{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:57:04Z","timestamp":1790787424856,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jaip.2021.11.032","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T11:45:00Z","timestamp":1640000700000},"page":"1077-1083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Long-Term Clinical Outcomes of Severe Combined Immunodeficiency Patients Given Nonablative Marrow Transplants"],"prefix":"10.1016","volume":"10","author":[{"given":"Olga","family":"Hardin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliya","family":"Lokhnygina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca H.","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2021.11.032_bib1","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.jaci.2013.09.044","article-title":"Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: the Primary Immune Deficiency Treatment Consortium experience","volume":"133","author":"Shearer","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.11.032_bib2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s10875-019-00737-x","article-title":"Human inborn errors of immunity: 2019 update on the classification from the International Union of Immunological Societies Expert Committee","volume":"40","author":"Tangye","year":"2020","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.jaip.2021.11.032_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12026-010-8191-9","article-title":"Transplantation of hematopoietic stem cells in human severe combined immunodeficiency: longterm outcomes","volume":"49","author":"Buckley","year":"2011","journal-title":"Immunol Res"},{"key":"10.1016\/j.jaip.2021.11.032_bib4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0140-6736(03)12513-5","article-title":"Long-term survival and transplantation of haemopoietic stem cells for immunodeficiencies: report of the European experience 1968-99","volume":"361","author":"Antoine","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2021.11.032_bib5","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1001\/jama.295.5.508","article-title":"Bone marrow transplantation for severe combined immune deficiency","volume":"295","author":"Grunebaum","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2021.11.032_bib6","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190607","article-title":"Gene therapy for severe combined immunodeficiencies and beyond","volume":"217","author":"Fischer","year":"2020","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaip.2021.11.032_bib7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1056\/NEJM198703053161005","article-title":"Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase (PEG-ADA)","volume":"316","author":"Hershfield","year":"1987","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2021.11.032_bib8","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1056\/NEJM199902183400703","article-title":"Hematopoietic stem cell transplantation for the treatment of severe combined immunodeficiency","volume":"340","author":"Buckley","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2021.11.032_bib9","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.4049\/jimmunol.136.7.2398","article-title":"Development of immunity in human severe primary T cell deficiency following haploidentical bone marrow stem cell transplantation","volume":"136","author":"Buckley","year":"1986","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaip.2021.11.032_bib10","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1182\/blood.V99.3.872","article-title":"Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival","volume":"99","author":"Myers","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2021.11.032_bib11","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.jaci.2007.08.007","article-title":"Long-term immune reconstitution and clinical outcome after stem cell transplantation for severe T-cell immunodeficiency","volume":"120","author":"Mazzolari","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.11.032_bib12","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1182\/blood-2006-07-034678","article-title":"Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications","volume":"109","author":"Honig","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2021.11.032_bib13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1067\/mpd.2001.115023","article-title":"Cognitive and behavioral abnormalities in adenosine deaminase deficient severe combined immunodeficiency","volume":"139","author":"Rogers","year":"2001","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jaip.2021.11.032_bib14","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1056\/NEJMoa1401177","article-title":"Transplantation outcomes for severe combined immunodeficiency, 2000-2009","volume":"371","author":"Pai","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2021.11.032_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2010.06.015","article-title":"Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: entering a new century, do we do better?","volume":"126","author":"Gennery","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2021.11.032_bib16","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jpeds.2009.07.049","article-title":"Long term clinical outcome of patients with severe combined immunodeficiency who received related donor bone marrow transplants without pre-transplant chemotherapy or post-transplant GVHD prophylaxis","volume":"155","author":"Railey","year":"2009","journal-title":"J\u00a0Pediatr"},{"key":"10.1016\/j.jaip.2021.11.032_bib17","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/bmt.2013.6","article-title":"Long-term outcome of non-ablative booster BMT in patients with SCID","volume":"48","author":"Teigland","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jaip.2021.11.032_bib18","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1056\/NEJMoa0805817","article-title":"Gene therapy for immunodeficiency due to adenosine deaminase deficiency","volume":"360","author":"Aiuti","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2021.11.032_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1182\/blood-2006-11-058933","article-title":"Gene therapy improves immune function in preadolescents with X-linked severe combined immunodeficiency","volume":"110","author":"Chinen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2021.11.032_bib21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaac.2013.09.001","article-title":"Trends in the parent-report of health care provider-diagnosed and medicated attention-deficit\/hyperactivity disorder: United States, 2003-2011","volume":"53","author":"Visser","year":"2014","journal-title":"J\u00a0Am Acad Child Adolesc Psychiatry"},{"key":"10.1016\/j.jaip.2021.11.032_bib22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.jaip.2021.11.032_bib24","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1182\/blood-2008-04-151332","article-title":"Cognitive and behavioural abnormalities in children following haematopoietic stem cell transplantation for severe congenital immunodeficiencies","volume":"112","author":"Titman","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2021.11.032_bib25","first-page":"994","article-title":"B\u00a0cell reconstitution for SCID: Should a conditioning regimen be used in SCID treatment?","volume":"131","author":"Haddad","year":"2013","journal-title":"JACI"},{"key":"10.1016\/j.jaip.2021.11.032_bib26","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/sj.bmt.1702382","article-title":"Dental manifestations in severe combined immunodeficiency following bone marrow transplantation","volume":"25","author":"Cole","year":"2000","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jaip.2021.11.032_bib27","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/sj.bmt.1704456","article-title":"Thyroid dysfunction after bone marrow transplantation for primary immunodeficiency without the use of total body irradiation in conditioning","volume":"33","author":"Slatter","year":"2004","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jaip.2021.11.032_bib28","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/sj.bmt.1702831","article-title":"Bone marrow transplantation for T-B- severe combined immunodeficiency disease in Athabascan-speaking native Americans","volume":"27","author":"O\u2019Marcaigh","year":"2001","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jaip.2021.11.032_bib29","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jaci.2010.02.012","article-title":"B\u00a0cell function in severe combined immunodeficiency after stem cell or gene therapy: a review","volume":"125","author":"Buckley","year":"2010","journal-title":"J\u00a0Allerg Clin Immunol"},{"key":"10.1016\/j.jaip.2021.11.032_bib30","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/S0140-6736(04)16457-X","article-title":"Severe cutaneous papillomavirus disease after haemopoietic stem-cell transplantation in patients with severe combined immune deficiency caused by common gammac cytokine receptor subunit or JAK-3 deficiency","volume":"363","author":"Laffort","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2021.11.032_bib31","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.jaci.2014.07.009","article-title":"Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined immunodeficiency","volume":"134","author":"Kamili","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219821013714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219821013714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:33:06Z","timestamp":1761975186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219821013714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S2213219821013714"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2021.11.032","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-Term Clinical Outcomes of Severe Combined Immunodeficiency Patients Given Nonablative Marrow Transplants","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2021.11.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}