{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:58:51Z","timestamp":1791295131557,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007723","name":"Takeda Pharmaceuticals U.S.A.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013995","name":"Sanofi Genzyme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017255","name":"Allergy Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017255","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004321","name":"Shire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jaip.2021.01.035","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T12:22:16Z","timestamp":1612527736000},"page":"1871-1878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Treatment Effect of the Tree Pollen SLIT-Tablet on Allergic Rhinoconjunctivitis During Oak Pollen Season"],"prefix":"10.1016","volume":"9","author":[{"given":"Hendrik","family":"Nolte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Waserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne K.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilo","family":"Biedermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"W\u00fcrtzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2021.01.035_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000151243","article-title":"The principle of homologous groups in regulatory affairs of allergen products\u2014a proposal","volume":"148","author":"Lorenz","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib2","series-title":"Guideline on Allergen Products: Production and Quality Issues. EMEA\/CHMP\/BWP\/304831. Committee for Medicinal Products for Human Use","year":"2008"},{"key":"10.1016\/j.jaip.2021.01.035_bib3","series-title":"Guideline on the Clinical Development of Products for Specific Immunotherapy for the Treatment of Allergic Diseases. CHMP\/EWP\/18504. Committee for Medicinal Products for Human Use","year":"2008"},{"key":"10.1016\/j.jaip.2021.01.035_bib4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.09.034","article-title":"Allergen immunotherapy: a practice parameter third update","volume":"127","author":"Cox","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib5","first-page":"253","article-title":"Hypersensitivity to common tree pollens in New York City patients","volume":"23","author":"Lin","year":"2002","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2021.01.035_bib6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.2500\/108854182779089391","article-title":"A\u00a0new look at New England tree pollen","volume":"3","author":"Farnham","year":"1982","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2021.01.035_bib7","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/j.1398-9995.2009.02089.x","article-title":"GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe","volume":"64","author":"Burbach","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.01.035_bib8","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4168\/aair.2014.6.5.434","article-title":"Changes in allergen sensitization over the last 30 years in Korea respiratory allergic patients: a single-center","volume":"6","author":"Park","year":"2014","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.jaip.2021.01.035_bib9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13223-019-0320-y","article-title":"Retrospective analysis of aeroallergen's sensitization patterns in Edmonton, Canada","volume":"15","author":"Ahmed","year":"2019","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib10","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1111\/j.1398-9995.2010.02399.x","article-title":"Geographical variations in the prevalence of atopic sensitization in six study sites across Canada","volume":"65","author":"Chan-Yeung","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.01.035_bib11","author":"Rankin"},{"key":"10.1016\/j.jaip.2021.01.035_bib12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1081-1206(10)61509-8","article-title":"Key pollen allergens in North America","volume":"91","author":"White","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.scitotenv.2019.01.212","article-title":"Oak pollen seasonality and severity across Europe and modelling the season start using a generalized phenological model","volume":"663","author":"Grundstrom","year":"2019","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jaip.2021.01.035_bib15","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00484-013-0674-7","article-title":"Climate change effect on Betula (birch) and Quercus (oak) pollen seasons in the United States","volume":"58","author":"Zhang","year":"2014","journal-title":"Int J Biometeorol"},{"key":"10.1016\/j.jaip.2021.01.035_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.anai.2010.01.005","article-title":"Pollen aeroallergens in the Washington, DC, metropolitan area: a 10-year volumetric survey (1998-2007)","volume":"104","author":"Kosisky","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12940-015-0057-0","article-title":"The associations between daily spring pollen counts, over-the-counter allergy medication sales, and asthma syndrome emergency department visits in New York City, 2002-2012","volume":"14","author":"Ito","year":"2015","journal-title":"Environ Health"},{"key":"10.1016\/j.jaip.2021.01.035_bib18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1159\/000116360","article-title":"Tree pollen and hospitalization for asthma in urban Canada","volume":"146","author":"Dales","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib19","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jaci.2012.06.020","article-title":"Ambient pollen concentrations and emergency department visits for asthma and wheeze","volume":"130","author":"Darrow","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib20","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/all.13606","article-title":"A\u00a0birch sublingual allergy immunotherapy tablet reduces rhinoconjunctivitis symptoms when exposed to birch and oak and induces IgG4 to allergens from all trees in the birch homologous group","volume":"74","author":"Couroux","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.01.035_bib21","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.clinthera.2018.02.012","article-title":"Immunotherapy with the SQ tree SLIT-tablet in adults and adolescents