{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:55:09Z","timestamp":1790398509399,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT 1139902"],"award-info":[{"award-number":["GNT 1139902"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT 1116876"],"award-info":[{"award-number":["GNT 1116876"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["1K12HS026395-01"],"award-info":[{"award-number":["1K12HS026395-01"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL87738"],"award-info":[{"award-number":["T32 HL87738"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R34AI136815"],"award-info":[{"award-number":["R34AI136815"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI139021"],"award-info":[{"award-number":["R21AI139021"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32 GM007569"],"award-info":[{"award-number":["T32 GM007569"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["1P50GM115305-01"],"award-info":[{"award-number":["1P50GM115305-01"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005617","name":"BHF Centre of Research Excellence, Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jaip.2020.07.056","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T22:40:14Z","timestamp":1597790414000},"page":"435-444.e13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Testing Strategies and Predictors for Evaluating Immediate and Delayed Reactions to Cephalosporins"],"prefix":"10.1016","volume":"9","author":[{"suffix":"Jr.","given":"Cosby A.","family":"Stone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Trubiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2020.07.056_bib1","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s11882-014-0476-y","article-title":"Penicillin and beta-lactam allergy: epidemiology and diagnosis","volume":"14","author":"Macy","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2020.07.056_bib2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.anai.2010.08.002","article-title":"Drug allergy: an updated practice parameter","volume":"105","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.07.056_bib3","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/all.12142","article-title":"Skin test concentrations for systemically administered drugs\u2014an ENDA\/EAACI Drug Allergy Interest Group position paper","volume":"68","author":"Brockow","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.07.056_bib4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/all.12350","article-title":"International Consensus on drug allergy","volume":"69","author":"Demoly","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.07.056_bib5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1586\/eci.11.14","article-title":"The basophil activation test in the diagnosis of immediate drug hypersensitivity","volume":"7","author":"Leysen","year":"2011","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jaip.2020.07.056_bib6","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.iac.2009.04.011","article-title":"The basophil activation test in immediate-type drug allergy","volume":"29","author":"Hausmann","year":"2009","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2020.07.056_bib7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.4168\/aair.2016.8.6.541","article-title":"The basophil activation test is safe and useful for confirming drug-induced anaphylaxis","volume":"8","author":"Kim","year":"2016","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaip.2020.07.056_bib8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1398-9995.2006.01268.x","article-title":"Relevance of the determination of serum-specific IgE antibodies in the diagnosis of immediate beta-lactam allergy","volume":"62","author":"Fontaine","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.07.056_bib9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jaci.2012.11.017","article-title":"False-positive penicillin immunoassay: an unnoticed common problem","volume":"132","author":"Johansson","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.07.056_bib10","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3349\/ymj.2014.55.6.1473","article-title":"Immunologic evaluation of immediate hypersensitivity to cefaclor","volume":"55","author":"Yoo","year":"2014","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.jaip.2020.07.056_bib11","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/all.12390","article-title":"Natural evolution of skin-test sensitivity in patients with IgE-mediated hypersensitivity to cephalosporins","volume":"69","author":"Romano","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.07.056_bib12","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.jaip.2019.08.033","article-title":"Cross-reactivity in IgE-mediated allergy to cefuroxime: focus on the R1 side chain","volume":"8","author":"Van Gasse","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.07.056_bib13","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.jaip.2018.01.020","article-title":"Cross-reactivity and tolerability of cephalosporins in patients with IgE-mediated hypersensitivity to penicillins","volume":"6","author":"Romano","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.07.056_bib14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jaci.2015.03.012","article-title":"IgE-mediated hypersensitivity to cephalosporins: cross-reactivity and tolerability of alternative cephalosporins","volume":"136","author":"Romano","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.07.056_bib15","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jmr.621","article-title":"Synthesis, characterization and immunochemical evaluation of cephalosporin antigenic determinants","volume":"16","author":"Sanchez-Sancho","year":"2003","journal-title":"J\u00a0Mol Recognit"},{"key":"10.1016\/j.jaip.2020.07.056_bib16","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1111\/j.1365-2222.1997.tb02987.x","article-title":"Allergic reactions to ampicillin. Studies on the specificity and selectivity in subjects with immediate reactions","volume":"27","author":"Romano","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2020.07.056_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jaci.2016.01.025","article-title":"Cross-reactivity and tolerability of aztreonam and cephalosporins in subjects with a T cell-mediated hypersensitivity to penicillins","volume":"138","author":"Romano","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.07.056_bib18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s11882-016-0594-9","article-title":"Cross-reactivity among beta-lactams","volume":"16","author":"Romano","year":"2016","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2020.07.056_bib19","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/imj.14229","article-title":"Immediate cephalosporin allergy","volume":"49","author":"Yuson","year":"2019","journal-title":"Intern Med J"},{"key":"10.1016\/j.jaip.2020.07.056_bib20","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jaip.2017.06.017","article-title":"The 3 Cs of antibiotic allergy-classification, cross-reactivity, and collaboration","volume":"5","author":"Trubiano","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.07.056_bib22","first-page":"398","article-title":"Prospective, multicenter clinical trial to validate new products for skin tests in the diagnosis of allergy to penicillin","volume":"23","author":"Fernandez","year":"2013","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2020.07.056_bib23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.anai.2018.09.459","article-title":"Penicillin minor determinants: history and relevance for current diagnosis","volume":"121","author":"Adkinson","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.07.056_bib24","article-title":"Improving the effectiveness of penicillin allergy de-labeling","volume":"3","author":"Bourke","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.07.056_bib25","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/cid\/cix244","article-title":"Impact of an integrated antibiotic allergy testing program on antimicrobial stewardship: a multicenter evaluation","volume":"65","author":"Trubiano","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2020.07.056_bib26","series-title":"StataCorp. Stata Statistical Software: Release 15","year":"2017"},{"key":"10.1016\/j.jaip.2020.07.056_bib27","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jaip.2016.05.011","article-title":"Cefazolin hypersensitivity: toward optimized diagnosis","volume":"4","author":"Uyttebroek","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.07.056_bib28","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/j.1365-2222.2005.02317.x","article-title":"Diagnosing immediate reactions to cephalosporins","volume":"35","author":"Romano","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2020.07.056_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.7326\/0003-4819-141-1-200407060-00010","article-title":"Cross-reactivity and tolerability of cephalosporins in patients with immediate hypersensitivity to penicillins","volume":"141","author":"Romano","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaip.2020.07.056_bib30","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0091-6749(96)70101-X","article-title":"Cross-reactivity between a penicillin and a cephalosporin with the same side chain","volume":"98","author":"Miranda","year":"1996","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.07.056_bib31","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jaip.2017.07.033","article-title":"Are cephalosporins safe for use in penicillin allergy without prior allergy evaluation?","volume":"6","author":"Macy","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.07.056_bib32","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1111\/all.13435","article-title":"Incidence of cephalosporin-induced anaphylaxis and clinical efficacy of screening intradermal tests with cephalosporins: a large multicenter retrospective cohort study","volume":"73","author":"Yang","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.07.056_bib33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/jama.2017.6510","article-title":"Penicillin allergy is not necessarily forever","volume":"318","author":"Trubiano","year":"2017","journal-title":"JAMA"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820308229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820308229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:51:06Z","timestamp":1778853066000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219820308229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S2213219820308229"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2020.07.056","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Testing Strategies and Predictors for Evaluating Immediate and Delayed Reactions to Cephalosporins","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2020.07.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}