{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:28:39Z","timestamp":1786991319374,"version":"build-2736575974"},"reference-count":128,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jaip.2020.02.021","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T13:22:52Z","timestamp":1583241772000},"page":"2533-2541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Utility of Measuring Urinary Metabolites of Mast Cell Mediators in Systemic Mastocytosis and Mast Cell Activation Syndrome"],"prefix":"10.1016","volume":"8","author":[{"given":"Joseph","family":"Butterfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine R.","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2020.02.021_bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000328760","article-title":"Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal","volume":"157","author":"Valent","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib2","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.jaip.2019.01.006","article-title":"Proposed diagnostic algorithm for patients with suspected mast cell activation syndrome","volume":"7","author":"Valent","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.021_bib3","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1056\/NEJMra1409760","article-title":"Mast cells, mastocytosis, and related disorders","volume":"373","author":"Theoharides","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib4","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1056\/NEJM198706253162603","article-title":"Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis","volume":"316","author":"Schwartz","year":"1987","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000323763","article-title":"Clinical and laboratory parameters of mast cell activation as basis for the formulation of diagnostic criteria","volume":"156","author":"Valent","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib6","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1182\/blood-2006-06-028100","article-title":"Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with \u201cidiopathic\u201d anaphylaxis","volume":"110","author":"Akin","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2020.02.021_bib7","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jaci.2019.08.023","article-title":"AAAAI Mast Cell Disorders Committee Work Group Report: mast cell activation syndrome (MCAS) diagnosis and management","volume":"144","author":"Weiler","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib8","first-page":"23","article-title":"The mast cell","volume":"3","author":"Metcalfe","year":"1981","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF02991229","article-title":"Enzyme mediators of mast cells and basophils","volume":"1","author":"Schwartz","year":"1983","journal-title":"Clin Rev Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4049\/jimmunol.135.1.483","article-title":"Isolation and characterization of human intestinal mucosal mast cells","volume":"135","author":"Fox","year":"1985","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib11","first-page":"614","article-title":"Characterization of inflammatory mediator release from purified human lung mast cells","volume":"133","author":"Schleimer","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.jaip.2020.02.021_bib12","first-page":"226","article-title":"Mediators of human mast cells and human mast cell subsets","volume":"58","author":"Schwartz","year":"1987","journal-title":"Ann Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib13","first-page":"36","article-title":"Different mast cell mediators produced by different mast cell phenotypes","volume":"147","author":"Gurish","year":"1989","journal-title":"Ciba Found Symp"},{"key":"10.1016\/j.jaip.2020.02.021_bib14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0952-7915(94)90039-6","article-title":"Mast cells: function and contents","volume":"6","author":"Schwartz","year":"1994","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib15","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","article-title":"Mast cells","volume":"77","author":"Metcalfe","year":"1997","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jaip.2020.02.021_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2222.2008.03136.x","article-title":"Biomarkers in the diagnosis of anaphylaxis: making nature disclose her mysteries","volume":"39","author":"Levy","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.iac.2006.05.005","article-title":"Mast cell mediators in allergic inflammation and mastocytosis","volume":"26","author":"Castells","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2020.02.021_bib18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2222.2007.02886.x","article-title":"The mast cell and allergic diseases: role in pathogenesis and implications for therapy","volume":"38","author":"Brown","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000189195","article-title":"Increases in urinary 9alpha,11beta-prostaglandin f2 indicate mast cell activation in wine-induced asthma","volume":"149","author":"Misso","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1365-2222.2008.03104.x","article-title":"Increased production of cysteinyl leukotrienes and prostaglandin D2 during human