{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:33:57Z","timestamp":1789774437693,"version":"4.0.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jaci-inpractice.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.jaip.2023.05.043","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T06:29:30Z","timestamp":1686205770000},"page":"3055-3061.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Patients With Asthma Only Sensitized to Staphylococcus aureus Enterotoxins Have More Exacerbations, Airflow Limitation, and Higher Levels of Sputum IL-5 and IgE"],"prefix":"10.1016","volume":"11","author":[{"given":"Florence","family":"Schleich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Moermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gerday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Ziant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bougard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Paulus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Guissard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Henket","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Bachert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2023.05.043_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaci.2014.11.011","article-title":"The microbiome in asthma","volume":"135","author":"Huang","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.05.043_bib2","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1183\/09031936.00201813","article-title":"Importance of concomitant local and systemic eosinophilia in uncontrolled asthma","volume":"44","author":"Schleich","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.05.043_bib3","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/nm.3300","article-title":"Eosinophils in the spotlight: eosinophilic airway inflammation in nonallergic asthma","volume":"19","author":"Brusselle","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.jaip.2023.05.043_bib4","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1365-2796.2012.02559.x","article-title":"Chronic rhinosinusitis and asthma: novel understanding of the role of IgE \u201cabove atopy.\u201d","volume":"272","author":"Bachert","year":"2012","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.jaip.2023.05.043_bib5","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.jaci.2019.01.018","article-title":"Nonatopic severe asthma might still be atopic: sensitization toward Staphylococcus aureus enterotoxins","volume":"143","author":"Schreiber","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.05.043_bib6","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00198-2019","article-title":"Sensitisation to staphylococcal enterotoxins and asthma severity: a longitudinal study in the EGEA cohort","volume":"54","author":"Sintobin","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.05.043_bib7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jaci.2012.05.012","article-title":"Specific IgE against Staphylococcus aureus enterotoxins: an independent risk factor for asthma","volume":"130","author":"Bachert","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.05.043_bib8","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1034\/j.1398-9995.2002.23608.x","article-title":"Sputum eosinophil count in a large population of patients with mild to moderate steroid-naive asthma: distribution and relationship with methacholine bronchial hyperresponsiveness","volume":"57","author":"Louis","year":"2002","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.05.043_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s40629-015-0067-z","article-title":"Molecular allergy diagnostics using IgE singleplex determinations: methodological and practical considerations for use in clinical routine: part 18 of the Series Molecular Allergology","volume":"24","author":"Kleine-Tebbe","year":"2015","journal-title":"Allergo J Int"},{"key":"10.1016\/j.jaip.2023.05.043_bib10","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/j.jaci.2017.05.008","article-title":"ImmunoCAP assays: pros and cons in allergology","volume":"140","author":"van Hage","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.05.043_bib11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1136\/thx.47.2.76","article-title":"Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials 1","volume":"47","author":"Juniper","year":"1992","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2023.05.043_bib12","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1034\/j.1399-3003.1999.14d29.x","article-title":"Development and validation of a questionnaire to measure asthma control","volume":"14","author":"Juniper","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.05.043_bib13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaci.2003.09.008","article-title":"Development of the Asthma Control Test: a survey for assessing asthma control","volume":"113","author":"Nathan","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.05.043_bib14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1136\/thorax.2003.011130","article-title":"Nebulised salbutamol administered during sputum induction improves bronchoprotection in patients with asthma","volume":"59","author":"Delvaux","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2023.05.043_bib15","article-title":"Asthmatics with concordant eosinophilic disease classified according to their serum IgE status","volume":"79","author":"Gerday","year":"2021","journal-title":"Respir Med Res"},{"key":"10.1016\/j.jaip.2023.05.043_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1378\/chest.12-1961","article-title":"A\u00a0proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma","volume":"144","author":"Garcia","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2023.05.043_bib17","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.chest.2023.01.037","article-title":"Sputum type 2 markers could predict remission in severe asthma treated with anti-IL-5","volume":"163","author":"Moermans","year":"2023","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2023.05.043_bib18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/all.15466","article-title":"Different aspects of severe asthma in real life: role of Staphylococcus aureus enterotoxins and correlation to comorbidities and disease severity","volume":"78","author":"Caruso","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.05.043_bib19","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2016.05.041","article-title":"Diversity of TH cytokine profiles in patients with chronic rhinosinusitis: a multicenter study in Europe, Asia, and Oceania","volume":"138","author":"Wang","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.05.043_bib20","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1378\/chest.09-0667","article-title":"Determinants of exhaled nitric oxide in chronic rhinosinusitis","volume":"137","author":"Guida","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2023.05.043_bib21","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jaip.2020.02.023","article-title":"Clinical research needs for the management of chronic rhinosinusitis with nasal polyps in the new era of biologics: a National Institute of Allergy and Infectious Diseases workshop","volume":"8","author":"Naclerio","year":"2020","journal-title":"J\u00a0allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.05.043_bib22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S1081-1206(10)62222-3","article-title":"A\u00a0superantigen hypothesis for the pathogenesis of chronic hypertrophic rhinosinusitis, allergic fungal sinusitis, and related disorders","volume":"87","author":"Schubert","year":"2001","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.05.043_bib23","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.jaci.2017.01.019","article-title":"Extracellular eosinophilic traps in association with Staphylococcus aureus at the site of epithelial barrier defects in patients with severe airway inflammation","volume":"139","author":"Gevaert","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.05.043_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaw4295","article-title":"Protein crystallization promotes type 2 immunity and is reversible by antibody treatment","volume":"364","author":"Persson","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.jaip.2023.05.043_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058388","article-title":"Sputum IgE and cytokines in asthma: relationship with sputum cellular profile","volume":"8","author":"Manise","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2023.05.043_bib26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0091-6749(97)80019-X","article-title":"IL-5 synthesis is upregulated in human nasal polyp tissue","volume":"99","author":"Bachert","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823006426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823006426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T08:06:57Z","timestamp":1734422817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219823006426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S2213219823006426"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2023.05.043","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patients With Asthma Only Sensitized to Staphylococcus aureus Enterotoxins Have More Exacerbations, Airflow Limitation, and Higher Levels of Sputum IL-5 and IgE","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2023.05.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}