{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:09:19Z","timestamp":1784257759310,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T00:00:00Z","timestamp":1739750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jaip.2025.01.041","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T12:54:13Z","timestamp":1739883253000},"page":"969-977","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum Sickness\u2013Like Reactions in Children\u2014Is Lifelong Avoidance Indicated?"],"prefix":"10.1016","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3218-2665","authenticated-orcid":false,"given":"Allison E.","family":"Norton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Risma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Ben-Shoshan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2025.01.041_bib1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/MOP.0000000000000184","article-title":"Importance of viruses in acute otitis media","volume":"27","author":"Nokso-Koivisto","year":"2015","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.jaip.2025.01.041_bib2","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1001\/jama.2010.1651","article-title":"Diagnosis, microbial epidemiology, and antibiotic treatment of acute otitis media in children: a systematic review","volume":"304","author":"Coker","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2025.01.041_bib3","doi-asserted-by":"crossref","first-page":"e1177","DOI":"10.1542\/peds.2006-1553","article-title":"\u201cUrticaria multiforme\u201d: a case series and review of acute annular urticarial hypersensitivity syndromes in children","volume":"119","author":"Shah","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2025.01.041_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.586407","article-title":"Viral infections and cutaneous drug-related eruptions","volume":"11","author":"Anci","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jaip.2025.01.041_bib5","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-2497","article-title":"Antibiotic allergy in pediatrics","volume":"141","author":"Norton","year":"2018","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2025.01.041_bib6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.anai.2020.03.012","article-title":"Children with reported penicillin allergy: public health impact and safety of delabeling","volume":"124","author":"Vyles","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.01.041_bib7","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1586\/1744666X.2013.852957","article-title":"Prediction of hypersensitivity to antibiotics: what factors need to be considered?","volume":"9","author":"Ariza","year":"2013","journal-title":"Expert Rev Clin Immunol"},{"key":"10.1016\/j.jaip.2025.01.041_bib8","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1398-9995.1995.tb05048.x","article-title":"Allergic reactions to penicillins. A changing world?","volume":"50","author":"Blanca","year":"1995","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2025.01.041_bib9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-med-050913-022745","article-title":"T\u00a0cell\u2013mediated hypersensitivity reactions to drugs","volume":"66","author":"Pavlos","year":"2015","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.jaip.2025.01.041_bib10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2222.2007.02870.x","article-title":"Drug allergy claims in children: from self-reporting to confirmed diagnosis","volume":"38","author":"Rebelo Gomes","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2025.01.041_bib11","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1080\/21645515.2019.1708669","article-title":"Why vaccines matter: understanding the broader health, economic, and child development benefits of routine vaccination","volume":"16","author":"Nandi","year":"2020","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.jaip.2025.01.041_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13223-024-00887-7","article-title":"A\u00a0case of pediatric serum sickness like reaction (SSLR) after a 2-month re-exposure to amoxicillin","volume":"20","author":"Bakshi","year":"2024","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaip.2025.01.041_bib13","doi-asserted-by":"crossref","first-page":"AB228","DOI":"10.1016\/j.jaci.2023.11.731","article-title":"Optimal timing of graded oral challenge in children with serum sickness\u2013like reactions to antibiotics","volume":"153","author":"Fernandez","year":"2024","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.01.041_bib14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/82691","article-title":"Clemens Freiherr von Pirquet: explaining immune complex disease in 1906","volume":"1","author":"Silverstein","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaip.2025.01.041_bib15","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jaip.2020.08.047","article-title":"Differentiating between \u03b2-lactam\u2013induced serum sickness\u2013like reactions and viral exanthem in children using a graded oral challenge","volume":"9","author":"Delli Colli","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.01.041_bib16","doi-asserted-by":"crossref","first-page":"e14058","DOI":"10.1111\/pai.14058","article-title":"Prolonged drug provocation with an initial full therapeutic dose to diagnose serum sickness\u2013like reaction to \u03b2-lactams in children","volume":"34","author":"Bergmann","year":"2023","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2025.01.041_bib17","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s10067-017-3777-4","article-title":"Demographic and clinical characteristics of patients with serum sickness\u2013like