anaphylaxis","volume":"39","author":"Ono","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib21","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.jaci.2018.02.024","article-title":"Leukotriene E4 induces airflow obstruction and mast cell activation through the cysteinyl leukotriene type 1 receptor","volume":"142","author":"Lazarinis","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib22","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.iac.2018.04.011","article-title":"Mast cell mediators of significance in clinical practice in mastocytosis","volume":"38","author":"Butterfield","year":"2018","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2020.02.021_bib23","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1080\/1744666X.2019.1596800","article-title":"Recent advances in our understanding of mast cell activation\u2014or should it be mast cell mediator disorders?","volume":"15","author":"Theoharides","year":"2019","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jaci.2018.09.014","article-title":"Effect of IL-33 on de novo synthesized mediators from human mast cells","volume":"143","author":"Theoharides","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2500\/108854194778702946","article-title":"Tryptase: a clinical indicator of mast cell-dependent events","volume":"15","author":"Schwartz","year":"1994","journal-title":"Allergy Proc"},{"key":"10.1016\/j.jaip.2020.02.021_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000501079","article-title":"Why the 20%\u00a0+ 2 tryptase formula is a diagnostic gold standard for severe systemic mast cell activation and mast cell activation syndrome","volume":"180","author":"Valent","year":"2019","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib27","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.iac.2006.05.010","article-title":"Diagnostic value of tryptase in anaphylaxis and mastocytosis","volume":"26","author":"Schwartz","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2020.02.021_bib28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000096442","article-title":"Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: monoclonal mast cell activation syndrome","volume":"142","author":"Sonneck","year":"2007","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib29","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.clim.2007.02.007","article-title":"Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels","volume":"123","author":"Akin","year":"2007","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/ajh.25371","article-title":"Systemic mastocytosis in adults: 2019 update on diagnosis, risk stratification and management","volume":"94","author":"Pardanani","year":"2019","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jaip.2020.02.021_bib31","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/all.12126","article-title":"Mast cell activation syndromes: definition and classification","volume":"68","author":"Valent","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib32","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1111\/all.13226","article-title":"Validation of international consensus equation for acute serum total tryptase in mast cell activation: a perioperative perspective","volume":"72","author":"Baretto","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib33","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.jaci.2011.06.051","article-title":"Regulation of the immune response and inflammation by histamine and histamine receptors","volume":"128","author":"O'Mahony","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/clpt.2010.256","article-title":"Histamine: new thoughts about a familiar mediator","volume":"89","author":"Jones","year":"2011","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jaip.2020.02.021_bib35","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.urology.2006.04.033","article-title":"Interleukin-6, histamine, and methylhistamine as diagnostic markers for interstitial cystitis","volume":"68","author":"Lamale","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.jaip.2020.02.021_bib36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2500\/108854186778995301","article-title":"Histamine in foods: its possible role in non-allergic adverse reactions to ingestants","volume":"7","author":"Malone","year":"1986","journal-title":"N\u00a0Engl Reg Allergy Proc"},{"key":"10.1016\/j.jaip.2020.02.021_bib37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2500\/108854193778811982","article-title":"Basophil histamine release by freshly prepared food extracts","volume":"14","author":"Kleine-Tebbe","year":"1993","journal-title":"Allergy Proc"},{"key":"10.1016\/j.jaip.2020.02.021_bib38","first-page":"233","article-title":"Food-induced histamine release from gastric and duodenal mucosa","volume":"31","author":"Baenkler","year":"1984","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.jaip.2020.02.021_bib39","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1056\/NEJM199103143241102","article-title":"Evidence that histamine is the causative toxin of scombroid-fish poisoning","volume":"324","author":"Morrow","year":"1991","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib40","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF01965099","article-title":"Plasma concentration: effect study of histamine infused in normal subjects","volume":"12","author":"Ind","year":"1982","journal-title":"Agents