{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:35:03Z","timestamp":1773189303879,"version":"3.50.1"},"reference-count":103,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jaci-inpractice.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.jaip.2023.04.016","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T01:17:54Z","timestamp":1682644674000},"page":"2024-2031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Venom Anaphylaxis: Decision Points for a More Aggressive Workup"],"prefix":"10.1016","volume":"11","author":[{"given":"Patrizia","family":"Bonadonna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Korosec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Nalin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.K.","family":"Golden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2023.04.016_bib1","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/j.1398-9995.2005.00963.x","article-title":"EAACI Interest Group on Insect Venom Hypersensitivity. Diagnosis of Hymenoptera venom allergy","volume":"60","author":"Bil\u00f3","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.anai.2016.10.031","article-title":"Stinging insect hypersensitivity: a practice parameter update 2016","volume":"118","author":"Golden","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJMoa022952","article-title":"Outcomes of allergy to insect stings in children, with and without venom immunotherapy","volume":"351","author":"Golden","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2023.04.016_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.anai.2015.12.032","article-title":"Natural history of Hymenoptera venom allergy in children not treated with immunotherapy","volume":"116","author":"Lange","year":"2016","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.iac.2021.09.003","article-title":"Anaphylaxis to stinging insect venom","volume":"42","author":"Adams","year":"2022","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2023.04.016_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2500\/aap.2022.43.210109","article-title":"Venom allergen immunotherapy","volume":"43","author":"Golden","year":"2022","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2023.04.016_bib7","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.jaci.2008.11.018","article-title":"Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels","volume":"123","author":"Bonadonna","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib8","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jaci.2013.06.015","article-title":"Anaphylaxis: clinical patterns, mediator release, and severity","volume":"132","author":"Brown","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib9","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jaci.2020.06.008","article-title":"Phenotype and risk factors of venom-induced anaphylaxis: a case-control study of the European Anaphylaxis Registry","volume":"147","author":"Francuzik","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib10","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.jaci.2016.04.024","article-title":"Predominant Api m 10 sensitization as risk factor for treatment failure in honey bee venom immunotherapy","volume":"138","author":"Frick","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib11","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1016\/j.jaip.2021.04.045","article-title":"Biomarkers of the severity of honeybee sting reactions and the severity and threshold of systemic adverse events during immunotherapy","volume":"9","author":"Kopac","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib12","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jaci.2020.06.035","article-title":"Heritable risk for severe anaphylaxis associated with increased alpha-tryptase-encoding germline copy number at TPSAB1","volume":"147","author":"Lyons","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib13","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jaci.2009.08.027","article-title":"Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase-a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity","volume":"124","author":"Rueff","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jaci.2010.04.025","article-title":"Predictors of side effects during the buildup phase of venom immunotherapy for Hymenoptera venom allergy: the importance of baseline serum tryptase","volume":"126","author":"Rueff","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaci.2021.02.043","article-title":"Routine KIT p.D816V screening identifies clonal mast cell disease in patients with Hymenoptera allergy regularly missed using baseline tryptase levels alone","volume":"148","author":"Selb","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib16","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.jaci.2022.11.017","article-title":"H\u03b1T is associated with increased risk for severe Hymenoptera venom-triggered anaphylaxis","volume":"151","author":"\u0160elb","year":"2023","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/all.13945","article-title":"Risk factors and indicators of severe systemic insect sting reactions","volume":"75","author":"Stoevesandt","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib18","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/all.13380","article-title":"Factors increasing the risk for a severe reaction in anaphylaxis: an analysis of data from the European Anaphylaxis Registry","volume":"73","author":"Worm","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jaci.2014.11.035","article-title":"Clonal mast cell disorders in patients with severe Hymenoptera venom allergy and normal serum tryptase levels","volume":"136","author":"Zanotti","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib20","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/j.1398-9995.2005.00960.x","article-title":"EAACI Interest Group on Insect Venom Hypersensitivity. Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice","volume":"60","author":"Bonifazi","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib21","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1111\/cea.12582","article-title":"Immunological and clinical factors associated with adverse systemic reactions during the build-up phase of honeybee venom immunotherapy","volume":"45","author":"Koro\u0161ec","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib22","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jaci.2012.03.024","article-title":"Over- and underestimated parameters in severe Hymenoptera venom-induced anaphylaxis: cardiovascular medication and absence of urticaria\/angioedema","volume":"130","author":"Stoevesandt","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib23","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1111\/all.14785","article-title":"\u03b2-Blockers and ACE inhibitors are not a risk factor for severe systemic sting reactions and adverse events during venom immunotherapy","volume":"76","author":"Sturm","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.anai.2015.10.007","article-title":"Venom allergy testing: is a graded approach necessary?","volume":"116","author":"Quirt","year":"2016","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/all.12123","article-title":"Simultaneous intradermal testing with Hymenoptera venoms is safe and more efficient than sequential testing","volume":"68","author":"Strohmeier","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib26","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1067\/mai.2001.114706","article-title":"Insect sting allergy with negative venom skin test responses","volume":"107","author":"Golden","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib27","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1111\/j.1365-2222.2009.03347.x","article-title":"Basophil responsiveness in patients with insect sting allergies and negative venom-specific immunoglobulin E and skin prick test results","volume":"39","author":"Korosec","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib28","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.jaci.2013.10.046","article-title":"Sensitization to Hymenoptera venoms is common, but systemic sting reactions are rare","volume":"133","author":"Sturm","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"Suppl 23","key":"10.1016\/j.jaip.2023.04.016_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/pai.12563","article-title":"EAACI Molecular Allergology user\u2019s guide","author":"Matricardi","year":"2016","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib30","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.jaci.2013.10.060","article-title":"Component resolution reveals additional major allergens in patients with\u00a0honeybee venom allergy","volume":"133","author":"Kohler","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib31","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jaci.2011.03.012","article-title":"Low sensitivity of commercially available rApi m 1 for diagnosis of honeybee venom allergy","volume":"128","author":"Korosec","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib32","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1398-9995.2011.02667.x","article-title":"Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts","volume":"66","author":"Blank","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib33","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.jaci.2011.12.975","article-title":"High sensitivity of CAP-FEIA rVes v 5 and rVes v 1 for diagnosis of Vespula venom allergy","volume":"129","author":"Korosec","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib34","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.molimm.2009.10.005","article-title":"Dissecting cross-reactivity in Hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation","volume":"47","author":"Seismann","year":"2010","journal-title":"Mol Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib35","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0091-6749(93)90007-3","article-title":"Selection of Hymenoptera venoms for immunotherapy on the basis of patient's IgE antibody cross-reactivity","volume":"92","author":"Hamilton","year":"1993","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199250","article-title":"The culprit insect but not severity of allergic reactions to bee and wasp venom can be determined by molecular diagnosis","volume":"13","author":"Gattinger","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2023.04.016_bib37","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jaci.2010.06.042","article-title":"Added value of IgE detection to rApi m 1 and rVes v 5 in patients with Hymenoptera venom allergy","volume":"127","author":"Hofmann","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib38","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jaci.2010.03.017","article-title":"Recombinant allergen-based IgE testing to distinguish bee and wasp allergy","volume":"125","author":"Mittermann","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib39","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/cea.12639","article-title":"Improved recombinant Api m 1- and Ves v 5-based IgE testing to dissect bee and yellow jacket\u00a0allergy and their correlation with the severity of the sting reaction","volume":"46","author":"Selb","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib40","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1111\/all.14185","article-title":"Fluorescent labeling of major honeybee allergens Api m 1 and Api m 2 with quantum dots and the development of a multiplex basophil activation test","volume":"75","author":"Koren","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib41","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1111\/all.14832","article-title":"CytoBas: precision component-resolved diagnostics for allergy using flow cytometric staining of basophils with recombinant allergen