{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:32:31Z","timestamp":1791149551408,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jaip.2020.12.051","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T01:19:49Z","timestamp":1610587189000},"page":"2001-2009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Piperacillin-Tazobactam Hypersensitivity: A Large, Multicenter Analysis"],"prefix":"10.1016","volume":"9","author":[{"given":"Rosamund Sara","family":"Casimir-Brown","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Kennard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyindamola Stephanie","family":"Kayode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard Q.C.","family":"Siew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Makris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olympia","family":"Tsilochristou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Chytiroglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Nakonechna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Rutkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Mirakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2020.12.051_bib3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1034\/j.1398-9995.2000.00725.x","article-title":"Selective hypersensitivity to piperacillin","volume":"55","author":"Romano","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.23822\/EurAnnACI.1764-1489.29","article-title":"Piperacillin-tazobactam anaphylaxis: a rare cause of occupational disease","volume":"50","author":"Gaspar-Marques","year":"2018","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.12.051_bib5","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3346\/jkms.2011.26.5.682","article-title":"A\u00a0case of piperacillin-induced occupational anaphylaxis: detection of serum IgE to piperacillin-HSA conjugate","volume":"26","author":"Kim","year":"2011","journal-title":"J\u00a0Korean Med Sci"},{"key":"10.1016\/j.jaip.2020.12.051_bib6","first-page":"132","article-title":"Fixed drug eruption caused by piperacillin-tazobactam","volume":"23","author":"Santosa","year":"2013","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2020.12.051_bib7","article-title":"Generalized fixed drug eruption to piperacillin\/tazobactam and review of literature","volume":"24","author":"Kornmehl","year":"2018","journal-title":"UC Davis Dermatol Online J"},{"key":"10.1016\/j.jaip.2020.12.051_bib8","first-page":"425","article-title":"Piperacillin-induced DRESS: distinguishing features observed in a clinical and allergy study of 8 patients","volume":"24","author":"Caba\u00f1as","year":"2014","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2020.12.051_bib9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jaip.2015.03.008","article-title":"DRESS induced by piperacillin-tazobactam in a child","volume":"3","author":"Gonzalez Diaz","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.12.051_bib10","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jaad.2004.08.030","article-title":"Acute generalized exanthematous pustulosis caused by piperacillin\/tazobactam","volume":"52","author":"Grieco","year":"2005","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.jaip.2020.12.051_bib11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/MJT.0b013e31818d5f6d","article-title":"Acute generalized exanthematous pustulosis: a rare clinical entity with use of piperacillin\/tazobactam","volume":"16","author":"Talati","year":"2009","journal-title":"Am J Ther"},{"key":"10.1016\/j.jaip.2020.12.051_bib12","first-page":"3273987","article-title":"Piperacillin\/tazobactam as cause of acute generalized exanthematous pustulosis","volume":"2019","author":"Kyriakou","year":"2019","journal-title":"Case Rep Dermatol Med"},{"key":"10.1016\/j.jaip.2020.12.051_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.5021\/ad.2016.28.1.98","article-title":"Piperacillin\/tazobactam-associated hypersensitivity syndrome with overlapping features of acute generalized exanthematous pustulosis and drug-related rash with eosinophilia and systemic symptoms syndrome","volume":"28","author":"Kim","year":"2016","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.jaip.2020.12.051_bib14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/ced.13030","article-title":"Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome\/toxic epidermal necrolysis overlap","volume":"42","author":"Adler","year":"2017","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jaip.2020.12.051_bib15","doi-asserted-by":"crossref","first-page":"460","DOI":"10.18203\/2349-3933.ijam20181091","article-title":"Piperacillin\/tazobactam induced toxic epidermal necrolysis and drug induced liver injury","volume":"5","author":"Deep","year":"2018","journal-title":"Int J Adv Med"},{"key":"10.1016\/j.jaip.2020.12.051_bib16","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/cid\/ciu126","article-title":"Severe cutaneous adverse reactions related to systemic antibiotics","volume":"58","author":"Lin","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2020.12.051_bib17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1440-1754.1998.00197.x","article-title":"Antibiotic hypersensitivity reactions in cystic fibrosis","volume":"34","author":"Wills","year":"1998","journal-title":"J\u00a0Paediatr Child Health"},{"key":"10.1016\/j.jaip.2020.12.051_bib18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0335-7457(02)00177-6","article-title":"Antibiotics allergy in cystic fibrosis","volume":"42","author":"Just","year":"2002","journal-title":"Rev Fr d\u2019Allergologie d\u2019Immunologie Clin"},{"key":"10.1016\/j.jaip.2020.12.051_bib19","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/thx.2004.027953","article-title":"Antibiotic allergy in cystic fibrosis","volume":"60","author":"Parmar","year":"2005","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2020.12.051_bib20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.2018.19283","article-title":"Evaluation and management of penicillin allergy: a review","volume":"321","author":"Shenoy","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2020.12.051_bib21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jaip.2018.07.051","article-title":"Controversies in drug allergy: beta-lactam hypersensitivity testing","volume":"7","author":"Torres","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.12.051_bib22","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/all.14122","article-title":"Towards a more precise diagnosis of hypersensitivity to beta-lactams \u2014 an EAACI position paper","volume":"75","author":"Romano","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib23","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1398-9995.2008.01691.x","article-title":"Delayed hypersensitivity to acylureidopenicillins: a case report","volume":"63","author":"Gaeta","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaip.2017.08.027","article-title":"Cross-reactivity in \u03b2-lactam allergy","volume":"6","author":"Zagursky","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.12.051_bib25","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/j.jaip.2019.03.018","article-title":"Flucloxacillin hypersensitivity: