{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:54:13Z","timestamp":1790301253903,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi US","doi-asserted-by":"publisher","award":["NCT02414854"],"award-info":[{"award-number":["NCT02414854"]}],"id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.jaip.2022.11.043","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T11:54:17Z","timestamp":1671191657000},"page":"1213-1220.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Baseline FeNO Independently Predicts the Dupilumab Response in Patients With Moderate-to-Severe Asthma"],"prefix":"10.1016","volume":"11","author":[{"given":"Ian D.","family":"Pavord","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamo","family":"Deniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Corren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B.","family":"Casale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Mark","family":"FitzGerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Izuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Daizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivan","family":"Harel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Djandji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ledia","family":"Goga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Crikelair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Busse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2022.11.043_bib1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0140-6736(94)90931-8","article-title":"Increased nitric oxide in exhaled air of asthmatic patients","volume":"343","author":"Kharitonov","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2022.11.043_bib2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0140-6736(94)90935-0","article-title":"Single-breath nitric oxide measurements in asthmatic patients and smokers","volume":"343","author":"Persson","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2022.11.043_bib3","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1183\/09031936.93.06091368","article-title":"Increased amount of nitric oxide in exhaled air of asthmatics","volume":"6","author":"Alving","year":"1993","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2022.11.043_bib4","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/rccm.9120-11ST","article-title":"An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications","volume":"184","author":"Dweik","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib5","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.rmed.2013.02.018","article-title":"Exhaled nitric oxide to predict corticosteroid responsiveness and reduce asthma exacerbation rates","volume":"107","author":"Donohue","year":"2013","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib6","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.alit.2019.01.004","article-title":"Biological treatments for severe asthma: a major advance in asthma care","volume":"68","author":"Busse","year":"2019","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2022.11.043_bib7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/joim.12466","article-title":"Asthma phenotyping: noninvasive biomarkers suitable for bedside science are the next step to implement precision medicine","volume":"279","author":"Dahl\u00e9n","year":"2016","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib8","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1183\/13993003.00699-2016","article-title":"Predictive value of exhaled nitric oxide in the management of asthma: a systematic review","volume":"48","author":"Lehtim\u00e4ki","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2022.11.043_bib9","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S2213-2600(21)00124-7","article-title":"Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations in patients with uncontrolled, moderate-to-severe asthma receiving placebo in the LIBERTY ASTHMA QUEST study: a post-hoc analysis","volume":"9","author":"Busse","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib10","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.3389\/fimmu.2018.02220","article-title":"Involvement and possible role of eosinophils in asthma exacerbation","volume":"9","author":"Nakagome","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2022.11.043_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.06.007","article-title":"Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects","volume":"132","author":"Malinovschi","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.043_bib12","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jaci.2016.01.044","article-title":"Simultaneously increased fraction of exhaled nitric oxide levels and blood eosinophil counts relate to increased asthma morbidity","volume":"138","author":"Malinovschi","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.043_bib13","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1365-2222.2005.02314.x","article-title":"The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma","volume":"35","author":"Berry","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2022.11.043_bib14","first-page":"239","article-title":"Comparison of exhaled nitric oxide measurement with conventional tests in steroid-na\u00efve asthma patients","volume":"16","author":"Zeitkowski","year":"2006","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.043_bib15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1164\/rccm.202104-1040LE","article-title":"Fractional exhaled nitric oxide nonsuppression identifies corticosteroid-resistant type 2 signaling in severe asthma","volume":"204","author":"Couillard","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib16","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI119598","article-title":"Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators","volume":"100","author":"Guo","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2022.11.043_bib17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/thoraxjnl-2015-207326","article-title":"Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK)","volume":"71","author":"Heaney","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2022.11.043_bib18","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.1073\/pnas.1323896111","article-title":"Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes","volume":"111","author":"MacDonald","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaip.2022.11.043_bib19","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1073\/pnas.1324022111","article-title":"Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice","volume":"111","author":"Murphy","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaip.2022.11.043_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/1744666X.2017.1298443","article-title":"Commonality of the IL-4\/IL-13 pathway in atopic diseases","volume":"13","author":"Gandhi","year":"2017","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.043_bib21","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/all.14151","article-title":"Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4R\u03b1 antibody, is required to broadly inhibit type 2 inflammation","volume":"75","author":"Le Floc'h","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2022.11.043_bib22","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1056\/NEJMoa1804092","article-title":"Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma","volume":"378","author":"Castro","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib23","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/all.14268","article-title":"Efficacy and safety of treatment with dupilumab for severe asthma: a systematic review of the EAACI guidelines\u2014recommendations on the use of biologicals in severe asthma","volume":"75","author":"Agache","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2022.11.043_bib24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(12)60988-X","article-title":"Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial","volume":"380","author":"Pavord","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2022.11.043_bib25","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1164\/rccm.201208-1414OC","article-title":"Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study","volume":"187","author":"Hanania","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib26","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1365-2222.2008.02969.x","article-title":"IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells","volume":"38","author":"Chibana","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2022.11.043_bib27","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1172\/JCI95693","article-title":"Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction","volume":"128","author":"Dunican","year":"2018","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2022.11.043_bib28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.rmed.2017.12.013","article-title":"Mucus hypersecretion in asthma is associated with rhinosinusitis, polyps and exacerbations","volume":"135","author":"Mart\u00ednez-Rivera","year":"2018","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229238","article-title":"Changes in airway diameter and mucus plugs in patients with asthma exacerbation","volume":"15","author":"Yoshida","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2022.11.043_bib30","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jaci.2019.10.037","article-title":"IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways","volume":"145","author":"Manson","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2022.11.043_bib31","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1164\/rccm.201903-0599LE","article-title":"Prognostic and predictive value of blood eosinophil count, fractional exhaled nitric oxide, and their combination in severe asthma: a post hoc analysis","volume":"200","author":"Shrimanker","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib32","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00413-2021","article-title":"Patient characteristics, biomarkers, and exacerbation risk in severe, uncontrolled asthma","volume":"58","author":"Kraft","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2022.11.043_bib33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1136\/thoraxjnl-2021-217325","article-title":"Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide","volume":"77","author":"Couillard","year":"2022","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2022.11.043_bib34","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1172\/JCI36130","article-title":"The cytokine network in asthma and chronic obstructive pulmonary disease","volume":"118","author":"Barnes","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaip.2022.11.043_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S2213-2600(20)30389-1","article-title":"Efficacy and safety of once-daily single-inhaler triple therapy (FF\/UMEC\/VI) versus FF\/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial","volume":"9","author":"Lee","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2022.11.043_bib36","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S2213-2600(20)30053-9","article-title":"Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial","volume":"8","author":"Pavord","year":"2020","journal-title":"Lancet Respir Med"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219822013034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219822013034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:35:25Z","timestamp":1761975325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219822013034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S2213219822013034"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2022.11.043","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baseline FeNO Independently Predicts the Dupilumab Response in Patients With Moderate-to-Severe Asthma","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2022.11.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}