaphylaxis","volume":"37","author":"Schuch","year":"2017","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2019.02.015_bib2","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1016\/j.jaip.2019.01.059","article-title":"Anaphylaxis to quinolones in mastocytosis: hypothesis on the mechanism","volume":"7","author":"Giavina-Bianchi","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.02.015_bib3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11882-017-0725-y","article-title":"Update on quinolone allergy","volume":"17","author":"Dona","year":"2017","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2019.02.015_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.jaip.2019.02.015_bib5","doi-asserted-by":"crossref","first-page":"eaav0216","DOI":"10.1126\/sciadv.aav0216","article-title":"MRGPR-mediated activation of local mast cells clears cutaneous bacterial infection and protects against reinfection","volume":"5","author":"Arifuzzaman","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.jaip.2019.02.015_bib6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jaci.2018.01.034","article-title":"Mast cells signal their importance in health and disease","volume":"142","author":"Olivera","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.02.015_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000453265","article-title":"Classification of drug hypersensitivity into allergic, p-i, and pseudo-allergic forms","volume":"171","author":"Pichler","year":"2016","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2019.02.015_bib8","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/all.13301","article-title":"Allergic FcepsilonRI- and pseudo-allergic MRGPRX2-triggered mast cell activation routes are independent and inversely regulated by SCF","volume":"73","author":"Babina","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2019.02.015_bib9","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1124\/pr.113.008425","article-title":"Pharmacology and signaling of MAS-related G protein-coupled receptors","volume":"66","author":"Solinski","year":"2014","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jaip.2019.02.015_bib10","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.3389\/fimmu.2018.03027","article-title":"Mas-related G protein-coupled receptor-X2 (MRGPRX2) in drug hypersensitivity reactions","volume":"9","author":"Porebski","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2019.02.015_bib11","doi-asserted-by":"crossref","first-page":"E1223","DOI":"10.3390\/ijms18061223","article-title":"Reclassifying anaphylaxis to neuromuscular blocking agents based on the presumed patho-mechanism: IgE-mediated, pharmacological adverse reaction or \u201cinnate hypersensitivity\u201d?","volume":"18","author":"Spoerl","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaip.2019.02.015_bib12","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1002\/eji.201746951","article-title":"Typical antimicrobials induce mast cell degranulation and anaphylactoid reactions via MRGPRX2 and its murine homologue MRGPRB2","volume":"47","author":"Zhang","year":"2017","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaip.2019.02.015_bib13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.anai.2017.07.022","article-title":"Management around invasive procedures in mastocytosis: an update","volume":"119","author":"Hermans","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2019.02.015_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4049\/jimmunol.1701793","article-title":"Naturally occurring missense MRGPRX2 variants display loss of function phenotype for mast cell degranulation in response to substance P, hemokinin-1, human beta-defensin-3, and icatibant","volume":"201","author":"Alkanfari","year":"2018","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2019.02.015_bib15","series-title":"Middleton's Allergy: Principles and Practice. Volume 2","first-page":"1280","article-title":"Drug allergy","author":"Celik","year":"2014"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819301813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819301813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:21:38Z","timestamp":1761974498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219819301813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S2213219819301813"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2019.02.015","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mastocytosis, Quinolones, MRGPRX2, and Anaphylaxis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2019.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2019.01.059","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}