{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:13:07Z","timestamp":1793729587283,"version":"4.6.1"},"reference-count":56,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.jaip.2023.01.011","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T15:48:24Z","timestamp":1675266504000},"page":"713-723","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Treatable Traits in Airway Disease: From Theory to Practice"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3271-3788","authenticated-orcid":false,"given":"Alvar","family":"Agusti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa M.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2023.01.011_bib1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1164\/rccm.202109-2205PP","article-title":"Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes","volume":"205","author":"Reddel","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2023.01.011_bib2","unstructured":"Global Initiative for Chronic Obstructive Lung Disease. 2023. Accessed January 27, 2023. https:\/\/goldcopd.org\/"},{"key":"10.1016\/j.jaip.2023.01.011_bib3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1056\/NEJMra2202819","article-title":"Bronchiectasis\u2014a clinical review","volume":"387","author":"O\u2019Donnell","year":"2022","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2023.01.011_bib4","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/thoraxjnl-2014-205507","article-title":"The path to personalized medicine in COPD","volume":"69","author":"Agusti","year":"2014","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2023.01.011_bib5","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1183\/13993003.01359-2015","article-title":"Treatable traits: toward precision medicine of airway diseases","volume":"47","author":"Agusti","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.01.011_bib6","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/resp.13134","article-title":"Multidimensional assessment of severe asthma: a systematic review and meta-analysis","volume":"22","author":"Clark","year":"2017","journal-title":"Respirology"},{"key":"10.1016\/j.jaip.2023.01.011_bib7","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.jaip.2022.05.012","article-title":"Effectiveness of interventions targeting treatable traits for the management of obstructive airway diseases: a systematic review and meta-analysis","volume":"10","author":"Sarwar","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.01.011_bib8","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01509-2019","article-title":"Targeting treatable traits in severe asthma: a randomised controlled trial","volume":"55","author":"McDonald","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.01.011_bib9","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/thoraxjnl-2012-202646","article-title":"Multidimensional assessment and tailored interventions for COPD: respiratory utopia or common sense?","volume":"68","author":"McDonald","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2023.01.011_bib10","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02058-2018","article-title":"Treatable traits: a new paradigm for 21(st) century management of chronic airway diseases","volume":"53","author":"McDonald","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.01.011_bib11","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1177\/2040622315609251","article-title":"Eosinophilic airway inflammation: role in asthma and\u00a0chronic obstructive pulmonary disease","volume":"7","author":"George","year":"2016","journal-title":"Ther Adv Chronic Dis"},{"key":"10.1016\/j.jaip.2023.01.011_bib12","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/resp.14325","article-title":"Treatable traits in the NOVELTY study","volume":"27","author":"Agust\u00ed","year":"2022","journal-title":"Respirology"},{"key":"10.1016\/j.jaip.2023.01.011_bib13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/ageing\/afq134","article-title":"Multidimensional assessment of older people with asthma and COPD: clinical management and health status","volume":"40","author":"McDonald","year":"2011","journal-title":"Age Ageing"},{"key":"10.1016\/j.jaip.2023.01.011_bib14","doi-asserted-by":"crossref","first-page":"00934","DOI":"10.1183\/23120541.00934-2020","article-title":"Treatable traits in an English cohort: prevalence and predictors of future decline in lung function and quality of life in COPD","volume":"7","author":"Sarwar","year":"2021","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.jaip.2023.01.011_bib15","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/all.13629","article-title":"Treatable traits in the European U-BIOPRED adult asthma cohorts","volume":"74","author":"Simpson","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.01.011_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.rmed.2019.03.006","article-title":"Unmet therapeutic goals and potential treatable traits in a population of patients with severe uncontrolled asthma in Spain. ENEAS study","volume":"151","author":"P\u00e9rez de Llano","year":"2019","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2023.01.011_bib17","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00629-2017","article-title":"European Respiratory Society guidelines for the management of adult bronchiectasis","volume":"50","author":"Polverino","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.01.011_bib18","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/all.13370","article-title":"Comorbid \"treatable traits\" in difficult asthma: current evidence and clinical evaluation","volume":"73","author":"Tay","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.01.011_bib19","article-title":"The use of treatable traits to