tetramers","volume":"76","author":"McKenzie","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib42","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/all.12698","article-title":"The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease","volume":"70","author":"Hoffmann","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib43","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1111\/all.14747","article-title":"Basophil activation test: mechanisms and considerations for use in clinical trials and clinical practice","volume":"76","author":"Santos","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib44","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jaci.2018.06.049","article-title":"The basophil activation test differentiates between patients with alpha-gal syndrome and asymptomatic alpha-gal sensitization","volume":"143","author":"Mehlich","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib45","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jaci.2020.03.035","article-title":"Biomarkers of severity and threshold of allergic reactions during oral peanut challenges","volume":"146","author":"Santos","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib46","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.jaci.2015.01.012","article-title":"IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergens","volume":"135","author":"Santos","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib47","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.3389\/fimmu.2020.01815","article-title":"Basophil activation as marker of clinically relevant allergy and therapy outcome","volume":"11","author":"Eberlein","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib48","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jaci.2018.01.043","article-title":"Mast cell activation test in the diagnosis of allergic disease and anaphylaxis","volume":"142","author":"Bahri","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib49","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.jaip.2021.12.040","article-title":"The indirect basophil activation test is a safe, reliable, and accessible tool to diagnose a peanut allergy in children","volume":"10","author":"Ruinemans-Koerts","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib50","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jaci.2018.03.011","article-title":"A\u00a0novel human mast cell activation test for peanut allergy","volume":"142","author":"Santos","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib51","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1159\/000348500","article-title":"Clinical routine utility of basophil activation testing for diagnosis of Hymenoptera-allergic patients with emphasis on individuals with negative venom-specific IgE antibodies","volume":"161","author":"Korosec","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib52","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jaip.2019.06.008","article-title":"Possible utility of basophil activation test in dual honeybee and vespid sensitization","volume":"8","author":"Bokanovic","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib53","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jaci.2012.02.008","article-title":"Double positivity to bee and wasp venom: improved diagnostic procedure by recombinant allergen-based IgE testing and basophil activation test including data about cross-reactive carbohydrate determinants","volume":"130","author":"Eberlein","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib54","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1016\/j.jaip.2021.05.006","article-title":"Biomarkers in insect venom allergy\u2014the key to all diagnostic problems?","volume":"9","author":"Aberer","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib55","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000116361","article-title":"Basophil sensitivity in patients not responding to venom immunotherapy","volume":"146","author":"Peternelj","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib56","first-page":"110","article-title":"Basophil activation can predict clinical sensitivity in patients after venom immunotherapy","volume":"20","author":"Kucera","year":"2010","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib57","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1399-3038.2011.01233.x","article-title":"Monitoring honeybee venom immunotherapy in children with the basophil activation test","volume":"23","author":"Zitnik","year":"2012","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib58","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1398-9995.2012.02817.x","article-title":"Basophil response and the induction of a tolerance in venom immunotherapy: a long-term sting challenge study","volume":"67","author":"Erzen","year":"2012","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib59","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jaci.2019.10.038","article-title":"Sustained successful peanut oral immunotherapy associated with low basophil activation and peanut-specific IgE","volume":"145","author":"Tsai","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib60","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1111\/all.15161","article-title":"Platelet-activating factor acetylhydrolase: a biomarker in Hymenoptera venom allergy?","volume":"77","author":"Bilo","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib61","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jaci.2021.02.023","article-title":"Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis","volume":"148","author":"Gulen","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib62","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1046\/j.1365-2133.1999.03214.x","article-title":"Mastocytosis associated with severe wasp sting anaphylaxis detected by elevated serum mast cell tryptase levels","volume":"141","author":"Biedermann","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaip.2023.04.016_bib63","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1046\/j.1365-2222.2003.01755.x","article-title":"Elevated basal serum tryptase and Hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy","volume":"33","author":"Haeberli","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib64","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0140-6736(00)03647-3","article-title":"Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings","volume":"357","author":"Ludolph-Hauser","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2023.04.016_bib65","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/j.1398-9995.2009.02108.x","article-title":"How much specific is the association between Hymenoptera venom allergy and mastocytosis?","volume":"64","author":"Bonadonna","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib66","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jaip.2017.02.008","article-title":"Risk factor analysis of anaphylactic reactions in patients with systemic mastocytosis","volume":"5","author":"Gulen","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib67","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.iac.2014.02.004","article-title":"Epidemiology, diagnosis, and treatment of Hymenoptera venom allergy in mastocytosis patients","volume":"34","author":"Niedoszytko","year":"2014","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2023.04.016_bib68","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1515\/CCLM.2010.124","article-title":"Factors influencing serum total tryptase concentrations in a general adult population","volume":"48","author":"Gonzalez-Quintela","year":"2010","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jaip.2023.04.016_bib69","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2500\/aap.2014.35.3769","article-title":"Serum basal tryptase levels in healthy children: correlation between age and gender","volume":"35","author":"Sahiner","year":"2014","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2023.04.016_bib70","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1016\/j.jaip.2021.12.031","article-title":"Elevated basal serum tryptase: disease distribution and variability in a regional health system","volume":"10","author":"Waters","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib71","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1111\/j.1365-2222.2011.03848.x","article-title":"An increase in serum tryptase even below 11.4 ng\/mL may indicate a mast cell-mediated hypersensitivity reaction: a prospective study in Hymenoptera venom allergic patients","volume":"41","author":"Borer-Reinhold","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib72","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000328760","article-title":"Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal","volume":"157","author":"Valent","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib73","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jaci.2021.08.007","article-title":"Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis","volume":"149","author":"Mateja","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib74","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1365-2222.2009.03251.x","article-title":"Elevated baseline serum tryptase, mastocytosis and anaphylaxis","volume":"39","author":"Muller","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib75","doi-asserted-by":"crossref","first-page":"193","DOI":"10.18176\/jiaci.0233","article-title":"Prevalence of clonal mast cell disorders in patients presenting with Hymenoptera venom anaphylaxis might be higher than expected","volume":"28","author":"Vazquez-Revuelta","year":"2018","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib76","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000329856","article-title":"Validation of the REMA score for predicting mast cell clonality and systemic mastocytosis in patients with systemic mast cell activation symptoms","volume":"157","author":"Alvarez-Twose","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib77","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jaci.2013.06.020","article-title":"Nonaggressive systemic mastocytosis (SM) without skin lesions associated with insect-induced anaphylaxis shows unique features versus other indolent SM","volume":"133","author":"Alvarez-Twose","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib78","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/j.jaip.2021.03.005","article-title":"The genetic basis and clinical impact of hereditary alpha-tryptasemia","volume":"9","author":"Luskin","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib79","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.jaip.2020.05.057","article-title":"Hereditary alpha-tryptasemia: UK prevalence and variability in disease expression","volume":"8","author":"Robey","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib80","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.jaci.2021.06.017","article-title":"Hereditary alpha tryptasemia is not associated with specific clinical phenotypes","volume":"149","author":"Chollet","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib81","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1067\/mai.2001.119154","article-title":"Patients still reacting to a sting challenge while receiving conventional Hymenoptera venom immunotherapy are protected by increased venom doses","volume":"108","author":"Rueff","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"Pt 1","key":"10.1016\/j.jaip.2023.04.016_bib82","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0091-6749(97)70314-2","article-title":"Fatal anaphylaxis after a yellow jacket sting, despite venom immunotherapy, in two patients with mastocytosis","volume":"99","author":"Oude Elberink","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib83","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.jaip.2017.03.019","article-title":"Fatal anaphylaxis to yellow jacket stings in mastocytosis: options for identification and treatment of at-risk patients","volume":"5","author":"Vos","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib84","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/ACI.0000000000000569","article-title":"Tryptase values in anaphylaxis and insect