{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:43:36Z","timestamp":1775004216649,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["101390"],"award-info":[{"award-number":["101390"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["20045"],"award-info":[{"award-number":["20045"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jaip.2023.04.038","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T21:57:04Z","timestamp":1683842224000},"page":"2484-2490.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hormonal Contraceptives Are Associated With an Increase in Incidence of Asthma in Women"],"prefix":"10.1016","volume":"11","author":[{"given":"Erik Soeren Halvard","family":"Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Aasbjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalie Lykkemark","family":"Moeller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amani","family":"Meaidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Gade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte Suppli","family":"Ulrik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke","family":"Backer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2023.04.038_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/aogs.13055","article-title":"Contraceptive use in the Nordic countries","volume":"96","author":"Lindh","year":"2017","journal-title":"Acta Obstet Gynaecol Scand"},{"key":"10.1016\/j.jaip.2023.04.038_bib2","series-title":"United Nations. World Contraceptive Patterns 2013","first-page":"11","year":"2013"},{"key":"10.1016\/j.jaip.2023.04.038_bib3","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.rmed.2015.03.007","article-title":"Early menarche is associated with increased risk of asthma: prospective population-based study of twins","volume":"109","author":"Lieberoth","year":"2015","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2023.04.038_bib4","first-page":"A4936","article-title":"Adolescent girls in Denmark use oral contraceptives at an increasingly young age, and with more pauses and shifts","volume":"61","author":"L\u00f8kkegaard","year":"2014","journal-title":"Dan Med J"},{"key":"10.1016\/j.jaip.2023.04.038_bib5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.jaip.2022.02.002","article-title":"Personalized treatment of asthma: the importance of sex and gender differences","volume":"10","author":"Jenkins","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.038_bib6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.chest.2021.01.054","article-title":"Hormone replacement therapy and development of new asthma","volume":"160","author":"Hansen","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2023.04.038_bib7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jaci.2020.02.027","article-title":"Hormonal contraceptives and onset of asthma in reproductive-age women: population-based cohort study","volume":"146","author":"Nwaru","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.038_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/thoraxjnl-2020-215540","article-title":"Hormonal contraception and the risk of severe asthma exacerbation: 17-year population-based cohort study","volume":"76","author":"Nwaru","year":"2021","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2023.04.038_bib9","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/0141076815588320","article-title":"Hormonal contraceptives and asthma in women of reproductive age: analysis of data from serial national Scottish Health Surveys","volume":"108","author":"Nwaru","year":"2015","journal-title":"J\u00a0R Soc Med"},{"key":"10.1016\/j.jaip.2023.04.038_bib10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1136\/thx.56.8.613","article-title":"Exogenous female sex steroid hormones and risk of asthma and asthma-like symptoms: a cross sectional study of the general population","volume":"56","author":"Lange","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2023.04.038_bib11","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00026-2015","article-title":"Hormonal contraception increases risk of asthma among obese but decreases it among nonobese subjects: a prospective, population-based cohort study","volume":"1","author":"Matheson","year":"2015","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.jaip.2023.04.038_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2020-046400","article-title":"Population-based study of the association between asthma and exogenous female sex hormone use","volume":"11","author":"Jung","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.jaip.2023.04.038_bib13","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1164\/rccm.200509-1493OC","article-title":"Spontaneous airway hyperresponsiveness in estrogen receptor-\u03b1\u2013deficient mice","volume":"175","author":"Carey","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2023.04.038_bib14","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jaci.2015.05.046","article-title":"Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23\/IL-23 receptor signaling and IL-17A production in patients with severe asthma","volume":"136","author":"Newcomb","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.038_bib15","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181117","article-title":"Estrogen ameliorates allergic airway inflammation by regulating activation of NLRP3 in mice","volume":"39","author":"Cheng","year":"2019","journal-title":"Biosci Rep"},{"key":"10.1016\/j.jaip.2023.04.038_bib16","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The STrengthening the Reporting of OBservational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.jaip.2023.04.038_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.2147\/CLEP.S91125","article-title":"The Danish National patient registry: a review of content, data quality, and research potential","volume":"7","author":"Schmidt","year":"2015","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.jaip.2023.04.038_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1403494810394717","article-title":"The Danish national prescription registry","volume":"39","author":"Wallach Kildemoes","year":"2011","journal-title":"Scand J Public Health"},{"key":"10.1016\/j.jaip.2023.04.038_bib20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2147\/CLEP.S99494","article-title":"The Danish National Database for Asthma","volume":"8","author":"Backer","year":"2016","journal-title":"Clin Epidemiol"},{"key":"10.1016\/j.jaip.2023.04.038_bib21","first-page":"35","article-title":"Risk set sampling in epidemiologic cohort studies","volume":"11","author":"Langholz","year":"1996","journal-title":"Stat Sci"},{"key":"10.1016\/j.jaip.2023.04.038_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00001648-199901000-00008","article-title":"Causal diagrams for epidemiologic research","volume":"10","author":"Greenland","year":"1999","journal-title":"Epidemiology"},{"key":"10.1016\/j.jaip.2023.04.038_bib23","first-page":"CD003987","article-title":"Combination contraceptives: effects on weight","volume":"1","author":"Gallo","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jaip.2023.04.038_bib24","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s11882-021-01024-9","article-title":"Obesity, inflammation, and severe asthma: an update","volume":"21","author":"Sharma","year":"2021","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2023.04.038_bib25","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.rmed.2010.02.018","article-title":"Increased serum IL-17 is an independent risk factor for severe asthma","volume":"104","author":"Agache","year":"2010","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2023.04.038_bib26","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.3389\/fimmu.2020.01724","article-title":"Contribution of IL-17 in steroid hyporesponsiveness in obese asthmatics through dysregulation of glucocorticoid receptors \u03b1 and \u03b2","volume":"11","author":"al Heialy","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jaip.2023.04.038_bib27","first-page":"27","article-title":"Effect of female hormones on the production of IL-4 and IL-13 from peripheral blood mononuclear cells","volume":"537","author":"Hamano","year":"1998","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.jaip.2023.04.038_bib28","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01509-2019","article-title":"Targeting treatable traits in severe asthma: a randomised controlled trial","volume":"55","author":"McDonald","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.04.038_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2022.106793","article-title":"The German severe asthma patient: baseline characteristics of patients in the German Severe Asthma Registry, and relationship with exacerbations and control","volume":"195","author":"Korn","year":"2022","journal-title":"Respir Med"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823005226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823005226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:37:09Z","timestamp":1761975429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219823005226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2213219823005226"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2023.04.038","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hormonal Contraceptives Are Associated With an Increase in Incidence of Asthma in Women","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2023.04.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}