{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:05:07Z","timestamp":1780913107541,"version":"3.54.1"},"reference-count":69,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P32470-B"],"award-info":[{"award-number":["P32470-B"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.jaip.2022.06.018","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T02:22:56Z","timestamp":1656382976000},"page":"2039-2051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mast Cell Diseases in Practice and Research: Issues and Perspectives Raised by Patients and Their Recommendations to the Scientific Community and Beyond"],"prefix":"10.1016","volume":"10","author":[{"given":"Susan V.","family":"Jennings","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste C.","family":"Finnerty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica S.","family":"Hobart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Mart\u00edn-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin A.","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie M.","family":"Slee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Agopian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cem","family":"Akin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"\u00c1lvarez-Twose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Bonadonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela S.","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Brockow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horia","family":"Bumbea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"de Haro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie Shen","family":"Fok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Hegmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Hermine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Kalisiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constance H.","family":"Katelaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Marcis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mayne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Moussy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genija","family":"Mudretzkyj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoleta Nidelea","family":"Vaia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Niedoszytko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke Oude","family":"Elberink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Orfao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti H.","family":"Radia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Rosenmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Ribada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waltraud","family":"Schinhofen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Schwaab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Siebenhaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Triggiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tripodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Velazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvon","family":"Wielink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Wimazal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Yigit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Zubrinich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Valent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2022.06.018_bib1","doi-asserted-by":"crossref","first-page":"e646","DOI":"10.1097\/HS9.0000000000000646","article-title":"Updated diagnostic criteria and classification of mast cell disorders: a consensus proposal","volume":"5","author":"Valent","year":"2021","journal-title":"Hemasphere"},{"key":"10.1016\/j.jaip.2022.06.018_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2017.06.007","article-title":"Mast cell activation syndromes","volume":"140","author":"Akin","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib3","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1056\/NEJMra1409760","article-title":"Mast cells, mastocytosis, and related disorders","volume":"373","author":"Theoharides","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2022.06.018_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jaci.2015.08.034","article-title":"Cutaneous manifestations in patients with mastocytosis: consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology","volume":"137","author":"Hartmann","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib5","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.3390\/ijms22052586","article-title":"Molecular background, clinical features and management of pediatric mastocytosis: status 2021","volume":"22","author":"Lange","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaip.2022.06.018_bib6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/ajh.26118","article-title":"Systemic mastocytosis in adults: 2021 update on diagnosis, risk stratification and management","volume":"96","author":"Pardanani","year":"2021","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jaip.2022.06.018_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2010.08.035","article-title":"Mast cell activation syndrome: proposed diagnostic criteria","volume":"126","author":"Akin","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000328760","article-title":"Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal","volume":"157","author":"Valent","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1182\/blood.2020006157","article-title":"Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis","volume":"137","author":"Greiner","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2022.06.018_bib10","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.3390\/ijms22052458","article-title":"Genetic regulation of tryptase production and clinical impact: hereditary alpha tryptasemia, mastocytosis and