{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:01:11Z","timestamp":1782205271541,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.jaip.2019.08.012","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T11:15:07Z","timestamp":1566040507000},"page":"283-291.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies"],"prefix":"10.1016","volume":"8","author":[{"given":"Paul J.","family":"Maglione","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaibin M.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minami","family":"Tokuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Gyimesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilia","family":"Soof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Radigan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Berenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cunningham-Rundles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2019.08.012_bib1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jaip.2016.09.004","article-title":"Primary immune deficiencies in the adult: a previously underrecognized common condition","volume":"4","author":"Rosenberg","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.08.012_bib2","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jaip.2016.09.011","article-title":"The nuts and bolts of immunoglobulin treatment for antibody deficiency","volume":"4","author":"Wasserman","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.08.012_bib3","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.jaip.2016.08.005","article-title":"Lung disease in primary antibody deficiencies","volume":"4","author":"Schussler","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.08.012_bib4","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jaip.2018.12.004","article-title":"Differentiation of common variable immunodeficiency from IgG deficiency","volume":"7","author":"Filion","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.08.012_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fimmu.2019.00033","article-title":"The expanding field of secondary antibody deficiency: causes, diagnosis, and management","volume":"10","author":"Patel","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/cei.12915","article-title":"When to initiate immunoglobulin replacement therapy (IGRT) in antibody deficiency: a practical approach","volume":"188","author":"Jolles","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1001\/jama.281.3.243","article-title":"Safety of revaccination with pneumococcal polysaccharide vaccine","volume":"281","author":"Jackson","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2019.08.012_bib8","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/rheumatology\/key394","article-title":"Recommendations for the management of secondary hypogammaglobulinaemia due to B cell targeted therapies in autoimmune rheumatic diseases","volume":"58","author":"Wijetilleka","year":"2019","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jaip.2019.08.012_bib9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10875-017-0404-8","article-title":"Health-related quality of life in adult patients with common variable immunodeficiency disorders and impact of treatment","volume":"37","author":"Rider","year":"2017","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib10","doi-asserted-by":"crossref","first-page":"5498","DOI":"10.4049\/jimmunol.175.8.5498","article-title":"Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients","volume":"175","author":"Taubenheim","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1182\/blood-2010-11-321695","article-title":"T\u00a0and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency","volume":"118","author":"Ochtrop","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2019.08.012_bib12","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.jaip.2016.03.023","article-title":"Eosinophilic esophagitis diagnosed in a patient with common variable immunodeficiency","volume":"4","author":"Chen","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.08.012_bib13","first-page":"171","article-title":"Role of Bruton\u2019s tyrosine kinase in B cell development","volume":"8","author":"Maas","year":"2001","journal-title":"Dev Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.cytogfr.2013.04.003","article-title":"The BAFF\/APRIL system: emerging functions beyond B cell biology and autoimmunity","volume":"24","author":"Vincent","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jaip.2019.08.012_bib15","doi-asserted-by":"crossref","first-page":"7333","DOI":"10.1038\/ncomms8333","article-title":"\u03b3-Secretase directly sheds the survival receptor BCMA from plasma cells","volume":"6","author":"Laurent","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaip.2019.08.012_bib16","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1365-2141.2012.09241.x","article-title":"Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival","volume":"158","author":"Sanchez","year":"2012","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaip.2019.08.012_bib17","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.jaci.2012.03.025","article-title":"Common variable immunodeficiency","volume":"129","author":"Cunningham-Rundles","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib18","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.jaip.2019.02.004","article-title":"The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity","volume":"7","author":"Seidel","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.08.012_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1365-2249.2007.03545.x","article-title":"Serum levels of immunoglobulins (IgG, IgA, IgM) in a general adult population and their relationship with alcohol consumption, smoking and common metabolic abnormalities","volume":"151","author":"Gonzalez-Quintela","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000135694","article-title":"Progression of selective IgA deficiency to common variable