{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:42:18Z","timestamp":1761986538771,"version":"build-2065373602"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jaip.2020.01.049","type":"journal-article","created":{"date-parts":[[2020,2,4]],"date-time":"2020-02-04T19:25:49Z","timestamp":1580844349000},"page":"1550-1555","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Persistence of Sinonasal Disease Despite Mepolizumab"],"prefix":"10.1016","volume":"8","author":[{"given":"Nicholas R.","family":"Rowan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Naclerio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2020.01.049_bib1","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1398-9995.2011.02646.x","article-title":"Chronic rhinosinusitis in Europe\u2014an underestimated disease. A GA2LEN study","volume":"66","author":"Hastan","year":"2011","journal-title":"Allergy"},{"issue":"260","key":"10.1016\/j.jaip.2020.01.049_bib2","first-page":"1","article-title":"Summary health statistics for U.S. adults: national health interview survey, 2012","volume":"10","author":"Blackwell","year":"2014","journal-title":"Vital Health Stat"},{"key":"10.1016\/j.jaip.2020.01.049_bib3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4193\/Rhino15.157","article-title":"Prevalence and risk factors of chronic rhinosinusitis in South Korea according to diagnostic criteria","volume":"54","author":"Kim","year":"2016","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2020.01.049_bib4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/all.12577","article-title":"Epidemiology of chronic rhinosinusitis: results from a cross-sectional survey in seven Chinese cities","volume":"70","author":"Shi","year":"2015","journal-title":"Allergy"},{"issue":"Suppl","key":"10.1016\/j.jaip.2020.01.049_bib5","first-page":"S1","article-title":"Clinical practice guideline (update): adult sinusitis","volume":"152","author":"Rosenfeld","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaip.2020.01.049_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino12.000","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists","volume":"50","author":"Fokkens","year":"2012","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2020.01.049_bib7","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1001\/jamaoto.2015.3810","article-title":"Depression-specific outcomes after treatment of chronic rhinosinusitis","volume":"142","author":"Schlosser","year":"2016","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaip.2020.01.049_bib8","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/alr.22406","article-title":"Effects of endoscopic sinus surgery on objective and subjective measures of cognitive dysfunction in chronic rhinosinusitis","volume":"9","author":"Yoo","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2020.01.049_bib9","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/alr.22323","article-title":"The impact of medical therapy on cognitive dysfunction in chronic rhinosinusitis","volume":"9","author":"Rowan","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2020.01.049_bib10","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/lary.21847","article-title":"Health state utility values in patients undergoing endoscopic sinus surgery","volume":"121","author":"Soler","year":"2011","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaip.2020.01.049_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/lary.24715","article-title":"The EQ-5D: a new tool for studying clinical outcomes in chronic rhinosinusitis","volume":"125","author":"Remenschneider","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaip.2020.01.049_bib12","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11882-017-0690-5","article-title":"Economics of chronic rhinosinusitis","volume":"17","author":"Rudmik","year":"2017","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2020.01.049_bib13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1056\/NEJMcibr1514013","article-title":"Aspirin-exacerbated respiratory disease\u2014new prime suspects","volume":"374","author":"Laidlaw","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2020.01.049_bib14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/all.13599","article-title":"Diagnosis and management of NSAID-exacerbated respiratory disease (N-ERD)\u2014a EAACI position paper","volume":"74","author":"Kowalski","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.01.049_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0091-6749(77)90171-3","article-title":"Nasal polyps in asthma and rhinitis. A review of 6,037 patients","volume":"59","author":"Settipane","year":"1977","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib16","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/ije\/28.4.717","article-title":"Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study","volume":"28","author":"Hedman","year":"1999","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaip.2020.01.049_bib17","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/lary.26391","article-title":"Prevalence of polyp recurrence after endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis","volume":"127","author":"DeConde","year":"2017","journal-title":"Laryngoscope"},{"issue":"Suppl 1","key":"10.1016\/j.jaip.2020.01.049_bib18","first-page":"S22","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis","volume":"6","author":"Orlandi","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2020.01.049_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","article-title":"Immunopathogenesis of chronic rhinosinusitis and nasal polyposis","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jaip.2020.01.049_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4193\/Rhin17.156","article-title":"Monoclonal antibodies for the treatment of chronic rhinosinusitis with nasal polyposis: a systematic review","volume":"56","author":"Tsetsos","year":"2018","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2020.01.049_bib21","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1111\/all.13875","article-title":"EUFOREA consensus on biologics for CRSwNP with or without asthma","volume":"74","author":"Fokkens","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.01.049_bib22","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(19)31881-1","article-title":"Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials","volume":"394","author":"Bachert","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2020.01.049_bib23","first-page":"183","article-title":"Mackay IS. Staging in rhinosinusitus","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2020.01.049_bib24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/all.13048","article-title":"Asthma quality of life and control after sinus surgery in patients with chronic rhinosinusitis","volume":"72","author":"Schlosser","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.01.049_bib25","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4193\/Rhin17.029","article-title":"Chronic rhinosinusitis severity is associated with need for asthma-related systemic corticosteroids","volume":"55","author":"Phillips","year":"2017","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2020.01.049_bib26","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/lary.26901","article-title":"Relationship between chronic rhinosinusitis exacerbation frequency and asthma control","volume":"128","author":"Banoub","year":"2018","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaip.2020.01.049_bib27","first-page":"E53","article-title":"Asthma and chronic rhinosinusitis: diagnosis and medical