{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:50:22Z","timestamp":1791528622872,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,10]],"date-time":"2026-12-10T00:00:00Z","timestamp":1796860800000},"content-version":"am","delay-in-days":374,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["4R00AI138586"],"award-info":[{"award-number":["4R00AI138586"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency","doi-asserted-by":"publisher","award":["J3-50099"],"award-info":[{"award-number":["J3-50099"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jaci-inpractice.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jaip.2025.10.018","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T17:11:29Z","timestamp":1761412289000},"page":"3180-3186","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Alpha-Tryptase Overexpression as a Modifier of Mast Cell\u2013Mediated Reactions"],"prefix":"10.1016","volume":"13","author":[{"given":"Peter","family":"Koro\u0161ec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gonz\u00e1lez-de-Olano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan J.","family":"Lyons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaip.2025.10.018_bib1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jaci.2021.08.007","article-title":"Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis","volume":"149","author":"Mateja","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib2","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.jaci.2006.02.026","article-title":"Tryptase genetics and anaphylaxis","volume":"117","author":"Caughey","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s11882-024-01136-y","article-title":"Alpha-tryptase as a risk-modifying factor for mast cell-mediated reactions","volume":"24","author":"Shin","year":"2024","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2025.10.018_bib4","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.jaci.2021.08.011","article-title":"On the complexities of tryptase genetics and impact on clinical phenotypes","volume":"148","author":"Lyons","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.anai.2021.12.008","article-title":"Hereditary alpha-tryptasemia despite normal tryptase-encoding gene copy number owing to copy number loss in trans","volume":"128","author":"Glover","year":"2022","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib6","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1182\/bloodadvances.2022007936","article-title":"Genetically defined individual reference ranges for tryptase limit unnecessary procedures and unmask myeloid neoplasms","volume":"7","author":"Chovanec","year":"2023","journal-title":"Blood Adv"},{"key":"10.1016\/j.jaip.2025.10.018_bib7","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.jaip.2022.05.003","article-title":"Incorporating tryptase genotyping into the workup and diagnosis of mast cell diseases and reactions","volume":"10","author":"Lyons","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.10.018_bib8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0022-2836(02)00625-3","article-title":"The crystal structure of human alpha1-tryptase reveals a blocked substrate-binding region","volume":"321","author":"Marquardt","year":"2002","journal-title":"J Mol Biol"},{"key":"10.1016\/j.jaip.2025.10.018_bib9","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1084\/jem.20190701","article-title":"Impact of naturally forming human alpha\/beta-tryptase heterotetramers in the pathogenesis of hereditary alpha-tryptasemia","volume":"216","author":"Le","year":"2019","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaip.2025.10.018_bib10","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jaci.2020.06.035","article-title":"Heritable risk for severe anaphylaxis associated with increased alpha-tryptase-encoding germline copy number at TPSAB1","volume":"147","author":"Lyons","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib11","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/ng.3696","article-title":"Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number","volume":"48","author":"Lyons","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaip.2025.10.018_bib12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1182\/blood.2020006157","article-title":"Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis","volume":"137","author":"Greiner","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2025.10.018_bib13","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaci.2021.02.043","article-title":"Routine KIT p.D816V screening identifies clonal mast cell disease in patients with Hymenoptera allergy regularly missed using baseline tryptase levels alone","volume":"148","author":"Selb","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib14","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1111\/all.16084","article-title":"High burden of clonal mast cell disorders and hereditary alpha-tryptasemia in patients who need Hymenoptera venom immunotherapy","volume":"79","author":"Korosec","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib15","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jaci.2022.09.038","article-title":"Disease correlates and clinical relevance of hereditary alpha-tryptasemia in patients with systemic mastocytosis","volume":"151","author":"Sordi","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib16","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/all.15911","article-title":"Clinical impact of the TPSAB1 genotype in mast cell diseases: a REMA study in a cohort of 959 individuals","volume":"79","author":"Gonzalez-de-Olano","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jaci.2023.08.015","article-title":"Pathophysiologic implications of elevated prevalence of hereditary alpha-tryptasemia in all mastocytosis subtypes","volume":"153","author":"Polivka","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib18","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1159\/000537958","article-title":"Emerging and novel elicitors of anaphylaxis: Collegium Internationale Allergologicum Update 2024","volume":"185","author":"Treudler","year":"2024","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib19","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/bjh.12916","article-title":"Epidemiology of systemic mastocytosis in Denmark","volume":"166","author":"Cohen","year":"2014","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaip.2025.10.018_bib20","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.3390\/cancers13246380","article-title":"A