{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:24:47Z","timestamp":1792106687506,"version":"4.4.0"},"reference-count":109,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jaip.2021.03.029","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T04:52:23Z","timestamp":1616820743000},"page":"1769-1778","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"title":["Immunological Responses and Biomarkers for Allergen-Specific Immunotherapy Against Inhaled Allergens"],"prefix":"10.1016","volume":"9","author":[{"given":"Mohamed H.","family":"Shamji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice A.","family":"Layhadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanisah","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Penagos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Durham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2021.03.029_bib1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/all.13749","article-title":"EAACI Guidelines on Allergen Immunotherapy: house dust mite-driven allergic asthma","volume":"74","author":"Agache","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/all.13317","article-title":"EAACI Guidelines on Allergen Immunotherapy: allergic rhinoconjunctivitis","volume":"73","author":"Roberts","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaci.2010.09.034","article-title":"Allergen immunotherapy: a practice parameter third update","volume":"127","author":"Cox","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib4","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0091-6749(96)70205-1","article-title":"Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma","volume":"97","author":"Durham","year":"1996","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib5","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jaci.2011.12.973","article-title":"SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial","volume":"129","author":"Durham","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib6","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1056\/NEJM199908123410702","article-title":"Long-term clinical efficacy of grass-pollen immunotherapy","volume":"341","author":"Durham","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2021.03.029_bib7","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/ACI.0000000000000585","article-title":"Duration of allergen immunotherapy for inhalant allergy","volume":"19","author":"Penagos","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0091-6749(91)90297-2","article-title":"Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity","volume":"88","author":"Furin","year":"1991","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib9","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.4049\/jimmunol.172.5.3252","article-title":"Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity","volume":"172","author":"Nouri-Aria","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib10","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1067\/mai.2001.115483","article-title":"Grass pollen immunotherapy: symptomatic improvement correlates with reductions in eosinophils and IL-5 mRNA expression in the nasal mucosa during the pollen season","volume":"107","author":"Wilson","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/ACI.0000000000000216","article-title":"Effect of allergen-specific immunotherapy on CD4+ T cells","volume":"15","author":"Wambre","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib12","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jaci.2011.08.034","article-title":"Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy","volume":"129","author":"Wambre","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib13","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.jaci.2018.06.041","article-title":"Role of IL-35 in sublingual allergen immunotherapy","volume":"143","author":"Shamji","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.jaci.2007.06.013","article-title":"Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation","volume":"120","author":"Bohle","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib15","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.jaci.2008.03.013","article-title":"Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa","volume":"121","author":"Radulovic","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib16","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1164\/rccm.200905-0686OC","article-title":"House dust mite sublingual immunotherapy: the role for transforming growth factor-beta and functional regulatory T cells","volume":"180","author":"O\u2019Hehir","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2021.03.029_bib17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/j.1365-2222.2010.03462.x","volume":"40","author":"Scadding","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib18","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.jaci.2020.10.035","article-title":"Altered chromatin landscape in circulating T follicular helper and regulatory cells following grass pollen subcutaneous and sublingual immunotherapy","volume":"147","author":"Sharif","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib19","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1111\/j.1365-2222.1997.tb01252.x","article-title":"Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen","volume":"27","author":"Ebner","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ebiom.2018.09.016","article-title":"Early IL-10 producing B-cells and coinciding Th\/Tr17 shifts during three year grass-pollen AIT","volume":"36","author":"Zissler","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jaip.2021.03.029_bib21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/ACI.0000000000000400","article-title":"The role of regulatory B cells in allergen immunotherapy","volume":"17","author":"van de Veen","year":"2017","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib22","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jaci.2016.07.006","article-title":"Role of regulatory B cells in immune tolerance to allergens and beyond","volume":"138","author":"van de Veen","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib23","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jaci.2013.01.014","article-title":"IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses","volume":"131","author":"van de Veen","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib24","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.jaci.2018.10.061","article-title":"Role of Der p 1-specific B cells in immune tolerance during 2 years of house dust mite-specific immunotherapy","volume":"143","author":"Boonpiyathad","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib25","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11882-020-00977-7","article-title":"Mechanisms of allergen immunotherapy in allergic rhinitis","volume":"21","author":"Drazdauskaite","year":"2020","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2021.03.029_bib26","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.jaci.2019.04.027","article-title":"Blocking histone deacetylase activity as a novel target for epithelial barrier defects in patients with allergic rhinitis","volume":"144","author":"Steelant","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib27","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/ni.2104","article-title":"Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161","volume":"12","author":"Mjosberg","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jaci.2015.09.015","article-title":"Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy","volume":"137","author":"Gueguen","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib29","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jaci.2015.07.025","article-title":"Nasal