management","volume":"7","author":"Massoth","year":"2019","journal-title":"Med Sci (Basel)"},{"key":"10.1016\/j.jaip.2020.01.049_bib28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2500\/ajra.2011.25.3613","article-title":"Association between severity of asthma and degree of chronic rhinosinusitis","volume":"25","author":"Lin","year":"2011","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaip.2020.01.049_bib29","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.jaip.2016.12.027","article-title":"Clinical characteristics of patients with chronic rhinosinusitis with nasal polyps, asthma, and aspirin-exacerbated respiratory disease","volume":"5","author":"Stevens","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.01.049_bib30","doi-asserted-by":"crossref","first-page":"e0127228","DOI":"10.1371\/journal.pone.0127228","article-title":"Airway inflammation in chronic rhinosinusitis with nasal polyps and asthma: the united airways concept further supported","volume":"10","author":"Hakansson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2020.01.049_bib31","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.jaci.2015.12.1324","article-title":"Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers","volume":"137","author":"Tomassen","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4193\/Rhin17.139","article-title":"Omalizumab treats chronic rhinosinusitis with nasal polyps and asthma together-a real life study","volume":"56","author":"Bidder","year":"2018","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2020.01.049_bib33","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1056\/NEJMoa1804092","article-title":"Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma","volume":"378","author":"Castro","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2020.01.049_bib34","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.jaci.2018.09.033","article-title":"Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma","volume":"143","author":"Khatri","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib35","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.jaci.2018.01.008","article-title":"Benralizumab attenuates airway eosinophilia in prednisone-dependent asthma","volume":"141","author":"Sehmi","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib36","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00408-018-0151-5","article-title":"Comparative efficacy of anti IL-4, IL-5 and IL-13 drugs for treatment of eosinophilic asthma: a network meta-analysis","volume":"196","author":"Iftikhar","year":"2018","journal-title":"Lung"},{"key":"10.1016\/j.jaip.2020.01.049_bib37","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.jaci.2017.05.044","article-title":"Reduced need for surgery in severe nasal polyposis with mepolizumab: randomized trial","volume":"140","author":"Bachert","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib38","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.jaci.2011.07.056","article-title":"Mepolizumab, a humanized anti-IL-5 mAb, as a treatment option for severe nasal polyposis","volume":"128","author":"Gevaert","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib39","doi-asserted-by":"crossref","first-page":"E61","DOI":"10.1002\/lary.27564","article-title":"Dexpramipexole depletes blood and tissue eosinophils in nasal polyps with no change in polyp size","volume":"129","author":"Laidlaw","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaip.2020.01.049_bib40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/alr.21021","article-title":"Increased percentage of mast cells within sinonasal mucosa of chronic rhinosinusitis with nasal polyp patients independent of atopy","volume":"2","author":"Shaw","year":"2012","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2020.01.049_bib41","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jaci.2012.02.046","article-title":"Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps","volume":"130","author":"Takabayashi","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib42","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.jaci.2013.12.1092","article-title":"Basophils are elevated in nasal polyps of patients with chronic rhinosinusitis without aspirin sensitivity","volume":"133","author":"Mahdavinia","year":"2014","journal-title":"The J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1164\/rccm.201207-1292OC","article-title":"Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression","volume":"187","author":"Takabayashi","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2020.01.049_bib44","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.jaci.2019.08.040","article-title":"Increased thrombin activatable fibrinolysis inhibitor (TAFI) in chronic rhinosinusitis with nasal polyps","volume":"144","author":"Imoto","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib45","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/PL00007645","article-title":"Thrombin in the airways of asthmatic patients","volume":"177","author":"Gabazza","year":"1999","journal-title":"Lung"},{"key":"10.1016\/j.jaip.2020.01.049_bib46","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1111\/j.1538-7836.2009.03523.x","article-title":"Early activation of coagulation after allergen challenge in patients with allergic asthma","volume":"7","author":"Schouten","year":"2009","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.jaip.2020.01.049_bib47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1053\/j.gastro.2017.06.065","article-title":"Pathophysiology of eosinophilic esophagitis","volume":"154","author":"O\u2019Shea","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaip.2020.01.049_bib48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jaci.2019.03.034","article-title":"Bagels and LOX in patients with eosinophilic esophagitis","volume":"144","author":"Ben Baruch-Morgenstern","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.01.049_bib49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4193\/Rhino14.077","article-title":"Does time to endoscopic sinus surgery impact outcomes in chronic rhinosinusitis? Retrospective analysis using the UK clinical practice research data","volume":"53","author":"Hopkins","year":"2015","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2020.01.049_bib50","first-page":"10","article-title":"Does time to endoscopic sinus surgery impact outcomes in Chronic Rhinosinusitis? Prospective findings from the National Comparative Audit of Surgery for Nasal Polyposis and Chronic Rhinosinusitis","volume":"53","author":"Hopkins","year":"2015","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2020.01.049_bib51","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/lary.27473","article-title":"Does delaying endoscopic sinus surgery adversely impact quality-of-life outcomes?","volume":"129","author":"Alt","year":"2019","journal-title":"Laryngoscope"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820301355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820301355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:24:46Z","timestamp":1761974686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219820301355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S2213219820301355"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2020.01.049","relation":{},"ISSN":["2213-2198"],"issn-type":[{"type":"print","value":"2213-2198"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Persistence of Sinonasal Disease Despite Mepolizumab","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2020.01.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}