address COPD complexity and heterogeneity and to inform the care","volume":"17","author":"Duszyk","year":"2021","journal-title":"Breathe (Sheff)"},{"key":"10.1016\/j.jaip.2023.01.011_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/resp.13389","article-title":"Treatable traits can be identified in a severe asthma registry and predict future exacerbations","volume":"24","author":"McDonald","year":"2019","journal-title":"Respirology"},{"key":"10.1016\/j.jaip.2023.01.011_bib21","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.jaip.2020.09.046","article-title":"Treatable traits that predict health status and treatment response in airway disease","volume":"9","author":"Hiles","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.01.011_bib22","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/j.1365-2222.2005.02344.x","article-title":"Multi-dimensional phenotyping: towards a new taxonomy for airway disease","volume":"35","author":"Wardlaw","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.01.011_bib23","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0140-6736(02)11679-5","article-title":"Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial","volume":"360","author":"Green","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2023.01.011_bib24","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1136\/thoraxjnl-2018-211540","article-title":"Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis","volume":"73","author":"Petsky","year":"2018","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2023.01.011_bib25","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1183\/09031936.00146306","article-title":"Eosinophilic airway inflammation and exacerbations of COPD: a randomised controlled trial","volume":"29","author":"Siva","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.01.011_bib26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S2213-2600(20)30389-1","article-title":"Efficacy and safety of once-daily single-inhaler triple therapy (FF\/UMEC\/VI) versus FF\/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial","volume":"9","author":"Lee","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2023.01.011_bib27","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1016\/j.jaip.2021.08.028","article-title":"Asthma and comorbid conditions\u2014pulmonary comorbidity","volume":"9","author":"Gibson","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.01.011_bib28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S2213-2600(20)30413-6","article-title":"Trajectories of asthma and allergies from 7 years to 53 years and associations with lung function and extrapulmonary comorbidity profiles: a prospective cohort study","volume":"9","author":"Bui","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2023.01.011_bib29","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/S2213-2600(17)30434-4","article-title":"Lung function in early adulthood and health in later life: a transgenerational cohort analysis","volume":"5","author":"Agust\u00ed","year":"2017","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2023.01.011_bib30","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S2213-2600(18)30529-0","article-title":"Lung function trajectories in health and disease","volume":"4","author":"Agusti","year":"2019","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2023.01.011_bib31","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S2213-2600(21)00555-5","article-title":"Pathogenesis of chronic obstructive pulmonary disease: understanding the contributions of gene\u2013environment interactions across the lifespan","volume":"10","author":"Agust\u00ed","year":"2022","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2023.01.011_bib32","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ejim.2021.04.027","article-title":"Spirometry: a practical lifespan predictor of global health and chronic respiratory and non-respiratory diseases","volume":"89","author":"Agusti","year":"2021","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jaip.2023.01.011_bib33","doi-asserted-by":"crossref","first-page":"00215","DOI":"10.1183\/23120541.00215-2022","article-title":"Multidisciplinary care in chronic airway diseases: the Newcastle model","volume":"8","author":"McDonald","year":"2022","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.jaip.2023.01.011_bib34","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1111\/resp.13626","article-title":"Treatable traits and their application in high-, middle- and low-income countries","volume":"24","author":"McDonald","year":"2019","journal-title":"Respirology"},{"key":"10.1016\/j.jaip.2023.01.011_bib35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12931-022-01954-6","article-title":"COPD profiles and treatable traits using minimal resources: identification, decision tree and stability over time","volume":"23","author":"Marques","year":"2022","journal-title":"Respir Res"},{"key":"10.1016\/j.jaip.2023.01.011_bib36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.5694\/j.1326-5377.2003.tb05167.x","article-title":"Inhaled corticosteroid doses in asthma: an evidence-based approach","volume":"178","author":"Powell","year":"2003","journal-title":"Med J Aust"},{"key":"10.1016\/j.jaip.2023.01.011_bib37","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/resp.12746","article-title":"Should we treat obesity in COPD? The effects of diet and resistance exercise training","volume":"21","author":"McDonald","year":"2016","journal-title":"Respirology"},{"key":"10.1016\/j.jaip.2023.01.011_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s13679-017-0262-y","article-title":"Weight loss and improvement in comorbidity: differences at 5%, 10%, 15%, and over","volume":"6","author":"Ryan","year":"2017","journal-title":"Curr