{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:55:33Z","timestamp":1784332533011,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.jaip.2025.02.018","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T11:21:56Z","timestamp":1740568916000},"page":"1755-1767.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Maintenance Regimens for Adolescent and Adult Asthmatics With Exercise-Induced Bronchospasm: Systematic Review and Network Meta-Analysis"],"prefix":"10.1016","volume":"13","author":[{"given":"Irin","family":"Vichara-anont","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalita","family":"Lumkul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phichayut","family":"Phinyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamard","family":"Wongsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torpong","family":"Thongngarm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2025.02.018_bib1","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.jaci.2016.05.029","article-title":"Exercise-induced bronchoconstriction update-2016","volume":"138","author":"Weiler","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.02.018_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.anai.2020.01.023","article-title":"Exercise-induced bronchoconstriction in elite or endurance athletes: pathogenesis and diagnostic considerations","volume":"125","author":"Atchley","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.02.018_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41533-018-0098-2","article-title":"Exercise-induced bronchoconstriction: prevalence, pathophysiology, patient impact, diagnosis and management","volume":"28","author":"Aggarwal","year":"2018","journal-title":"NPJ Prim Care Respir Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib4","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1016\/j.jaip.2020.05.020","article-title":"Work group report: perspectives in diagnosis and management of exercise-induced bronchoconstriction in athletes","volume":"8","author":"Greiwe","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.02.018_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002739.pub2","article-title":"Inhaled corticosteroids compared to placebo for prevention of exercise induced bronchoconstriction","volume":"2007","author":"Koh","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jaip.2025.02.018_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2332\/allergolint.08-OA-0034","article-title":"Exercise-induced asthma is associated with impaired quality of life among children with asthma in Japan","volume":"58","author":"Kojima","year":"2009","journal-title":"Allergol Int"},{"key":"10.1016\/j.jaip.2025.02.018_bib7","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1164\/rccm.201209-1739PP","article-title":"\u03b22-Agonist therapy in lung disease","volume":"187","author":"Cazzola","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S1081-1206(10)61377-4","article-title":"Onset and duration of protection against exercise-induced bronchoconstriction by a single oral dose of montelukast","volume":"97","author":"Pearlman","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.02.018_bib10","series-title":"Cochrane handbook for systematic reviews of interventions","year":"2019"},{"key":"10.1016\/j.jaip.2025.02.018_bib11","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jaip.2025.02.018_bib12","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1164\/rccm.201303-0437ST","article-title":"An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction","volume":"187","author":"Parsons","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1164\/ajrccm.161.1.ats11-99","article-title":"Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999","volume":"161","author":"Crapo","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib14","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0091-6749(99)70420-3","article-title":"Time to onset of effect of fluticasone propionate in patients with asthma","volume":"103","author":"Szefler","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.02.018_bib15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s42256-020-00287-7","article-title":"An open source machine learning framework for efficient and transparent systematic reviews","volume":"3","author":"van de Schoot","year":"2021","journal-title":"Nat Mach Intell"},{"key":"10.1016\/j.jaip.2025.02.018_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmal.2024.100101","article-title":"Utilizing ASReview in screening primary studies for meta-research in SLA: a step-by-step tutorial","volume":"3","author":"Quan","year":"2024","journal-title":"Res Methods Appl Linguist"},{"key":"10.1016\/j.jaip.2025.02.018_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/frma.2021.685591","article-title":"SYMBALS: a systematic review methodology blending active learning and snowballing","volume":"6","author":"van Haastrecht","year":"2021","journal-title":"Front Res Metr Anal"},{"key":"10.1016\/j.jaip.2025.02.018_bib18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"key":"10.1016\/j.jaip.2025.02.018_bib19","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1177\/0962280216669183","article-title":"Optimally estimating the sample mean from the sample size, median, mid-range, and\/or mid-quartile range","volume":"27","author":"Luo","year":"2018","journal-title":"Stat Methods Med Res"},{"key":"10.1016\/j.jaip.2025.02.018_bib20","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jaip.2025.02.018_bib21","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.jaip.2025.02.018_bib22","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1002\/sim.1875","article-title":"Combination of direct and indirect evidence in mixed treatment comparisons","volume":"23","author":"Lu","year":"2004","journal-title":"Stat Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12874-015-0060-8","article-title":"Ranking treatments in frequentist network meta-analysis works without resampling methods","volume":"15","author":"Rucker","year":"2015","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jaip.2025.02.018_bib24","doi-asserted-by":"crossref","first-page":"e76654","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical tools for network meta-analysis in STATA","volume":"8","author":"Chaimani","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2025.02.018_bib25","doi-asserted-by":"crossref","first-page":"e99682","DOI":"10.1371\/journal.pone.0099682","article-title":"Evaluating the quality of evidence from a network meta-analysis","volume":"9","author":"Salanti","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaip.2025.02.018_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003082","article-title":"CINeMA: an approach for assessing confidence in the results of a network meta-analysis","volume":"17","author":"Nikolakopoulou","year":"2020","journal-title":"PLoS Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib27","doi-asserted-by":"crossref","first-page":"e1080","DOI":"10.1002\/cl2.1080","article-title":"CINeMA: software for semiautomated assessment of the confidence in the results of network meta-analysis","volume":"16","author":"Papakonstantinou","year":"2020","journal-title":"Campbell Syst Rev"},{"key":"10.1016\/j.jaip.2025.02.018_bib28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0091-6749(99)70322-2","article-title":"Montelukast versus salmeterol in patients with asthma and exercise-induced bronchoconstriction. Montelukast\/Salmeterol Exercise Study Group","volume":"104","author":"Villaran","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.02.018_bib29","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/01.MLR.0000062554.74615.4C","article-title":"Interpretation of changes in health-related quality of life: the remarkable universality of half a standard deviation","volume":"41","author":"Norman","year":"2003","journal-title":"Med Care"},{"key":"10.1016\/j.jaip.2025.02.018_bib30","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/02770903.2019.1579344","article-title":"Fluticasone