with allergic rhinoconjunctivitis","volume":"40","author":"Makela","year":"2018","journal-title":"Clin Ther"},{"key":"10.1016\/j.jaip.2021.01.035_bib22","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.jaci.2018.12.1001","article-title":"The SQ tree SLIT-tablet is highly effective and well tolerated: results from a randomized, double-blind, placebo-controlled phase III trial","volume":"143","author":"Biedermann","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib23","doi-asserted-by":"crossref","first-page":"S147","DOI":"10.1067\/mai.2001.118891","article-title":"Allergic rhinitis and its impact on asthma","volume":"108","author":"Bousquet","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib24","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1081-1206(10)61576-1","article-title":"Montelukast for treating fall allergic rhinitis: effect of pollen exposure in 3 studies","volume":"92","author":"Chervinsky","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib25","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.jaci.2013.03.019","article-title":"Randomized controlled trial of a ragweed allergy immunotherapy tablet in North American and European adults","volume":"131","author":"Creticos","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib26","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jaci.2010.11.035","article-title":"Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults","volume":"127","author":"Nelson","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10453-011-9221-3","article-title":"Allergy symptoms in relation to alder and birch pollen concentrations in Finland","volume":"28","author":"Jantunen","year":"2012","journal-title":"Aerobiologia"},{"key":"10.1016\/j.jaip.2021.01.035_bib28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2222.1978.tb00474.x","article-title":"The seasonal symptoms of hyposensitized and untreated hay fever patients in relation to birch pollen counts: correlations with nasal sensitivity, prick tests and RAST","volume":"8","author":"Viander","year":"1978","journal-title":"Clin Allergy"},{"key":"10.1016\/j.jaip.2021.01.035_bib29","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000234576","article-title":"Pollen count, symptom and medicine score in birch pollinosis. A mathematical approach","volume":"86","author":"Taudorf","year":"1988","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib30","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000355630","article-title":"Effects of airborne birch pollen levels on clinical symptoms of seasonal allergic rhinoconjunctivitis","volume":"163","author":"Caillaud","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib31","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.jaci.2015.11.025","article-title":"Rapid recruitment of CD14(+) monocytes in experimentally induced allergic rhinitis in human subjects","volume":"137","author":"Egu\u00edluz-Gracia","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib32","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.4049\/jimmunol.165.7.4062","article-title":"Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy","volume":"165","author":"Jahnsen","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib33","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jaci.2020.02.037","article-title":"Defining biomarkers to predict symptoms in subjects with and without allergy under natural pollen exposure","volume":"147","author":"Gokkaya","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib34","doi-asserted-by":"crossref","first-page":"136861","DOI":"10.1016\/j.scitotenv.2020.136861","article-title":"Cross-reactivity between the Betulaceae family and fallout in the real atmospheric aeroallergen load","volume":"715","author":"Fern\u00e1ndez-Gonz\u00e1lez","year":"2020","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jaip.2021.01.035_bib35","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1067\/mai.2000.109621","article-title":"Basophil and eosinophil accumulation and mast cell degranulation in the nasal mucosa of patients with hay fever after local allergen provocation","volume":"106","author":"KleinJan","year":"2000","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib36","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/all.12373","article-title":"Magnitude of efficacy measurements in grass allergy immunotherapy trials is highly dependent on pollen exposure","volume":"69","author":"Durham","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.01.035_bib37","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1111\/j.1365-2222.2011.03866.x","article-title":"Bet v 1-like pollen allergens of multiple Fagales species can sensitize atopic individuals","volume":"41","author":"Hauser","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2021.01.035_bib38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0091-6749(98)70273-8","article-title":"Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations","volume":"102","author":"Niederberger","year":"1998","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.01.035_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1398-9995.1972.tb01638.x","article-title":"An investigation of pollen extracts from different deciduous trees in patients with springtime allergy in Sweden","volume":"27","author":"Zetterstrom","year":"1972","journal-title":"Acta Allergol"},{"key":"10.1016\/j.jaip.2021.01.035_bib40","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2222.2009.03207.x","article-title":"Immunoglobulin G4: an odd antibody","volume":"39","author":"Aalberse","year":"2009","journal-title":"Clin Exp Allergy"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321982100163X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321982100163X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:26:15Z","timestamp":1761974775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221321982100163X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S221321982100163X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2021.01.035","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment Effect of the Tree Pollen SLIT-Tablet on Allergic Rhinoconjunctivitis During Oak Pollen Season","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2021.01.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}