{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:38:25Z","timestamp":1780497505883,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jaip.2019.07.004","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T12:19:19Z","timestamp":1563193159000},"page":"292-301.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Skewed Lymphocyte Subpopulations and Associated Phenotypes in Patients with Mastocytosis"],"prefix":"10.1016","volume":"8","author":[{"given":"Joseph M.","family":"Kulinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Eisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakuntala","family":"Rampertaap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Stoddard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Monsale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Romito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio D.","family":"Rosenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean D.","family":"Metcalfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirsh D.","family":"Komarow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2019.07.004_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.iac.2013.09.001","article-title":"Mastocytosis","volume":"34","author":"Carter","year":"2014","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2019.07.004_bib2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev-pathol-052016-100312","article-title":"Pathogenesis and pathology of mastocytosis","volume":"12","author":"Metcalfe","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jaip.2019.07.004_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejphar.2015.03.087","article-title":"Integrating innate and adaptive immune cells: mast cells as crossroads between regulatory and effector B and T cells","volume":"778","author":"Mekori","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jaip.2019.07.004_bib4","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4161\/self.1.2.11795","article-title":"Cognate interactions between mast cells and helper T lymphocytes","volume":"1","author":"Valitutti","year":"2010","journal-title":"Self Nonself"},{"key":"10.1016\/j.jaip.2019.07.004_bib5","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fimmu.2012.00120","article-title":"Mast cell: an emerging partner in immune interaction","volume":"3","author":"Gri","year":"2012","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2019.07.004_bib6","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1182\/blood-2016-09-731893","article-title":"Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts","volume":"129","author":"Valent","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2019.07.004_bib7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.imbio.2014.02.010","article-title":"Reference ranges of lymphocyte subsets in healthy adults and adolescents with special mention of T cell maturation subsets in adults of South Florida","volume":"219","author":"Valiathan","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.jaip.2019.07.004_bib8","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1056\/NEJMoa1512234","article-title":"Loss of B cells in patients with heterozygous mutations in IKAROS","volume":"374","author":"Kuehn","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2019.07.004_bib9","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jmoldx.2010.10.004","article-title":"Improved detection of the KIT D816V mutation in patients with systemic mastocytosis using a quantitative and highly sensitive real-time qPCR assay","volume":"13","author":"Kristensen","year":"2011","journal-title":"J\u00a0Mol Diagn"},{"key":"10.1016\/j.jaip.2019.07.004_bib10","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/ng.3696","article-title":"Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number","volume":"48","author":"Lyons","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaip.2019.07.004_bib11","doi-asserted-by":"crossref","first-page":"7708","DOI":"10.1038\/s41598-018-26064-6","article-title":"Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases","volume":"8","author":"Mao","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.jaip.2019.07.004_bib12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00223-012-9647-9","article-title":"Long-term effects of amino-bisphosphonates on circulating gammadelta T cells","volume":"91","author":"Rossini","year":"2012","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jaip.2019.07.004_bib13","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.annemergmed.2006.01.018","article-title":"Second symposium on the definition and management of anaphylaxis: summary report\u2014second National Institute of Allergy and Infectious Disease\/Food Allergy and Anaphylaxis Network symposium","volume":"47","author":"Sampson","year":"2006","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.jaip.2019.07.004_bib14","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1172\/JCI116761","article-title":"Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product","volume":"92","author":"Furitsu","year":"1993","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2019.07.004_bib15","doi-asserted-by":"crossref","first-page":"10560","DOI":"10.1073\/pnas.92.23.10560","article-title":"Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder","volume":"92","author":"Nagata","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaip.2019.07.004_bib16","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1038\/modpathol.2015.72","article-title":"Detection of the KIT D816V mutation in peripheral blood of systemic mastocytosis: diagnostic implications","volume":"28","author":"Jara-Acevedo","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jaip.2019.07.004_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000048184","article-title":"Surrogate markers of disease