{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:21:45Z","timestamp":1769221305605,"version":"3.49.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012128","name":"Austin Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Centre for Infections in Cancer"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1P50GM115305-01"],"award-info":[{"award-number":["1P50GM115305-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI139021"],"award-info":[{"award-number":["R21AI139021"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R34AI136815"],"award-info":[{"award-number":["R34AI136815"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HG01086301"],"award-info":[{"award-number":["R01HG01086301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jaip.2019.10.005","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T09:38:39Z","timestamp":1572773919000},"page":"1142-1146.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Safety of cephalosporins in penicillin class severe delayed hypersensitivity reactions"],"prefix":"10.1016","volume":"8","author":[{"given":"Jason A.","family":"Trubiano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra Y.L.","family":"Chua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha E.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby P.","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Effie","family":"Mouhtouris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Goh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth J.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2019.10.005_bib1","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1016\/j.jaip.2019.05.038","article-title":"Cross-reactivity to cephalosporins and carbapenems in penicillin-allergic patients: two systematic reviews and meta-analyses","volume":"7","author":"Picard","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.10.005_bib2","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/bjd.12501","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study","volume":"169","author":"Kardaun","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2019.10.005_bib3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1034\/j.1600-0560.2001.028003113.x","article-title":"Acute generalized exanthematous pustulosis (AGEP)\u2013a clinical reaction pattern","volume":"28","author":"Sidoroff","year":"2001","journal-title":"J\u00a0Cutan Pathol"},{"key":"10.1016\/j.jaip.2019.10.005_bib4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/cid\/cix244","article-title":"Impact of an integrated antibiotic allergy testing program on antimicrobial stewardship: a multicenter evaluation","volume":"65","author":"Trubiano","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2019.10.005_bib5","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.jaip.2018.09.014","article-title":"The safety of antibiotic skin testing in severe T-cell-mediated hypersensitivity of immunocompetent and immunocompromised hosts","volume":"7","author":"Trubiano","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.10.005_bib6","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1097\/QAD.0000000000000345","article-title":"HLA class I restricted CD8+ and class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity","volume":"28","author":"Keane","year":"2014","journal-title":"AIDS"},{"key":"10.1016\/j.jaip.2019.10.005_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jaci.2016.01.025","article-title":"Cross-reactivity and tolerability of aztreonam and cephalosporins in subjects with a T cell-mediated hypersensitivity to penicillins","volume":"138","author":"Romano","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2019.10.005_bib8","first-page":"331","article-title":"Cross-reactivity and tolerability of cephalosporins in patients with cell-mediated allergy to penicillins","volume":"24","author":"Buonomo","year":"2014","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2019.10.005_bib9","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.jaip.2018.01.011","article-title":"DRESS syndrome due to benzylpenicillin with cross-reactivity to amoxicillin","volume":"6","author":"Watts","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2019.10.005_bib10","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.1016\/j.jaad.2014.07.013","article-title":"Toxic epidermal necrolysis in the absence of circulating T cells: a possible role for resident memory T cells","volume":"71","author":"Iriki","year":"2014","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jaip.2019.10.005_bibE1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/icb.2011.34","article-title":"High-avidity, high-IFNgamma-producing CD8 T-cell responses following immune selection during HIV-1 infection","volume":"90","author":"Keane","year":"2012","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.jaip.2019.10.005_bibE2","series-title":"The Sanford Guide to Antimicrobial Therapy","year":"2019"},{"key":"10.1016\/j.jaip.2019.10.005_bibE3","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1097\/QAD.0000000000000345","article-title":"HLA class I restricted CD8+ and class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity","volume":"28","author":"Keane","year":"2014","journal-title":"AIDS"},{"key":"10.1016\/j.jaip.2019.10.005_bibE4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/cid\/cix244","article-title":"Impact of an integrated antibiotic allergy testing program on antimicrobial stewardship: a multicenter evaluation","volume":"65","author":"Trubiano","year":"2017","journal-title":"Clin Infect Dis"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819308943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219819308943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:19:54Z","timestamp":1761974394000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219819308943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S2213219819308943"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2019.10.005","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety of cephalosporins in penicillin class severe delayed hypersensitivity reactions","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2019.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}