multidisciplinary diagnostic approach reveals a higher prevalence of indolent systemic mastocytosis: 15-years\u2019 experience of the GISM Network","volume":"13","author":"Zanotti","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.jaip.2025.10.018_bib21","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/all.13262","article-title":"EAACI guidelines on allergen immunotherapy: Hymenoptera venom allergy","volume":"73","author":"Sturm","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3109\/02770906609106941","article-title":"Diagnosis and treatment of insect sensitivity","volume":"3","author":"Mueller","year":"1966","journal-title":"J Asthma Res"},{"key":"10.1016\/j.jaip.2025.10.018_bib23","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0140-6736(77)91953-5","article-title":"Incidence and severity of anaphylactoid reactions to colloid volume substitutes","volume":"1","author":"Ring","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.jaip.2025.10.018_bib24","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.jaci.2013.11.039","article-title":"Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities","volume":"133","author":"Lyons","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib25","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s10875-018-0506-y","article-title":"First identification of an inherited TPSAB1 quintuplication in a patient with clonal mast cell disease","volume":"38","author":"Sabato","year":"2018","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib26","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1016\/j.jaip.2020.05.057","article-title":"Hereditary alpha-tryptasemia: UK prevalence and variability in disease expression","volume":"8","author":"Robey","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.10.018_bib27","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.anai.2021.01.016","article-title":"Hereditary alpha-tryptasemia in 101 patients with mast cell activation-related symptomatology including anaphylaxis","volume":"126","author":"Giannetti","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib28","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1046\/j.1365-2222.2003.01755.x","article-title":"Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy","volume":"33","author":"Haeberli","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib29","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jaci.2009.08.027","article-title":"Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase\u2014a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity","volume":"124","author":"Ru\u00ebff","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib30","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.jaci.2020.06.008","article-title":"Phenotype and risk factors of venom-induced anaphylaxis: a case-control study of the European Anaphylaxis Registry","volume":"147","author":"Francuzik","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib31","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.jaip.2023.04.016","article-title":"Venom anaphylaxis: decision points for a more aggressive workup","volume":"11","author":"Bonadonna","year":"2023","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.10.018_bib32","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.anai.2021.06.019","article-title":"Inherited and acquired determinants of serum tryptase levels in humans","volume":"127","author":"Lyons","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2019.100067","article-title":"Worldwide perspectives on venom allergy","volume":"12","author":"Koro\u0161ec","year":"2019","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.jaip.2025.10.018_bib34","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12016-021-08858-1","article-title":"Global view on ant venom allergy: from allergenic components to clinical management","volume":"62","author":"Wanandy","year":"2022","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5694\/j.1326-5377.2011.tb03209.x","article-title":"Causes of ant sting anaphylaxis in Australia: the Australian Ant Venom Allergy Study","volume":"195","author":"Brown","year":"2011","journal-title":"Med J Aust"},{"key":"10.1016\/j.jaip.2025.10.018_bib36","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1111\/cea.12987","article-title":"Factors influencing the quality of Myrmecia pilosula (Jack Jumper) ant venom for use in in vitro and in vivo diagnoses of allergen sensitization and in allergen immunotherapy","volume":"47","author":"Wanandy","year":"2017","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib37","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jaci.2021.04.013","article-title":"Prevalence of mastocytosis and Hymenoptera venom allergy in the United States","volume":"148","author":"Schuler","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib38","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.jaci.2012.10.015","article-title":"Prevalence of indolent systemic mastocytosis in a Dutch region","volume":"131","author":"van Doormaal","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib39","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1373\/clinchem.2017.277897","article-title":"Digital PCR: a sensitive and precise method for KIT D816V quantification in mastocytosis","volume":"64","author":"Greiner","year":"2018","journal-title":"Clin Chem"},{"key":"10.1016\/j.jaip.2025.10.018_bib40","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jmoldx.2010.10.004","article-title":"Improved detection of the KIT D816V mutation in patients with systemic mastocytosis using a quantitative and highly sensitive real-time qPCR assay","volume":"13","author":"Kristensen","year":"2011","journal-title":"J Mol Diagn"},{"key":"10.1016\/j.jaip.2025.10.018_bib41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1002\/ajh.23672","article-title":"Sensitive KIT analysis D816V mutation of blood as a diagnostic test in mastocytosis","volume":"89","author":"Kristensen","year":"2014","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jaip.2025.10.018_bib42","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.jaci.2022.03.029","article-title":"Advances in mast cell biology","volume":"149","author":"Boyce","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib43","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1111\/all.16132","article-title":"Prevalence of hypersensitivity reactions in various forms of mastocytosis: a pilot study of 2485 adult patients with mastocytosis collected in the ECNM