beyond","volume":"22","author":"Sprinzl","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaip.2022.06.018_bib11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11882-021-01010-1","article-title":"Hereditary alpha-tryptasemia: a commonly inherited modifier of anaphylaxis","volume":"21","author":"Wu","year":"2021","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2022.06.018_bib12","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.iac.2018.04.003","article-title":"Hereditary alpha tryptasemia: genotyping and associated clinical features","volume":"38","author":"Lyons","year":"2018","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2022.06.018_bib13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.anai.2021.10.006","article-title":"Mast cell disorders are associated with decreased cerebral blood flow and small fiber neuropathy","volume":"128","author":"Novak","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib14","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ajmg.c.31940","article-title":"Mast cell activation disease and immunoglobulin deficiency in patients with hypermobile Ehlers-Danlos syndrome\/hypermobility spectrum disorder","volume":"187","author":"Brock","year":"2021","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jaip.2022.06.018_bib16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.anai.2021.07.004","article-title":"Symptoms of mast cell activation: the patient perspective","volume":"127","author":"Jennings","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib17","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.iac.2018.04.006","article-title":"Patient perceptions in mast cell disorders","volume":"38","author":"Jennings","year":"2018","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2022.06.018_bib18","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.3390\/ijms21239030","article-title":"Diagnosis, classification and management of mast cell activation syndromes (MCAS) in the era of personalized medicine","volume":"21","author":"Valent","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaip.2022.06.018_bib19","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1398-9995.2007.01569.x","article-title":"Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients","volume":"63","author":"Brockow","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2022.06.018_bib20","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3390\/ijms22031454","article-title":"A\u00a0challenge for allergologist: application of allergy diagnostic methods in mast cell disorders","volume":"22","author":"Romantowski","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaip.2022.06.018_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/cea.12225","article-title":"High prevalence of anaphylaxis in patients with systemic mastocytosis - a single-centre experience","volume":"44","author":"Gulen","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2022.06.018_bib22","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1016\/j.jaip.2020.05.005","article-title":"Importance of adequate diagnostic workup for correct diagnosis of advanced systemic mastocytosis","volume":"8","author":"Schwaab","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.06.018_bib23","doi-asserted-by":"crossref","first-page":"e2266","DOI":"10.1371\/journal.pone.0002266","article-title":"Case-control cohort study of patients' perceptions of disability in mastocytosis","volume":"3","author":"Hermine","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2022.06.018_bib24","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/all.12842","article-title":"Development and validation of the mastocytosis quality of life questionnaire: MC-QoL","volume":"71","author":"Siebenhaar","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2022.06.018_bib25","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1177\/1359105315626784","article-title":"Psychosocial impact of mast cell disorders: pilot investigation of a rare and understudied disease","volume":"22","author":"Nicoloro-SantaBarbara","year":"2017","journal-title":"J\u00a0Health Psychol"},{"key":"10.1016\/j.jaip.2022.06.018_bib26","doi-asserted-by":"crossref","unstructured":"Nicoloro SantaBarbara J, Lobel M. Depression, psychosocial correlates, and psychosocial resources in individuals with mast cell activation syndrome. J Health Psychol. Published online May 18, 2021. https:\/\/doi.org\/10.1177\/13591053211014583","DOI":"10.1177\/13591053211014583"},{"key":"10.1016\/j.jaip.2022.06.018_bib27","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00508-012-0293-z","article-title":"European Competence Network on Mastocytosis (ECNM): 10-year jubilee, update, and future perspectives","volume":"124","author":"Valent","year":"2012","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.jaip.2022.06.018_bib28","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1080\/10428194.2019.1703974","article-title":"New developments in the field of mastocytosis and mast cell activation syndromes: a summary of the Annual Meeting of the European Competence Network on Mastocytosis (ECNM) 2019","volume":"61","author":"Arock","year":"2020","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.jaip.2022.06.018_bib29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaip.2013.09.004","article-title":"The Mastocytosis Society survey on mast cell disorders: patient experiences and perceptions","volume":"2","author":"Jennings","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.06.018_bib30","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.jaip.2018.07.032","article-title":"The Mastocytosis Society Survey on Mast Cell Disorders: part 2-patient clinical experiences and beyond","volume":"7","author":"Russell","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.06.018_bib32","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.jaci.2021.03.008","article-title":"Proceedings from the Inaugural American Initiative in Mast Cell Diseases (AIM) Investigator