{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:03:04Z","timestamp":1788814984853,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014935","name":"BioCryst","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014935","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004321","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005629","name":"Viropharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005629","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","award":["K124557"],"award-info":[{"award-number":["K124557"]}],"id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jaip.2020.08.052","type":"journal-article","created":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T03:24:00Z","timestamp":1599535440000},"page":"947-955","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Importance of Complement Testing in Acquired Angioedema Related to Angiotensin-Converting Enzyme Inhibitors"],"prefix":"10.1016","volume":"9","author":[{"given":"Zsuzsanna","family":"Balla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna","family":"Zsilinszky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zs\u00f3fia","family":"P\u00f3lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Andr\u00e1si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinga Vikt\u00f3ria","family":"K\u0151halmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorottya","family":"Csuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2020.08.052_bib1","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH Guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaip.2020.08.052_bib2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2125.1995.tb04447.x","article-title":"Bronchospasm and cough as adverse reactions to the ACE inhibitors captopril, enalapril and lisinopril: a controlled retrospective cohort study","volume":"39","author":"Wood","year":"1995","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.jaip.2020.08.052_bib3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.7326\/0003-4819-117-3-234","article-title":"Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy: a review of the literature and pathophysiology","volume":"117","author":"Israili","year":"1992","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaip.2020.08.052_bib4","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0002-8703(96)90365-8","article-title":"Adverse effects of enalapril in the studies of left ventricular dysfunction (SOLVD)","volume":"131","author":"Kostis","year":"1996","journal-title":"Am Heart J"},{"key":"10.1016\/j.jaip.2020.08.052_bib5","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa0801317","article-title":"Telmisartan, ramipril, or both in patients at high risk for vascular events","volume":"358","author":"Yusuf","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2020.08.052_bib6","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.amjmed.2010.06.014","article-title":"Angiotensin-converting enzyme inhibitor associated cough: deceptive information from the physicians\u2019 desk reference","volume":"123","author":"Bangalore","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.jaip.2020.08.052_bib7","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1365-2753.2003.00484.x","article-title":"An evaluation of risk factors for adverse drug events associated with angiotensin-converting enzyme inhibitors","volume":"10","author":"Morimoto","year":"2004","journal-title":"J\u00a0Eval Clin Pract"},{"key":"10.1016\/j.jaip.2020.08.052_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11096-009-9288-x","article-title":"Incidence of risk factors for developing hyperkalemia when using ACE inhibitors in cardiovascular diseases","volume":"31","author":"Amir","year":"2009","journal-title":"Pharm World Sci"},{"key":"10.1016\/j.jaip.2020.08.052_bib9","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1111\/j.1755-5922.2010.00258.x","article-title":"Hyperkalemia associated with use of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers","volume":"30","author":"Raebel","year":"2012","journal-title":"Cardiovasc Ther"},{"key":"10.1016\/j.jaip.2020.08.052_bib10","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1161\/HYPERTENSIONAHA.108.110270","article-title":"Angioedema incidence in US veterans initiating angiotensin-converting enzyme inhibitors","volume":"51","author":"Miller","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.jaip.2020.08.052_bib11","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/archinte.165.14.1637","article-title":"Incidence and characteristics of angioedema associated with enalapril","volume":"165","author":"Kostis","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jaip.2020.08.052_bib12","first-page":"A4449","article-title":"Increasing rate of angiotensin-converting enzyme inhibitor-related upper airway angio-oedema","volume":"59","author":"Holm","year":"2012","journal-title":"Dan Med J"},{"key":"10.1016\/j.jaip.2020.08.052_bib13","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0140-6736(00)02596-4","article-title":"Vasopeptidase inhibition and angio-oedema","volume":"356","author":"Messerli","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2020.08.052_bib14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1517\/14656566.2013.778826","article-title":"Current pharmacotherapy of bradykinin-mediated angioedema","volume":"14","author":"Farkas","year":"2013","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.jaip.2020.08.052_bib15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/all.13270","article-title":"Hereditary angioedema with a mutation in the plasminogen gene","volume":"73","author":"Bork","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.08.052_bib16","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.jaci.2017.05.020","article-title":"Mutation of the angiopoietin-1 gene (ANGPT1) associates with a new type of hereditary angioedema","volume":"141","author":"Bafunno","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.052_bib17","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1111\/all.13869","article-title":"Hereditary angioedema cosegregating with a novel kininogen 1 gene mutation changing the N-terminal cleavage site of bradykinin","volume":"74","author":"Bork","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.08.052_bib18","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/all.12380","article-title":"Classification, diagnosis, and approach to treatment for angioedema: consensus report from the Hereditary Angioedema International Working Group","volume":"69","author":"Cicardi","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.08.052_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0196-9781(99)00020-0","article-title":"Des-Arg 