{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T02:45:48Z","timestamp":1789526748946,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100002567","name":"American Academy of Allergy Asthma and Immunology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002567","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019212","name":"American Academy of Allergy, Asthma and Immunology Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.jaip.2020.08.018","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T11:47:26Z","timestamp":1598269646000},"page":"2958-2967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Patient Characteristics and Concerns about Drug Allergy: A Report from the United States Drug Allergy Registry"],"prefix":"10.1016","volume":"8","author":[{"given":"Kimberly G.","family":"Blumenthal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Harkness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Ramsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleena","family":"Banerji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upeka","family":"Samarakoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosby","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Otani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Carlos A.","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Donelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly G.","family":"Blumenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleena","family":"Banerji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Harkness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Upeka","family":"Samarakoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Ahola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen D.","family":"Judd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weaam","family":"Arman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosby","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald Eugene","family":"Osea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Ramsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Shahzad","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Blue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Otani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Autumn","family":"Guyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2020.08.018_bib1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.anai.2011.11.006","article-title":"Multiple drug intolerance syndrome: prevalence, clinical characteristics, and management","volume":"108","author":"Macy","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.08.018_bib2","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/all.12881","article-title":"Drug allergies documented in electronic health records of a large healthcare system","volume":"71","author":"Zhou","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.08.018_bib3","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.2018.19283","article-title":"Evaluation and management of penicillin allergy: a review","volume":"321","author":"Shenoy","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2020.08.018_bib4","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1016\/j.jaci.2009.10.028","article-title":"Drug allergy","volume":"125","author":"Khan","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.018_bib5","doi-asserted-by":"crossref","first-page":"e20170471","DOI":"10.1542\/peds.2017-0471","article-title":"Allergy testing in children with low-risk penicillin allergy symptoms","volume":"140","author":"Vyles","year":"2017","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2020.08.018_bib6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ajhp\/zxy043","article-title":"A\u00a0practical guide for pharmacists to successfully implement penicillin allergy skin testing","volume":"76","author":"Bland","year":"2019","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.jaip.2020.08.018_bib7","doi-asserted-by":"crossref","first-page":"ofw155","DOI":"10.1093\/ofid\/ofw155","article-title":"Implementation of an infectious disease fellow-managed penicillin allergy skin testing service","volume":"3","author":"Heil","year":"2016","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.jaip.2020.08.018_bib8","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.anai.2012.11.007","article-title":"Adverse reactions during drug challenges: a single US institution's experience","volume":"110","author":"Kao","year":"2013","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.08.018_bib9","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jaip.2015.05.014","article-title":"Reply: To PMID 25439369","volume":"3","author":"Iammatteo","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib10","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jaip.2017.04.045","article-title":"Designing predictive models for beta-lactam allergy using the drug allergy and hypersensitivity database","volume":"6","author":"Chiriac","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jaip.2019.09.025","article-title":"Multicenter Australian study to determine criteria for low- and high-risk penicillin testing in outpatients","volume":"8","author":"Stevenson","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib12","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jaip.2019.06.023","article-title":"A\u00a05-year retrospective review of outpatient graded drug challenges","volume":"8","author":"Lutz","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib13","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jaip.2018.05.008","article-title":"Safety and outcomes of oral graded challenges to amoxicillin without prior skin testing","volume":"7","author":"Iammatteo","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaip.2013.02.002","article-title":"Safely diagnosing clinically significant penicillin allergy using only penicilloyl-poly-lysine, penicillin, and oral amoxicillin","volume":"1","author":"Macy","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jaip.2013.01.006","article-title":"Treatment of patients with a history of penicillin allergy in a large tertiary-care academic hospital","volume":"1","author":"Picard","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciaa567","article-title":"Penicillin allergy evaluation