reaction","volume":"37","author":"Yorulmaz","year":"2018","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.jaip.2025.01.041_bib18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1399-3038.2011.01169.x","article-title":"Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests","volume":"22","author":"Ponvert","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.jaip.2025.01.041_bib19","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/pch\/pxab003","article-title":"Paediatric serum sickness\u2013like reaction: a 10-year retrospective cohort study","volume":"26","author":"Del Pozzo-Maga\u00f1a","year":"2021","journal-title":"Paediatr Child Health"},{"key":"10.1016\/j.jaip.2025.01.041_bib20","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/j.anai.2024.08.062","article-title":"Dermatographism may be an unrecognized feature of serum sickness\u2013like reaction","volume":"133","author":"Suara-Istanbouli","year":"2024","journal-title":"Ann Allergy Asthma Immunology"},{"key":"10.1016\/j.jaip.2025.01.041_bib21","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1016\/j.jaip.2022.06.048","article-title":"Predictors of acute care reutilization in pediatric patients with amoxicillin-associated reactions","volume":"10","author":"Xie","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.01.041_bib22","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1016\/j.jaip.2022.07.002","article-title":"Distinct characteristics and chronology of amoxicillin-associated reactions in pediatric\u00a0acute care settings","volume":"10","author":"Guarnieri","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.01.041_bib23","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1016\/j.jaip.2024.08.022","article-title":"Clinical presentation and management of children with suspected serum sickness\u2013like reaction","volume":"12","author":"Gibson","year":"2024","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.01.041_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2025.01.018","article-title":"Serum sickness\u2013like reactions in children taking antibiotics represent a distressing form of infection-associated urticaria and may recur unpredictably in susceptible children","author":"Fernandez","year":"2025","journal-title":"J\u00a0Allergy Clin Immunol Pract. Published online"},{"key":"10.1016\/j.jaip.2025.01.041_bib25","article-title":"Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome in childhood: a narrative review","volume":"10","author":"Manieri","year":"2023","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jaip.2025.01.041_bib26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s43856-023-00404-8","article-title":"Mathematical-based morphological classification of skin eruptions corresponding to the pathophysiological state of chronic spontaneous urticaria","volume":"3","author":"Seirin-Lee","year":"2023","journal-title":"Commun Med (Lond)"},{"key":"10.1016\/j.jaip.2025.01.041_bib27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11926-022-01088-0","article-title":"A\u00a0spotlight on drug-induced vasculitis","volume":"24","author":"Yaseen","year":"2022","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.jaip.2025.01.041_bib28","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/bjh.15177","article-title":"Rituximab-induced acute and delayed serum sickness in thrombotic thrombocytopenic purpura: the role of anti-rituximab antibodies","volume":"184","author":"Vendramin","year":"2019","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaip.2025.01.041_bib29","first-page":"259","article-title":"Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Drug allergy: an updated practice parameter","volume":"105","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.01.041_bib30","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.jaci.2022.02.007","article-title":"Urticarial vasculitis: clinical and laboratory findings with a particular emphasis on differential diagnosis","volume":"149","author":"Marzano","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.01.041_bib31","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.jaip.2018.05.006","article-title":"Mimickers of urticaria: urticarial vasculitis and autoinflammatory diseases","volume":"6","author":"Davis","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.01.041_bib32","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/j.jaip.2023.05.040","article-title":"Cold urticaria syndromes: diagnosis and management","volume":"11","author":"Diaz","year":"2023","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.01.041_bib33","article-title":"Severe serum sickness\u2013like reaction: challenges in diagnosis and management","volume":"6","author":"De Schryver","year":"2015","journal-title":"J\u00a0C Exp Dermatol Res"},{"key":"10.1016\/j.jaip.2025.01.041_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.619690","article-title":"Endothelial cells in emerging viral infections","volume":"8","author":"Fosse","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.jaip.2025.01.041_bib35","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/all.15558","article-title":"Viral infections and drug hypersensitivity","volume":"78","author":"Pichler","year":"2023","journal-title":"Allergy"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219825001680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219825001680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T23:11:44Z","timestamp":1753225904000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219825001680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2213219825001680"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2025.01.041","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum Sickness\u2013Like Reactions in Children\u2014Is Lifelong Avoidance Indicated?","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2025.01.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}