{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:06:09Z","timestamp":1781143569560,"version":"3.54.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016040","name":"Takeda Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017255","name":"Allergy Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017255","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007343","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016300","name":"Octapharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016300","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jaip.2020.08.016","type":"journal-article","created":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T01:45:03Z","timestamp":1598060703000},"page":"735-744.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Increased Respiratory Viral Detection and Symptom Burden Among Patients with Primary Antibody Deficiency: Results from the BIPAD Study"],"prefix":"10.1016","volume":"9","author":[{"given":"Mark J.","family":"Ponsford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Farewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicky","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Cottrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael","family":"Steven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"El-Shanawany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Carne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Cousins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Vonarburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Jolles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2020.08.016_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1081-1206(10)60853-8","article-title":"Pulmonary complications of common variable immunodeficiency","volume":"98","author":"Busse","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib2","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/j.jaci.2010.02.040","article-title":"Infection outcomes in patients with common variable immunodeficiency disorders: relationship to immunoglobulin therapy over 22 years","volume":"125","author":"Lucas","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib3","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3389\/fimmu.2018.01837","article-title":"The lung in primary immunodeficiencies: new concepts in infection and inflammation","volume":"9","author":"Baumann","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib4","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.jaci.2011.03.041","article-title":"Longitudinal decline in lung function in patients with primary immunoglobulin deficiencies","volume":"127","author":"Chen","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10875-011-9511-0","article-title":"Effectiveness of immunoglobulin replacement therapy on clinical outcome in patients with primary antibody deficiencies: results from a multicenter prospective cohort study","volume":"31","author":"Quinti","year":"2011","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s10875-013-9942-x","article-title":"Activity, severity and impact of respiratory disease in primary antibody deficiency syndromes","volume":"34","author":"Hurst","year":"2014","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3389\/fimmu.2014.00629","article-title":"Is dosing of therapeutic immunoglobulins optimal? A review of a three-decade long debate in Europe","volume":"5","author":"Kerr","year":"2014","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib8","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jaci.2019.01.051","article-title":"Double-blind, placebo-controlled, randomized trial on low-dose azithromycin prophylaxis in patients with primary antibody deficiencies","volume":"144","author":"Milito","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/cei.12600","article-title":"Immune deficiency: changing spectrum of pathogens","volume":"181","author":"Duraisingham","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jaci.2010.04.016","article-title":"Recurrent and persistent respiratory tract viral infections in patients with primary hypogammaglobulinemia","volume":"126","author":"Kainulainen","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jaip.2017.05.024","article-title":"Respiratory infections and antibiotic usage in common variable immunodeficiency","volume":"6","author":"Sperlich","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.016_bib12","doi-asserted-by":"crossref","first-page":"E322","DOI":"10.1111\/1469-0691.12193","article-title":"Virus shedding after human rhinovirus infection in children, adults and patients with hypogammaglobulinaemia","volume":"19","author":"Peltola","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jaip.2020.08.016_bib14","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1183\/13993003.00535-2015","article-title":"The minimal important difference for the St George\u2019s Respiratory Questionnaire in patients with severe COPD","volume":"46","author":"Welling","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2020.08.016_bib15","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1002\/alr.22028","article-title":"Investigating the minimal clinically important difference for SNOT-22 symptom domains in surgically managed chronic rhinosinusitis","volume":"7","author":"Chowdhury","year":"2017","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2020.08.016_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/archinte.1958.00260140099015","article-title":"Transmission of the common cold to volunteers under controlled conditions, I: the common cold as a clinical entity","volume":"101","author":"Jackson","year":"1958","journal-title":"AMA Arch Intern Med"},{"key":"10.1016\/j.jaip.2020.08.016_bib17","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jviromet.2008.08.001","article-title":"Dry cotton or flocked respiratory swabs as a simple collection technique for the molecular detection of respiratory viruses using real-time NASBA","volume":"153","author":"Moore","year":"2008","journal-title":"J\u00a0Virol Methods"},{"key":"10.1016\/j.jaip.2020.08.016_bib18","doi-asserted-by":"crossref","first-page":"30119","DOI":"10.2807\/1560-7917.ES.2016.21.4.30119","article-title":"Cluster of atypical adult Guillain-Barr\u00e9 syndrome temporally associated with neurological illness due to EV-D68 in children, South Wales, United Kingdom, October 2015 to January 2016","volume":"21","author":"Williams","year":"2016","journal-title":"Eurosurveillance"},{"key":"10.1016\/j.jaip.2020.08.016_bib19","doi-asserted-by":"crossref","first-page":"788.e1","DOI":"10.1016\/j.cmi.2015.05.004","article-title":"Development of two real-time multiplex PCR assays for the detection and quantification of eight key bacterial pathogens in lower respiratory tract