{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:11:49Z","timestamp":1782511909736,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jaip.2023.08.027","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:02:18Z","timestamp":1692964938000},"page":"111-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["The Impact of Airway Obstruction on Feno Values in Asthma Patients"],"prefix":"10.1016","volume":"12","author":[{"given":"Alain","family":"Michils","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Akset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaryllis","family":"Haccuria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Perez-Bogerd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre\u00ef","family":"Malinovschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Van Muylem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2023.08.027_bib1","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(17)30879-6","article-title":"After asthma: redefining airways diseases","volume":"391","author":"Pavord","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2023.08.027_bib2","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1365-2222.2008.02969.x","article-title":"IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells","volume":"38","author":"Chibana","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.08.027_bib3","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1165\/rcmb.2006-0419OC","article-title":"Measurement of IL-13-induced iNOS-derived gas phase nitric oxide in human bronchial epithelial cells","volume":"37","author":"Suresh","year":"2007","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jaip.2023.08.027_bib5","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1164\/rccm.201208-1414OC","article-title":"Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study","volume":"187","author":"Hanania","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib6","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1056\/NEJMoa1804092","article-title":"Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma","volume":"378","author":"Castro","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S2213-2600(20)30389-1","article-title":"Efficacy and safety of once-daily single-inhaler triple therapy (FF\/UMEC\/VI) versus FF\/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial","volume":"9","author":"Lee","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1164\/ajrccm.158.1.9703005","article-title":"Exhaled nitric oxide (NO) is reduced shortly after bronchoconstriction to direct and indirect stimuli in asthma","volume":"158","author":"de Gouw","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib9","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.jaci.2013.12.1070","article-title":"Exhaled nitric oxide: a biomarker integrating both lung function and airway inflammation changes","volume":"134","author":"Haccuria","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.08.027_bib10","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1034\/j.1399-3003.2000.01506.x","article-title":"The current single exhalation method of measuring exhales nitric oxide is affected by airway calibre","volume":"15","author":"Ho","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.08.027_bib11","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1136\/thorax.57.9.771","article-title":"Reduction in exhaled nitric oxide immediately after methacholine challenge in asthmatic children","volume":"57","author":"Piacentini","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2023.08.027_bib12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.resp.2012.09.011","article-title":"Axial distribution of nitric oxide airway production in asthma patients","volume":"185","author":"Van Muylem","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.jaip.2023.08.027_bib13","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1152\/japplphysiol.01019.2007","article-title":"Effect of airways constriction on exhaled nitric oxide","volume":"104","author":"Verbanck","year":"2008","journal-title":"J\u00a0Appl Physiol (1985)"},{"key":"10.1016\/j.jaip.2023.08.027_bib14","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/japplphysiol.00530.2017","article-title":"A\u00a0new role for the exhaled nitric oxide as a functional marker of peripheral airway caliber changes: a theoretical study","volume":"124","author":"Karamaoun","year":"2018","journal-title":"J\u00a0Appl Physiol (1985)"},{"key":"10.1016\/j.jaip.2023.08.027_bib15","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01749-2017","article-title":"Small airways dysfunction: the link between allergic rhinitis and allergic asthma","volume":"51","author":"Haccuria","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.08.027_bib16","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/rccm.9120-11ST","article-title":"An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications","volume":"184","author":"Dweik","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1164\/ajrccm.152.2.7543345","article-title":"Acute and chronic effects of cigarette smoking on exhaled nitric oxide","volume":"152","author":"Kharitonov","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.08.027_bib19","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib20","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1183\/09031936.00080312","article-title":"Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations","volume":"40","author":"Quanjer","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.08.027_bib21","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.rmed.2004.10.008","article-title":"Measurement properties and interpretation of three shortened versions of the asthma control questionnaire","volume":"99","author":"Juniper","year":"2005","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib22","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1034\/j.1399-3003.1999.14d29.x","article-title":"Development and validation of a questionnaire to measure asthma control","volume":"14","author":"Juniper","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.08.027_bib23","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.rmed.2005.08.012","article-title":"Identifying \u2018well-controlled\u2019 and \u2018not well-controlled\u2019 asthma using the Asthma Control Questionnaire","volume":"100","author":"Juniper","year":"2006","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib24","series-title":"Team Rc. R Core Team R: A Language and Environment for Statistical Computing","year":"2018"},{"key":"10.1016\/j.jaip.2023.08.027_bib25","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jaci.2015.09.054","article-title":"Different patterns of exhaled nitric oxide response to beta2-agonists in asthmatic patients according to the site of bronchodilation","volume":"137","author":"Michils","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.08.027_bib26","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jaip.2021.09.020","article-title":"A\u00a0low FEV1 confounds interpretation of FeNO as an eligibility criterion for dupilumab","volume":"10","author":"Michils","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.08.027_bib27","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1164\/ajrccm.164.5.2012125","article-title":"The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control","volume":"164","author":"Jones","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib28","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00392-2017","article-title":"Airway calibre variation is a major determinant of exhaled nitric oxide\u2019s ability to capture asthma control","volume":"50","author":"Michils","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2023.08.027_bib29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.jaci.2013.06.007","article-title":"Exhaled nitric oxide levels and blood eosinophil counts independently associate with wheeze and asthma events in National Health and Nutrition Examination Survey subjects","volume":"132","author":"Malinovschi","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.08.027_bib30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5603\/ARM.a2022.0015","article-title":"The levels and correlations of FeNO, blood eosinophils and lung function in well-controlled asthma","volume":"90","author":"Nakwan","year":"2022","journal-title":"Adv Respir Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib31","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1016\/S0140-6736(00)03496-6","article-title":"Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway\u00a0hyper-responsiveness, and the late asthmatic response","volume":"356","author":"Leckie","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2023.08.027_bib32","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJMoa0808991","article-title":"Mepolizumab and exacerbations of refractory eosinophilic asthma","volume":"360","author":"Haldar","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2023.08.027_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1136\/thx.53.2.91","article-title":"Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma","volume":"53","author":"Jatakanon","year":"1998","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2023.08.027_bib34","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1136\/thorax.57.10.889","article-title":"Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma","volume":"57","author":"Kharitonov","year":"2002","journal-title":"Thorax"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823009492?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219823009492?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:40:34Z","timestamp":1761975634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219823009492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S2213219823009492"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2023.08.027","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Impact of Airway Obstruction on Feno Values in Asthma Patients","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2023.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}