IL-4(+)CXCR5(+)CD4(+) T follicular helper cell counts correlate with local IgE production in eosinophilic nasal polyps","volume":"137","author":"Zhang","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jaci.2018.03.008","article-title":"Correlation of allergen-specific T follicular helper cell counts with specific IgE levels and efficacy of allergen immunotherapy","volume":"142","author":"Yao","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib31","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/S0091-6749(97)70276-8","article-title":"The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells","volume":"100","author":"Punnonen","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib32","doi-asserted-by":"crossref","first-page":"S382","DOI":"10.1016\/S0091-6749(99)70216-2","article-title":"Clinical manifestations of the release of histamine and other inflammatory mediators","volume":"103","author":"Naclerio","year":"1999","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib33","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1128\/MCB.15.8.4149","article-title":"Activation of the high-affinity immunoglobulin E receptor Fc epsilon RI in RBL-2H3 cells is inhibited by Syk SH2 domains","volume":"15","author":"Taylor","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jaip.2021.03.029_bib34","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1172\/JCI117650","article-title":"Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells","volume":"95","author":"Iademarco","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2021.03.029_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1165\/ajrcmb.14.1.8534490","article-title":"Role of interleukin-4 and vascular cell adhesion molecule-1 in selective eosinophil migration into the airways in allergic asthma","volume":"14","author":"Fukuda","year":"1996","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaip.2021.03.029_bib36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jaci.2015.01.021","article-title":"TH9 cells are required for tissue mast cell accumulation during allergic inflammation","volume":"136","author":"Sehra","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/rr41","article-title":"Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic disease","volume":"2","author":"Greenfeder","year":"2001","journal-title":"Respir Res"},{"key":"10.1016\/j.jaip.2021.03.029_bib38","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1172\/JCI119341","article-title":"Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids","volume":"99","author":"Lilly","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2021.03.029_bib39","doi-asserted-by":"crossref","first-page":"L907","DOI":"10.1152\/ajplung.00120.2003","article-title":"IL-13 and IL-4 promote TARC release in human airway smooth muscle cells: role of IL-4 receptor genotype","volume":"285","author":"Faffe","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jaip.2021.03.029_bib40","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/35100503","article-title":"Role of chemokines in the pathogenesis of asthma","volume":"1","author":"Lukacs","year":"2001","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib41","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.jaci.2008.01.072","article-title":"Grass pollen immunotherapy: IL-10 induction and suppression of late responses precedes IgG4 inhibitory antibody activity","volume":"121","author":"Francis","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0091-6749(97)70240-9","article-title":"A\u00a0double-blind study of the discontinuation of ragweed immunotherapy","volume":"100","author":"Naclerio","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1398-9995.2011.02745.x","article-title":"Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy","volume":"67","author":"Shamji","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jaci.2009.10.035","article-title":"Long-term clinical efficacy in grass pollen-induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet","volume":"125","author":"Durham","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib45","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13601-015-0057-8","article-title":"Prolonged efficacy of the 300IR 5-grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score","volume":"5","author":"Didier","year":"2015","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib46","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/jama.2016.21040","article-title":"Effect of 2 years of treatment with sublingual grass pollen immunotherapy on nasal response to allergen challenge at 3 years among patients with moderate to severe seasonal allergic rhinitis: the GRASS randomized clinical trial","volume":"317","author":"Scadding","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2021.03.029_bib47","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1398-9995.2007.01451.x","article-title":"Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study","volume":"62","author":"Jacobsen","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib48","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jaci.2017.06.014","article-title":"Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy","volume":"141","author":"Valovirta","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib49","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jaci.2010.11.030","article-title":"Mechanisms of allergen-specific immunotherapy","volume":"127","author":"Akdis","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib50","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jaci.2017.10.010","article-title":"Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers","volume":"140","author":"Shamji","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib51","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1365-2222.2011.03804.x","article-title":"Mechanisms of immunotherapy to aeroallergens","volume":"41","author":"Shamji","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib52","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jaci.2012.02.014","article-title":"A\u00a0regulatory dendritic cell signature correlates with the clinical efficacy of allergen-specific sublingual immunotherapy","volume":"129","author":"Zimmer","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib53","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s12519-011-0242-3","article-title":"Dendritic cells modification during sublingual immunotherapy in children with allergic symptoms to house dust mites","volume":"7","author":"Angelini","year":"2011","journal-title":"World J Pediatr"},{"key":"10.1016\/j.jaip.2021.03.029_bib54","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1067\/mai.2001.117177","article-title":"Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells","volume":"108","author":"Bellinghausen","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib55","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0008-8749(02)00021-7","article-title":"Human peripheral blood monocyte-derived interleukin-10-induced semi-mature dendritic cells induce anergic CD4(+) and CD8(+) T cells via presentation of the internalized soluble antigen and cross-presentation of the phagocytosed necrotic cellular