infections","volume":"21","author":"Gadsby","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jaip.2020.08.016_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaip.2015.07.025","article-title":"International Consensus Document (ICON): common variable immunodeficiency disorders","volume":"4","author":"Bonilla","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.016_bib21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.jaci.2017.09.027","article-title":"Association of rhinovirus species with common cold and asthma symptoms and bacterial pathogens","volume":"141","author":"Bashir","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib22","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1084\/jem.20161759","article-title":"Recurrent rhinovirus infections in a child with inherited MDA5 deficiency","volume":"214","author":"Lamborn","year":"2017","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaip.2020.08.016_bib23","doi-asserted-by":"crossref","first-page":"8342","DOI":"10.1073\/pnas.1704259114","article-title":"Severe viral respiratory infections in children with IFIH1 loss-of-function mutations","volume":"114","author":"Asgari","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaip.2020.08.016_bib24","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.aaa1578","article-title":"Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency","volume":"348","author":"Ciancanelli","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jaip.2020.08.016_bib25","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1542\/peds.2014-2132","article-title":"Duration of rhinovirus shedding in the upper respiratory tract in the first year of life","volume":"134","author":"Loeffelholz","year":"2014","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2020.08.016_bib26","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1136\/thoraxjnl-2016-209023","article-title":"A\u00a0prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD","volume":"72","author":"Wilkinson","year":"2017","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2020.08.016_bib27","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1378\/chest.129.2.317","article-title":"Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD","volume":"129","author":"Wilkinson","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2020.08.016_bib28","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1111\/resp.12197","article-title":"Exacerbation phenotyping in chronic obstructive pulmonary disease","volume":"18","author":"MacDonald","year":"2013","journal-title":"Respirology"},{"key":"10.1016\/j.jaip.2020.08.016_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12931-016-0483-8","article-title":"The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in\u00a0smokers and patients with chronic airflow limitation (CAL)","volume":"18","author":"Shukla","year":"2017","journal-title":"Respir Res"},{"key":"10.1016\/j.jaip.2020.08.016_bib30","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1096\/fj.06-5806fje","article-title":"H.\u00a0influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression","volume":"20","author":"Sajjan","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jaip.2020.08.016_bib31","doi-asserted-by":"crossref","first-page":"e1002969","DOI":"10.1371\/journal.ppat.1002969","article-title":"Rhinovirus attenuates non-typeable Hemophilus influenzae-stimulated IL-8 responses via TLR2-dependent degradation of IRAK-1","volume":"8","author":"Unger","year":"2012","journal-title":"PLOS Pathog"},{"key":"10.1016\/j.jaip.2020.08.016_bib32","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1093\/cid\/civ272","article-title":"Clinical outcomes associated with respiratory virus detection before allogeneic hematopoietic stem cell transplant","volume":"61","author":"Campbell","year":"2015","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2020.08.016_bib33","doi-asserted-by":"crossref","first-page":"e1003520","DOI":"10.1371\/journal.ppat.1003520","article-title":"An anti-human ICAM-1 antibody inhibits rhinovirus-induced exacerbations of lung inflammation","volume":"9","author":"Traub","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jaip.2020.08.016_bib34","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jsbmb.2018.11.013","article-title":"Vitamin D attenuates rhinovirus-induced expression of intercellular adhesion molecule-1 (ICAM-1) and platelet-activating factor receptor (PAFR) in respiratory epithelial cells","volume":"187","author":"Greiller","year":"2019","journal-title":"J\u00a0Steroid Biochem Mol Biol"},{"key":"10.1016\/j.jaip.2020.08.016_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12931-019-1057-3","article-title":"Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates","volume":"20","author":"Vonarburg","year":"2019","journal-title":"Respir Res"},{"key":"10.1016\/j.jaip.2020.08.016_bib36","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1038\/s41591-018-0211-7","article-title":"Expanded skin virome in DOCK8-deficient patients","volume":"24","author":"Tirosh","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.jaip.2020.08.016_bib37","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/s41591-020-0819-2","article-title":"Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19","volume":"26","author":"Thevarajan","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.jaip.2020.08.016_bib38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ni.3328","article-title":"Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events","volume":"17","author":"Sobolev","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaip.2020.08.016_bib39","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0140-6736(20)30567-5","article-title":"How will country-based mitigation measures influence the course of the COVID-19 epidemic?","volume":"395","author":"Anderson","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2020.08.016_bibE1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jviromet.2008.08.001","article-title":"Dry cotton or flocked respiratory swabs as a simple collection technique for the molecular detection of respiratory viruses using real-time NASBA","volume":"153","author":"Moore","year":"2008","journal-title":"J\u00a0Virol Methods"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820308321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820308321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:25:23Z","timestamp":1761974723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219820308321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S2213219820308321"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2020.08.016","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Respiratory Viral Detection and Symptom Burden Among Patients with Primary Antibody Deficiency: Results from the BIPAD Study","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2020.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}