furoate\/vilanterol versus fluticasone propionate in patients with asthma and exercise-induced bronchoconstriction","volume":"57","author":"Martin","year":"2020","journal-title":"J Asthma"},{"key":"10.1016\/j.jaip.2025.02.018_bib31","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/thoraxjnl-2013-203557","article-title":"Combination of budesonide\/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction","volume":"69","author":"Lazarinis","year":"2014","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2025.02.018_bib32","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jaci.2012.02.051","article-title":"The effect of montelukast, budesonide alone, and in combination on exercise-induced bronchoconstriction","volume":"130","author":"Duong","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.02.018_bib33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1081-1206(10)61288-4","article-title":"Effect of fluticasone\/salmeterol administered via a single device on exercise-induced bronchospasm in patients with persistent asthma","volume":"94","author":"Weiler","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.02.018_bib34","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.rmed.2004.05.008","article-title":"A comparison of the effects of oral montelukast and inhaled salmeterol on response to rescue bronchodilation after challenge","volume":"98","author":"Storms","year":"2004","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.7326\/0003-4819-132-2-200001180-00002","article-title":"Oral montelukast compared with inhaled salmeterol to prevent exercise-induced bronchoconstriction. A randomized, double-blind trial. Exercise Study Group","volume":"132","author":"Edelman","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib36","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0091-6749(99)70007-2","article-title":"The effect of zafirlukast on repetitive exercise-induced bronchoconstriction: the possible role of leukotrienes in exercise-induced refractoriness","volume":"104","author":"Dessanges","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.02.018_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1056\/NEJM199807163390302","article-title":"Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction","volume":"339","author":"Leff","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib38","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1136\/thx.46.11.811","article-title":"Effect of inhaled budesonide on bronchial reactivity to histamine, exercise, and eucapnic dry air hyperventilation in patients with asthma","volume":"46","author":"Vathenen","year":"1991","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2025.02.018_bib39","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1183\/09031936.93.02040308","article-title":"Effects of long-term treatment with inhaled cromoglycate and budesonide on bronchial hyperresponsiveness in patients with allergic asthma","volume":"2","author":"Molema","year":"1989","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.02.018_bib40","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1183\/09031936.02.00208102","article-title":"Lung and thorax development during adolescence: relationship with pubertal status","volume":"20","author":"Neve","year":"2002","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.02.018_bib41","first-page":"CD003137","article-title":"Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma","volume":"2014","author":"Chauhan","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jaip.2025.02.018_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/falgy.2023.1004170","article-title":"A proposal to account for the stimulus, the mechanism, and the mediators released in exercise-induced bronchoconstriction","volume":"4","author":"Anderson","year":"2023","journal-title":"Front Allergy"},{"key":"10.1016\/j.jaip.2025.02.018_bib43","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1183\/09031936.06.00020606","article-title":"Lack of tolerance to the protective effect of montelukast in exercise-induced bronchoconstriction in children","volume":"28","author":"de Benedictis","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.02.018_bib45","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1378\/chest.115.3.623","article-title":"A bolus of inhaled budesonide rapidly reverses airway subsensitivity and beta2-adrenoceptor down-regulation after regular inhaled formoterol","volume":"115","author":"Aziz","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2025.02.018_bib46","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1513\/pats.200402-010MS","article-title":"Interactions between corticosteroids and beta2-agonists in asthma and chronic obstructive pulmonary disease","volume":"1","author":"Johnson","year":"2004","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.jaip.2025.02.018_bib47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0091-6749(99)70467-7","article-title":"Sustained bronchoprotection, bronchodilatation, and symptom control during regular formoterol use in asthma of moderate or greater severity. The Canadian FO\/OD1 Study Group","volume":"103","author":"FitzGerald","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.02.018_bib48","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1183\/09031936.98.11051091","article-title":"Tolerance to the protective effects of salmeterol on methacholine-induced bronchoconstriction: influence of inhaled corticosteroids","volume":"11","author":"Boulet","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.02.018_bib49","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1378\/chest.109.4.953","article-title":"Inhaled corticosteroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol","volume":"109","author":"Kalra","year":"1996","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2025.02.018_bib50","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0002-9343(98)00086-2","article-title":"Effects of treatment with formoterol on bronchoprotection against methacholine","volume":"104","author":"Lipworth","year":"1998","journal-title":"Am J Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib51","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1542\/peds.99.5.655","article-title":"Tolerance to the bronchoprotective effect of salmeterol in adolescents with exercise-induced asthma using concurrent inhaled glucocorticoid treatment","volume":"99","author":"Simons","year":"1997","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2025.02.018_bib52","first-page":"529","article-title":"Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction during high dose treatment with long acting beta2 agonists","volume":"56","author":"van der Woude","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2025.02.018_bib53","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1164\/ajrccm.154.6.8970342","article-title":"An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta 2-agonist","volume":"154","author":"Yates","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.02.018_bib55","article-title":"Inhaled corticosteroids versus sodium cromoglycate in children and adults with asthma","volume":"2006","author":"Guevara","year":"2006","journal-title":"Cochrane Database Syst Rev"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219825001898?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219825001898?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:43:46Z","timestamp":1755650626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219825001898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S2213219825001898"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2025.02.018","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and Safety of Maintenance Regimens for Adolescent and Adult Asthmatics With Exercise-Induced Bronchospasm: Systematic Review and Network Meta-Analysis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2025.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}