{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:57:08Z","timestamp":1792270628697,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jaci-inpractice.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jaip.2023.12.016","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T09:02:50Z","timestamp":1705568570000},"page":"1049-1061","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Efficacy of EDS-FLU for Chronic Rhinosinusitis: Two Randomized Controlled Trials (ReOpen1 and ReOpen2)"],"prefix":"10.1016","volume":"12","author":[{"given":"James N.","family":"Palmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithin D.","family":"Adappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh K.","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg E.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobeh","family":"Mahdavinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall A.","family":"Ow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara M.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju T.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Sacks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Sindwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Wise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy A.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2023.12.016_bib1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jaci.2011.08.004","article-title":"Chronic rhinosinusitis: epidemiology and medical management","volume":"128","author":"Hamilos","year":"2011","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.12.016_bib2","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/lary.21847","article-title":"Health state utility values in patients undergoing endoscopic sinus surgery","volume":"121","author":"Soler","year":"2011","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaip.2023.12.016_bib3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0194-59989570152-4","article-title":"The health impact of chronic sinusitis in patients seeking otolaryngologic care","volume":"113","author":"Gliklich","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaip.2023.12.016_bib4","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1097\/01.jom.0000121151.40413.bd","article-title":"Health, absence, disability, and presenteeism cost estimates of certain physical and mental health conditions affecting U.S. employers","volume":"46","author":"Goetzel","year":"2004","journal-title":"J\u00a0Occup Environ Med"},{"key":"10.1016\/j.jaip.2023.12.016_bib5","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.jaci.2015.08.037","article-title":"Direct costs of adult chronic rhinosinusitis by using 4 methods of estimation: results of the US Medical Expenditure Panel Survey","volume":"136","author":"Caulley","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.12.016_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11882-017-0690-5","article-title":"Economics of chronic rhinosinusitis","volume":"17","author":"Rudmik","year":"2017","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2023.12.016_bib7","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.jaci.2013.07.009","article-title":"National burden of antibiotic use for adult rhinosinusitis","volume":"132","author":"Smith","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.12.016_bib8","first-page":"1","article-title":"Ambulatory surgery in the United States, 2006","author":"Cullen","year":"2009","journal-title":"Natl Health Stat Rep"},{"key":"10.1016\/j.jaip.2023.12.016_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.otc.2016.08.006","article-title":"Refractory chronic rhinosinusitis with nasal polyposis","volume":"50","author":"Hull","year":"2017","journal-title":"Otolaryngol Clin North Am"},{"key":"10.1016\/j.jaip.2023.12.016_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/alr.22741","article-title":"International consensus statement on allergy and rhinology: rhinosinusitis 2021","volume":"11","author":"Orlandi","year":"2021","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2023.12.016_bib11","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.jaci.2010.02.020","article-title":"Oral steroids and doxycycline: two different approaches to treat nasal polyps","volume":"125","author":"Van Zele","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.12.016_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2023.12.016_bib13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.2500\/aap.2019.40.4182","article-title":"A\u00a0cross-sectional, population-based survey of U.S. adults with symptoms of chronic rhinosinusitis","volume":"40","author":"Palmer","year":"2019","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.jaip.2023.12.016_bib14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1089\/jamp.2014.1180","article-title":"Nasal deposition of HFA-beclomethasone, aqueous fluticasone propionate and aqueous mometasone furoate in allergic rhinitis patients","volume":"28","author":"Leach","year":"2015","journal-title":"J\u00a0Aerosol Med Pulm Drug Deliv"},{"key":"10.1016\/j.jaip.2023.12.016_bib15","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/alr.22376","article-title":"Magnetic resonance imaging evaluation of the distribution of spray and irrigation devices within the sinonasal cavities","volume":"9","author":"Siu","year":"2019","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2023.12.016_bib16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1089\/jamp.2011.0924","article-title":"Nasal deposition and clearance in man: comparison of a bidirectional powder device and a traditional liquid spray pump","volume":"25","author":"Djupesland","year":"2012","journal-title":"J\u00a0Aerosol Med Pulm Drug Deliv"},{"key":"10.1016\/j.jaip.2023.12.016_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.anai.2022.09.008","article-title":"Review of evidence supporting the use of nasal corticosteroid irrigation for chronic rhinosinusitis","volume":"130","author":"Bernstein","year":"2023","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.12.016_bib18","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/01.MLG.0000199741.08517.99","article-title":"Breath actuated device improves delivery to target sites beyond the nasal valve","volume":"116","author":"Djupesland","year":"2006","journal-title":"Laryngoscope"},{"key":"10.1016\/j.jaip.2023.12.016_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s13346-012-0108-9","article-title":"Nasal drug delivery devices: characteristics and performance in a clinical perspective\u2014a review","volume":"3","author":"Djupesland","year":"2013","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.jaip.2023.12.016_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.anai.2021.10.014","article-title":"Yardstick for the medical management of chronic rhinosinusitis","volume":"128","author":"Borish","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2023.12.016_bib21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1749-4486.2009.01995.x","article-title":"Psychometric validity of the 22-item Sinonasal Outcome Test","volume":"34","author":"Hopkins","year":"2009","journal-title":"Clin Otolaryngol"},{"key":"10.1016\/j.jaip.2023.12.016_bib22","first-page":"25","article-title":"EXHANCE-3: a cohort study of the exhalation delivery system with fluticasone for chronic sinusitis with or