immunodeficiency","volume":"147","author":"Aghamohammadi","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib21","first-page":"614","article-title":"Biostatistics 104: correlational analysis","volume":"44","author":"Chan","year":"2003","journal-title":"Singapore Med J"},{"key":"10.1016\/j.jaip.2019.08.012_bib22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tjem.2018.08.001","article-title":"User\u2019s guide to correlation coefficients","volume":"18","author":"Akoglu","year":"2018","journal-title":"Turk J Emerg Med"},{"key":"10.1016\/j.jaip.2019.08.012_bib23","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1038\/ajg.2016.329","article-title":"A\u00a0cross-sectional study of the prevalence of gastrointestinal symptoms and pathology in patients with common variable immunodeficiency","volume":"111","author":"Jorgensen","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jaip.2019.08.012_bib24","doi-asserted-by":"crossref","first-page":"122728","DOI":"10.1172\/jci.insight.122728","article-title":"BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency","volume":"4","author":"Maglione","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaip.2019.08.012_bib25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11882-016-0597-6","article-title":"Autoimmune and lymphoproliferative complications of common variable immunodeficiency","volume":"16","author":"Maglione","year":"2016","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2019.08.012_bib26","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3109\/08916934.2014.976627","article-title":"Inhibition of B lymphocyte-induced maturation protein-1 reduces the production of autoantibody and alleviates symptoms of systemic lupus erythematosus","volume":"48","author":"Luo","year":"2015","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaip.2019.08.012_bib27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3109\/08916934.2010.509122","article-title":"Increased BCMA expression in lupus marks activated B cells, and BCMA receptor engagement enhances the response to TLR9 stimulation","volume":"44","author":"Kim","year":"2011","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaip.2019.08.012_bib28","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.4049\/jimmunol.1001931","article-title":"B\u00a0cell maturation antigen deficiency exacerbates lymphoproliferation and autoimmunity in murine lupus","volume":"186","author":"Jiang","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood-2007-11-124545","article-title":"Common variable immunodeficiency disorders: division into distinct clinical phenotypes","volume":"112","author":"Chapel","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2019.08.012_bib31","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.coi.2015.03.005","article-title":"BAFF receptors and ligands create independent homeostatic niches for B cell subsets","volume":"34","author":"Naradikian","year":"2015","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib32","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1182\/blood-2014-05-575845","article-title":"Differential induction of plasma cells by isoforms of human TACI","volume":"125","author":"Garcia-Carmona","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2019.08.012_bib33","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1615\/CritRevImmunol.v32.i4.10","article-title":"Regulatory roles of the tumor necrosis factor receptor BCMA","volume":"32","author":"Coquery","year":"2012","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1084\/jem.20031330","article-title":"BCMA is essential for the survival of long-lived bone marrow plasma cells","volume":"199","author":"O\u2019Connor","year":"2004","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaip.2019.08.012_bib35","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3324\/haematol.2015.137273","article-title":"A\u00a0distinct plasmablast and naive B-cell phenotype in primary immune thrombocytopenia","volume":"101","author":"Flint","year":"2016","journal-title":"Haematologica"},{"key":"10.1016\/j.jaip.2019.08.012_bib36","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.4049\/jimmunol.1601746","article-title":"Human plasmacytoid dendritic cells display and shed B cell maturation antigen upon TLR engagement","volume":"198","author":"Schuh","year":"2017","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.it.2018.07.002","article-title":"Shedding of BAFF\/APRIL receptors controls B cells","volume":"39","author":"Meinl","year":"2018","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaip.2019.08.012_bib38","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.clinbiochem.2008.10.024","article-title":"Correlation of expression levels of BLyS and its receptors with multiple myeloma","volume":"42","author":"Ju","year":"2009","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jaip.2019.08.012_bib39","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1182\/blood-2013-10-535088","article-title":"Novel anti-B-cell maturation antigen antibody-drug conjugate (GSK2857916) selectively induces killing of multiple myeloma","volume":"123","author":"Tai","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2019.08.012_bib40","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1172\/JCI126397","article-title":"B\u00a0cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma","volume":"129","author":"Cohen","year":"2019","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2019.08.012_bib41","series-title":"The role of serum BCMA in monitoring, predicting outcomes and immune deficiency of multiple myeloma","author":"Berenson","year":"2017"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819307184?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819307184?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:20:09Z","timestamp":1761974409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219819307184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S2213219819307184"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2019.08.012","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2019.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}