{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:35:39Z","timestamp":1787646939850,"version":"build-2736575974"},"reference-count":24,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jaip.2021.06.060","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T13:04:07Z","timestamp":1627563847000},"page":"4103-4116.e14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Disease-Modifying Effect of Japanese Cedar Pollen Sublingual Immunotherapy Tablets"],"prefix":"10.1016","volume":"9","author":[{"given":"Syuji","family":"Yonekura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiro","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl","key":"10.1016\/j.jaip.2021.06.060_bib1","first-page":"1","article-title":"Allergen immunotherapy: therapeutic vaccines for allergic diseases. Geneva: January 27\u201329 1997","volume":"53","year":"1998","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.06.060_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1939-4551-7-6","article-title":"Sublingual immunotherapy: World Allergy Organization position paper 2013 update","volume":"7","author":"Canonica","year":"2014","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaip.2021.06.060_bib3","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1398-9995.2007.01451.x","article-title":"Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study","volume":"62","author":"Jacobsen","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.06.060_bib4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jaci.2010.08.030","article-title":"Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study","volume":"126","author":"Marogna","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.06.060_bib5","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.alit.2020.05.008","article-title":"Long-term treatment of Japanese cedar pollinosis with Japanese cedar pollen SLIT drops and persistence of treatment effect: a post-marketing clinical trial","volume":"70","author":"Nomura","year":"2021","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2021.06.060_bib6","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jaci.2011.12.973","article-title":"SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial","volume":"129","author":"Durham","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.06.060_bib7","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jaip.2018.11.044","article-title":"Long-term efficacy and dose-finding trial of Japanese cedar pollen sublingual immunotherapy tablet","volume":"7","author":"Gotoh","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2021.06.060_bib8","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.alit.2019.05.002","article-title":"Treatment duration-dependent efficacy of Japanese cedar pollen sublingual immunotherapy: evaluation of a phase II\/III trial over three pollen dispersal seasons","volume":"68","author":"Yonekura","year":"2019","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2021.06.060_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2332\/allergolint.46.135","article-title":"A\u00a0basic policy for allergen standardization in our country and standardization of Japanese cedar (Cryptomeria japonica) pollen extracts","volume":"46","author":"Yasueda","year":"1997","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2021.06.060_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.alit.2016.11.001","article-title":"Japanese guidelines for allergic rhinitis 2017","volume":"66","author":"Okubo","year":"2017","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2021.06.060_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000381059","article-title":"Efficacy and safety of sublingual immunotherapy for two seasons in patients with Japanese cedar pollinosis","volume":"166","author":"Okamoto","year":"2015","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2021.06.060_bib12","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/00016480510026944","article-title":"Comparative study of two Japanese rhinoconjunctivitis quality-of-life questionnaires","volume":"125","author":"Okuda","year":"2005","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jaip.2021.06.060_bib13","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.2517-6161.1954.tb00159.x","article-title":"Some problems in interval estimation","volume":"16","author":"Fieller","year":"1954","journal-title":"J\u00a0Roy Stat Soc B"},{"key":"10.1016\/j.jaip.2021.06.060_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000151243","article-title":"The principle of homologous groups in regulatory affairs of allergen products\u2014a proposal","volume":"148","author":"Lorenz","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2021.06.060_bib15","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0161-5890(95)00147-6","article-title":"Purification, characterization and molecular cloning of cha o 1, a major allergen of Chamaecyparis obtusa (Japanese cypress) pollen","volume":"33","author":"Suzuki","year":"1996","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaip.2021.06.060_bib16","first-page":"233","article-title":"Sub-lingual immunotherapy: World Allergy Organization position paper 2009","volume":"2","author":"Canonica","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2021.06.060_bib20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/jama.2016.21040","article-title":"Effect of 2 years of treatment with sublingual grass pollen immunotherapy on nasal response to allergen challenge at 3 years among patients with moderate to severe seasonal allergic rhinitis: the GRASS randomized clinical trial","volume":"317","author":"Scadding","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2021.06.060_bib21","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaci.2007.10.039","article-title":"Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years","volume":"121","author":"Dahl","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.06.060_bib22","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jaip.2018.11.044","article-title":"Long-term efficacy and dose-finding trial of Japanese cedar pollen sublingual immunotherapy tablet","volume":"7","author":"Gotoh","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2021.06.060_bib23","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.alit.2019.05.002","article-title":"Treatment duration-dependent efficacy of Japanese cedar pollen sublingual immunotherapy: evaluation of a phase II\/III trial over three pollen dispersal seasons","volume":"68","author":"Yonekura","year":"2019","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2021.06.060_bib24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.alit.2016.11.001","article-title":"Japanese guidelines for allergic rhinitis 2017","volume":"66","author":"Okubo","year":"2017","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2021.06.060_bib25","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000381059","article-title":"Efficacy and safety of sublingual immunotherapy for two seasons in patients with Japanese cedar pollinosis","volume":"166","author":"Okamoto","year":"2015","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2021.06.060_bib26","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/00016480510026944","article-title":"Comparative study of two Japanese rhinoconjunctivitis quality-of-life questionnaires","volume":"125","author":"Okuda","year":"2005","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.jaip.2021.06.060_bib27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.2517-6161.1954.tb00159.x","article-title":"Some problems in interval estimation","volume":"16","author":"Fieller","year":"1954","journal-title":"J\u00a0R Stat Soc B"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219821008254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219821008254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:29:48Z","timestamp":1761974988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219821008254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S2213219821008254"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2021.06.060","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disease-Modifying Effect of Japanese Cedar Pollen Sublingual Immunotherapy Tablets","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2021.06.060","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}