{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:18:01Z","timestamp":1790101081709,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.jaip.2022.11.034","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T11:54:01Z","timestamp":1671018841000},"page":"621-628","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trends in Treatments With Disease-Specific and Interfering Drugs in Patients With Hereditary Angioedema in Sweden"],"prefix":"10.1016","volume":"11","author":[{"given":"Linda","family":"Sundler Bj\u00f6rkman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e5ns","family":"Thulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Nordenfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Egesten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2022.11.034_bib1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1808012","article-title":"Hereditary Angioedema","volume":"382","author":"Busse","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2022.11.034_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0002-9343(63)90162-1","article-title":"A\u00a0biochemical abnormality in hereditary angioneurotic edema: absence of serum inhibitor of C\u2032 1-esterase","volume":"35","author":"Donaldson","year":"1963","journal-title":"Am J Med"},{"key":"10.1016\/j.jaip.2022.11.034_bib3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1126\/science.148.3672.957","article-title":"Hereditary angioneurotic edema: two genetic variants","volume":"148","author":"Rosen","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.jaip.2022.11.034_bib4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jaci.2012.05.055","article-title":"Fatal laryngeal attacks and mortality in hereditary angioedema due to C1-INH deficiency","volume":"130","author":"Bork","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.034_bib5","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.2500\/aap.2020.41.200042","article-title":"Hereditary angioedema: special considerations in children","volume":"41","author":"Johnston","year":"2020","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2022.11.034_bib6","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2500\/aap.2014.35.3738","article-title":"Quantifying the burden of disease and perceived health state in patients with hereditary angioedema in Sweden","volume":"35","author":"Nordenfelt","year":"2014","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2022.11.034_bib7","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0140-6736(69)91295-1","article-title":"Replacement therapy in hereditary angioedema: successful treatment of two patients with fresh frozen plasma","volume":"1","author":"Pickering","year":"1969","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2022.11.034_bib8","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0091-6749(89)90082-1","article-title":"Long-term prophylaxis with C1-inhibitor (C1 INH) concentrate in patients with recurrent angioedema caused by hereditary and acquired C1-inhibitor deficiency","volume":"83","author":"Bork","year":"1989","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.034_bib9","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1056\/NEJM199606203342503","article-title":"Treatment of hereditary angioedema with a vapor-heated C1 inhibitor concentrate","volume":"334","author":"Waytes","year":"1996","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2022.11.034_bib10","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/j.1398-9995.2007.01577.x","article-title":"Treatment of skin swellings with C1-inhibitor concentrate in patients with hereditary angio-oedema","volume":"63","author":"Bork","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2022.11.034_bib11","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.jaci.2009.07.017","article-title":"Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacks","volume":"124","author":"Craig","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.034_bib12","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jaci.2010.07.021","article-title":"Recombinant human C1-inhibitor for the treatment of acute angioedema attacks in patients with hereditary angioedema","volume":"126","author":"Zuraw","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.034_bib13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1139\/y95-108","article-title":"Kinin receptor antagonists: unique probes in basic and clinical research","volume":"73","author":"Wirth","year":"1995","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.jaip.2022.11.034_bib14","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1056\/NEJMoa0906393","article-title":"Icatibant, a new bradykinin-receptor antagonist, in hereditary angioedema","volume":"363","author":"Cicardi","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2022.11.034_bib15","doi-asserted-by":"crossref","first-page":"739","DOI":"10.7326\/0003-4819-53-4-739","article-title":"Methyltestosterone therapy for heredity episodic edema (hereditary angioneurotic edema)","volume":"53","author":"Spaulding","year":"1960","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaip.2022.11.034_bib16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-2362.2010.02402.x","article-title":"Long-term efficacy of danazol treatment in hereditary angioedema","volume":"41","author":"F\u00fcst","year":"2011","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.jaip.2022.11.034_bib17","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1056\/NEJM197612232952602","article-title":"Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities","volume":"295","author":"Gelfand","year":"1976","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2022.11.034_bib18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jaci.2007.10.048","article-title":"Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P","volume":"121","author":"Drouet","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.034_bib19","first-page":"603","article-title":"Danazol in the treatment of endometriosis and hereditary angio-oedema","volume":"237","author":"Hoogerbrugge","year":"1995","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.jaip.2022.11.034_bib20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1081-1206(10)60424-3","article-title":"Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients","volume":"100","author":"Bork","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2022.11.034_bib21","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1016\/j.clinthera.2008.12.021","article-title":"Effects