Actions"},{"key":"10.1016\/j.jaip.2020.02.021_bib41","series-title":"Middleton\u2019s Allergy Principles and Practice","first-page":"189","article-title":"Mast cell-derived mediators","author":"Church","year":"2003"},{"key":"10.1016\/j.jaip.2020.02.021_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01976745","article-title":"Histamine N-methyltransferase: inhibition by monoamine oxidase inhibitors","volume":"40","author":"Boudikova-Girard","year":"1993","journal-title":"Agents Actions"},{"issue":"Suppl","key":"10.1016\/j.jaip.2020.02.021_bib43","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.anai.2010.08.005","article-title":"The basics of histamine biology","volume":"106","author":"Lieberman","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib44","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.4049\/jimmunol.117.4.1356","article-title":"Release of chemical mediators from partially purified human lung mast cells","volume":"117","author":"Paterson","year":"1976","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib45","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.4049\/jimmunol.131.4.1936","article-title":"Heterogeneity of human mast cells","volume":"131","author":"Schulman","year":"1983","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib46","doi-asserted-by":"crossref","first-page":"861","DOI":"10.4049\/jimmunol.138.3.861","article-title":"Human skin mast cells: their dispersion, purification, and secretory characterization","volume":"138","author":"Benyon","year":"1987","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib47","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000233799","article-title":"Inhibition of human basophil leukotriene release by antiinflammatory steroids","volume":"77","author":"Schleimer","year":"1985","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib48","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1182\/blood.V29.5.722.722","article-title":"Release of histamine from human basophils","volume":"29","author":"Sampson","year":"1967","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2020.02.021_bib49","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1096\/fj.12-223867","article-title":"Histamine production by human neutrophils","volume":"27","author":"Alcaniz","year":"2013","journal-title":"FASEB J"},{"key":"10.1016\/j.jaip.2020.02.021_bib50","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1126\/science.2928797","article-title":"Histamine is an intracellular messenger mediating platelet aggregation","volume":"243","author":"Saxena","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.jaip.2020.02.021_bib51","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/ajcp\/89.5.622","article-title":"Increased histamine content in leukocytes and platelets of patients with peripheral vascular disease","volume":"89","author":"Gill","year":"1988","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.jaip.2020.02.021_bib52","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0003-2697(84)90037-X","article-title":"Measurement of plasma histamine by stable isotope dilution gas chromatography-mass spectrometry: methodology and normal values","volume":"139","author":"Keyzer","year":"1984","journal-title":"Anal Biochem"},{"key":"10.1016\/j.jaip.2020.02.021_bib53","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/BF01965099","article-title":"Concentration effect relationships of infused histamine in normal volunteers","volume":"12","author":"Ind","year":"1982","journal-title":"Agents Actions"},{"key":"10.1016\/j.jaip.2020.02.021_bib54","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.jpba.2015.11.001","article-title":"Comparison of two enzymatic immunoassays, high resolution mass spectrometry method and radioimmunoassay for the quantification of human plasma histamine","volume":"118","author":"Poli","year":"2016","journal-title":"J\u00a0Pharm Biomed Anal"},{"key":"10.1016\/j.jaip.2020.02.021_bib55","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0190-9622(96)90679-9","article-title":"Value of urinary N-methylhistamine measurements in childhood mastocytosis","volume":"35","author":"Van Gysel","year":"1996","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jaip.2020.02.021_bib56","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1046\/j.1365-2230.2002.01072.x","article-title":"Urinary N-methylhistamine as an indicator of bone marrow involvement in mastocytosis","volume":"27","author":"Oranje","year":"2002","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaip.2020.02.021_bib57","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1111\/j.1572-0241.2002.07028.x","article-title":"Urinary excretion of N-methylhistamine as a marker of disease activity in inflammatory bowel disease","volume":"97","author":"Winterkamp","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jaip.2020.02.021_bib58","first-page":"193","article-title":"The urinary excretion of 1-methylimidazole-4-acetic acid, a histamine metabolite, by healthy and asthmatic children","volume":"45","author":"Thom","year":"1973","journal-title":"Clin Sci Mol Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000184449","article-title":"Urinary histamine excretion in proteinuric states","volume":"47","author":"Trachtman","year":"1987","journal-title":"Nephron"},{"key":"10.1016\/j.jaip.2020.02.021_bib60","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000236493","article-title":"Measurement