Conference","volume":"147","author":"Gotlib","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib34","series-title":"Mastocytosis: a comprehensive guide","first-page":"267","article-title":"International support and advocacy for mast cell disease patients and caregivers","author":"Jennings","year":"2020"},{"key":"10.1016\/j.jaip.2022.06.018_bib35","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1016\/j.jaip.2021.04.059","article-title":"Health-related quality of life and influencing factors in adults with nonadvanced mastocytosis-a cross-sectional study and qualitative approach","volume":"9","author":"Pulfer","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.06.018_bib36","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1111\/all.12920","article-title":"Patient-reported disease-specific quality-of-life and symptom severity in systemic mastocytosis","volume":"71","author":"van Anrooij","year":"2016","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2022.06.018_bib37","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/eci.12607","article-title":"Impact of centralized evaluation of bone marrow histology in systemic mastocytosis","volume":"46","author":"Jawhar","year":"2016","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jaip.2022.06.018_bib38","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1016\/j.jaip.2021.06.011","article-title":"Selecting the right criteria and proper classification to diagnose mast cell activation syndromes: a critical review","volume":"9","author":"Gulen","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.06.018_bib39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/bjh.13789","article-title":"Diagnosis and classification of mastocytosis in non-specialized versus reference centres: a Spanish Network on Mastocytosis (REMA) study on 122 patients","volume":"172","author":"Sanchez-Munoz","year":"2016","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaip.2022.06.018_bib40","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3324\/haematol.2019.217950","article-title":"Molecular quantification of tissue disease burden is a new biomarker and independent predictor of survival in mastocytosis","volume":"105","author":"Greiner","year":"2020","journal-title":"Haematologica"},{"key":"10.1016\/j.jaip.2022.06.018_bib41","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.anai.2021.07.014","article-title":"Pathogenic and diagnostic relevance of KIT in primary mast cell activation disorders","volume":"127","author":"Munoz-Gonzalez","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib42","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.3390\/cancers13246380","article-title":"A\u00a0multidisciplinary diagnostic approach reveals a higher prevalence of indolent systemic mastocytosis: 15-years' experience of the GISM network","volume":"13","author":"Zanotti","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jaip.2022.06.018_bib43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11920-017-0780-z","article-title":"Challenges and opportunities in global mental health: a research-to-practice perspective","volume":"19","author":"Wainberg","year":"2017","journal-title":"Curr Psychiatry Rep"},{"key":"10.1016\/j.jaip.2022.06.018_bib44","doi-asserted-by":"crossref","first-page":"AB427","DOI":"10.1016\/j.jaci.2018.12.962","article-title":"The Mastocytosis Society (TMS) mast cell activation syndrome (MCAS) patient perceptions survey","volume":"143","author":"Jennings","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib45","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000048188","article-title":"Mastocytosis: mediator-related signs and symptoms","volume":"127","author":"Castells","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib46","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/all.13945","article-title":"Risk factors and indicators of severe systemic insect sting reactions","volume":"75","author":"Stoevesandt","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2022.06.018_bib47","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.jaci.2017.06.012","article-title":"Diagnosis and management of anaphylaxis in precision medicine","volume":"140","author":"Castells","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib48","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jaci.2020.01.017","article-title":"Anaphylaxis-a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis","volume":"145","author":"Shaker","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib49","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/all.15032","article-title":"EAACI guidelines: anaphylaxis (2021 update)","volume":"77","author":"Muraro","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2022.06.018_bib50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.iac.2021.09.007","article-title":"Anaphylaxis and mast cell disorders","volume":"42","author":"Gulen","year":"2022","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2022.06.018_bib51","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.3390\/ijms20122976","article-title":"Multidisciplinary challenges in mastocytosis and how to address with personalized medicine approaches","volume":"20","author":"Valent","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jaip.2022.06.018_bib52","unstructured":"Agency for Healthcare Research and Quality. Project ECHO. Accessed February 17, 2022. https:\/\/www.ahrq.gov\/patient-safety\/resources\/project-echo\/index.html"},{"key":"10.1016\/j.jaip.2022.06.018_bib53","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1016\/S2352-3026(20)30400-2","article-title":"Proposed global prognostic score for systemic mastocytosis: a retrospective prognostic modelling