{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:17:24Z","timestamp":1789168644258,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.jaip.2020.02.033","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T11:41:49Z","timestamp":1583581309000},"page":"2294-2301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Direct Challenges to Penicillin-Based Antibiotics in the Inpatient Setting"],"prefix":"10.1016","volume":"8","author":[{"given":"Allison","family":"Ramsey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Shahzad","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Holly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"Staicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2020.02.033_bib1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.2018.19283","article-title":"Evaluation and management of penicillin allergy: a review","volume":"321","author":"Shenoy","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2020.02.033_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.anai.2010.08.002","article-title":"Drug allergy: an updated practice parameter","volume":"105","author":"Solensky","year":"2010","journal-title":"Ann Allerg Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.02.033_bib3","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1001\/archinte.160.18.2819","article-title":"The incidence of antimicrobial allergies in hospitalized patients: implication regarding prescribing patters and emerging bacterial resistance","volume":"160","author":"Lee","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jaip.2020.02.033_bib4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jaip.2013.01.006","article-title":"Treatment of patients with a history of penicillin allergy in a large tertirary care academic hospital","volume":"1","author":"Picard","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib5","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1592\/phco.28.11.1348","article-title":"Antibiotic allergies in the medical record: effect on drug selection and assessment of validity","volume":"28","author":"Lutomski","year":"2008","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jaip.2020.02.033_bib6","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1093\/cid\/civ394","article-title":"Improving clinical outcomes in patients with methicillin-sensitive Staphylococcus aureus bacteremia and reported penicillin allergy","volume":"61","author":"Blumenthal","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2020.02.033_bib7","doi-asserted-by":"crossref","first-page":"k2400","DOI":"10.1136\/bmj.k2400","article-title":"Risk of methicillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study","volume":"361","author":"Blumenthal","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.jaip.2020.02.033_bib8","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/ACI.0000000000000173","article-title":"Penicillin allergy: optimizing diagnostic protocols, public health implications, and future research needs","volume":"15","author":"Macy","year":"2015","journal-title":"Curr Opin Clin Allergy Immunol"},{"key":"10.1016\/j.jaip.2020.02.033_bib9","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jaci.2013.09.021","article-title":"Health care use and serious infection prevalence associated with penicillin \u201callergy\u201d in hospitalized patients: a cohort study","volume":"133","author":"Macy","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.033_bib10","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s11606-019-04991-y","article-title":"Recorded penicillin allergy and risk of mortality: a population-based cohort study","volume":"34","author":"Blumenthal","year":"2019","journal-title":"J\u00a0Gen Intern Med"},{"key":"10.1016\/j.jaip.2020.02.033_bib11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.jaip.2016.12.010","article-title":"Penicillin allergy testing should be performed routinely in patients with self-reported penicillin allergy","volume":"5","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib12","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1093\/cid\/ciw118","article-title":"Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America","volume":"62","author":"Barlam","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2020.02.033_bib14","first-page":"1106","article-title":"A\u00a0pilot study of penicillin skin testing in patients with a history of penicillin allergy admitted to a medical ICU","volume":"4","author":"Arroglia","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2020.02.033_bib15","first-page":"347","article-title":"A\u00a0prospective observational study of the effect of penicillin skin testing on antibiotic use in the intensive care unit","volume":"5","author":"Arroglia","year":"2003","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jaip.2020.02.033_bib16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jhm.2036","article-title":"The impact of penicillin skin testing on clinical practice and antimicrobial stewardship","volume":"8","author":"Rimawi","year":"2013","journal-title":"J\u00a0Hosp Med"},{"key":"10.1016\/j.jaip.2020.02.033_bib17","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/jac\/dkz082","article-title":"Evaluation of a pharmacist-led penicillin allergy de-labelling ward round: a novel antimicrobial stewardship intervention","volume":"74","author":"Devchand","year":"2019","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jaip.2020.02.033_bib18","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/cid\/cix512","article-title":"Point-of-care \u03b2-lactam allergy skin testing by antimicrobial stewardship programs: a pragmatic multicenter prospective evaluation","volume":"65","author":"Leis","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2020.02.033_bib19","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jaip.2016.09.045","article-title":"A\u00a0proactive approach to penicillin allergy in hospitalized