{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:10:43Z","timestamp":1789582243664,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"am","delay-in-days":370,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL168539"],"award-info":[{"award-number":["HL168539"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL152475"],"award-info":[{"award-number":["HL152475"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.jaip.2025.04.040","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T01:00:48Z","timestamp":1746061248000},"page":"2075-2082.e2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and Potential Risk Factors for T2-Low Asthma Among School-Aged Children in the National Health and Nutrition Examination Survey, 2007\u20132012"],"prefix":"10.1016","volume":"13","author":[{"given":"Yueh-Ying","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Gaietto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molin","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska J.","family":"Rosser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Celed\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2025.04.040_bib1","series-title":"Data, Statistics, and Surveillance\u2014Most Recent Asthma Data","year":"2022"},{"key":"10.1016\/j.jaip.2025.04.040_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/cea.12880","article-title":"Revisiting type 2-high and type 2-low airway inflammation in asthma: current knowledge and therapeutic implications","volume":"47","author":"Robinson","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2025.04.040_bib3","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/j.jaip.2024.06.010","article-title":"Type 2 inflammation and asthma in children: a narrative review","volume":"12","author":"Papadopoulos","year":"2024","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.04.040_bib4","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2021.02.016","article-title":"The basic immunology of asthma","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jaip.2025.04.040_bib5","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02288-2021","article-title":"T2-high asthma phenotypes across lifespan","volume":"60","author":"Maison","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.04.040_bib6","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00938-2018","article-title":"\"T2-high\" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin","volume":"53","author":"Pavlidis","year":"2019","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.04.040_bib7","doi-asserted-by":"crossref","first-page":"00309","DOI":"10.1183\/23120541.00309-2020","article-title":"Identification and treatment of T2-low asthma in the era of biologics","volume":"7","author":"Kyriakopoulos","year":"2021","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.jaip.2025.04.040_bib8","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/S2213-2600(23)00369-7","article-title":"T2-low asthma in school-aged children: unacknowledged and understudied","volume":"11","author":"Mishra","year":"2023","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.jaip.2025.04.040_bib9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1001\/jama.2024.22684","article-title":"Transcriptomic profiles in nasal epithelium and asthma endotypes in youth","volume":"333","author":"Yue","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.jaip.2025.04.040_bib10","first-page":"1","article-title":"National Health and Nutrition Examination Survey: plan and operations, 1999\u20132010, National Center for Health Statistics","volume":"56","author":"Zipf","year":"2013","journal-title":"Vital Health Stat"},{"key":"10.1016\/j.jaip.2025.04.040_bib11","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.anai.2022.02.021","article-title":"Allergic and eosinophilic asthma in the era of biomarkers and biologics: similarities, differences and misconceptions","volume":"129","author":"Oppenheimer","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.04.040_bib12","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1164\/rccm.9120-11ST","article-title":"An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FeNO) for clinical applications","volume":"184","author":"Dweik","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.04.040_bib13","article-title":"ERS\/ATS technical standard on interpretive strategies for routine lung function tests","volume":"60","author":"Stanojevic","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.04.040_bib14","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1183\/09031936.00080312","article-title":"Multi-ethnic reference values for spirometry for the 3\u201395-yr age range: the Global Lung Function 2012 equations","volume":"40","author":"Quanjer","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jaip.2025.04.040_bib15","first-page":"1","article-title":"Evaluation of alternative body mass index (BMI) metrics to monitor weight status in children and adolescents with extremely high BMI Using CDC BMI-for-age growth charts, National Center for Health Statistics","volume":"195","author":"Hales","year":"2022","journal-title":"Vital Health Stat"},{"key":"10.1016\/j.jaip.2025.04.040_bib16","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1542\/peds.2008-2041","article-title":"Serum 25-hydroxyvitamin D levels among US children aged 1 to 11 years: do children need more vitamin D?","volume":"124","author":"Mansbach","year":"2009","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaip.2025.04.040_bib17","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/aje\/kwn301","article-title":"Optimal serum cotinine levels for distinguishing cigarette smokers and nonsmokers within different racial\/ethnic groups in the United States between 1999 and 2004","volume":"169","author":"Benowitz","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jaip.2025.04.040_bib18","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1017\/S1368980013002115","article-title":"Designing and developing a literature-derived, population-based dietary inflammatory index","volume":"17","author":"Shivappa","year":"2014","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.jaip.2025.04.040_bib19","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.jaip.2017.12.029","article-title":"The Dietary Inflammatory Index and current wheeze among children and adults in the United States","volume":"6","author":"Han","year":"2018","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.04.040_bib20","series-title":"National Health and Nutrition Examination Survey: Analytic Guidelines, 2011\u20132014 and 2015\u20132016","year":"2018"},{"key":"10.1016\/j.jaip.2025.04.040_bib21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm.3423","article-title":"Interleukin-17\u2013producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity","volume":"20","author":"Kim","year":"2014","journal-title":"Nat