allergy","volume":"19","author":"Bonadonna","year":"2019","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib85","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.iac.2018.04.010","article-title":"Hymenoptera anaphylaxis as a clonal mast cell disorder","volume":"38","author":"Bonadonna","year":"2018","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2023.04.016_bib86","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/ajh.24382","article-title":"Clinical presentation and management practice of systemic mastocytosis. A survey on 460 Italian patients","volume":"91","author":"Pieri","year":"2016","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jaip.2023.04.016_bib87","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1398-9995.2007.01569.x","article-title":"Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients","volume":"63","author":"Brockow","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib88","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1365-2222.2007.02804.x","article-title":"Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA)","volume":"37","author":"Gonzalez de Olano","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib89","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/bjh.12916","article-title":"Epidemiology of systemic mastocytosis in Denmark","volume":"166","author":"Cohen","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaip.2023.04.016_bib90","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.jaci.2012.10.015","article-title":"Prevalence of indolent systemic mastocytosis in a Dutch region","volume":"131","author":"van Doormaal","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib91","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.3390\/cancers13246380","article-title":"A\u00a0multidisciplinary diagnostic approach reveals a higher prevalence of indolent systemic mastocytosis: 15-years' experience of the GISM network","volume":"13","author":"Zanotti","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jaip.2023.04.016_bib92","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41375-021-01406-y","article-title":"Refined diagnostic criteria for bone marrow mastocytosis: a proposal of the European competence network on mastocytosis","volume":"36","author":"Zanotti","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.jaip.2023.04.016_bib93","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3324\/haematol.2010.034553","article-title":"Isolated bone marrow mastocytosis: an underestimated subvariant of indolent systemic mastocytosis","volume":"96","author":"Zanotti","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.jaip.2023.04.016_bib94","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1182\/blood-2009-10-249979","article-title":"WHO subvariants of indolent mastocytosis: clinical details and prognostic evaluation in 159 consecutive adults","volume":"115","author":"Pardanani","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2023.04.016_bib95","doi-asserted-by":"crossref","first-page":"e646","DOI":"10.1097\/HS9.0000000000000646","article-title":"Updated diagnostic criteria and classification of mast cell disorders: a consensus proposal","volume":"5","author":"Valent","year":"2021","journal-title":"Hemasphere"},{"key":"10.1016\/j.jaip.2023.04.016_bib96","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"key":"10.1016\/j.jaip.2023.04.016_bib97","doi-asserted-by":"crossref","DOI":"10.4084\/MJHID.2021.068","article-title":"Systemic mastocytosis: multidisciplinary approach","volume":"13","author":"Zanotti","year":"2021","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"10.1016\/j.jaip.2023.04.016_bib98","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.jaci.2022.04.004","article-title":"Clinical impact and proposed application of molecular markers, genetic variants, and cytogenetic analysis in mast cell neoplasms: status 2022","volume":"149","author":"Arock","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.016_bib99","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.iac.2006.05.010","article-title":"Diagnostic value of tryptase in anaphylaxis and mastocytosis","volume":"26","author":"Schwartz","year":"2006","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2023.04.016_bib100","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/all.13262","article-title":"EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy","volume":"73","author":"Sturm","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.04.016_bib101","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2796.1993.tb00984.x","article-title":"Anaphylactoid shock following Hymenoptera sting as a presenting symptom of systemic mastocytosis","volume":"233","author":"Kors","year":"1993","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.jaip.2023.04.016_bib102","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.jaip.2017.11.025","article-title":"Anaphylactic reactions after discontinuation of Hymenoptera venom immunotherapy: a clonal mast cell disorder should be suspected","volume":"6","author":"Bonadonna","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.016_bib103","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.anai.2012.09.014","article-title":"Efficacy of venom immunotherapy given every 3 or 4 months: a prospective comparison with the conventional regimen","volume":"110","author":"Simioni","year":"2013","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823004567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823004567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T16:37:57Z","timestamp":1736872677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219823004567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":103,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S2213219823004567"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2023.04.016","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Venom Anaphylaxis: Decision Points for a More Aggressive Workup","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2023.04.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}