{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:28:46Z","timestamp":1793039326264,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T00:00:00Z","timestamp":1741651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jaip.2025.03.006","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T15:53:22Z","timestamp":1741881202000},"page":"1094-1102.e1","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Real-World Effectiveness of Biologic Therapy in Allergic Bronchopulmonary Aspergillosis"],"prefix":"10.1016","volume":"13","author":[{"given":"Charlotte","family":"Carter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Berrar","family":"Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Nwankwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Semple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavin","family":"Rawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Armstrong-James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pujan H.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2025.03.006_bib1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1034\/j.1399-3003.2000.016003464.x","article-title":"Allergic bronchopulmonary aspergillosis in cystic fibrosis. A European epidemiological study. Epidemiologic Registry of Cystic Fibrosis","volume":"16","author":"Mastella","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.03.006_bib2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3109\/13693786.2012.738312","article-title":"Global burden of allergic bronchopulmonary aspergillosis with asthma and its complication chronic pulmonary aspergillosis in adults","volume":"51","author":"Denning","year":"2013","journal-title":"Med Mycol"},{"key":"10.1016\/j.jaip.2025.03.006_bib3","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/cea.12595","article-title":"Prevalence of Aspergillus sensitization and allergic bronchopulmonary aspergillosis in cystic fibrosis: systematic review and meta-analysis","volume":"45","author":"Maturu","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2025.03.006_bib4","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00061-2024","article-title":"Revised ISHAM-ABPA working group clinical practice guidelines for diagnosing, classifying and treating allergic bronchopulmonary aspergillosis\/mycoses","volume":"63","author":"Agarwal","year":"2024","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.03.006_bib5","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/myc.13640","article-title":"Long-term follow-up of allergic bronchopulmonary aspergillosis treated with glucocorticoids: a study of 182 subjects","volume":"66","author":"Agarwal","year":"2023","journal-title":"Mycoses"},{"key":"10.1016\/j.jaip.2025.03.006_bib6","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1001\/archinte.1986.00360170130020","article-title":"Allergic bronchopulmonary aspergillosis. Natural history and classification of early disease by serologic and roentgenographic studies","volume":"146","author":"Patterson","year":"1986","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jaip.2025.03.006_bib7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1378\/chest.130.2.442","article-title":"Allergic bronchopulmonary aspergillosis: lessons from 126 patients attending a chest clinic in north India","volume":"130","author":"Agarwal","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2025.03.006_bib8","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.rmed.2012.03.001","article-title":"Serologic allergic bronchopulmonary aspergillosis (ABPA-S): long-term outcomes","volume":"106","author":"Agarwal","year":"2012","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2025.03.006_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/myc.13388","article-title":"Epidemiology and outcomes of allergic bronchopulmonary aspergillosis in the elderly","volume":"65","author":"Muthu","year":"2022","journal-title":"Mycoses"},{"key":"10.1016\/j.jaip.2025.03.006_bib10","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1183\/13993003.01475-2015","article-title":"A\u00a0randomised trial of glucocorticoids in acute-stage allergic bronchopulmonary aspergillosis complicating asthma","volume":"47","author":"Agarwal","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.03.006_bib11","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01159-2018","article-title":"A\u00a0randomised trial of voriconazole and prednisolone monotherapy in acute-stage allergic bronchopulmonary aspergillosis complicating asthma","volume":"52","author":"Agarwal","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.03.006_bib12","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.chest.2018.01.005","article-title":"A\u00a0randomized trial of itraconazole vs prednisolone in acute-stage allergic bronchopulmonary aspergillosis complicating asthma","volume":"153","author":"Agarwal","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2025.03.006_bib13","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJM200003163421102","article-title":"A\u00a0randomized trial of itraconazole in allergic bronchopulmonary aspergillosis","volume":"342","author":"Stevens","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaip.2025.03.006_bib14","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1067\/mai.2003.1388","article-title":"Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: a randomized controlled trial","volume":"111","author":"Wark","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.03.006_bib15","article-title":"A\u00a0randomised trial of prednisolone versus prednisolone and itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma","volume":"59","author":"Agarwal","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.03.006_bib17","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0140-6736(12)60988-X","article-title":"Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial","volume":"380","author":"Pavord","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2025.03.006_bib18","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(16)31324-1","article-title":"Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting \u03b2(2)-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial","volume":"388","author":"Bleecker","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2025.03.006_bib19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s12325-018-0702-4","article-title":"Liberty Asthma QUEST: phase 3 randomized, double-blind, placebo-controlled, parallel-group study to evaluate dupilumab efficacy\/safety in patients with uncontrolled, moderate-to-severe asthma","volume":"35","author":"Busse","year":"2018","journal-title":"Adv Ther"},{"key":"10.1016\/j.jaip.2025.03.006_bib20","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1164\/rccm.201103-0396OC","article-title":"Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study","volume":"184","author":"Castro","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.03.006_bib21","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/cea.14112","article-title":"Real-world efficacy of treatment with benralizumab, dupilumab, mepolizumab and reslizumab for severe asthma: a systematic review and meta-analysis","volume":"52","author":"Charles","year":"2022","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2025.03.006_bib22","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jaip.2022.12.012","article-title":"Omalizumab in allergic bronchopulmonary aspergillosis: a systematic review and meta-analysis","volume":"11","author":"Jin","year":"2023","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.03.006_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jaip.2014.12.008","article-title":"Clinical