access: a national survey [published online ahead of\u00a0print May 18, 2020].","author":"Mancini","year":"2020","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.jaip.2020.08.018_bib17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.anai.2017.04.023","article-title":"A\u00a0survey of inpatient practitioner knowledge of penicillin allergy at 2 community teaching hospitals","volume":"119","author":"Staicu","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.08.018_bib18","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1080\/00325481.2017.1370360","article-title":"Proactive penicillin allergy testing in primary care patients labeled as allergic: outcomes and barriers","volume":"129","author":"Sundquist","year":"2017","journal-title":"Postgrad Med"},{"key":"10.1016\/j.jaip.2020.08.018_bib21","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J\u00a0Gen Intern Med"},{"key":"10.1016\/j.jaip.2020.08.018_bib22","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A\u00a0brief measure for assessing\u00a0Generalized Anxiety Disorder: The GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch Int Med"},{"key":"10.1016\/j.jaip.2020.08.018_bib23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jaip.2016.09.041","article-title":"Identifying allergic drug reactions through placebo-controlled graded challenges","volume":"5","author":"Iammatteo","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib24","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jaip.2019.07.003","article-title":"Oral challenge with trimethoprim-sulfamethoxazole in patients with \u201csulfa\u201d antibiotic allergy","volume":"8","author":"Krantz","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib25","first-page":"129","article-title":"Assessment of validity and reliability of drug hypersensitivity quality of life questionnaire: the Dutch experience","volume":"49","author":"Moayeri","year":"2017","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.018_bib26","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.jaip.2019.02.036","article-title":"Patient and primary care physician perceptions of penicillin allergy testing and subsequent use of penicillin-containing antibiotics: a qualitative study","volume":"7","author":"Wanat","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib27","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.anai.2010.12.014","article-title":"Development and validation of the drug hypersensitivity quality of life questionnaire","volume":"106","author":"Baiardini","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2020.08.018_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11136-015-1051-2","article-title":"Turkish version of the drug hypersensitivity quality of life questionnaire: assessment of reliability and validity","volume":"25","author":"Bavbek","year":"2016","journal-title":"Qual Life Res"},{"key":"10.1016\/j.jaip.2020.08.018_bib29","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/intqhc\/mzy207","article-title":"Reliability and validity of the Thai drug hypersensitivity quality of life questionnaire: a multi-center study","volume":"31","author":"Chongpison","year":"2019","journal-title":"Int J Qual Health Care"},{"key":"10.1016\/j.jaip.2020.08.018_bib30","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1016\/j.jaip.2019.05.017","article-title":"Quality of life in patients with allergic reactions to medications: influence of a drug allergy evaluation","volume":"7","author":"Gastaminza","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mpr.1359","article-title":"Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States","volume":"21","author":"Kessler","year":"2012","journal-title":"Int J Methods Psychiatr Res"},{"key":"10.1016\/j.jaip.2020.08.018_bib32","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ypmed.2008.02.016","article-title":"Depression and anxiety associated with cardiovascular disease among persons aged 45 years and older in 38 states of the United States, 2006","volume":"46","author":"Fan","year":"2008","journal-title":"Prev Med"},{"key":"10.1016\/j.jaip.2020.08.018_bib33","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/13651500500443233","article-title":"Allergy to drugs: is there an association with mental ill-health?","volume":"10","author":"Bavbek","year":"2006","journal-title":"Int J Psychiatry Clin Pract"},{"key":"10.1016\/j.jaip.2020.08.018_bib34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11739-011-0510-1","article-title":"Allergy and psychologic evaluations of patients with multiple drug intolerance syndrome","volume":"7","author":"De Pasquale","year":"2012","journal-title":"Intern Emerg Med"},{"key":"10.1016\/j.jaip.2020.08.018_bib35","first-page":"138","article-title":"Multiple drug intolerance: allergological and psychological findings","volume":"1","author":"Patriarca","year":"1991","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.018_bib36","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.psym.2018.07.016","article-title":"Polyallergy (multiple chemical sensitivity) is associated with excessive healthcare utilization, greater psychotropic use, and greater mental health\/functional somatic syndrome disorder diagnoses: a large cohort retrospective study","volume":"60","author":"Jimenez","year":"2019","journal-title":"Psychosomatics"},{"key":"10.1016\/j.jaip.2020.08.018_bib37","first-page":"104","article-title":"Evaluation of the nocebo effect during oral challenge in patients with adverse drug reactions","volume":"14","author":"Liccardi","year":"2004","journal-title":"J\u00a0Investig Allergol Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820308345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820308345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:25:31Z","timestamp":1761974731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219820308345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S2213219820308345"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2020.08.018","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patient Characteristics and Concerns about Drug Allergy: A Report from the United States Drug Allergy Registry","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2020.08.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}