without nasal polyps","volume":"58","author":"Sher","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2023.12.016_bib23","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/1945892418810281","article-title":"NAVIGATE I: randomized, placebo-controlled, double-blind trial of the exhalation delivery system with fluticasone for chronic rhinosinusitis with nasal polyps","volume":"33","author":"Sindwani","year":"2019","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jaip.2023.12.016_bib24","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jaci.2018.06.010","article-title":"NAVIGATE II: randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis","volume":"143","author":"Leopold","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.12.016_bib25","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/alr.21219","article-title":"Camp J, et\u00a0al. Three-dimensional volumetric computed tomographic scoring as an objective outcome measure for chronic rhinosinusitis: clinical correlations and comparison to Lund-Mackay scoring","volume":"3","author":"Pallanch","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2023.12.016_bib26","series-title":"XHANCE\u00ae (fluticasone propionate) [package insert]","year":"2021"},{"key":"10.1016\/j.jaip.2023.12.016_bib27","series-title":"NUCALA (mepolizumab) [package insert]","year":"2022"},{"key":"10.1016\/j.jaip.2023.12.016_bib28","series-title":"XOLAIR\u00ae (omalizumab, [package insert]","year":"2021"},{"key":"10.1016\/j.jaip.2023.12.016_bib29","series-title":"DUPIXENT\u00ae (dupilumab, [package insert]","year":"2022"},{"key":"10.1016\/j.jaip.2023.12.016_bib30","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.jaci.2020.10.003","article-title":"2020 Focused Updates to the Asthma Management Guidelines: a report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group [published correction appears in J Allergy Clin Immunol 2021;147:1528-30]","volume":"146","author":"Cloutier","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.12.016_bib31","first-page":"57","article-title":"Efficacy and tolerability of budesonide aqueous nasal spray in chronic rhinosinusitis patients","volume":"42","author":"Lund","year":"2004","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2023.12.016_bib32","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1111\/j.1365-2222.2004.02044.x","article-title":"Fluticasone propionate aqueous nasal spray does not influence the recurrence rate of chronic rhinosinusitis and nasal polyps 1 year after functional endoscopic sinus surgery","volume":"34","author":"Dijkstra","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2023.12.016_bib33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jaip.2016.09.015","article-title":"Acute exacerbations mediate quality of life impairment in chronic rhinosinusitis","volume":"5","author":"Phillips","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2023.12.016_bib34","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fcimb.2019.00415","article-title":"Current understanding of the acute exacerbation of chronic rhinosinusitis","volume":"9","author":"Wu","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jaip.2023.12.016_bib35","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1080\/17512433.2018.1524753","article-title":"Development of a clinical decision rule for diagnosing sinus infections\u2014to reduce unnecessary antibiotic prescribing","volume":"11","author":"Mainz","year":"2018","journal-title":"Expert Rev Clin Pharmacol"},{"key":"10.1016\/j.jaip.2023.12.016_bib36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/2042098614554919","article-title":"Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem","volume":"5","author":"Llor","year":"2014","journal-title":"Ther Adv Drug Saf"},{"key":"10.1016\/j.jaip.2023.12.016_bib37","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/alr.22693","article-title":"Efficacy of the exhalation delivery system with fluticasone in patients who remain symptomatic on standard nasal steroid sprays","volume":"11","author":"Senior","year":"2021","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2023.12.016_bib38","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/alr.22141","article-title":"EXHANCE-12: 1-year study of the exhalation delivery system with fluticasone (EDS-FLU) in chronic rhinosinusitis","volume":"8","author":"Palmer","year":"2018","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jaip.2023.12.016_bib39","first-page":"75","article-title":"Topical corticosteroids in chronic rhinosinusitis: a randomized, double-blind, placebo-controlled trial using fluticasone propionate aqueous nasal spray","volume":"39","author":"Parikh","year":"2001","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2023.12.016_bib40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0140-6736(86)90051-6","article-title":"Relative importance of antibiotic and improved clearance in topical treatment of chronic mucopurulent rhinosinusitis. A controlled study","volume":"2","author":"Sykes","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2023.12.016_bib41","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.2147\/JAA.S321332","article-title":"Intranasal corticosteroids: topical potency, systemic activity and therapeutic index","volume":"14","author":"Daley-Yates","year":"2021","journal-title":"J\u00a0Asthma Allergy"},{"key":"10.1016\/j.jaip.2023.12.016_bib42","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/archotol.132.2.179","article-title":"A\u00a0randomized controlled trial of mometasone furoate nasal spray for the treatment of nasal polyposis","volume":"132","author":"Stj\u00e4rne","year":"2006","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.jaip.2023.12.016_bib43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0091-6749(05)80069-7","article-title":"A\u00a0dose-ranging study of fluticasone propionate aqueous nasal spray for seasonal allergic rhinitis assessed by symptoms, rhinomanometry, and nasal cytology","volume":"86","author":"Meltzer","year":"1990","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2023.12.016_bib45","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4193\/Rhin09.024","article-title":"Effective treatment of mild-to-moderate nasal polyposis with fluticasone delivered by a novel device","volume":"47","author":"Vlckova","year":"2009","journal-title":"Rhinology"},{"key":"10.1016\/j.jaip.2023.12.016_bib46","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4193\/Rhino09.178","article-title":"Preliminary efficacy of fluticasone delivered by a novel device in recalcitrant chronic rhinosinusitis","volume":"48","author":"Hansen","year":"2010","journal-title":"Rhinology"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321982301365X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321982301365X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T03:20:15Z","timestamp":1712546415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221321982301365X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S221321982301365X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2023.12.016","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of EDS-FLU for Chronic Rhinosinusitis: Two Randomized Controlled Trials (ReOpen1 and ReOpen2)","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2023.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}