efficacy and immunologic effects of omalizumab in allergic bronchopulmonary aspergillosis","volume":"3","author":"Voskamp","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.03.006_bib24","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.jaip.2021.02.048","article-title":"Real-world effectiveness of anti-IL-5\/5R therapy in severe atopic eosinophilic asthma with fungal sensitization","volume":"9","author":"Dhariwal","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.03.006_bib25","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.jaip.2019.11.031","article-title":"Dupilumab treatment for allergic bronchopulmonary aspergillosis: a case series","volume":"8","author":"Ramonell","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.03.006_bib26","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1016\/j.jaip.2023.05.026","article-title":"Allergic bronchopulmonary aspergillosis successfully treated with tezepelumab","volume":"11","author":"Matsuno","year":"2023","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.03.006_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/rcr2.1147","article-title":"Tezepelumab treatment for allergic bronchopulmonary aspergillosis","volume":"11","author":"Ogata","year":"2023","journal-title":"Respirol Case Rep"},{"key":"10.1016\/j.jaip.2025.03.006_bib28","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00819-2023","article-title":"Clinical remission in severe asthma with biologic therapy: an analysis from the UK Severe Asthma Registry","volume":"62","author":"McDowell","year":"2023","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.03.006_bib29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.chest.2023.10.046","article-title":"Clinical response and remission in patients with severe asthma treated with biologic therapies","volume":"165","author":"Hansen","year":"2024","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2025.03.006_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2147\/JAA.S328653","article-title":"Real world biologic use and switch patterns in severe asthma: data from the International Severe Asthma Registry and the US CHRONICLE study","volume":"15","author":"Menzies-Gow","year":"2022","journal-title":"J\u00a0Asthma Allergy"},{"key":"10.1016\/j.jaip.2025.03.006_bib31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2017.07.048","article-title":"Eosinophils release extracellular DNA traps in response to Aspergillus fumigatus","volume":"141","author":"Muniz","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.03.006_bib32","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.coi.2021.03.013","article-title":"Charcot-Leyden crystals and other protein crystals driving type 2 immunity and allergy","volume":"72","author":"Aegerter","year":"2021","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaip.2025.03.006_bib33","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.jaip.2022.11.043","article-title":"Baseline FeNO independently predicts the dupilumab response in patients with moderate-to-severe asthma","volume":"11","author":"Pavord","year":"2023","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.03.006_bib34","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1111\/all.15197","article-title":"Baseline type 2 biomarker levels and response to tezepelumab in severe asthma","volume":"77","author":"Corren","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2025.03.006_bib35","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12931-023-02409-2","article-title":"Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials","volume":"24","author":"Chen","year":"2023","journal-title":"Respir Res"},{"key":"10.1016\/j.jaip.2025.03.006_bib36","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1164\/rccm.202305-0808OC","article-title":"Association between T2-related comorbidities and effectiveness of biologics in severe asthma","volume":"209","author":"Wechsler","year":"2024","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.03.006_bib37","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2300135","article-title":"Tezepelumab and mucus plugs in patients with moderate-to-severe asthma","volume":"2","author":"Nordenmark","year":"2023","journal-title":"NEJM Evid"},{"key":"10.1016\/j.jaip.2025.03.006_bib38","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1159\/000530392","article-title":"Effect of benralizumab on mucus plugs in severe eosinophilic asthma","volume":"184","author":"Sakai","year":"2023","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2025.03.006_bib39","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1164\/rccm.202306-1102LE","article-title":"Effects of dupilumab on mucus plugging and ventilation defects in patients with moderate-to-severe asthma: a randomized, double-blind, placebo-controlled trial","volume":"208","author":"Svenningsen","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.03.006_bib40","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.jaci.2018.01.008","article-title":"Benralizumab attenuates airway eosinophilia in prednisone-dependent asthma","volume":"141","author":"Sehmi","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.03.006_bib41","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3390\/biom14050546","article-title":"The possible roles of IL-4\/IL-13 in the development of eosinophil-predominant severe asthma","volume":"14","author":"Nakagome","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.jaip.2025.03.006_bib42","first-page":"A106","article-title":"S146 Aspergillus in bronchiectasis: data from the EMBARC registry","volume":"78","author":"Pollock","year":"2023","journal-title":"Thorax"},{"key":"10.1016\/j.jaip.2025.03.006_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103503","article-title":"Combination of monoclonal antibodies targeting type 2 inflammation for severe asthma and eosinophilic granulomatosis with polyangiitis","volume":"23","author":"Davanzo","year":"2024","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaip.2025.03.006_bib44","doi-asserted-by":"crossref","DOI":"10.1177\/20406223211047003","article-title":"Review of current and future therapeutics in ABPA","volume":"12","author":"Lewington-Gower","year":"2021","journal-title":"Ther Adv Chronic Dis"},{"key":"10.1016\/j.jaip.2025.03.006_bib45","first-page":"260","article-title":"Allergic bronchopulmonary aspergillosis (ABPA) sans asthma: a distinct subset of ABPA with a lesser risk of exacerbation","volume":"58","author":"Muthu","year":"2020","journal-title":"Med Mycol"},{"key":"10.1016\/j.jaip.2025.03.006_bib46","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/myc.13553","article-title":"Identification of distinct immunophenotypes in chronic pulmonary aspergillosis using cluster analysis","volume":"66","author":"Sehgal","year":"2023","journal-title":"Mycoses"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219825002533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219825002533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T23:10:44Z","timestamp":1753225844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219825002533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2213219825002533"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2025.03.006","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Real-World Effectiveness of Biologic Therapy in Allergic Bronchopulmonary Aspergillosis","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2025.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.","name":"copyright","label":"Copyright"}]}}