registry","volume":"79","author":"Niedoszytko","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib44","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1111\/all.16185","article-title":"A high prevalence of hereditary alpha-tryptasemia in pediatric mastocytoma","volume":"79","author":"Madrange","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib45","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.iac.2018.04.003","article-title":"Hereditary alpha tryptasemia: genotyping and associated clinical features","volume":"38","author":"Lyons","year":"2018","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.jaip.2025.10.018_bib46","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000646","article-title":"Updated diagnostic criteria and classification of mast cell disorders: a consensus proposal","volume":"5","author":"Valent","year":"2021","journal-title":"Hemasphere"},{"key":"10.1016\/j.jaip.2025.10.018_bib47","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jaip.2025.10.018_bib48","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.jaip.2022.05.007","article-title":"Global classification of mast cell activation disorders: an ICD-10-CM-adjusted proposal of the ECNM-AIM Consortium","volume":"10","author":"Valent","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.10.018_bib49","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1016\/j.jaci.2020.11.017","article-title":"Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology","volume":"147","author":"Giannetti","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib50","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1097\/PAS.0000000000001676","article-title":"Distinct small intestine mast cell histologic changes in patients with hereditary alpha-tryptasemia and mast cell activation syndrome","volume":"45","author":"Hamilton","year":"2021","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.jaip.2025.10.018_bib51","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jaci.2021.04.004","article-title":"Small intestinal immunopathology and GI-associated antibody formation in hereditary alpha-tryptasemia","volume":"148","author":"Konnikova","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib52","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4049\/jimmunol.156.1.275","article-title":"Mast cell tryptase is a mitogen for epithelial cells. Stimulation of IL-8 production and intercellular adhesion molecule-1 expression","volume":"156","author":"Cairns","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11882-021-01010-1","article-title":"Hereditary alpha-tryptasemia: a commonly inherited modifier of anaphylaxis","volume":"21","author":"Wu","year":"2021","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaip.2025.10.018_bib54","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1398-9995.2007.01569.x","article-title":"Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients","volume":"63","author":"Brockow","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib55","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1365-2222.2007.02804.x","article-title":"Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA)","volume":"37","author":"Gonz\u00e1lez de Olano","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib56","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/cea.12225","article-title":"High prevalence of anaphylaxis in patients with systemic mastocytosis - a single-centre experience","volume":"44","author":"G\u00fclen","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib57","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.jaip.2017.02.008","article-title":"Risk factor analysis of anaphylactic reactions in patients with systemic mastocytosis","volume":"5","author":"G\u00fclen","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.10.018_bib58","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.aller.2014.05.002","article-title":"Clinical characteristics and risk profile of patients with elevated baseline serum tryptase","volume":"42","author":"Fellinger","year":"2014","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jaip.2025.10.018_bib59","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1710-1492-10-19","article-title":"Non-steroidal anti-inflammatory drug hypersensitivity: association with elevated basal serum tryptase?","volume":"10","author":"Seitz","year":"2014","journal-title":"Allergy Asthma Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib60","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.jaip.2025.04.013","article-title":"Hereditary alpha-tryptasemia is associated with anaphylaxis to antibiotics and monoclonal antibodies","volume":"13","author":"Korosec","year":"2025","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jaip.2025.10.018_bib61","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.jaci.2023.07.014","article-title":"Severe food allergy reactions are associated with alpha-tryptase","volume":"152","author":"Lang","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jaip.2025.10.018_bib62","article-title":"Case report: a family history of peanut allergy and hereditary alpha-tryptasemia","volume":"4","author":"Chantran","year":"2023","journal-title":"Front Allergy"},{"key":"10.1016\/j.jaip.2025.10.018_bib63","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1111\/all.16623","article-title":"Basal serum tryptase outperforms hereditary alpha tryptasemia as a biomarker of food allergy severity","volume":"80","author":"Loli-Ausejo","year":"2025","journal-title":"Allergy"}],"container-title":["The Journal of Allergy and Clinical Immunology: In Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219825009699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213219825009699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:08:00Z","timestamp":1778893680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213219825009699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":63,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2213219825009699"],"URL":"https:\/\/doi.org\/10.1016\/j.jaip.2025.10.018","relation":{},"ISSN":["2213-2198"],"issn-type":[{"value":"2213-2198","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alpha-Tryptase Overexpression as a Modifier of Mast Cell\u2013Mediated Reactions","name":"articletitle","label":"Article Title"},{"value":"The Journal of Allergy and Clinical Immunology: In Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaip.2025.10.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology","name":"copyright","label":"Copyright"}]}}