{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:36:59Z","timestamp":1790426219650,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.jaip.2023.04.051","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T21:33:30Z","timestamp":1683927210000},"page":"2557-2567.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of an Inpatient Allergy Guideline on \u03b2-Lactam and Alternative Antibiotic Use"],"prefix":"10.1016","volume":"11","author":[{"given":"Iris M.","family":"Otani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lusha","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Anstey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Hilts-Horeczko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent P.","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Bystritsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Mulliken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L.","family":"Wattier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly G.","family":"Blumenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah B.","family":"Doernberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2023.04.051_bib1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.anai.2015.05.011","article-title":"Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy","volume":"115","author":"Blumenthal","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.04.051_bib2","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.2018.19283","article-title":"Evaluation and management of penicillin allergy: a review","volume":"321","author":"Shenoy","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2023.04.051_bib3","article-title":"Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study","volume":"361","author":"Blumenthal","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.jaip.2023.04.051_bib4","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.jaip.2016.09.045","article-title":"A\u00a0proactive approach to penicillin allergy testing in hospitalized patients","volume":"5","author":"Chen","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.051_bib5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jaci.2017.02.005","article-title":"Tackling inpatient penicillin allergies: assessing tools for antimicrobial stewardship","volume":"140","author":"Blumenthal","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.04.051_bib6","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1093\/ajhp\/61.12.1271","article-title":"Pharmacist-managed service providing penicillin allergy skin tests","volume":"61","author":"Wall","year":"2004","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.jaip.2023.04.051_bib7","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2146\/ajhp150288","article-title":"Implementation of a penicillin allergy screening tool to optimize aztreonam use","volume":"73","author":"Staicu","year":"2016","journal-title":"Am J Health Syst Pharm"},{"issue":"Suppl 1","key":"10.1016\/j.jaip.2023.04.051_bib8","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.2146\/ajhp150440","article-title":"Impact of an antimicrobial stewardship initiative to evaluate \u03b2-lactam allergy in patients ordered aztreonam","volume":"73","author":"Estep","year":"2016","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/j.jaip.2023.04.051_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.anai.2016.04.021","article-title":"Penicillin skin testing in hospitalized patients with \u03b2-lactam allergies: effect on antibiotic selection and cost","volume":"117","author":"King","year":"2016","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.04.051_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s11096-016-0248-y","article-title":"A\u00a0multidimensional antimicrobial stewardship intervention targeting aztreonam use in patients with a reported penicillin allergy","volume":"38","author":"Swearingen","year":"2016","journal-title":"Int J Clin Pharm"},{"key":"10.1016\/j.jaip.2023.04.051_bib11","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jaip.2017.11.012","article-title":"Use of a penicillin allergy screening algorithm and penicillin skin testing for transitioning hospitalized patients to first-line antibiotic therapy","volume":"6","author":"Ramsey","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.04.051_bib12","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1017\/ice.2019.50","article-title":"Outcomes from an inpatient beta-lactam allergy guideline across a large US health system","volume":"40","author":"Blumenthal","year":"2019","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jaip.2023.04.051_bib13","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.anai.2018.11.008","article-title":"Inpatient \u03b2-lactam test-dose protocol and antimicrobial stewardship in patients with a history of penicillin allergy","volume":"122","author":"Sacco","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.04.051_bib14","first-page":"147","article-title":"Improving antibiotic stewardship for inpatients with reported beta-lactam allergies and limited access to penicillin skin testing","volume":"48","author":"Berger","year":"2022","journal-title":"Jt Comm J Qual Patient Saf"},{"key":"10.1016\/j.jaip.2023.04.051_bib15","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jaip.2017.02.019","article-title":"Addressing inpatient beta-lactam allergies: a multihospital implementation","volume":"5","author":"Blumenthal","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"Suppl","key":"10.1016\/j.jaip.2023.04.051_bib16","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.1016\/j.diagmicrobio.2006.12.004","article-title":"Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift","volume":"57","author":"Pichichero","year":"2007","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jaip.2023.04.051_bib17","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1542\/peds.2004-1276","article-title":"A\u00a0review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillin-allergic patients","volume":"115","author":"Pichichero","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2023.04.051_bib19","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1086\/420936","article-title":"The use and interpretation of quasi-experimental studies in infectious diseases","volume":"38","author":"Harris","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2023.04.051_bib21","first-page":"348","article-title":"Interrupted time series regression for the evaluation of public health interventions: a tutorial","volume":"46","author":"Bernal","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaip.2023.04.051_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1365-2710.2002.00430.x","article-title":"Segmented regression analysis of interrupted time series studies in medication use research","volume":"27","author":"Wagner","year":"2002","journal-title":"J\u00a0Clin Pharm Ther"},{"key":"10.1016\/j.jaip.2023.04.051_bib23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/1536867X1501500208","article-title":"Conducting interrupted time-series analysis for single- and multiple-group comparisons","volume":"15","author":"Linden","year":"2015","journal-title":"Stata J"},{"key":"10.1016\/j.jaip.2023.04.051_bib24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/1536867X1701700105","article-title":"A\u00a0comprehensive set of postestimation measures to enrich interrupted time series analysis","volume":"17","author":"Linden","year":"2017","journal-title":"Stata J"},{"key":"10.1016\/j.jaip.2023.04.051_bib25","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.8367","article-title":"Association between removal of a warning against cephalosporin use in patients with penicillin allergy and antibiotic prescribing","volume":"4","author":"Macy","year":"2021","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.jaip.2023.04.051_bib26","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/jac\/dkz082","article-title":"Evaluation of a pharmacist-led penicillin allergy de-labelling ward round: a novel antimicrobial stewardship intervention","volume":"74","author":"Devchand","year":"2019","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.jaip.2023.04.051_bib27","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/cid\/ciaa653","article-title":"The penicillin allergy delabeling program: a multicenter whole-of-hospital health services intervention and comparative effectiveness study","volume":"73","author":"Chua","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jaip.2023.04.051_bib28","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.anai.2022.03.010","article-title":"Association of antibiotic allergy labels with hospital length of stay","volume":"128","author":"Lanoue","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.04.051_bib29","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1001\/jamainternmed.2020.2227","article-title":"Association between penicillin allergy documentation and antibiotic use","volume":"180","author":"Blumenthal","year":"2020","journal-title":"JAMA Intern Med"},{"key":"10.1016\/j.jaip.2023.04.051_bib30","first-page":"348","article-title":"Interrupted time series regression for the evaluation of public health interventions: a tutorial","volume":"46","author":"Bernal","year":"2017","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.jaip.2023.04.051_bib31","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1365-2710.2002.00430.x","article-title":"Segmented regression analysis of interrupted time series studies in medication use research","volume":"27","author":"Wagner","year":"2002","journal-title":"J\u00a0Clin Pharm Ther"},{"key":"10.1016\/j.jaip.2023.04.051_bib32","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1177\/1536867X1501500208","article-title":"Conducting interrupted time-series analysis for single- and multiple-group comparisons","volume":"15","author":"Linden","year":"2015","journal-title":"Stata J"},{"key":"10.1016\/j.jaip.2023.04.051_bib33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/1536867X1701700105","article-title":"A\u00a0comprehensive set of postestimation measures to enrich interrupted time series analysis","volume":"17","author":"Linden","year":"2017","journal-title":"Stata J"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823005366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823005366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:39:39Z","timestamp":1761975579000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219823005366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2213219823005366"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2023.04.051","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of an Inpatient Allergy Guideline on \u03b2-Lactam and Alternative Antibiotic Use","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2023.04.051","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}