and characterization of histamine and methylhistamine in human urine under histamine-rich and histamine-poor diets","volume":"101","author":"Hermann","year":"1993","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib61","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3324\/haematol.11558","article-title":"Biochemical markers predictive for bone marrow involvement in systemic mastocytosis","volume":"93","author":"Donker","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.jaip.2020.02.021_bib62","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0378-4347(98)00481-2","article-title":"Determination of 1-methylhistamine and 1-methylimidazoleacetic acid in human urine as a tool for the diagnosis of mastocytosis","volume":"721","author":"Martens-Lobenhoffer","year":"1999","journal-title":"J\u00a0Chromatogr B Biomed Sci Appl"},{"key":"10.1016\/j.jaip.2020.02.021_bib63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0952-3278(91)90138-U","article-title":"Leukotriene C4 formation by enriched human basophil preparations from normal and asthmatic subjects","volume":"44","author":"van der Donk","year":"1991","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.jaip.2020.02.021_bib64","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1136\/bmj.4.5631.618","article-title":"Appearance of prostaglandin F2-alpha in human blood during labour","volume":"4","author":"Karim","year":"1968","journal-title":"Br Med J"},{"key":"10.1016\/j.jaip.2020.02.021_bib65","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0002-9378(88)80117-0","article-title":"C19 adrenal steroids enhance prostaglandin F2 alpha output by human endometrium in\u00a0vitro","volume":"159","author":"Markiewicz","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jaip.2020.02.021_bib66","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0015-0282(16)60314-X","article-title":"In\u00a0vitro effects of clomiphene citrate on human endometrium","volume":"50","author":"Markiewicz","year":"1988","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jaip.2020.02.021_bib67","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0015-0282(16)61029-4","article-title":"Prostaglandin F2 alpha synthesis and metabolism by luteal phase endometrium in\u00a0vitro","volume":"52","author":"Brumsted","year":"1989","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jaip.2020.02.021_bib68","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1210\/jc.2004-2496","article-title":"Identification of 9alpha,11beta-prostaglandin F2 in human amniotic fluid and characterization of its production by human gestational tissues","volume":"90","author":"Mitchell","year":"2005","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.jaip.2020.02.021_bib69","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1530\/REP-07-0514","article-title":"Two pathways for prostaglandin F2 alpha synthesis by the primate periovulatory follicle","volume":"136","author":"Dozier","year":"2008","journal-title":"Reproduction"},{"key":"10.1016\/j.jaip.2020.02.021_bib70","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0021-9258(19)85049-4","article-title":"Enzymatic conversion of prostaglandin H2 to prostaglandin F2 alpha by aldehyde reductase from human liver: comparison to the prostaglandin F synthetase from bovine lung","volume":"264","author":"Hayashi","year":"1989","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaip.2020.02.021_bib71","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1073\/pnas.82.18.6030","article-title":"Transformation of prostaglandin D2 to 9 alpha, 11 beta-(15S)-trihydroxyprosta-(5Z,13E)-dien-1-oic acid (9 alpha, 11 beta-prostaglandin F2): a unique biologically active prostaglandin produced enzymatically in\u00a0vivo in humans","volume":"82","author":"Liston","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaip.2020.02.021_bib72","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1172\/JCI110938","article-title":"Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells","volume":"71","author":"Schleimer","year":"1983","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2020.02.021_bib73","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.4049\/jimmunol.129.4.1627","article-title":"Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE","volume":"129","author":"Lewis","year":"1982","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib74","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.4049\/jimmunol.132.4.1972","article-title":"Arachidonic acid metabolism in purified human lung mast cells","volume":"132","author":"Peters","year":"1984","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib75","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.ajpath.2011.04.023","article-title":"FcepsilonRI, but not FcgammaR, signals induce prostaglandin D2 and E2 production from basophils","volume":"179","author":"Ugajin","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaip.2020.02.021_bib76","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.4049\/jimmunol.164.5.2277","article-title":"Cutting edge: differential production of prostaglandin D2 by human helper T cell