Obes Rep"},{"key":"10.1016\/j.jaip.2023.01.011_bib39","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/cea.12004","article-title":"Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial","volume":"43","author":"Scott","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.01.011_bib40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.5694\/mja2.51464","article-title":"Treatable traits in asthma: moving beyond diagnostic labels","volume":"216","author":"McDonald","year":"2022","journal-title":"Med J Aust"},{"key":"10.1016\/j.jaip.2023.01.011_bib41","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(17)30879-6","article-title":"After asthma\u2014redefining airways diseases","volume":"391","author":"Pavord","year":"2017","journal-title":"A\u00a0Lancet commission Lancet"},{"key":"10.1016\/j.jaip.2023.01.011_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2019.04.025","article-title":"Implementation science: what is it and why should I care?","volume":"283","author":"Bauer","year":"2020","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.jaip.2023.01.011_bib43","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","volume":"37","author":"Piepoli","year":"2016","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jaip.2023.01.011_bib44","doi-asserted-by":"crossref","first-page":"00570","DOI":"10.1183\/23120541.00570-2021","article-title":"Predicting the benefits of type-2 targeted anti-inflammatory treatment with the prototype Oxford Asthma Attack Risk Scale (ORACLE)","volume":"8","author":"Couillard","year":"2022","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.jaip.2023.01.011_bib45","series-title":"Case for action\u00a0-\u00a0proposal to NHMRC: targeted therapy for asthma. 2015","author":"Gibson","year":"2015"},{"key":"10.1016\/j.jaip.2023.01.011_bib46","doi-asserted-by":"crossref","first-page":"00812","DOI":"10.1183\/23120541.00812-2020","article-title":"It's like being on a roller coaster\u201d: the burden of caring for people with severe asthma","volume":"7","author":"Majellano","year":"2021","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.jaip.2023.01.011_bib47","doi-asserted-by":"crossref","first-page":"497","DOI":"10.3109\/02770903.2013.790415","article-title":"Insight into older peoples' healthcare experiences with managing COPD, asthma, and asthma-COPD overlap","volume":"50","author":"McDonald","year":"2013","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.jaip.2023.01.011_bib48","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/resp.14341","article-title":"Adding some NOVELTY to treatable traits","volume":"27","author":"Gibson","year":"2022","journal-title":"Respirology"},{"key":"10.1016\/j.jaip.2023.01.011_bib49","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.anai.2022.02.005","article-title":"Should we apply a treatable traits approach to asthma care?","volume":"128","author":"Melhorn","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.01.011_bib50","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.2147\/COPD.S330817","article-title":"Treatable traits in COPD\u2014a proposed approach","volume":"16","author":"Cardoso","year":"2021","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.jaip.2023.01.011_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0269038","article-title":"Using a knowledge translation framework to identify health care professionals\u2019 perceived barriers and enablers for personalised severe asthma care","volume":"17","author":"Majellano","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2023.01.011_bib52","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1748-5908-7-38","article-title":"Developing theory-informed behaviour change interventions to implement evidence into practice: a systematic approach using the Theoretical Domains Framework","volume":"7","author":"French","year":"2012","journal-title":"Implement Sci"},{"key":"10.1016\/j.jaip.2023.01.011_bib53","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4104\/pcrj.2011.00025","article-title":"The importance of clinical management problems in older people with COPD and asthma: do patients and physicians agree?","volume":"20","author":"McDonald","year":"2011","journal-title":"Prim Care Respir J"},{"key":"10.1016\/j.jaip.2023.01.011_bib54","doi-asserted-by":"crossref","first-page":"00497","DOI":"10.1183\/23120541.00497-2020","article-title":"What matters to people with severe asthma? Exploring add-on asthma medication and outcomes of importance","volume":"7","author":"Clark","year":"2021","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.jaip.2023.01.011_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1183\/13993003.01655-2017","article-title":"Precision medicine in airway diseases: moving to clinical practice","volume":"50","author":"Agust\u00ed","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.01.011_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106572","article-title":"Moving towards a treatable traits model of care for the management of obstructive airways diseases","volume":"187","author":"Agusti","year":"2021","journal-title":"Respir Med"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823000764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823000764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:36:40Z","timestamp":1761975400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219823000764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S2213219823000764"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2023.01.011","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatable Traits in Airway Disease: From Theory to Practice","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2023.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}