fragments","volume":"215","author":"Sato","year":"2002","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib56","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1067\/mai.2003.1570","article-title":"Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy","volume":"111","author":"Francis","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib57","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jaci.2012.04.021","article-title":"Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy","volume":"130","author":"Swamy","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib58","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1084\/jem.194.5.629","article-title":"Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta","volume":"194","author":"Nakamura","year":"2001","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaip.2021.03.029_bib59","doi-asserted-by":"crossref","first-page":"4773","DOI":"10.4049\/jimmunol.165.9.4773","article-title":"Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression","volume":"165","author":"Gorelik","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib60","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.4049\/jimmunol.178.7.4658","article-title":"Grass pollen immunotherapy induces an allergen-specific IgA2 antibody response associated with mucosal TGF-beta expression","volume":"178","author":"Pilette","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib61","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0091-6749(97)70106-4","article-title":"Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy","volume":"99","author":"Hamid","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib62","doi-asserted-by":"crossref","first-page":"AB203","DOI":"10.1016\/j.jaci.2012.12.1393","article-title":"Immunomodulatory effects of IL-27 on allergen-induced Th2 responses","volume":"131","author":"Matsuoka","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib63","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jaci.2010.12.1080","article-title":"Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies","volume":"127","author":"James","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib64","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jaci.2005.06.004","article-title":"Allergen-specific immunotherapy with recombinant grass pollen allergens","volume":"116","author":"Jutel","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib65","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0091-6749(03)02022-0","article-title":"Inhibition of allergen-IgE binding to B cells by IgG antibodies after grass pollen immunotherapy","volume":"112","author":"Wachholz","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib66","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1046\/j.0954-7894.2002.01327.x","article-title":"Grass pollen sublingual immunotherapy for seasonal rhinoconjunctivitis: a randomized controlled trial","volume":"32","author":"Lima","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib67","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jaci.2005.12.1358","article-title":"Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis","volume":"117","author":"Durham","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib68","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.4049\/jimmunol.163.5.2944","article-title":"Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation","volume":"163","author":"van Neerven","year":"1999","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib69","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/all.13138","article-title":"Biomarkers for monitoring clinical efficacy of allergen immunotherapy for allergic rhinoconjunctivitis and allergic asthma: an EAACI position paper","volume":"72","author":"Shamji","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib70","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1046\/j.1365-2222.1999.00653.x","article-title":"The recombinant allergen-based concept of component-resolved diagnostics and immunotherapy (CRD and CRIT)","volume":"29","author":"Valenta","year":"1999","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib71","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jaci.2011.10.045","article-title":"Molecular profiles of IgE to Phleum pratense in children with grass pollen allergy: implications for specific immunotherapy","volume":"129","author":"Tripodi","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib72","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jaci.2018.12.1021","article-title":"Molecular diagnosis for allergen immunotherapy","volume":"143","author":"Matricardi","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib73","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jaci.2016.08.014","article-title":"Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life","volume":"139","author":"Posa","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib74","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/all.13338","article-title":"Diagnostic relevance of IgE sensitization profiles to eight recombinant Phleum pratense molecules","volume":"73","author":"Cipriani","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib75","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1365-2362.2008.02048.x","article-title":"Variability of IgE reactivity profiles among European mite allergic patients","volume":"38","author":"Weghofer","year":"2008","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jaip.2021.03.029_bib76","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40413-018-0199-y","article-title":"Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study","volume":"11","author":"Mothes-Luksch","year":"2018","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaip.2021.03.029_bib77","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000477442","article-title":"Greater real-life diagnostic efficacy of allergen molecule-based diagnosis for prescription of immunotherapy in an area with multiple pollen exposure","volume":"173","author":"Saltabayeva","year":"2017","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib78","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jaci.2020.03.029","article-title":"Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy","volume":"146","author":"Rodriguez-Dominguez","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib79","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1398-9995.2011.02728.x","article-title":"Practical guide to skin prick tests in allergy to aeroallergens","volume":"67","author":"Bousquet","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib80","first-page":"430","article-title":"Immunotherapy with a standardized Dermatophagoides pteronyssinus extract, V: duration of the efficacy of immunotherapy after its cessation","volume":"51","author":"Des Roches","year":"1996","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib81","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/sj.cr.7290301","article-title":"Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulation","volume":"15","author":"Hennersdorf","year":"2005","journal-title":"Cell Res"},{"key":"10.1016\/j.jaip.2021.03.029_bib82","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/cyto.b.21084","article-title":"Basophilic histamine content and release during venom immunotherapy: insights by flow cytometry","volume":"84","author":"Nullens","year":"2013","journal-title":"Cytometry B Clin Cytom"},{"key":"10.1016\/j.jaip.2021.03.029_bib83","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jaci.2014.09.049","article-title":"Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response","volume":"135","author":"Shamji","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib84","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0091-6749(82)90062-8","article-title":"Effect of immunotherapy on immunoglobulin E and immunoglobulin G antibodies to ragweed antigens: a six-year prospective