{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:45:30Z","timestamp":1789623930855,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi US","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jaci-inpractice.org","clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jaip.2024.08.038","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T01:20:10Z","timestamp":1724808010000},"page":"3303-3312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Dupilumab Efficacy in Children With Type 2 Asthma Receiving High- to Medium-Dose Inhaled Corticosteroids (VOYAGE)"],"prefix":"10.1016","volume":"12","author":[{"given":"Jorge F.","family":"Maspero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martti A.","family":"Antila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Deschildre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard B.","family":"Bacharier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Altincatal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Laws","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Radwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juby A.","family":"Jacob-Nara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamo","family":"Deniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Lederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Hardin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2024.08.038_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.5334\/aogh.2416","article-title":"Pediatric asthma: a global epidemic","volume":"85","author":"Serebrisky","year":"2019","journal-title":"Ann Glob Health"},{"key":"10.1016\/j.jaip.2024.08.038_bib3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1183\/09031936.00202013","article-title":"International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma","volume":"43","author":"Chung","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2024.08.038_bib4","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2147\/JAA.S327659","article-title":"Severe asthma in a general population study: prevalence and clinical characteristics","volume":"14","author":"R\u00f6nnebjerg","year":"2021","journal-title":"J\u00a0Asthma Allergy"},{"key":"10.1016\/j.jaip.2024.08.038_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s40272-020-00387-2","article-title":"Dupilumab to treat type 2 inflammatory diseases in children and adolescents","volume":"22","author":"Licari","year":"2020","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.jaip.2024.08.038_bib6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1056\/NEJMra2032506","article-title":"Biologic therapies for severe asthma","volume":"386","author":"Brusselle","year":"2022","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2024.08.038_bib7","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1056\/NEJMoa1513737","article-title":"Patterns of growth and decline in lung function in persistent childhood asthma","volume":"374","author":"McGeachie","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2024.08.038_bib8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S2213-2600(18)30100-0","article-title":"Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life","volume":"6","author":"Bui","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2024.08.038_bib9","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1084\/jem.20052448","article-title":"Type 2 immunity is controlled by IL-4\/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system","volume":"203","author":"Voehringer","year":"2006","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaip.2024.08.038_bib10","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1080\/14712598.2017.1387245","article-title":"Dupilumab for the treatment of asthma","volume":"17","author":"Pelaia","year":"2017","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jaip.2024.08.038_bib11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/1744666X.2017.1298443","article-title":"Commonality of the IL-4\/IL-13 pathway in atopic diseases","volume":"13","author":"Gandhi","year":"2017","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jaip.2024.08.038_bib12","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S2213-2600(20)30399-4","article-title":"Advances in understanding and reducing the burden of severe asthma in children","volume":"8","author":"Pijnenburg","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2024.08.038_bib13","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s40265-020-01298-9","article-title":"Dupilumab: a review in chronic rhinosinusitis with nasal polyps","volume":"80","author":"Hoy","year":"2020","journal-title":"Drugs"},{"key":"10.1016\/j.jaip.2024.08.038_bib16","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1056\/NEJMoa2106567","article-title":"Dupilumab in children with uncontrolled moderate-to-severe asthma","volume":"385","author":"Bacharier","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2024.08.038_bib17","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.jaip.2023.12.006","article-title":"Dupilumab improves lung function parameters in pediatric type 2 asthma: VOYAGE study","volume":"12","author":"Bacharier","year":"2024","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2024.08.038_bib18","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00558-2023","article-title":"Dupilumab leads to better-controlled asthma and quality of life in children: the VOYAGE study","volume":"62","author":"Fiocchi","year":"2023","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2024.08.038_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S2213-2600(23)00303-X","article-title":"Assessment of long-term safety and efficacy of dupilumab in children with asthma (LIBERTY ASTHMA EXCURSION): an open-label extension study","volume":"12","author":"Bacharier","year":"2024","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2024.08.038_bib21","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.rmed.2004.10.008","article-title":"Measurement properties and interpretation of three shortened versions of the asthma control questionnaire","volume":"99","author":"Juniper","year":"2005","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2024.08.038_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/all.14611","article-title":"Dupilumab is effective in type 2-high asthma patients receiving high-dose inhaled corticosteroids at baseline","volume":"76","author":"Bourdin","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2024.08.038_bib23","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3390\/biomedicines9091096","article-title":"The role of dupilumab in severe asthma","volume":"9","author":"Ricciardolo","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.jaip.2024.08.038_bib24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ecl.2020.07.003","article-title":"Inhaled corticosteroids and endocrine effects in childhood","volume":"49","author":"Allen","year":"2020","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.jaip.2024.08.038_bib25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jaci.2022.08.014","article-title":"Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3","volume":"151","author":"Gaffin","year":"2023","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2024.08.038_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/ACI.0000000000000348","article-title":"Childhood asthma is a risk factor for the development of chronic obstructive pulmonary disease","volume":"17","author":"McGeachie","year":"2017","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2024.08.038_bib27","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jaip.2019.08.050","article-title":"Dupilumab efficacy in patients with uncontrolled, moderate-to-severe allergic asthma","volume":"8","author":"Corren","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2024.08.038_bib28","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1016\/j.jaip.2022.06.036","article-title":"Dupilumab is effective in patients with moderate-to-severe uncontrolled GINA-defined type 2 asthma irrespective of an allergic asthma phenotype","volume":"10","author":"Rabe","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2024.08.038_bib29","doi-asserted-by":"crossref","first-page":"AB18","DOI":"10.1016\/j.jaci.2022.12.059","article-title":"Consistent efficacy of dupilumab in children (6 to 11 years) with type 2 asthma regardless of baseline demographics and disease characteristics","volume":"151","author":"Maspero","year":"2023","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2024.08.038_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jaci.2023.09.044","article-title":"Blood eosinophils and FeNO are prognostic and predictive biomarkers in childhood asthma","volume":"154","author":"Bacharier","year":"2024","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219824008584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219824008584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T09:41:53Z","timestamp":1733391713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219824008584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S2213219824008584"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2024.08.038","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dupilumab Efficacy in Children With Type 2 Asthma Receiving High- to Medium-Dose Inhaled Corticosteroids (VOYAGE)","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2024.08.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}