9-bradykinin metabolism in patients who presented hypersensitivity reactions during hemodialysis: role of serum ACE and aminopeptidase P","volume":"20","author":"Blais","year":"1999","journal-title":"Peptides"},{"key":"10.1016\/j.jaip.2020.08.052_bib20","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1001\/archderm.1997.03890440040006","article-title":"Examination of baseline levels of carboxypeptidase N and complement components as potential predictors of angioedema associated with the use of an angiotensin-converting enzyme inhibitor","volume":"133","author":"Sigler","year":"1997","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaip.2020.08.052_bib21","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1016\/S0140-6736(02)08914-6","article-title":"Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors","volume":"359","author":"Adam","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2020.08.052_bib22","doi-asserted-by":"crossref","first-page":"106305","DOI":"10.1016\/j.intimp.2020.106305","article-title":"Bradykinin receptors: agonists, antagonists, expression, signaling, and adaptation to sustained stimulation","volume":"82","author":"Marceau","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaip.2020.08.052_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0163-7258(92)90016-S","article-title":"Bradykinin receptors: pharmacological properties and biological roles","volume":"56","author":"Hall","year":"1992","journal-title":"Pharmacol Therapeut"},{"key":"10.1016\/j.jaip.2020.08.052_bib24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1567-5769(02)00162-5","article-title":"Bradykinin and the pathophysiology of angioedema","volume":"3","author":"Cugno","year":"2003","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaip.2020.08.052_bib25","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1136\/bmj.38803.528113.55","article-title":"Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine","volume":"332","author":"McDowell","year":"2006","journal-title":"Br Med J"},{"key":"10.1016\/j.jaip.2020.08.052_bib26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0002-9343(91)90561-B","article-title":"Contraindications to the use of ACE inhibitors in patients with C1 esterase inhibitor deficiency","volume":"90","author":"Agostoni","year":"1991","journal-title":"Am J Med"},{"key":"10.1016\/j.jaip.2020.08.052_bib27","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1016\/j.jemermed.2019.10.031","article-title":"C1 esterase inhibitor for ACE-inhibitor angioedema: a case series and literature review","volume":"58","author":"Perza","year":"2020","journal-title":"J\u00a0Emerg Med"},{"key":"10.1016\/j.jaip.2020.08.052_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0022-1759(88)90160-3","article-title":"An ELISA technique for the measurement of Clq in cerebrospinal fluid","volume":"114","author":"Delamarche","year":"1988","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jaip.2020.08.052_bib29","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/0961203309357059","article-title":"C1-inhibitor autoantibodies in SLE","volume":"19","author":"M\u00e9sz\u00e1ros","year":"2010","journal-title":"Lupus"},{"key":"10.1016\/j.jaip.2020.08.052_bib30","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1067\/mai.2000.110471","article-title":"Frequent de novo mutations and exon deletions in the Cl inhibitor gene of patients with angioedema","volume":"106","author":"Pappalardo","year":"2000","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.08.052_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.iac.2006.08.002","article-title":"Acquired deficiency of the inhibitor of the first complement component: presentation, diagnosis, course, and conventional management","volume":"26","author":"Zingale","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2020.08.052_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13023-019-1043-3","article-title":"Angioedema due to acquired C1-inhibitor deficiency: spectrum and treatment with C1-inhibitor concentrate","volume":"14","author":"Bork","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.jaip.2020.08.052_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/cei.12910","article-title":"Comparing acquired angioedema with hereditary angioedema (types I\/II): findings from the icatibant outcome survey","volume":"188","author":"Longhurst","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaip.2020.08.052_bib34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.amjmed.2005.09.064","article-title":"Hereditary angioedema: new findings concerning symptoms, affected organs, and course","volume":"119","author":"Bork","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.jaip.2020.08.052_bib35","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/20009666.2019.1698259","article-title":"Clinical features of angioedema induced by renin-angiotensin-aldosterone system inhibition: a retrospective analysis of 84 patients","volume":"9","author":"Pfaue","year":"2019","journal-title":"J\u00a0Community Hospital Intern Med Perspect"},{"key":"10.1016\/j.jaip.2020.08.052_bib36","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/all.13397","article-title":"The EAACI\/GA2LEN\/EDF\/WAO guideline for the definition, classification, diagnosis and management of urticaria","volume":"73","author":"Zuberbier","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.08.052_bib37","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13601-018-0229-4","article-title":"Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey","volume":"8","author":"Zanichelli","year":"2018","journal-title":"Clin Translational Allergy"},{"key":"10.1016\/j.jaip.2020.08.052_bib38","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1177\/0009922815616886","article-title":"Pediatric hereditary angioedema: onset, diagnostic delay, and disease severity","volume":"55","author":"Christiansen","year":"2016","journal-title":"Clin Pediatr"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820309363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219820309363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:28:39Z","timestamp":1761974919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219820309363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S2213219820309363"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2020.08.052","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Importance of Complement Testing in Acquired Angioedema Related to Angiotensin-Converting Enzyme Inhibitors","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2020.08.052","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}