study","volume":"8","author":"Munoz-Gonzalez","year":"2021","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jaip.2022.06.018_bib54","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jaci.2021.04.004","article-title":"Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia","volume":"148","author":"Konnikova","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib55","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.jaci.2018.10.063","article-title":"Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: a Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology","volume":"143","author":"Carter","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib56","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jaip.2019.02.002","article-title":"Mast cell activation syndrome and mastocytosis: initial treatment options and long-term management","volume":"7","author":"Castells","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.06.018_bib57","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.6004\/jnccn.2018.0088","article-title":"Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology","volume":"16","author":"Gotlib","year":"2018","journal-title":"J\u00a0Natl Compr Canc Netw"},{"key":"10.1016\/j.jaip.2022.06.018_bib58","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1182\/blood.2019000932","article-title":"New developments in diagnosis, prognostication, and treatment of advanced systemic mastocytosis","volume":"135","author":"Reiter","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2022.06.018_bib59","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00277-020-04323-9","article-title":"Catching the clinical and biological diversity for an appropriate therapeutic approach in systemic mastocytosis","volume":"100","author":"Mannelli","year":"2021","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jaip.2022.06.018_bib60","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0091-6749(90)90067-E","article-title":"Cromolyn sodium in the management of systemic mastocytosis","volume":"85","author":"Horan","year":"1990","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib61","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.jaip.2019.04.030","article-title":"Omalizumab and mast cell disorders: are we there yet?","volume":"7","author":"Weiler","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.06.018_bib62","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1016\/j.jaip.2019.03.039","article-title":"Omalizumab therapy for mast cell-mediator symptoms in patients with ISM, CM, MMAS, and MCAS","volume":"7","author":"Lemal","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.06.018_bib63","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/cea.13592","article-title":"Omalizumab in the treatment of adult patients with mastocytosis: a systematic review","volume":"50","author":"Jendoubi","year":"2020","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2022.06.018_bib64","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41577-021-00622-y","article-title":"Understanding human mast cells: lesson from therapies for allergic and non-allergic diseases","volume":"22","author":"Kolkhir","year":"2022","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib65","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.iac.2021.12.003","article-title":"Mas-related G protein-coupled receptor-X2 and its role in non-immunoglobulin E-mediated drug hypersensitivity","volume":"42","author":"Chompunud Na Ayudhya","year":"2022","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2022.06.018_bib66","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.jaci.2020.11.017","article-title":"Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology","volume":"147","author":"Giannetti","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.06.018_bib67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jaip.2018.09.024","article-title":"The data registry of the European Competence Network on Mastocytosis (ECNM): set up, projects, and perspectives","volume":"7","author":"Valent","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.06.018_bib68","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1515\/dx-2020-0005","article-title":"Diagnosis of mast cell activation syndrome: a global \"consensus-2","volume":"8","author":"Afrin","year":"2021","journal-title":"Diagnosis (Berl)"},{"key":"10.1016\/j.jaip.2022.06.018_bib69","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11882-012-0326-8","article-title":"Immunology and clinical manifestations of non-clonal mast cell activation syndrome","volume":"13","author":"Cardet","year":"2013","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2022.06.018_bib70","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/pde.13066","article-title":"Longitudinal study of pediatric urticaria pigmentosa","volume":"34","author":"Heinze","year":"2017","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.jaip.2022.06.018_bib72","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ajmg.c.31942","article-title":"The power of patient-led global collaboration","volume":"187","author":"Bloom","year":"2021","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jaip.2022.06.018_bib73","unstructured":"Rare Diseases International. Joint Declaration. Accessed February 18, 2022. https:\/\/www.rarediseasesinternational.org\/joint-declaration\/"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219822006407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219822006407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:33:43Z","timestamp":1761975223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219822006407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":69,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2213219822006407"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2022.06.018","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mast Cell Diseases in Practice and Research: Issues and Perspectives Raised by Patients and Their Recommendations to the Scientific Community and Beyond","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2022.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}