patients","volume":"5","author":"Chen","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib20","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jaip.2017.11.012","article-title":"Use of a penicillin allergy screening algorithm and penicillin skin testing for transitioning hospitalized patients to first-line antibiotic therapy","volume":"6","author":"Ramsey","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib21","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/all.13168","article-title":"Clinical outcomes following inpatient penicillin allergy testing: a systematic review and meta-analysis","volume":"72","author":"Sacco","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.02.033_bib22","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/phar.1288","article-title":"Penicillin skin testing: implications for antimicrobial stewardship","volume":"33","author":"Unger","year":"2013","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.jaip.2020.02.033_bib23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jaci.2017.02.005","article-title":"Tackling inpatient penicillin allergies: assessing tools for antimicrobial stewardship","volume":"140","author":"Blumenthal","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.02.033_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1001\/jamapediatrics.2016.0033","article-title":"Assessing the diagnostic properties of a graded oral provocation challenge for the diagnosis of immediate and non immediate reactions to amoxicillin in children","volume":"170","author":"Mill","year":"2016","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jaip.2020.02.033_bib25","doi-asserted-by":"crossref","first-page":"ofy306","DOI":"10.1093\/ofid\/ofy306","article-title":"The safety and efficacy of an oral penicillin challenge program in cancer patients: a multicenter pilot study","volume":"5","author":"Trubiano","year":"2018","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jaip.2020.02.033_bib26","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jaip.2017.01.023","article-title":"Amoxicillin challenge without penicillin skin testing in evaluation of penicillin allergy in a cohort of Marine recruits","volume":"5","author":"Tucker","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib27","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jaip.2017.02.023","article-title":"Oral challenge without skin testing safely excludes significant delayed onset penicillin hypersensitivity","volume":"5","author":"Confino-Cohen","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib28","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jaip.2018.05.008","article-title":"Safety and outcomes of oral graded challenges to amoxicillin without prior skin testing","volume":"7","author":"Iammatteo","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11882-019-0854-6","article-title":"Evaluating penicillin allergies without skin testing","volume":"19","author":"Banks","year":"2019","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2020.02.033_bib30","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.jaip.2019.05.037","article-title":"Comparing direct challenge to penicillin skin testing for the outpatient evaluation of penicillin allergy: a randomized controlled trial","volume":"7","author":"Mustafa","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib31","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.jaip.2018.04.038","article-title":"The use of telemedicine for penicillin allergy skin testing","volume":"6","author":"Staicu","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib32","series-title":"Lexicomp Online. Lexi-Drugs Online","year":"2019"},{"key":"10.1016\/j.jaip.2020.02.033_bib33","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.anai.2015.05.011","article-title":"Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy","volume":"115","author":"Blumenthal","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.02.033_bib34","doi-asserted-by":"crossref","first-page":"ofw153","DOI":"10.1093\/ofid\/ofw153","article-title":"Improving antimicrobial stewardship by antibiotic allergy delabeling: evaluation of knowledge, attitude, and practices throughout the Emerging Infections Network","volume":"3","author":"Trubiano","year":"2016","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jaip.2020.02.033_bib35","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.jaip.2019.03.025","article-title":"Safety, efficacy, and clinical impact of penicillin skin testing in immunocompromised cancer patients","volume":"7","author":"Teremi","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib36","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.jaip.2019.05.045","article-title":"Risk stratification and prediction in beta-lactam allergic patients","volume":"7","author":"Ramsey","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.02.033_bib37","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/jhm.2083","article-title":"Risk of redocumenting penicillin allergy in a cohort of patients with negative penicillin skin tests","volume":"8","author":"Rimawi","year":"2013","journal-title":"J\u00a0Hosp Med"},{"key":"10.1016\/j.jaip.2020.02.033_bib38","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jaip.2017.02.012","article-title":"The effect of penicillin allergy testing on future health care utilization: a matched cohort study","volume":"5","author":"Macy","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820302324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820302324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:25:01Z","timestamp":1761974701000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219820302324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S2213219820302324"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2020.02.033","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Direct Challenges to Penicillin-Based Antibiotics in the Inpatient Setting","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2020.02.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}