study","volume":"70","author":"Gleich","year":"1982","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib85","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jaci.2005.11.014","article-title":"Efficacy and safety of specific immunotherapy with SQ allergen extract in treatment-resistant seasonal allergic rhinoconjunctivitis","volume":"117","author":"Frew","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib86","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaci.2007.10.039","article-title":"Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years","volume":"121","author":"Dahl","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib87","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jaci.2009.02.012","article-title":"Evaluation of serum s-IgE\/total IgE ratio in predicting clinical response to allergen-specific immunotherapy","volume":"123","author":"Di Lorenzo","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib88","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jaci.2005.04.003","article-title":"Allergen-specific nasal IgG antibodies induced by vaccination with genetically modified allergens are associated with reduced nasal allergen sensitivity","volume":"116","author":"Reisinger","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib89","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1084\/jem.62.6.733","article-title":"Serological evidence of immunity with coexisting sensitization in a type of human allergy (hay fever)","volume":"62","author":"Cooke","year":"1935","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaip.2021.03.029_bib90","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.jaci.2017.09.041","article-title":"Synchronous immune alterations mirror clinical response during allergen immunotherapy","volume":"141","author":"Renand","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2021.03.030","article-title":"Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy","author":"Shamji","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib92","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.jaci.2013.05.025","article-title":"Cell-free detection of allergen-IgE cross-linking with immobilized phase CD23: inhibition by blocking antibody responses after immunotherapy","volume":"132","author":"Shamji","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib93","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.immuni.2020.12.013","article-title":"Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response","volume":"54","author":"Golebski","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.jaip.2021.03.029_bib94","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jaci.2019.02.023","article-title":"Immunologic mechanisms of a short-course of Lolium perenne peptide immunotherapy: a randomized, double-blind, placebo-controlled trial","volume":"144","author":"Sharif","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib95","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.jaci.2018.12.1018","article-title":"Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid","volume":"143","author":"Morita","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2020.10.029","article-title":"IL-10\u2013producing innate lymphoid cells increased in patients with house dust mite allergic rhinitis following immunotherapy","volume":"147","author":"Boonpiyathad","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib97","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.jaci.2014.07.029","article-title":"Seasonal increases in peripheral innate lymphoid type 2 cells are inhibited by subcutaneous grass pollen immunotherapy","volume":"134","author":"Lao-Araya","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib98","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jaci.2015.12.1325","article-title":"Circulating innate lymphoid cells are differentially regulated in allergic and nonallergic subjects","volume":"138","author":"Lombardi","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib99","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/all.12608","article-title":"Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge","volume":"70","author":"Scadding","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.03.029_bib100","doi-asserted-by":"crossref","first-page":"107211","DOI":"10.1016\/j.intimp.2020.107211","article-title":"Prediction of sublingual immunotherapy efficacy in allergic rhinitis by serum metabolomics analysis","volume":"90","author":"Xie","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaip.2021.03.029_bib101","doi-asserted-by":"crossref","first-page":"559746","DOI":"10.3389\/fimmu.2020.559746","article-title":"Leukotriene A4 hydrolase is a candidate predictive biomarker for successful allergen immunotherapy","volume":"11","author":"Ma","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib102","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.clim.2010.12.022","article-title":"Increase of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis","volume":"139","author":"Fujimura","year":"2011","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib103","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/0091-6749(91)90094-5","article-title":"Monitoring human basophil activation via CD63 monoclonal antibody 435","volume":"88","author":"Knol","year":"1991","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib104","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jim.2011.09.003","article-title":"Analyzing histamine release by flow cytometry (HistaFlow): a novel instrument to study the degranulation patterns of basophils","volume":"375","author":"Ebo","year":"2012","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jaip.2021.03.029_bib105","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jim.2006.09.004","article-title":"The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses","volume":"317","author":"Shamji","year":"2006","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jaip.2021.03.029_bib106","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/mi.2016.87","article-title":"The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation","volume":"10","author":"Mascarell","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib107","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jaci.2013.09.043","article-title":"Grass tablet sublingual immunotherapy downregulates the TH2 cytokine response followed by regulatory T-cell generation","volume":"133","author":"Suarez-Fueyo","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib108","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jaci.2017.04.032","article-title":"Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells","volume":"141","author":"Schulten","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.03.029_bib109","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jaci.2019.02.008","article-title":"Allergen immunotherapy improves defective follicular regulatory T cells in patients with allergic rhinitis","volume":"144","author":"Yao","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219821003639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219821003639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:27:14Z","timestamp":1761974834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219821003639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":109,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S2213219821003639"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2021.03.029","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunological Responses and Biomarkers for Allergen-Specific Immunotherapy Against Inhaled Allergens","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2021.03.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}