in mastocytosis","volume":"127","author":"Akin","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2019.07.004_bib18","doi-asserted-by":"crossref","first-page":"e76116","DOI":"10.1371\/journal.pone.0076116","article-title":"Serum tryptase monitoring in indolent systemic mastocytosis: association with disease features and patient outcome","volume":"8","author":"Matito","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2019.07.004_bib19","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.iac.2018.04.003","article-title":"Hereditary alpha tryptasemia: genotyping and associated clinical features","volume":"38","author":"Lyons","year":"2018","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2019.07.004_bib20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1615\/CritRevImmunol.v31.i6.30","article-title":"Regulation of mast cell responses in health and disease","volume":"31","author":"Gilfillan","year":"2011","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.jaip.2019.07.004_bib21","first-page":"620","article-title":"Mast cell: a multi-functional master cell","volume":"6","author":"Krystel-Whittemore","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2019.07.004_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.molimm.2014.02.016","article-title":"Mast cells, basophils and B cell connection network","volume":"63","author":"Merluzzi","year":"2015","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaip.2019.07.004_bib23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/imr.12725","article-title":"Emerging insights into human health and NK cell biology from the study of NK cell deficiencies","volume":"287","author":"Mace","year":"2019","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaip.2019.07.004_bib24","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1182\/blood-2010-03-275438","article-title":"Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates","volume":"116","author":"Lugli","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2019.07.004_bib25","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jaip.2019.07.004_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3389\/fimmu.2018.00095","article-title":"Senescent T-cells promote bone loss in rheumatoid arthritis","volume":"9","author":"Fessler","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2019.07.004_bib27","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/jcb.25726","article-title":"IL-15 and RANKL play a synergistically important role in osteoclastogenesis","volume":"118","author":"Okabe","year":"2017","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.jaip.2019.07.004_bib28","doi-asserted-by":"crossref","first-page":"ii32","DOI":"10.1136\/ard.61.suppl_2.ii32","article-title":"Role of RANKL and RANK in bone loss and arthritis","volume":"61","author":"Jones","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaip.2019.07.004_bib29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.iac.2014.01.011","article-title":"Bone involvement and osteoporosis in mastocytosis","volume":"34","author":"Rossini","year":"2014","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2019.07.004_bib30","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/nm1615","article-title":"IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities","volume":"13","author":"Orinska","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jaip.2019.07.004_bib31","doi-asserted-by":"crossref","first-page":"6550","DOI":"10.4049\/jimmunol.1102022","article-title":"Expansion of functionally anergic CD21-\/low marginal zone-like B cell clones in hepatitis C virus infection-related autoimmunity","volume":"187","author":"Terrier","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2019.07.004_bib32","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1182\/blood-2009-09-243071","article-title":"Complement receptor 2\/CD21- human naive B cells contain mostly autoreactive unresponsive clones","volume":"115","author":"Isnardi","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2019.07.004_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.clim.2004.05.010","article-title":"A\u00a0new CD21low B cell population in the peripheral blood of patients with SLE","volume":"113","author":"Wehr","year":"2004","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaip.2019.07.004_bib34","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/art.37828","article-title":"Expansion of autoreactive unresponsive CD21-\/low B cells in Sjogren\u2019s syndrome-associated lymphoproliferation","volume":"65","author":"Saadoun","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaip.2019.07.004_bib35","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/cei.12795","article-title":"CD21(-\/low) B cells in human blood are memory cells","volume":"185","author":"Thorarinsdottir","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaip.2019.07.004_bib36","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1007\/s10067-016-3368-9","article-title":"Association between rheumatoid arthritis and systemic mastocytosis: a case report and literature review","volume":"35","author":"Latar","year":"2016","journal-title":"Clin Rheumatol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819306208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819306208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:19:33Z","timestamp":1761974373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219819306208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S2213219819306208"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2019.07.004","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skewed Lymphocyte Subpopulations and Associated Phenotypes in Patients with Mastocytosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2019.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}