subsets","volume":"164","author":"Tanaka","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib77","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2353\/ajpath.2010.090111","article-title":"Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin","volume":"176","author":"Shimura","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jaip.2020.02.021_bib78","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jaci.2016.04.042","article-title":"Eosinophil production of prostaglandin D2 in patients with aspirin-exacerbated respiratory disease","volume":"138","author":"Feng","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib79","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1006\/bbrc.1996.1287","article-title":"IgE-anti-IgE-induced prostaglandin D2 release from cultured human mast cells","volume":"225","author":"Obata","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaip.2020.02.021_bib80","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0090-6980(89)90088-9","article-title":"Release of markedly increased quantities of prostaglandin D2 in\u00a0vivo in humans following the administration of nicotinic acid","volume":"38","author":"Morrow","year":"1989","journal-title":"Prostaglandins"},{"key":"10.1016\/j.jaip.2020.02.021_bib81","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/1523-1747.ep12499963","article-title":"Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans","volume":"98","author":"Morrow","year":"1992","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jaip.2020.02.021_bib82","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2332\/allergolint.11-RA-0403","article-title":"Aspirin-intolerant asthma (AIA) assessment using the urinary biomarkers, leukotriene E4 (LTE4) and prostaglandin D2 (PGD2) metabolites","volume":"61","author":"Higashi","year":"2012","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2020.02.021_bib83","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1182\/blood-2011-10-384826","article-title":"Cysteinyl leukotriene overproduction in aspirin-exacerbated respiratory disease is driven by platelet-adherent leukocytes","volume":"119","author":"Laidlaw","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2020.02.021_bib84","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2222.1995.tb01079.x","article-title":"Validation and application of a new simple strategy for measurements of urinary leukotriene E4 in humans","volume":"25","author":"Kumlin","year":"1995","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib85","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1398-9995.1997.tb00966.x","article-title":"Measurements of leukotrienes in the urine: strategies and applications","volume":"52","author":"Kumlin","year":"1997","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib86","first-page":"2504","article-title":"Comparative studies of human basophils and mast cells","volume":"42","author":"MacGlashan","year":"1983","journal-title":"Fed Proc"},{"issue":"Suppl 128","key":"10.1016\/j.jaip.2020.02.021_bib87","first-page":"53","article-title":"Purified human basophils and mast cells: current concepts of mediator release","volume":"64","author":"Schulman","year":"1983","journal-title":"Eur J Respir Dis"},{"key":"10.1016\/j.jaip.2020.02.021_bib88","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1172\/JCI110670","article-title":"Generation of leukotrienes by purified human lung mast cells","volume":"70","author":"MacGlashan","year":"1982","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2020.02.021_bib89","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/0952-3278(93)90026-S","article-title":"Purification of human blood basophils and leukotriene C4 generation following calcium ionophore stimulation","volume":"49","author":"Mita","year":"1993","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"10.1016\/j.jaip.2020.02.021_bib90","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1084\/jem.172.6.1577","article-title":"Interleukin 5 modifies histamine release and leukotriene generation by human basophils in response to diverse agonists","volume":"172","author":"Bischoff","year":"1990","journal-title":"J.\u00a0Exp Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib91","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1073\/pnas.87.17.6813","article-title":"Interleukin 3 and granulocyte\/macrophage-colony-stimulating factor render human basophils responsive to low concentrations of complement component C3a","volume":"87","author":"Bischoff","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaip.2020.02.021_bib92","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1172\/JCI115222","article-title":"Eosinophils altered phenotypically and primed by culture with granulocyte\/macrophage colony-stimulating factor and 3T3 fibroblasts generate leukotriene C4 in response to FMLP","volume":"87","author":"Owen","year":"1991","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2020.02.021_bib93","doi-asserted-by":"crossref","first-page":"7626","DOI":"10.1073\/pnas.80.24.7626","article-title":"Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4","volume":"80","author":"Weller","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaip.2020.02.021_bib94","doi-asserted-by":"crossref","first-page":"532","DOI":"10.4049\/jimmunol.138.2.532","article-title":"Synthesis and release of leukotriene C4 by human eosinophils","volume":"138","author":"Owen","year":"1987","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib95","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.4049\/jimmunol.147.11.3855","article-title":"IL-3 