{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:55:54Z","timestamp":1774572954083,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["162419"],"award-info":[{"award-number":["162419"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jaip.2023.10.009","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T19:19:28Z","timestamp":1697051968000},"page":"156-164.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Assessing Pediatric Cephalosporin Allergic Reactions Through Direct Graded Oral Challenges"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9613-3681","authenticated-orcid":false,"given":"Carly","family":"Sillcox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofianne","family":"Gabrielli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"O\u2019Keefe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"McCusker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissa M.","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eiwegger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelle","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vy","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana-Maria","family":"Copaescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Ben-Shoshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2023.10.009_bib1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1469-0691.2000.tb02050.x","article-title":"New oral cephalosporins in pediatric community-acquired infections","volume":"6","author":"Adam","year":"2000","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jaip.2023.10.009_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11882-014-0476-y","article-title":"Penicillin and beta-lactam allergy: epidemiology and diagnosis","volume":"14","author":"Macy","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2023.10.009_bib3","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1399-3038.2011.01134.x","article-title":"Diagnosis of drug hypersensitivity in children and adolescents: discrepancy between physician-based assessment and results of testing","volume":"22","author":"Seitz","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2023.10.009_bib4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jaip.2013.01.006","article-title":"Treatment of patients with a history of penicillin allergy in a large tertiary-care academic hospital","volume":"1","author":"Picard","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.10.009_bib5","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2016.0033","article-title":"Assessing the diagnostic properties of a graded oral provocation challenge for the diagnosis of immediate and nonimmediate reactions to amoxicillin in children","volume":"170","author":"Mill","year":"2016","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.jaip.2023.10.009_bib6","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1016\/j.jaip.2021.06.057","article-title":"Establishing amoxicillin allergy in children through direct graded oral challenge (GOC): evaluating risk factors for positive challenges, safety, and risk of cross-reactivity to cephalosporines","volume":"9","author":"Exius","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.10.009_bib7","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/all.12182","article-title":"Validation of the cephalosporin intradermal skin test for predicting immediate hypersensitivity: a prospective study with drug challenge","volume":"68","author":"Yoon","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.10.009_bib8","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jaci.2005.12.1303","article-title":"Second symposium on the definition and management of anaphylaxis: summary report\u2014Second National Institute of Allergy and Infectious Disease\/Food Allergy and Anaphylaxis Network symposium","volume":"117","author":"Sampson","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.10.009_bib9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jaci.2015.03.012","article-title":"IgE-mediated hypersensitivity to cephalosporins: cross-reactivity and tolerability of alternative cephalosporins","volume":"136","author":"Romano","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.10.009_bib10","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.jaci.2019.08.001","article-title":"Early-life antibiotic exposure and childhood food allergy: a systematic review","volume":"144","author":"Netea","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.10.009_bib11","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jaip.2018.09.036","article-title":"Antibiotic exposure and the risk of food allergy: evidence in the US Medicaid pediatric population","volume":"7","author":"Li","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.10.009_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.jmii.2013.04.005","article-title":"Early life exposure to antibiotics and the risk of childhood allergic diseases: an update from the perspective of the hygiene hypothesis","volume":"46","author":"Kuo","year":"2013","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jaip.2023.10.009_bib13","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.3390\/nu13103315","article-title":"Antibiotic-induced gut microbiota dysbiosis damages the intestinal barrier, increasing food allergy in adult mice","volume":"13","author":"Zhang","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jaip.2023.10.009_bib14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/jama.2017.6510","article-title":"Penicillin allergy is not necessarily forever","volume":"318","author":"Trubiano","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2023.10.009_bib15","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1034\/j.1398-9995.2003.00279.x","article-title":"Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations","volume":"58","author":"Aberer","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2023.10.009_bib16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-2567.2007.02719.x","article-title":"Immunological decision-making: how does the immune system decide to mount a helper T-cell response?","volume":"123","author":"Kaiko","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.jaip.2023.10.009_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.290.5489.92","article-title":"Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells","volume":"290","author":"Lanzavecchia","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jaip.2023.10.009_bib18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0140-6736(98)05104-6","article-title":"Development of allergen-specific T-cell memory in atopic and normal children","volume":"353","author":"Prescott","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2023.10.009_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-7961-11-2","article-title":"\u03b2-lactam allergy: clinical implications and costs","volume":"11","author":"Satta","year":"2013","journal-title":"Clin Mol Allergy"},{"key":"10.1016\/j.jaip.2023.10.009_bib20","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1001\/archfami.9.8.722","article-title":"Costs of beta-lactam allergies: selection and costs of antibiotics for patients with a reported beta-lactam allergy","volume":"9","author":"MacLaughlin","year":"2000","journal-title":"Arch Fam Med"},{"key":"10.1016\/j.jaip.2023.10.009_bib21","first-page":"697","article-title":"Increased use of medical services and antibiotics by children who claim a prior penicillin sensitivity","volume":"146","author":"Kraemer","year":"1987","journal-title":"West J Med"},{"key":"10.1016\/j.jaip.2023.10.009_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1742-7843.2006.pto_230.x","article-title":"The prevalence of suspected and challenge-verified penicillin allergy in a university hospital population","volume":"98","author":"Borch","year":"2006","journal-title":"Basic Clin Pharmacol Toxicol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321982301125X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321982301125X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:38:45Z","timestamp":1761975525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221321982301125X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S221321982301125X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2023.10.009","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing Pediatric Cephalosporin Allergic Reactions Through Direct Graded Oral Challenges","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2023.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}