of short-term and long-term danazol treatment on lipoproteins,coagulation, and progression of atherosclerosis: two clinical trials in healthy volunteers and patients with hereditary angio-edema","volume":"30","author":"Birjmohun","year":"2008","journal-title":"Clin Ther"},{"key":"10.1016\/j.jaip.2022.11.034_bib22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.2500\/aap.2013.34.3702","article-title":"Assessment of hereditary angioedema treatment risks","volume":"34","author":"Kalaria","year":"2013","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2022.11.034_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.anai.2015.01.003","article-title":"Critical appraisal of androgen use in hereditary angioedema: a systematic review","volume":"114","author":"Riedl","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2022.11.034_bib24","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jaip.2016.03.024","article-title":"Tolerability and effectiveness of 17-\u03b1-alkylated androgen therapy for hereditary angioedema: a re-examination","volume":"4","author":"Zuraw","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.11.034_bib25","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.anai.2017.01.015","article-title":"Anabolic androgen use in the management of hereditary angioedema: not so cheap after all","volume":"118","author":"Tse","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2022.11.034_bib26","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1056\/NEJM197208312870907","article-title":"Tranexamic acid therapy in hereditary angioneurotic edema","volume":"287","author":"Sheffer","year":"1972","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2022.11.034_bib27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.0954-6820.1972.tb04818.x","article-title":"Treatment of hereditary angioneurotic oedema with tranexamic acid. A random double-blind cross-over study","volume":"192","author":"Blohme","year":"1972","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.jaip.2022.11.034_bib28","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12948-021-00164-7","article-title":"Angioedema associated with dipeptidyl peptidase-IV inhibitors","volume":"19","author":"Cassano","year":"2021","journal-title":"Clin Mol Allergy"},{"key":"10.1016\/j.jaip.2022.11.034_bib29","first-page":"153","article-title":"Angiotensin-converting enzyme (ACE) inhibitors and angio-oedema","volume":"136","author":"Sabroe","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2022.11.034_bib30","doi-asserted-by":"crossref","first-page":"484.e1","DOI":"10.1016\/j.ajog.2008.04.034","article-title":"Disease expression in women with hereditary angioedema","volume":"199","author":"Bouillet","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jaip.2022.11.034_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106080","article-title":"Exogenous hormones and hereditary angioedema","volume":"78","author":"Gompel","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaip.2022.11.034_bib32","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaip.2017.03.017","article-title":"Cardiovascular and diabetic medications that cause bradykinin-mediated angioedema","volume":"5","author":"Hudey","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2022.11.034_bib33","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/pds.1294","article-title":"The new Swedish Prescribed Drug Register\u2014opportunities for pharmacoepidemiological research and experience from the first six months","volume":"16","author":"Wettermark","year":"2007","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jaip.2022.11.034_bib34","unstructured":"R Core Team. 2021. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing. Accessed June 10, 2022. https:\/\/www.R-project.org\/"},{"key":"10.1016\/j.jaip.2022.11.034_bib35","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.jaip.2022.11.034_bib36","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/01621459.1988.10478639","article-title":"Locally weighted regression: an approach to regression analysis by local fitting","volume":"83","author":"Cleveland","year":"1988","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.jaip.2022.11.034_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/clt2.12135","article-title":"Comorbidities in hereditary angioedema\u2014a population-based cohort study","volume":"12","author":"Sundler Bj\u00f6rkman","year":"2022","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.jaip.2022.11.034_bib38","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000068456","article-title":"Angioedema and oral contraception","volume":"206","author":"Bouillet","year":"2003","journal-title":"Dermatology"},{"key":"10.1016\/j.jaip.2022.11.034_bib39","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41574-020-0399-8","article-title":"Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus","volume":"16","author":"Deacon","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jaip.2022.11.034_bib40","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.iac.2013.07.006","article-title":"Hereditary angioedema in women: specific challenges","volume":"33","author":"Bouillet","year":"2013","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2022.11.034_bib41","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1398-9995.2007.01427.x","article-title":"Nonallergic angioedema: role of bradykinin","volume":"62","author":"Bas","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2022.11.034_bib42","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/cea.12055","article-title":"Benefits of progestin contraception in non-allergic angioedema","volume":"43","author":"Saule","year":"2013","journal-title":"Clin Exp Allergy"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219822012946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219822012946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:34:48Z","timestamp":1761975288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219822012946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S2213219822012946"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2022.11.034","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trends in Treatments With Disease-Specific and Interfering Drugs in Patients With Hereditary Angioedema in Sweden","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2022.11.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}