Med"},{"key":"10.1016\/j.jaip.2025.04.040_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41586-022-04536-0","article-title":"Obesity alters pathology and treatment response in inflammatory disease","volume":"604","author":"Bapat","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jaip.2025.04.040_bib23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1164\/rccm.201403-0565OC","article-title":"Adiposity, fractional exhaled nitric oxide, and asthma in U.S. children","volume":"190","author":"Han","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.04.040_bib24","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1164\/rccm.201605-1039OC","article-title":"Obesity and airway dysanapsis in children with and without asthma","volume":"195","author":"Forno","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.04.040_bib25","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1164\/rccm.201203-0573OC","article-title":"Obesity and asthma: an inflammatory disease of adipose tissue not the airway","volume":"186","author":"Sideleva","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.04.040_bib26","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.jaci.2024.09.018","article-title":"Obesity and hormonal influences on asthma: mechanisms, management challenges, and emerging therapeutic strategies","volume":"154","author":"Weare-Regales","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.04.040_bib27","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/ppul.24930","article-title":"Risk factors for atopic and nonatopic asthma in Puerto Rican children","volume":"55","author":"Landeo-Gutierrez","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaip.2025.04.040_bib28","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1002\/ppul.24961","article-title":"The association between secondhand smoke and childhood asthma: a systematic review and meta-analysis","volume":"55","author":"He","year":"2020","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.jaip.2025.04.040_bib29","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.anai.2015.08.005","article-title":"Effects of secondhand smoke exposure on asthma morbidity and health care utilization in children: a systematic review and meta-analysis","volume":"115","author":"Wang","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.04.040_bib30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/all.13985","article-title":"Mechanisms and therapeutic strategies for non-T2 asthma","volume":"75","author":"Sze","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2025.04.040_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1513\/AnnalsATS.201701-065OC","article-title":"distinct phenotypes of smokers with fixed airflow limitation identified by cluster analysis of severe asthma","volume":"15","author":"Konno","year":"2018","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jaip.2025.04.040_bib32","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1164\/rccm.200510-1589OC","article-title":"Effects of smoking cessation on lung function and airway inflammation in smokers with asthma","volume":"174","author":"Chaudhuri","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jaip.2025.04.040_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ccm.2023.03.008","article-title":"Asthma and chronic obstructive pulmonary disease","volume":"44","author":"Forno","year":"2023","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.jaip.2025.04.040_bib34","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jaci.2004.12.1138","article-title":"Variation in total and specific IgE: effects of ethnicity and socioeconomic status","volume":"115","author":"Litonjua","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.04.040_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1378\/chest.125.1.85","article-title":"Ethnicity and skin test reactivity to aeroallergens among asthmatic children in Connecticut","volume":"125","author":"Celedon","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.jaip.2025.04.040_bib36","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nri2378","article-title":"Vitamin effects on the immune system: vitamins A and D take centre stage","volume":"8","author":"Mora","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaip.2025.04.040_bib37","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ncpendmet0716","article-title":"Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity","volume":"4","author":"Adams","year":"2008","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"10.1016\/j.jaip.2025.04.040_bib38","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.anai.2018.06.004","article-title":"Vitamin D insufficiency, T(H)2 cytokines, and allergy markers in Puerto Rican children with asthma","volume":"121","author":"Han","year":"2018","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.04.040_bib39","article-title":"Vitamin D for the management of asthma","volume":"2","author":"Williamson","year":"2023","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jaip.2025.04.040_bib40","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jaci.2025.01.012","article-title":"Is there a role for vitamin supplementation in pollutant-related childhood asthma?","volume":"155","author":"Joe","year":"2025","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.04.040_bib41","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jaip.2019.11.020","article-title":"Diagnosis and management of T2-high asthma","volume":"8","author":"Coverstone","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.04.040_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2022.106924","article-title":"Reduced bronchodilator reversibility correlates with non\u2013type 2 high asthma and future exacerbations: a prospective cohort study","volume":"200","author":"Liu","year":"2022","journal-title":"Respir Med"},{"key":"10.1016\/j.jaip.2025.04.040_bib43","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.anai.2021.05.027","article-title":"Treatment approaches for the patient with T2 low asthma","volume":"127","author":"Carr","year":"2021","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321982500409X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221321982500409X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:54:34Z","timestamp":1778853274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221321982500409X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S221321982500409X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2025.04.040","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence and Potential Risk Factors for T2-Low Asthma Among School-Aged Children in the National Health and Nutrition Examination Survey, 2007\u20132012","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2025.04.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}