patient outcomes in a multicenter retrospective study","volume":"7","author":"Kennard","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.12.051_bib26","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1016\/j.jaip.2020.04.008","article-title":"Sensitization phenotypes in immediate reactions to piperacillin-tazobactam","volume":"8","author":"Gallardo","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.12.051_bib27","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jaip.2017.06.017","article-title":"The 3 Cs of antibiotic allergy\u2014classification, cross-reactivity, and collaboration","volume":"5","author":"Trubiano","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.12.051_bib28","first-page":"275","article-title":"Drug allergy and potentially inappropriate medication in hospitalised patients","volume":"40","author":"Pfister","year":"2018","journal-title":"Int J Clin Pharm"},{"key":"10.1016\/j.jaip.2020.12.051_bib29","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/all.12350","article-title":"International Consensus on drug allergy","volume":"69","author":"Demoly","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jaci.2004.04.029","article-title":"Clinical features and severity grading of anaphylaxis","volume":"114","author":"Brown","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.12.051_bib31","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4168\/aair.2014.6.3.216","article-title":"Comparison of diagnostic criteria and determination of prognostic factors for drug reaction with eosinophilia and systemic symptoms syndrome","volume":"6","author":"Kim","year":"2014","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaip.2020.12.051_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-7022-2-10","article-title":"Comprehensive allergy work-up is mandatory in cystic fibrosis patients who report a history suggestive of drug allergy to beta-lactam antibiotics","volume":"2","author":"Caimmi","year":"2012","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11882-014-0476-y","article-title":"Penicillin and beta-lactam allergy: epidemiology and diagnosis","volume":"14","author":"Macy","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2020.12.051_bib34","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.jaip.2018.09.014","article-title":"The safety of antibiotic skin testing in severe T cell mediated hypersensitivity in immunocompetent and immunocompromised hosts","volume":"7","author":"Trubiano","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.12.051_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jaci.2018.10.030","article-title":"Controversies in drug allergy: testing for delayed reactions","volume":"143","author":"Phillips","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.12.051_bib36","doi-asserted-by":"crossref","first-page":"AB172","DOI":"10.1016\/j.jaci.2012.12.1275","article-title":"DRESS syndrome induced by piperacillin-tazobactam in eight patients","volume":"131","author":"Calderon","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.12.051_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jaci.2017.11.002","article-title":"Drug hypersensitivity: we need to do more","volume":"141","author":"Pichler","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2020.12.051_bib38","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jaip.2016.10.008","article-title":"HLA B62 as a possible risk factor for drug reaction with eosinophilia and systemic symptoms to piperacillin\/tazobactam","volume":"5","author":"Rutkowski","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.12.051_bib39","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1034\/j.1398-9995.2003.00280.x","article-title":"Diagnosis of immediate allergic reactions to beta-lactam antibiotics","volume":"58","author":"Torres","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib40","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1034\/j.1398-9995.2003.00279.x","article-title":"Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations","volume":"58","author":"Aberer","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib41","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1021\/acs.chemrestox.7b00291","article-title":"Assessment of antipiperacillin IgG binding to structurally related drug protein adducts","volume":"30","author":"Amali","year":"2017","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.jaip.2020.12.051_bib42","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1034\/j.1398-9995.2002.23612.x","article-title":"Delayed hypersensitivity to piperacillin","volume":"57","author":"Romano","year":"2002","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib43","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1046\/j.1365-2222.1999.00575.x","article-title":"Penicillins and cephalosporins as allergens\u2014structural aspects of recognition and cross-reactions","volume":"29","author":"Baldo","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib44","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.jaip.2019.06.018","article-title":"Optimizing penicillin allergy delabeling: one big step forward and several small steps sideways","volume":"7","author":"Macy","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2020.12.051_bib45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11882-019-0854-6","article-title":"Evaluating penicillin allergies without skin testing","volume":"19","author":"Banks","year":"2019","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2020.12.051_bib46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/pharmacy7030077","article-title":"Allergic reactions and cross-reactivity potential with beta-lactamase inhibitors","volume":"7","author":"Stover","year":"2019","journal-title":"Pharmacy"},{"key":"10.1016\/j.jaip.2020.12.051_bib47","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1398-9995.2007.01418.x","article-title":"Anaphylaxis to piperacillin\/tazobactam despite a negative penicillin skin test","volume":"62","author":"Rank","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib48","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1111\/all.12299","article-title":"Absence of cross-reactivity to carbapenems in patients with delayed hypersensitivity to penicillins","volume":"68","author":"Romano","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2020.12.051_bib49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000458725","article-title":"Multiple drug hypersensitivity","volume":"172","author":"Pichler","year":"2017","journal-title":"Int Arch Allergy Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219821000416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219821000416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:28:08Z","timestamp":1761974888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219821000416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S2213219821000416"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2020.12.051","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Piperacillin-Tazobactam Hypersensitivity: A Large, Multicenter Analysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2020.12.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}