and IL-5 prime normal human eosinophils to produce leukotriene C4 in response to soluble agonists","volume":"147","author":"Takafuji","year":"1991","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib96","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/archderm.1962.01590080087011","article-title":"Histamine liberation by codeine and polymyxin B in urticaria pigmentosa","volume":"86","author":"Sutter","year":"1962","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaip.2020.02.021_bib97","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0002-9343(89)80398-5","article-title":"Analysis of plasma histamine levels in patients with mast cell disorders","volume":"87","author":"Friedman","year":"1989","journal-title":"Am J Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib98","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1056\/NEJM197902013000506","article-title":"Blockade of the flush associated with metastatic gastric carcinoid by combined histamine H1 and H2 receptor antagonists. Evidence for an important role of H2 receptors in human vasculature","volume":"300","author":"Roberts","year":"1979","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib99","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/iid3.94","article-title":"Prostaglandin D2 metabolites as a biomarker of in\u00a0vivo mast cell activation in systemic mastocytosis and rheumatoid arthritis","volume":"4","author":"Cho","year":"2016","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.jaip.2020.02.021_bib100","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.clinbiochem.2016.02.007","article-title":"Analytical and clinical validation of an LC-MS\/MS method for urine leukotriene E4: a marker of systemic mastocytosis","volume":"49","author":"Lueke","year":"2016","journal-title":"Clin Biochem"},{"key":"10.1016\/j.jaip.2020.02.021_bib101","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1001\/archderm.1986.01660160078023","article-title":"The bone marrow in urticaria pigmentosa and systemic mastocytosis. Cell composition and mast cell density in relation to urinary excretion of tele-methylimidazoleacetic acid","volume":"122","author":"Ridell","year":"1986","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaip.2020.02.021_bib102","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000329856","article-title":"Validation of the REMA score for predicting mast cell clonality and systemic mastocytosis in patients with systemic mast cell activation symptoms","volume":"157","author":"Alvarez-Twose","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib103","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/all.12436","article-title":"Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis","volume":"69","author":"Valent","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib104","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1398-9995.2012.02809.x","article-title":"Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions","volume":"67","author":"van Doormaal","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib105","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/all.12668","article-title":"Urinary 11beta-PGF2alpha and N-methyl histamine correlate with bone marrow biopsy findings in mast cell disorders","volume":"70","author":"Divekar","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.02.021_bib106","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0091-6749(93)90076-R","article-title":"Comparison of azelastine and chlorpheniramine in the treatment of mastocytosis","volume":"92","author":"Friedman","year":"1993","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib107","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0002-9343(85)90454-1","article-title":"Comparison of the therapeutic efficacy of cromolyn sodium with that of combined chlorpheniramine and cimetidine in systemic mastocytosis. Results of a double-blind clinical trial","volume":"78","author":"Frieri","year":"1985","journal-title":"Am J Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib108","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.exphem.2010.05.008","article-title":"H1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells","volume":"38","author":"Hadzijusufovic","year":"2010","journal-title":"Exp Hematol"},{"key":"10.1016\/j.jaip.2020.02.021_bib109","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1365-2796.1991.tb00379.x","article-title":"A\u00a0case of systemic mastocytosis; therapeutic efficacy of ketotifen","volume":"229","author":"Povoa","year":"1991","journal-title":"J\u00a0Int Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib110","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/0091-6749(89)90097-3","article-title":"A\u00a0double-blind, placebo-controlled, crossover trial of ketotifen versus hydroxyzine in the treatment of pediatric mastocytosis","volume":"83","author":"Kettelhut","year":"1989","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib111","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1365-2125.1989.tb05339.x","article-title":"The effect of disodium cromoglycate and ketotifen on the excretion of histamine and N tau-methylimidazole acetic acid in urine of patients with mastocytosis","volume":"27","author":"Mallet","year":"1989","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jaip.2020.02.021_bib112","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jaip.2014.06.011","article-title":"Mast cell activation syndrome: improved identification by combined determinations of serum tryptase and 24-hour urine 11beta-prostaglandin2alpha","volume":"2","author":"Ravi","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.021_bib113","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1056\/NEJM198012113032405","article-title":"Increased production of prostaglandin D2 in patients with systemic mastocytosis","volume":"303","author":"Roberts","year":"1980","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib114","first-page":"141","article-title":"Markedly increased synthesis of prostaglandin D2 in systemic mastocytosis","volume":"93","author":"Roberts","year":"1980","journal-title":"Trans Assoc Am Physicians"},{"key":"10.1016\/j.jaip.2020.02.021_bib115","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/1523-1747.ep12606209","article-title":"Improved diagnosis of mastocytosis by measurement of the major urinary metabolite of prostaglandin D2","volume":"104","author":"Morrow","year":"1995","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jaip.2020.02.021_bib116","first-page":"18","article-title":"The flush syndrome: an expression of systemic mastocytosis with increased prostaglandin D2 production","volume":"26","author":"Kootte","year":"1983","journal-title":"Neth J Med"},{"issue":"Pt 1","key":"10.1016\/j.jaip.2020.02.021_bib117","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/01.HYP.6.2.285","article-title":"Recurrent syncope due to systemic mastocytosis","volume":"6","author":"Roberts","year":"1984","journal-title":"Hypertension"},{"key":"10.1016\/j.jaip.2020.02.021_bib118","doi-asserted-by":"crossref","first-page":"481","DOI":"10.4065\/70.5.481","article-title":"Aspirin idiosyncrasy in systemic mast cell disease: a new look at mediator release during aspirin desensitization","volume":"70","author":"Butterfield","year":"1995","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jaip.2020.02.021_bib119","first-page":"36","article-title":"Mastocytosis without urticaria pigmentosa: a frequently unrecognized cause of recurrent syncope","volume":"95","author":"Roberts","year":"1982","journal-title":"Trans Assoc Am Physicians"},{"key":"10.1016\/j.jaip.2020.02.021_bib120","first-page":"1","article-title":"Systemic mastocytosis: management of an unusual case with histamine (H1 and H2) antagonists and cyclooxygenase inhibition","volume":"10","author":"Crawhall","year":"1987","journal-title":"Clin Invest Med"},{"key":"10.1016\/j.jaip.2020.02.021_bib121","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(89)91516-X","article-title":"Aspirin and systemic mastocytosis","volume":"2","author":"Lorcerie","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2020.02.021_bib122","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000144042","article-title":"Prevention of mast cell activation disorder-associated clinical sequelae of excessive prostaglandin D(2) production","volume":"147","author":"Butterfield","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib123","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0090-6980(98)00027-6","article-title":"Immunoaffinity resin for purification of urinary leukotriene E4","volume":"55","author":"Westcott","year":"1998","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jaip.2020.02.021_bib124","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.iac.2007.09.004","article-title":"Urinary leukotriene E4","volume":"27","author":"Rabinovitch","year":"2007","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2020.02.021_bib125","first-page":"469","article-title":"The measurement of leukotrienes in urine as diagnostic option in systemic mastocytosis","volume":"62","author":"Raithel","year":"2011","journal-title":"J\u00a0Physiol Pharmacol"},{"key":"10.1016\/j.jaip.2020.02.021_bib126","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.prostaglandins.2010.03.003","article-title":"Increased leukotriene E4 excretion in systemic mastocytosis","volume":"92","author":"Butterfield","year":"2010","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"10.1016\/j.jaip.2020.02.021_bib127","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000237133","article-title":"Cysteinyl leukotriene production in anaphylactic reactions","volume":"108","author":"Denzlinger","year":"1995","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.021_bib128","series-title":"The Mast Cells","author":"Riley","year":"1959"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820301811?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820301811?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:24:01Z","timestamp":1761974641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219820301811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":128,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S2213219820301811"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2020.02.021","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Utility of Measuring Urinary Metabolites of Mast Cell Mediators in Systemic Mastocytosis and Mast Cell Activation Syndrome","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2020.02.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}